LOCUS       NM_024337               2080 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens iroquois homeobox 1 (IRX1), mRNA.
ACCESSION   NM_024337 XM_098320
VERSION     NM_024337.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Hartmann,S., Yasmeen,S., Jacobs,B.M., Denaxas,S., Pirmohamed,M.,
            Gamazon,E.R., Caulfield,M.J., Hemingway,H., Pietzner,M. and
            Langenberg,C.
  CONSRTM   Genes & Health Research Team
  TITLE     ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon
  JOURNAL   Nat Commun 14 (1), 6156 (2023)
   PUBMED   37828025
  REMARK    GeneRIF: ADRA2A and IRX1 are putative risk genes for Raynaud's
            phenomenon.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Sugur,H.S., Rao,S., Sravya,P., Athul Menon,K., Arivazhagan,A.,
            Mehta,B. and Santosh,V.
  TITLE     IRX1 is a novel gene, overexpressed in high-grade IDH-mutant
            astrocytomas
  JOURNAL   Pathol Res Pract 245, 154464 (2023)
   PUBMED   37116364
  REMARK    GeneRIF: IRX1 is a novel gene, overexpressed in high-grade
            IDH-mutant astrocytomas.
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Nagel,S., Pommerenke,C., Meyer,C. and MacLeod,R.A.F.
  TITLE     The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in
            Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5
            in Acute Myeloid Leukemia
  JOURNAL   Int J Mol Sci 23 (6), 3192 (2022)
   PUBMED   35328612
  REMARK    GeneRIF: The Hematopoietic TALE-Code Shows Normal Activity of IRX1
            in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and
            IRX5 in Acute Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Symeonidou,V. and Ottersbach,K.
  TITLE     HOXA9/IRX1 expression pattern defines two subgroups of infant
            MLL-AF4-driven acute lymphoblastic leukemia
  JOURNAL   Exp Hematol 93, 38-43 (2021)
   PUBMED   33069783
  REMARK    GeneRIF: HOXA9/IRX1 expression pattern defines two subgroups of
            infant MLL-AF4-driven acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Lee,J.Y., Lee,W.K., Park,J.Y. and Kim,D.S.
  TITLE     Prognostic value of Iroquois homeobox 1 methylation in non-small
            cell lung cancers
  JOURNAL   Genes Genomics 42 (5), 571-579 (2020)
   PUBMED   32200543
  REMARK    GeneRIF: Prognostic value of Iroquois homeobox 1 methylation in
            non-small cell lung cancers.
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Lam,C.Y., Tam,P.O., Fan,D.S., Fan,B.J., Wang,D.Y., Lee,C.W.,
            Pang,C.P. and Lam,D.S.
  TITLE     A genome-wide scan maps a novel high myopia locus to 5p15
  JOURNAL   Invest Ophthalmol Vis Sci 49 (9), 3768-3778 (2008)
   PUBMED   18421076
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Bennett,K.L., Karpenko,M., Lin,M.T., Claus,R., Arab,K.,
            Dyckhoff,G., Plinkert,P., Herpel,E., Smiraglia,D. and Plass,C.
  TITLE     Frequently methylated tumor suppressor genes in head and neck
            squamous cell carcinoma
  JOURNAL   Cancer Res 68 (12), 4494-4499 (2008)
   PUBMED   18559491
  REMARK    GeneRIF: Frequent methylation of IRX1 gene is associated with head
            and neck squamous cell carcinoma
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Ogura,K., Matsumoto,K., Kuroiwa,A., Isobe,T., Otoguro,T.,
            Jurecic,V., Baldini,A., Matsuda,Y. and Ogura,T.
  TITLE     Cloning and chromosome mapping of human and chicken Iroquois (IRX)
            genes
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 320-325 (2001)
   PUBMED   11435706
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Lewis,M.T., Ross,S., Strickland,P.A., Snyder,C.J. and Daniel,C.W.
  TITLE     Regulated expression patterns of IRX-2, an Iroquois-class homeobox
            gene, in the human breast
  JOURNAL   Cell Tissue Res 296 (3), 549-554 (1999)
   PUBMED   10370142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016595.4, AY335938.1 and BC029160.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024337.3.
