LOCUS       NM_006084               1626 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interferon regulatory factor 9 (IRF9), transcript
            variant 2, mRNA.
ACCESSION   NM_006084
VERSION     NM_006084.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Ritter,J., Szelinski,F., Aue,A., Stefanski,A.L., Rincon-Arevalo,H.,
            Chen,Y., Nitschke,E., Dang,V.D., Wiedemann,A., Schrezenmeier,E.,
            Lino,A.C. and Dorner,T.
  TITLE     Elevated unphosphorylated STAT1 and IRF9 in T and B cells of
            primary sjogren's syndrome: Novel biomarkers for disease activity
            and subsets
  JOURNAL   J Autoimmun 147, 103243 (2024)
   PUBMED   38788537
  REMARK    GeneRIF: Elevated unphosphorylated STAT1 and IRF9 in T and B cells
            of primary sjogren's syndrome: Novel biomarkers for disease
            activity and subsets.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Calvo-Apalategi,A., Nevado,M.L., Bravo-Gallego,L.Y.,
            Gonzalez-Granado,L.I., Allende,L.M., Pena,R.R., Lopez-Granados,E.
            and Reyburn,H.T.
  TITLE     The lack of either IRF9, or STAT2, has surprisingly little effect
            on human natural killer cell development and function
  JOURNAL   Immunology 172 (3), 440-450 (2024)
   PUBMED   38514903
  REMARK    GeneRIF: The lack of either IRF9, or STAT2, has surprisingly little
            effect on human natural killer cell development and function.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Nowicka,H., Sekrecka,A., Blaszczyk,K., Kluzek,K., Chang,C.Y.,
            Wesoly,J., Lee,C.K. and Bluyssen,H.A.R.
  TITLE     ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription
            through Genome-Wide Binding of Phosphorylated and Unphosphorylated
            Complexes to Common ISRE-Containing ISGs
  JOURNAL   Int J Mol Sci 24 (24), 17635 (2023)
   PUBMED   38139463
  REMARK    GeneRIF: ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced
            Transcription through Genome-Wide Binding of Phosphorylated and
            Unphosphorylated Complexes to Common ISRE-Containing ISGs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   You,Y., Grasso,E., Alvero,A., Condon,J., Dimova,T., Hu,A., Ding,J.,
            Alexandrova,M., Manchorova,D., Dimitrova,V., Liao,A. and Mor,G.
  TITLE     Twist1-IRF9 Interaction Is Necessary for IFN-Stimulated Gene
            Anti-Zika Viral Infection
  JOURNAL   J Immunol 210 (12), 1899-1912 (2023)
   PUBMED   37144865
  REMARK    GeneRIF: Twist1-IRF9 Interaction Is Necessary for IFN-Stimulated
            Gene Anti-Zika Viral Infection.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Drury,S., Claussen,G., Zetterman,A., Moriyama,H., Moriyama,E.N. and
            Zhang,L.
  TITLE     Evolution and emergence of primate-specific interferon regulatory
            factor 9
  JOURNAL   J Med Virol 95 (2), e28521 (2023)
   PUBMED   36691924
  REMARK    GeneRIF: Evolution and emergence of primate-specific interferon
            regulatory factor 9.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Martinez-Moczygemba,M., Gutch,M.J., French,D.L. and Reich,N.C.
  TITLE     Distinct STAT structure promotes interaction of STAT2 with the p48
            subunit of the interferon-alpha-stimulated transcription factor
            ISGF3
  JOURNAL   J Biol Chem 272 (32), 20070-20076 (1997)
   PUBMED   9242679
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Horvath,C.M., Stark,G.R., Kerr,I.M. and Darnell,J.E. Jr.
  TITLE     Interactions between STAT and non-STAT proteins in the
            interferon-stimulated gene factor 3 transcription complex
  JOURNAL   Mol Cell Biol 16 (12), 6957-6964 (1996)
   PUBMED   8943351
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   David,M., Romero,G., Zhang,Z.Y., Dixon,J.E. and Larner,A.C.
  TITLE     In vitro activation of the transcription factor ISGF3 by interferon
            alpha involves a membrane-associated tyrosine phosphatase and
            tyrosine kinase
  JOURNAL   J Biol Chem 268 (9), 6593-6599 (1993)
   PUBMED   8454630
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Veals,S.A., Schindler,C., Leonard,D., Fu,X.Y., Aebersold,R.,
            Darnell,J.E. Jr. and Levy,D.E.
  TITLE     Subunit of an alpha-interferon-responsive transcription factor is
            related to interferon regulatory factor and Myb families of
            DNA-binding proteins
  JOURNAL   Mol Cell Biol 12 (8), 3315-3324 (1992)
   PUBMED   1630447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI919023.1, AL136295.3 and BI497082.1.
            
            On May 17, 2019 this sequence version replaced NM_006084.4.
            
            Summary: This gene encodes a member of the interferon regulatory
            factor (IRF) family, a group of transcription factors with diverse
            roles, including virus-mediated activation of interferon, and
            modulation of cell growth, differentiation, apoptosis, and immune
            system activity. Members of the IRF family are characterized by a
            conserved N-terminal DNA-binding domain containing tryptophan (W)
            repeats. Mutations in this gene result in Immunodeficiency 65.
