LOCUS       NM_001007561            9686 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens immunity related GTPase Q (IRGQ), mRNA.
ACCESSION   NM_001007561 XM_065026
VERSION     NM_001007561.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9686)
  AUTHORS   Herhaus,L., Gestal-Mato,U., Eapen,V.V., Macinkovic,I., Bailey,H.J.,
            Prieto-Garcia,C., Misra,M., Jacomin,A.C., Ammanath,A.V.,
            Bagaric,I., Michaelis,J., Vollrath,J., Bhaskara,R.M., Bundgen,G.,
            Covarrubias-Pinto,A., Husnjak,K., Zoller,J., Gikandi,A.,
            Ribicic,S., Bopp,T., van der Heden van Noort,G.J., Langer,J.D.,
            Weigert,A., Harper,J.W., Mancias,J.D. and Dikic,I.
  TITLE     IRGQ-mediated autophagy in MHC class I quality control promotes
            tumor immune evasion
  JOURNAL   Cell 187 (25), 7285-7302 (2024)
   PUBMED   39481378
REFERENCE   2  (bases 1 to 9686)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   3  (bases 1 to 9686)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9686)
  AUTHORS   Bekpen,C., Hunn,J.P., Rohde,C., Parvanova,I., Guethlein,L.,
            Dunn,D.M., Glowalla,E., Leptin,M. and Howard,J.C.
  TITLE     The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of
            the cell autonomous resistance mechanism in the human lineage
  JOURNAL   Genome Biol 6 (11), R92 (2005)
   PUBMED   16277747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN315405.1, BC137020.1, AC006276.1 and BM669904.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001007561.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2504402.1,
                                           SRR11853564.14507.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422989.6/ ENSP00000387535.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               CN315405.1         4-566
            564-2092            BC137020.1         527-2055
            2093-9187           AC006276.1         6082-13176          c
            9188-9686           BM669904.1         17-515              c
FEATURES             Location/Qualifiers
     source          1..9686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..9686
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="immunity related GTPase Q"
                     /db_xref="GeneID:126298"
                     /db_xref="HGNC:HGNC:24868"
                     /db_xref="MIM:621081"
     exon            1..153
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..685
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2027
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="immunity-related GTPase family, Q1"
                     /codon_start=1
                     /product="immunity-related GTPase family Q protein"
                     /protein_id="NP_001007562.1"
                     /db_xref="CCDS:CCDS33040.1"
                     /db_xref="GeneID:126298"
                     /db_xref="HGNC:HGNC:24868"
                     /db_xref="MIM:621081"
                     /translation="MPPPQGDVTALFLGPPGLGKSALIAALCDKDVETLEAPEGRPDS
                     GVPSLRAAGPGLFLGELSCPPAAPGPWAAEANVLVLVLPGPEGNGEPLAPALGEAALA
                     ALARGTPLLAVRNLRPGDSQTAAQARDQTAALLNSAGLGAADLFVLPANCGSSDGCEE
                     LERLRAALQSQAEALRRLLPPAQDGFEVLGAAELEAVREAFETGGLEAALSWVRSGLE
                     RLGSARLDLAVAGKADVGLVVDMLLGLDPGDPGAAPASVPTAPTPFPAPERPNVVLWT