            
            Summary: This gene encodes a member of the Iroquois homeobox
            protein family. Homeobox genes in this family are involved in
            pattern formation in the embryo. The gene product has been
            identified as a tumor suppressor in gastric (PMID: 21602894,
            20440264) and head and neck cancers (PMID: 18559491). A pseudogene
            of this gene is located on chromosome 13. [provided by RefSeq, Dec
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY335938.1, BC029160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302006.4/ ENSP00000305244.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC016595.4         41008-41229         c
            223-520             AY335938.1         1-298
            521-2080            BC029160.1         1-1560
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2080
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /note="iroquois homeobox 1"
                     /db_xref="GeneID:79192"
                     /db_xref="HGNC:HGNC:14358"
                     /db_xref="MIM:606197"
     exon            1..550
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1717
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /note="iroquois homeobox protein 1; homeodomain protein
                     IRXA1"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-1"
                     /protein_id="NP_077313.3"
                     /db_xref="CCDS:CCDS34132.1"
                     /db_xref="GeneID:79192"
                     /db_xref="HGNC:HGNC:14358"
                     /db_xref="MIM:606197"
                     /translation="MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPG
                     AAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNP
                     GVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEK
                     IMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAE
                     DDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLK
                     PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASP
                     PPPAGHPGAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFL
                     GVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQ
                     QLKSPFQPVRDNSLAPQEGTPRILAALPSA"
     exon            551..1586
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1659
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2080
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="IRX1"
                     /gene_synonym="IRX-5; IRXA1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtctgaaa gccccgccgc cgagcggagg gcggccgccg cagtcggcgc gcgattgcgg
       61 atccgggcgc agccgggagc cgggcgcctg cgagcaccgg gcagaggagc cgcgaccggc
      121 ctccatctcc cggcccgccc gagcgcgccc ggccggccgc ccgctcctcc ctagacccct
      181 cgcggcgccc cctgcaaccc cctccggccg gcctccgcct ccctccccgc gcctttaata
      241 ctcgcccgct gcggcggtcg ccgagtccgc ggacatgtcc ttcccgcagc tgggctaccc
      301 gcagtacctg agcgccgcgg ggccgggcgc ctacggcggc gagcgcccgg gggtgctggc
      361 cgcggccgct gcggcggctg ccgccgcctc gtcgggccga ccgggggccg cggagctggg
      421 cggcggggca ggcgcggctg cagtcacctc ggtgctgggc atgtacgcgg cggcggggcc
      481 gtacgcgggc gcgcccaact acagcgcctt cctgccctac gccgcggatc tcagcctctt
      541 ctcgcagatg ggctcgcagt atgaactgaa ggacaaccct ggggtgcacc ccgccacctt
      601 cgcagcccac acggcgccgg cttattaccc ctacggccag ttccaatacg gggaccccgg
      661 gcggcccaag aacgccaccc gcgagagcac cagcacgctc aaggcctggc tcaacgagca
      721 ccgcaagaat ccctacccca ccaagggcga gaagatcatg ctggccatca tcaccaagat
      781 gaccctcacg caggtctcca cctggttcgc caacgcgcgc cggcgcctca agaaggagaa
      841 caaggtgaca tggggagcgc gcagcaagga ccaggaagat ggagcgctct tcggcagcga
      901 caccgagggc gacccggaga aggccgagga cgacgaggag atcgacctgg aaagcatcga
      961 cattgacaag atcgacgagc acgatggcga ccagagcaac gaggatgacg aggacaaggc
     1021 cgaggctccg cacgcgcccg cagccccttc tgctcttgcc cgggaccaag gctcgccgct
     1081 ggcagcagcc gacgttctca agccccagga ctcgcccttg ggcctggcaa aggaggcccc
     1141 agagccgggc agcacgcgcc tgctgagccc cggcgctgca gcgggcggcc tgcagggtgc
     1201 gccgcacggc aagcccaaga tctggtcgct ggcggagaca gccacgagcc ccgacggtgc
     1261 gcccaaggct tcgccaccac cacccgcggg ccaccccggc gcgcacgggc cctccgccgg
     1321 ggcgccgctg caacaccccg ccttcctgcc tagccacgga ctgtacacct gccacatcgg
     1381 caagttctcc aactggacca acagcgcatt cctcgcacag ggctccctgc tcaacatgcg
     1441 ctccttcctg ggcgttggcg ctccccacgc cgcgccccat ggccctcacc ttcctgcacc
     1501 tccaccaccg cagccgccgg tcgctattgc cccgggggca ctcaatggag acaaggcctc
     1561 ggtccgcagc agccccacgc tcccagagag agacctcgtc cccaggccag attcgccggc
     1621 acagcagtta aagtcgccct tccagccggt acgcgacaac tctctggccc cgcaggaggg
     1681 aacgccgcgg atcctagcag ccctcccgtc cgcctgatta agggtcttct tttacttttg
     1741 cgggggggag gggggaggag ttggggaggg agggaatgtg ggaggaatta agacaaatat
     1801 ttcagactgg tgtaaaggac aaatatgaca acgacgtcaa ggactcgcat ccgtcgcttt
     1861 ctgcagaaag gggcttcttc ggtcccgagc tcgcgtccag gtggccaggc ctctgccggc
     1921 ggctccagtg gctgcgatta tcgggttcgg taaatgcccc cacgtgcttg tgtctctttc
     1981 cccccttttc tgtatataga gtggtttcag attgtaaata gcgcgtcagc gaacttgtct
     2041 aaatcatata tttttgtcta ataaactaaa tgaaatgaca
//
