LOCUS       NM_002163               2668 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens interferon regulatory factor 8 (IRF8), transcript
            variant 2, mRNA.
ACCESSION   NM_002163
VERSION     NM_002163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Zhou,L., Zhong,Y., Wang,F., Guo,Y., Mao,R., Xie,H., Zhang,Y. and
            Li,J.
  TITLE     WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives
            Cellular Senescence by Upregulating IRF8
  JOURNAL   Int J Biol Sci 20 (5), 1763-1777 (2024)
   PUBMED   38481803
  REMARK    GeneRIF: WTAP Mediated N6-methyladenosine RNA Modification of ELF3
            Drives Cellular Senescence by Upregulating IRF8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Liang,K.L., Laurenti,E. and Taghon,T.
  TITLE     Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors: key
            players in human hematopoiesis
  JOURNAL   Trends Immunol 44 (9), 678-692 (2023)
   PUBMED   37591714
  REMARK    GeneRIF: Circulating IRF8-expressing CD123[+]CD127[+] lymphoid
            progenitors: key players in human hematopoiesis.
            Review article
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Friebus-Kardash,J., Kuang,F., Peitz,T., Hamdan,T.A.,
            Eisenberger,U., Boss,K., Kribben,A., Lang,K.S. and Jahn,M.
  TITLE     Expression of Interferon Regulatory Factor 8 (IRF8) and Its
            Association with Infections in Dialysis Patients
  JOURNAL   Cells 12 (14), 1892 (2023)
   PUBMED   37508555
  REMARK    GeneRIF: Expression of Interferon Regulatory Factor 8 (IRF8) and
            Its Association with Infections in Dialysis Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Zhuang,H., Li,F., Xu,Y., Pei,R., Chen,D., Liu,X., Li,S., Ye,P.,
            Yuan,J., Lian,J. and Lu,Y.
  TITLE     Loss of IRF8 inhibits the growth of acute myeloid leukemia cells
  JOURNAL   Ann Hematol 102 (5), 1063-1072 (2023)
   PUBMED   36959484
  REMARK    GeneRIF: Loss of IRF8 inhibits the growth of acute myeloid leukemia
            cells.
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Liang,K.L., Roels,J., Lavaert,M., Putteman,T., Boehme,L.,
            Tilleman,L., Velghe,I., Pegoretti,V., Van de Walle,I., Sontag,S.,
            Vandewalle,J., Vandekerckhove,B., Leclercq,G., Van Vlierberghe,P.,
            Libert,C., Van Nieuwerburgh,F., Fischer,R., Kontermann,R.E.,
            Pfizenmaier,K., Doody,G., Zenke,M. and Taghon,T.
  TITLE     Intrathymic dendritic cell-biased precursors promote human T cell
            lineage specification through IRF8-driven transmembrane TNF
  JOURNAL   Nat Immunol 24 (3), 474-486 (2023)
   PUBMED   36703005
  REMARK    GeneRIF: Intrathymic dendritic cell-biased precursors promote human
            T cell lineage specification through IRF8-driven transmembrane TNF.
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Li,W., Nagineni,C.N., Ge,H., Efiok,B., Chepelinsky,A.B. and
            Egwuagu,C.E.
  TITLE     Interferon consensus sequence-binding protein is constitutively
            expressed and differentially regulated in the ocular lens
  JOURNAL   J Biol Chem 274 (14), 9686-9691 (1999)
   PUBMED   10092656
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Schaper,F., Kirchhoff,S., Posern,G., Koster,M., Oumard,A.,
            Sharf,R., Levi,B.Z. and Hauser,H.
  TITLE     Functional domains of interferon regulatory factor I (IRF-1)
  JOURNAL   Biochem J 335 (Pt 1) (Pt 1), 147-157 (1998)
   PUBMED   9742224
REFERENCE   8  (bases 1 to 2668)
  AUTHORS   Holtschke,T., Lohler,J., Kanno,Y., Fehr,T., Giese,N.,
            Rosenbauer,F., Lou,J., Knobeloch,K.P., Gabriele,L., Waring,J.F.,
            Bachmann,M.F., Zinkernagel,R.M., Morse,H.C. 3rd, Ozato,K. and
            Horak,I.
  TITLE     Immunodeficiency and chronic myelogenous leukemia-like syndrome in
            mice with a targeted mutation of the ICSBP gene
  JOURNAL   Cell 87 (2), 307-317 (1996)
   PUBMED   8861914
REFERENCE   9  (bases 1 to 2668)
  AUTHORS   Sharf,R., Azriel,A., Lejbkowicz,F., Winograd,S.S., Ehrlich,R. and
            Levi,B.Z.