                     VPLGHTGTATTAAAASHPTHYDALILVTPGAPTEKDWAQVQALLLPDAPLVCVRTDGE
                     GEDPECLGEGKMENPKGESLKNAGGGGLENALSKGREKCSAGSQKAGSGEGPGKAGSE
                     GLQQVVGMKKSGGGDSERAAALSPEDETWEVLEEAPPPVFPLRPGGLPGLCEWLRRAL
                     PPAQAGALLLALPPASPSAARTKAAALRAGAWRPALLASLAAAAAPLPGLGWACDVAL
                     LRGQLAEWRRGLGLEPTALARRERALGLASGELAARAHFPGPVTRAEVEARLGAWAGE
                     GTAGGAALGALSFLWPAGGAAATGGLGYRAAHGVLLQALDEMRADAEAVLAPPEPAQ"
     exon            686..9686
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8095..8100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="hexamer: AATAAA"
     polyA_site      8117
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="major polyA site"
     regulatory      9662..9667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="hexamer: AATAAA"
     regulatory      9667..9672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
                     /note="hexamer: AATGAA"
     polyA_site      9682
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
     polyA_site      9686
                     /gene="IRGQ"
                     /gene_synonym="FKSG27; IRGQ1"
ORIGIN      
        1 aggttaaagc taccgggacg ggtcccggca tctctaaatc accgctccct ggcctcttcg
       61 gcctccgtcc gccgcggccc aggggccggg cttctcagct gctgacctac tgccaccgac
      121 tgcgctctct cccgtgggtc ggctttttgc tcgccatgcc tccgccgcag ggtgacgtga
      181 ccgccttgtt cctggggcct ccgggcttgg ggaagtccgc gctgatcgca gcgctgtgcg
      241 acaaggatgt ggagacgctc gaggcccccg agggacggcc ggactccggg gttcccagcc
      301 taagagctgc gggcccaggc ctttttctgg gcgagctgag ctgcccaccc gcagcgccgg
      361 ggccctgggc ggcggaagcc aacgtgctgg tactggtgct gcccggaccc gaggggaacg
      421 gggaaccgtt ggctccagcc ctgggagagg cagcgctggc cgccctggcc cgagggaccc
      481 cgctactggc tgtgcggaac ctccgtcctg gggattcaca gactgccgcc caggcccgtg
      541 atcagacagc agctctgctg aacagcgcgg ggttaggagc tgcggatctg tttgtgctac
      601 cggcgaactg cggcagcagc gacggctgcg aggagctaga gcgcctccgg gcggcgctgc
      661 agagccaggc agaagcgctg cggaggctcc tgccaccggc gcaggatggc ttcgaggtgt
      721 tgggtgcagc agagctagag gctgtgcgtg aggcctttga gaccggcggc cttgaggctg
      781 cgctgtcgtg ggtgcgctca ggcctggagc gcctgggcag cgcacggcta gacctggccg
      841 tggctggcaa ggctgacgtg ggccttgtgg tggacatgct gcttggattg gatcctggcg
      901 acccaggcgc tgcgcctgct tcggtcccca cagcacccac tcccttccca gccccagagc
      961 gcccgaatgt ggtgctctgg accgtgcctc tgggccacac gggcactgcc accaccgcgg
     1021 ccgccgcctc tcacccaacg cactacgacg ccctcatcct cgtcacccct ggggccccca
     1081 ctgagaagga ctgggcccag gtccaggcct tgctgctacc agatgcgcct cttgtctgcg
     1141 tgcgcacaga cggcgagggc gaggatccgg agtgtctggg agaaggcaag atggagaatc
     1201 ccaagggcga gagcttaaag aacgcaggtg gagggggatt ggagaatgca ctcagtaagg
     1261 gaagggagaa atgtagcgct ggatcgcaga aagcaggcag cggggaaggt cctgggaaag
     1321 ctggcagcga gggtttgcag caggttgtcg gcatgaagaa atcaggtggt ggcgactcag
     1381 agcgggccgc tgcgttaagc ccggaggacg agacgtggga ggtgctggag gaggcgccgc
     1441 cgccagtgtt ccccctacgg cctggcggac tcccagggct atgcgaatgg ctgcggcgag
     1501 cgctcccccc agcccaggca ggggcactgc tgctggcgtt gccaccagca tctcccagcg
     1561 ctgcccgaac caaggctgcg gcgttgcgag ccggggcgtg gaggccagct ctgctggcta
     1621 gtctggcggc ggcggcggca ccactcccag ggctgggctg ggcatgcgac gtggcacttc
     1681 tgcggggtca gctggcggag tggcgacggg gcctggggct ggaacccacg gcactggctc
