LOCUS       NM_019612               1596 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunity related GTPase cinema (IRGC), mRNA.
ACCESSION   NM_019612
VERSION     NM_019612.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Li,J., Xu,X., Liu,J., Zhang,S., Wang,T., Liu,Y. and Wang,Z.
  TITLE     The immunity-related GTPase IRGC mediates interaction between lipid
            droplets and mitochondria to facilitate sperm motility
  JOURNAL   FEBS Lett 597 (12), 1595-1605 (2023)
   PUBMED   37195149
  REMARK    GeneRIF: The immunity-related GTPase IRGC mediates interaction
            between lipid droplets and mitochondria to facilitate sperm
            motility.
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Bekpen,C., Xavier,R.J. and Eichler,E.E.
  TITLE     Human IRGM gene 'to be or not to be'
  JOURNAL   Semin Immunopathol 32 (4), 437-444 (2010)
   PUBMED   20737271
  REMARK    Review article
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC033853.1 and BC066939.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019612.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066939.1, SRR5189667.230285.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244314.6/ ENSP00000244314.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC033853.1         15-24
            11-1596             BC066939.1         1-1586
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1596
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /note="immunity related GTPase cinema"
                     /db_xref="GeneID:56269"
                     /db_xref="HGNC:HGNC:28835"
                     /db_xref="MIM:620634"
     exon            1..67
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..1596
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1525
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /note="immunity-related GTPase family, cinema 1;
                     immunity-related GTPase cinema 1;
                     interferon-gamma-inducible GTPase IFGGE protein"
                     /codon_start=1
                     /product="interferon-inducible GTPase 5"
                     /protein_id="NP_062558.1"
                     /db_xref="CCDS:CCDS12629.1"
                     /db_xref="GeneID:56269"
                     /db_xref="HGNC:HGNC:28835"
                     /db_xref="MIM:620634"
                     /translation="MATSKLPVVPGEEENTILMAKERLEALRTAFESGDLPQAASHLQ
                     ELLASTESIRLEVGVTGESGAGKSSLINALRGLEAEDPGAALTGVMETTMQPSPYPHP
                     QFPDVTLWDLPGAGSPGCPADKYLKQVDFSRYDFFLLVSPRRCGAVETRLAAEILCQG
                     KKFYFVRTKVDEDLAATRTQRPSGFREAAVLQEIRDHCAERLREAGVADPRIFLVSNL
                     SPARYDFPTLVSTWEHDLPSHRRHAGLLSLPDISLEALQKKKAMLQEQVLKTALVLGV
                     IQALPVPGLAAAYDDALLIHSLRGYHRSFGLDDDSLAKLAEQVGKQAGDLRSVIRSPL
                     ANEVSPETVLRLYSQSSDGAMRVARAFERGIPVFGTLVAGGISFGAVYTMLQGCLNEM
                     AEDAQRVRIKALEDDEPQPEVSLEVASDNGVEKGGSGEGGGEEAPLSTCRKLGLLLKY
                     ILDSWKKHDSEEK"
     regulatory      1570..1575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /note="hexamer: AACAAA"
     polyA_site      1596
                     /gene="IRGC"
                     /gene_synonym="CINEMA; IFGGE; Iigp5; IRGC1; R30953_1"
                     /note="major polyA site"
ORIGIN      
        1 ggctaagagg gaaggagatc ctatcagtgg ggagagtgtg aggggagagg gagagcctgc
       61 agggcaggcg ctgaggatca cgcatcctgt gactctcccc tgtcccccgc caccctctga
      121 accactggcc accatggcta cttcaaagtt gcccgtggtg cctggggagg aggaaaacac
      181 catccttatg gccaaggaaa ggctggaggc cctgcgcaca gcctttgagt cgggtgacct
      241 cccccaggcc gcctctcacc tccaggagct gctggcctcc acggaaagca tccgcctgga
      301 ggtgggcgtc acgggcgagt cgggcgcggg caagtcctcc ctcatcaatg ccctgcgtgg
      361 cctggaggcc gaggaccctg gcgcggctct cacgggcgtc atggagacca cgatgcaacc
      421 gtcgccctat ccacacccac agttccctga cgtgaccctc tgggacctgc caggagccgg
      481 ctctccaggc tgcccggctg acaagtacct aaagcaggta gacttcagcc gctatgactt
      541 cttcctgctg gtctcccccc gccgctgcgg ggccgtcgag acccgcctgg ccgctgagat
      601 cctgtgccag ggcaagaagt tctactttgt gcgcaccaag gtggacgagg acctggcggc
      661 cacgcgcacc cagcggccgt cgggcttcag agaggccgct gtcctgcagg agatccgaga
      721 ccactgtgcc gagcggctgc gggaggccgg cgtggctgac cctcgcatct tcctggtgtc
      781 caacctctcg ccggcccgct acgactttcc cacgctggtg tccacctggg agcacgacct
      841 gccctcccac cggcgccacg ctggcctgct gtcgctcccc gacatctcgc tggaggcctt
      901 gcagaagaag aaggccatgc ttcaagagca agtcctcaag accgccctgg tgttgggcgt
      961 catccaggcc ctgccggtcc cagggctggc ggccgcctac gatgatgcgt tgctcatcca
     1021 ctcactgcgt ggctaccacc gcagctttgg tctggacgac gactcgctgg ccaagctggc
     1081 cgagcaggtg ggcaaacagg caggtgacct gcgctcggtc atccgctccc cactggccaa
     1141 cgaggtctcg cctgagactg tcctgcggct ctattcccag tcgtccgacg gcgccatgcg
     1201 ggtggcccgc gcctttgaga ggggcatccc tgtgtttggg acgctggtgg ctggcggcat
     1261 cagctttggc gctgtctaca ccatgctcca gggctgcctc aacgagatgg ctgaggacgc
     1321 ccagcgtgtc cgcatcaagg ccctggagga tgacgagccg cagccggagg tcagcttgga
     1381 agtggccagt gacaatggcg tggaaaaggg gggctccggg gagggaggtg gggaggaagc
     1441 cccactctca acctgcagga agctcggcct ccttcttaag tacattctgg acagctggaa
     1501 gaaacacgac tcagaagaga aataaagagt gcagccccgc ccccctgcct cacccacaaa
     1561 ctaagtctta acaaaatcca aattaccaac aaaaaa
//