            [provided by RefSeq, Jul 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.559655.1,
                                           SRR1163658.135954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000396864.8/ ENSP00000380073.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BI919023.1         240-270
            32-74               AL136295.3         48694-48736         c
            75-255              AL136295.3         47708-47888         c
            256-439             AL136295.3         46883-47066         c
            440-570             AL136295.3         46524-46654         c
            571-652             AL136295.3         46073-46154         c
            653-724             AL136295.3         45898-45969         c
            725-1066            AL136295.3         45077-45418         c
            1067-1182           AL136295.3         44070-44185         c
            1183-1588           AL136295.3         43505-43910         c
            1589-1626           BI497082.1         381-418
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1626
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /note="interferon regulatory factor 9"
                     /db_xref="GeneID:10379"
                     /db_xref="HGNC:HGNC:6131"
                     /db_xref="MIM:147574"
     exon            1..74
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            75..255
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1257
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     interferon-stimulated transcription factor 3, gamma 48kDa;
                     interferon-stimulated transcription factor 3, gamma
                     (48kD); ISGF-3 gamma; ISGF3 p48 subunit;
                     interferon-stimulated gene factor 3 gamma; transcriptional
                     regulator ISGF3 subunit gamma; IFN-alpha-responsive
                     transcription factor subunit"
                     /codon_start=1
                     /product="interferon regulatory factor 9 isoform 2"
                     /protein_id="NP_006075.3"
                     /db_xref="CCDS:CCDS9615.1"
                     /db_xref="GeneID:10379"
                     /db_xref="HGNC:HGNC:6131"
                     /db_xref="MIM:147574"
                     /translation="MASGRARCTRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKH
                     AGKQDFREDQDAAFFKAWAIFKGKYKEGDTGGPAVWKTRLRCALNKSSEFKEVPERGR
                     MDVAEPYKVYQLLPPGIVSGQPGTQKVPSKRQHSSVSSERKEEEDAMQNCTLSPSVLQ
                     DSLNNEEEGASGGAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDY
                     SLLLTFIYNGRVVGEAQVQSLDCRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLE
                     RGILVASNPRGLFVQRLCPIPISWNAPQAPPGPGPHLLPSNECVELFRTAYFCRDLVR
                     YFQGLGPPPKFQVTLNFWEESHGSSHTPQNLITVKMEQAFARYLLEQTPEQQAAILSL
                     V"
     exon            256..439
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            440..570
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            571..652
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            653..724
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1066
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1182
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1626
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="IRF9"
                     /gene_synonym="IRF-9; ISGF3; ISGF3G; p48"
                     /note="major polyA site"
ORIGIN      
        1 ggagagatca gccgcccagc caggagttaa gctgaggtcg tctgagccct gcgacagcct
       61 ggacagcaac tcaggatggc atcaggcagg gcacgctgca cccgaaaact ccggaactgg
      121 gtggtggagc aagtggagag tgggcagttt cccggagtgt gctgggatga tacagctaag
      181 accatgttcc ggattccctg gaaacatgca ggcaagcagg acttccggga ggaccaggat
      241 gctgccttct tcaaggcctg ggcaatattt aagggaaagt ataaggaggg ggacacagga
      301 ggtccagctg tctggaagac tcgcctgcgc tgtgcactca acaagagttc tgaatttaag
      361 gaggttcctg agaggggccg catggatgtt gctgagccct acaaggtgta tcagttgctg
      421 ccaccaggaa tcgtctctgg ccagccaggg actcagaaag taccatcaaa gcgacagcac
      481 agttctgtgt cctctgagag gaaggaggaa gaggatgcca tgcagaactg cacactcagt
      541 ccctctgtgc tccaggactc cctcaataat gaggaggagg gggccagtgg gggagcagtc
      601 cattcagaca ttgggagcag cagcagcagc agcagccctg agccacagga agttacagac
      661 acaactgagg ccccctttca aggggatcag aggtccctgg agtttctgct tcctccagag
      721 ccagactact cactgctgct caccttcatc tacaacgggc gcgtggtggg cgaggcccag
      781 gtgcaaagcc tggattgccg ccttgtggct gagccctcag gctctgagag cagcatggag
      841 caggtgctgt tccccaagcc tggcccactg gagcccacgc agcgcctgct gagccagctt
      901 gagaggggca tcctagtggc cagcaacccc cgaggcctct tcgtgcagcg cctttgcccc
      961 atccccatct cctggaatgc accccaggct ccacctgggc caggcccgca tctgctgccc
     1021 agcaacgagt gcgtggagct cttcagaacc gcctacttct gcagagactt ggtcaggtac
     1081 tttcagggcc tgggcccccc accgaagttc caggtaacac tgaatttctg ggaagagagc
     1141 catggctcca gccatactcc acagaatctt atcacagtga agatggagca ggcctttgcc
     1201 cgatacttgc tggagcagac tccagagcag caggcagcca ttctgtccct ggtgtagagc
     1261 ctgggggacc catcttccac ctcacctctt tgttcttcct gtctcctttg aagtagactc
     1321 attcttcaca cgattgacct gtcctctttg tgataattct cagtagttgt ccgtgataat
     1381 cgtgtcctga aaatcctcgc acacactggc tggtggagaa ctcaaggcta attttttatc
     1441 cttttttttt tttaattttg agatatacgc cctctttcat ctgtaaggga ctaggaaatt
     1501 ccaaatggtg tgaacccagg gggcctttcc ctcttccctg acctcccaac tctaaagcca
     1561 agcactttat attttcctct tagatattca ctaaggactt aaaataaaat tttattgaaa
     1621 gaggaa
//