     1741 gacgtgagcg tgccctgggc ctggcttctg gagagctggc agcgcgcgct catttcccag
     1801 gcccggtgac gcgcgccgag gtggaagcaa gactgggcgc ctgggcgggc gagggcactg
     1861 ctgggggcgc agcactgggg gctctctcct tcctgtggcc tgcgggtggt gcagcggcga
     1921 caggtggcct gggctaccga gcggctcacg gcgtcctgct gcaggctctc gatgagatgc
     1981 gggctgatgc tgaggctgtg ctggcacccc ctgagcctgc ccagtgagga gtgggagggg
     2041 gcttgggagt ccagactctg acaggggatg cctgggctta atcctgggtg cttgaagggg
     2101 atgtggactc ttgacttcca gctgggatgt gtgacttctt atcacctgga ttcagagagt
     2161 ctgggggaca ggaatcctga tttttttttt tttttttctt ttttttgtga gacgaagtct
     2221 cttgttgccc aggctggagt gcaatggcgc gacctcggct cactgcaacc tccgcctccc
     2281 gggttcaagc gattctcctg cctcagcgtc cggagtagct gggattacag gtgcctgcca
     2341 ccacacctgg ctaatttttg tatttttagt agagacgggg tttcaccatg ttggccaggc
     2401 tggcctcgaa ctcctgacct caggcgatcg acccgctccg gcctcccaaa gtgctaggat
     2461 tacaggcgtg agccaccgcc cctggccagg aatcctgata cctttgggaa ccatggtgaa
     2521 tgacatctag acccttctgt cctgaaggga gttggtggcc cagactctag cagggactat
     2581 gtctttgtct cctagggagt agaaactgga gttactggat gtttagtcct ccagggaggc
     2641 tggtagaagt cctgtttcct aattggtggg gaggtgtcca tgactgggac ctgaactcca
     2701 gtatagggga gggagacctg agcgccccag ggagctggaa ctcttgggct tcagagcctc
     2761 agagggaaac agggtctaca tttctctggg agaaaaagcc tgcacacagg tccccaagga
     2821 gcagtgggct ttgaatcttg atggggtggc ggaggcccct ggggtctgag acttccgggg
     2881 ttctaagatg gctgtggacc ttggttccta aatattgggt aaggggaggt ctgcatctgg
     2941 aggagggatc gggggcttgt gcgagaaagc tggagacttc ttgatctctc ctggggagtg
     3001 gatgggtttc tataattgcc ctccaaaagc atgtagggag ggtggtccca caaaaatgag
     3061 gtgaggtggg taagaggtct gggcatggtg ggctctggga gtagccaggg accaggaatg
     3121 aggtcttttg ggtgtggaag ggcagtaaag catacctcag agacagctcc tccaaacctt
     3181 gtattgggat cccggcaact gcctctgtga gtgtgactgg gaagggatat gactgccttc
     3241 atcttctagg tgctgagcaa ttcaggtgat ctctggggag tctgtttctc tgtctctttt
     3301 ctttaggagt ttctatcttt ttttggcctt tttctcctgg tatttaacca taacccttta
     3361 tggccttggt gttttgtgca ccttcctttt cagaagagca gctgtactgc tgcactggtc
     3421 caaacacttc tgtatggaca cctcgggtat ccccaagagg ctctgctttc tgatgtacat
     3481 agagggtgct gcattgagcc aggggcccac caaatgggtg gtcaggcact tgagaccatg
     3541 ggaatatgcc aggagtgaat gaagcaaagg cagaaaccac agtgcctgga atgttctagg
     3601 ctgctagcca catgtggggg aaaagttgca ggttacagaa ttcttcagtg tcaaaaacag
     3661 aaaaggagga tctgagaatc caagcgatag aatccctttt gtcgtagaca gaaagagcaa
     3721 agtccagaga gggcaggctt gaggcccaac agcacacagt aaggccctgt gggtctggcc
     3781 cttgcctatt ctcattcact gccccttccc actcctgtcc agcctgatag actttccttc
     3841 tttttttttt tgaaatggag tctcaccttg tcacccagtc tggagtacag ggatgtgatg
     3901 actgtagctg agatgacagg catgtgccac cacacctggc taatttttgt agtttagtag
     3961 agaagggatt tcaccctgtt ggtcaggctg gtctcgaact cctgacctca ggtgatccac
     4021 ccgactcaga ctcccaaagt gctgggatta caggtgtgag ccatcatggc cgcctgactc
     4081 tttctgatgc ctgagtggct accttgagtc ctgcctgggg acccatgcac ctgctgttct
     4141 ctttccttca aggctctact cacaacttcc tgttctactc tcaaaccttc ctgtgacggg
     4201 ctcagtcaga tctcagctca cgtatcccct cagagaggac ttcccctccc tgaccaccct
     4261 atctgaagta gctcacattc ccccactatt catttcggcc agttgagttt ccttgtagca
     4321 attattactg tcaaaaatga tcttatttat ttacctgttt attggctttt gacccgttgc
     4381 ctgtcctgtt ctctgttgtt tccccagcat ctagaacaat aggtgcctga cacaataggt
     4441 gcttcgtaaa tatttattat tattattatt attttagaga cagggtcttg ctctgttgcc
     4501 ccggctggaa tacagtggga tgatcatggc tcactgccat ctccaactcc tgggctcaaa
     4561 cgatcctccc acctccgcct acagagtagc tgggactata ggtacacagc accaaatttt
     4621 ctgtagagac gggggtcttg ctttgtagcc cacactagtg ttgaactcct ggcctcaagt
     4681 gatcctcctg ccttgatggg attacaggtg tgagccacca cacccagcct aaatgtttat
     4741 ttcattggtc agtgtcagaa ctaggattgg aatttagatt gttaatctct tgccacaaga
     4801 taggaaaatg gagcaagatg aggagaaaaa agcatttaat gggagagaac acccttgtct
     4861 gaggtcaggg acctgggaag caagcacgac tttgccactg tcactgtgtg ttacttggac
     4921 agtgccttat tttcccatct gtgaaataaa agagctggat aagaacctta gttttgagat
     4981 cctgtctccc ttaaaagctg aagacaaagg taactgatcc aagggcagac aagggatggt
     5041 accatcatct ccagcttgga ctcccactgc tgacaaaatt tgtcccttca aagttgagat
     5101 agctaccatg gggaagagca cttagttcta tactgaatgg ctccaggcat tttcatgaaa
     5161 gctctttcag ctttggggaa gaatattcat ccatatcttt accccatcat attagtgtct
     5221 aagccctgca atcaggcatg tcagccacgt gatggaatgg gagggctgca gggcagcact
     5281 gtccagtaga aacgaaatgc aagccacata tgtcatttta agttttcttt ttttgagatg
     5341 gagtttcact ccatcaccca ggctggagtg cagtggcacg atctcgcctc actgcaacct
     5401 ccgcctccca ggttcatgtg attctcctgc ctcagcctcc tgagtagctg ggattacagg
     5461 catatgccac catgcctggc taatttttgt atttttagta gagatggggt ttcaccatgt
     5521 tgatcaggct ggtctggaac tactgacctc aggccacccg ccttggcctc ccaaagtgct
     5581 gggattacag gcatgagcca ccgcgcccag ctaatttttg tatttttatt ttatttattt
     5641 atttattttt tgggagacgg agtcttgctc tgtcacccag gctggagtgc agttgtgcga
     5701 tcttggctca ctgcaacctc agcctcccaa gtagctggga ttacaggcat gcaccatcat
     5761 gcccagctaa tttttgtatt tttagtagag atggggtttc actgtgttgg ccaggctggt
     5821 cttgaactcc tgacctcagg tgatccaccg gcctcagcct cccaaagtgc tgggattata
     5881 ggcgtgagcc actgcacccg tcctaatttt tgtattttta gtagagatgg ggtttcacca
     5941 tgttggctaa gctggtctgg aactcatggc ctcaagttat ctgcccacct cagcctccca
     6001 aagtgctgag taagccaagt tttctaatag ccacattaga caagtaaaag gaaacaggtt
     6061 aaattcattt taacatgttt tacttaaccc aatgtatcca aaatagcatt tcaacatgtc
     6121 atcggttttt tagttttttt tttttttgag atagtgcttc gctttgttgc ccaggctgga
     6181 gtgcagtggc acaatctcgg ctcactgcaa cctccacctt ccaggttcaa gtgattctcc
     6241 tgcctcagcc tcccgagtag ctgggattac aggcacccgc caccatgccc actaattttt
     6301 gtatttttgg ttagagatgg ggtttcgcca tgttggccag gctagtctca aactcctgac
     6361 ctcaggtgat ccacccacct cggcctccca aagtgctagg attacaggcg tgaggcaccg
     6421 tgcctggcgt catcggtatt atttaaatga attatgttac gttcttttgt gctgtcttca
     6481 aaatctgtta tatattttac acttacacca aatctcaatt accatggtac atttttatct
     6541 gaaatgcttg acctttattt tgatttcata aaattcatag ttggagaagt agattcacat
     6601 atccaagttg ttccaattat ataatagttt tccaaaaact gagatgggtg tccatttttt
     6661 ttttaagtaa agatgcaggt ctggttatgt tgaccaagtt gctgggttgt tttgttttgt
     6721 tttgagacag agtctcactt tgtcacccag gctggagtgc agtggcatga cctcagctca
     6781 ctgcaacctc tgcctcccag gttcaactga ttctcttgca tcatcctcct gagtagctgg
     6841 gactacaggt gtatgccacc atgcctggct aattttggta tttttctcag agacggggtt
     6901 tcaccatgtt gggcatgctg gtcttgaact gctgacctca ggtgatccgc ccacctcggc
     6961 ctcccaaagt gctggtatta caggcatggg ccaccacacc tggcctcagc tgttcaatta
     7021 aaagtaaata caacttaaaa ttctatgttt cattggcagt agtgcaacat taatactgag
     7081 tagccacatg tgattagtgg ctatggtatt ggacagggaa ggtacagaat acttccatca
     7141 acatagaaaa ttctatcagt ctagctctag gggcagatag tccttccact gacttgggca
     7201 agtcactcta caaatggcat ctacctcaca tggttatggt gagaattcag cgtatgtatg
     7261 tacatgcagg cacacaatat gcacacagac acataacata gtacaccctt tcctgaaaag
     7321 cctgacacat ggagctcaaa catgagtgcc acccacccct gggcagcacc aagatggctc
     7381 tagtctgggt gcctttgtct cacccccatg cctttgctcg gagtgtgctc ctcatttttc
     7441 tgccactttg accctgtctc tgatttggtc ctgtctgaca tcactgctat atgctttgct
     7501 cctctcaatt tcctctgccc tcatgccagc aggagtcatg ccagagatca tatctgagaa
     7561 agcaagacaa ttttgtgtgt gtgtctgtgc ccatagagga gtgctggttg tgttgatata
     7621 gttgtagatt ggttgtgttt acacagttgt atatattgac acccttgagt gttatgactt
     7681 cttttggggg tggtcgcctt ttaaatcata acttttaatg ggattccatt ttagtctttg
     7741 tgaagacata aggttgttgg caggcatctg tccctgggag catccaagca gaaaagacta
     7801 agactccctt gtagacagat cactggccgc cactgaagtg tgtctgcatg gcaccacagg
     7861 gctggaagac ccttgaaggc aggaattcaa ggaaatgtat gatgaatttt ggcattgcca
     7921 tcaaaagcag aacaggcatg gaaaacttgg gtgagtgggc gagacaacct cctcaccaca
     7981 gcagagttcc atccatgcct ggataatgat ggagggattt gtgtccactg cagtggggaa
     8041 ccatgaagga cacatcaagg gtgtggttgg cctgtggtgc tctttggagg aatgaataaa
     8101 aatgaataga aatcctattg cgtgtctgtt cttttggagt ttgagggaaa agaaagatcc
     8161 ttgagatttt gactgggctg gaaacctaga ctccagcgtc tggggatagg agggatggtg
     8221 gggaatccgc tgggaaaaac tgggctgtga tcaagagaat ttatcagtat ctgagttttt
     8281 ccaccctgga aggagtgcgg gcagacttac tgtttaaaca ttgggagctt atgatggtaa
     8341 agcgccttag ttctggagcc aggtataccc attaatgacc ccaactgggc cagcctttct
     8401 gtagccatgc ccttggattg ttgctctcct tctaggtttg actatgtggt ttgcttcagc
     8461 cactagaaca atagcaaaca tgatacaagc agaggcttgg aaagtgctta tgcggccggg
     8521 tgtggtggct cacacctata atcccagcac tttgggaggc cagggcgggc agatcacaag
     8581 gtcaggagat cgagaccatc ctggctaaca cagtgaaacc ccgtctctct actaaaaata
     8641 caaaaaatta gctgggtgtg gtggtgcaca cctgtagtcc cagctactcg ggaggctgag
     8701 gcaggagaat agcttgaacc tgggaggcgg aggttgtagt gagctgagac tgcgccgctg
     8761 cactccagcc tgggcaacag agcgagactt ctctcaaaaa aaaaaaacca aagtgcttat
     8821 gcactgggac ttcctctctt gctccccttg ggacccctac caccactgcc acatccaaac
     8881 cccgggctgg ctgagcatgg tggcatatgg gtataaaccc ataatcccag cacttaggga
     8941 ggcaaaggtg gaagaatttc atgagcccag gagatcgaga ctagcctgag caacatggca
     9001 agacccccat ctctacaaaa aagcaacaac aacagaatta gccagatgtg gtggtgtgca
     9061 cctgtggtcc caactacatg ggggaggctg aggcaagtgg attgtttgag cccaggaagt
     9121 cgaggctgaa gtgagctatg atggctccac tgcactccag cctgggtgac agagcaagac
     9181 aatgtctaaa aaaataaaaa gaaggaaaga aaaggaaaag atctgggcta acctgctggg
     9241 taataaaggg aaaagagaca catggctccg tcatccttga tccctgccac ccatagccaa
     9301 ccaacctctg aaacagagct ccctagctga taggcagctg aacccagctg agaccagcaa
     9361 aagaactgcc cagctgatcc cagaccaagt tgcaacccag agaatcatta actaaatagg
     9421 tgattgttct aaaccactaa attttggagt ggtttgttat gtagcaaaag caactaatac
     9481 agacttgttc tctctgtgtg tgatgtggtc tctttctccc caacaacatg acccaatgat
     9541 taaaatctta aattctgcca ctttttagct gtgtgactgc caatgtgaca gccttctgag
     9601 cctctgatgt ctcctgaaaa cagagatgtg aataatagtg cctatgacat agagttgtga
     9661 aaataaaatg aaaaacagct tcttaa
//