  TITLE     Functional domain analysis of interferon consensus sequence binding
            protein (ICSBP) and its association with interferon regulatory
            factors
  JOURNAL   J Biol Chem 270 (22), 13063-13069 (1995)
   PUBMED   7768900
REFERENCE   10 (bases 1 to 2668)
  AUTHORS   Weisz,A., Marx,P., Sharf,R., Appella,E., Driggers,P.H., Ozato,K.
            and Levi,B.Z.
  TITLE     Human interferon consensus sequence binding protein is a negative
            regulator of enhancer elements common to interferon-inducible genes
  JOURNAL   J Biol Chem 267 (35), 25589-25596 (1992)
   PUBMED   1460054
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092723.3, BI835080.1,
            BG107396.1, M91196.1, CB214983.1, BF110315.1, AA232881.1 and
            AI307662.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002163.3.
            
            Summary: Interferon consensus sequence-binding protein (ICSBP) is a
            transcription factor of the interferon (IFN) regulatory factor
            (IRF) family. Proteins of this family are composed of a conserved
            DNA-binding domain in the N-terminal region and a divergent
            C-terminal region that serves as the regulatory domain. The IRF
            family proteins bind to the IFN-stimulated response element (ISRE)
            and regulate expression of genes stimulated by type I IFNs, namely
            IFN-alpha and IFN-beta. IRF family proteins also control expression
            of IFN-alpha and IFN-beta-regulated genes that are induced by viral
            infection. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.397423.1,
                                           SRR1163657.7028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268638.10/ ENSP00000268638.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC092723.3         172252-172257       c
            7-37                BI835080.1         1-31
            38-62               BG107396.1         14-38
            63-1517             M91196.1           47-1501
            1518-1686           CB214983.1         473-641
            1687-2133           BF110315.1         95-541
            2134-2334           AA232881.1         89-289
            2335-2668           AI307662.1         17-350              c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..2668
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /note="interferon regulatory factor 8"
                     /db_xref="GeneID:3394"
                     /db_xref="HGNC:HGNC:5358"
                     /db_xref="MIM:601565"
     exon            1..62
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            63..237
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1344
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     interferon consensus sequence binding protein 1"
                     /codon_start=1
                     /product="interferon regulatory factor 8 isoform 2"
                     /protein_id="NP_002154.1"
                     /db_xref="CCDS:CCDS10956.1"
                     /db_xref="GeneID:3394"
                     /db_xref="HGNC:HGNC:5358"
                     /db_xref="MIM:601565"
                     /translation="MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAG
                     KQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLD
                     ISEPYKVYRIVPEEEQKCKLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIK
                     RSPSPPEACRSQLLPDWWAQQPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQ
                     ATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLER
                     GVLLHSSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQF
                     YNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQ
                     APEEPPPDQVFRMFPDICASHQRSFFRENQQITV"
     exon            238..421
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            422..510
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            511..616
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            617..664
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1051
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1167
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..2668
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /note="hexamer: AATAAA"
     polyA_site      2668
                     /gene="IRF8"
                     /gene_synonym="H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B;
                     IRF-8"
                     /note="major polyA site"
ORIGIN      
        1 gcctggagcg cggcagcaag cgtgggaacg cgggcggcga gacggcggca ggacggcggc
       61 aggatgtgtg accggaatgg tggtcggcgg cttcgacagt ggctgatcga gcagattgac
      121 agtagcatgt atccaggact gatttgggag aatgaggaga agagcatgtt ccggatccct
      181 tggaaacacg ctggcaagca agattataat caggaagtgg atgcctccat ttttaaggcc
      241 tgggcagttt ttaaagggaa gtttaaagaa ggggacaaag ctgaaccagc cacttggaag
      301 acgaggttac gctgtgcttt gaataagagc ccagattttg aggaagtgac ggaccggtcc
      361 caactggaca tttccgagcc atacaaagtt taccgaattg ttcctgagga agagcaaaaa
      421 tgcaaactag gcgtggcaac tgctggctgc gtgaatgaag ttacagagat ggagtgcggt
      481 cgctctgaaa tcgacgagct gatcaaggag ccttctgtgg acgattacat ggggatgatc
      541 aaaaggagcc cttccccgcc ggaggcctgt cggagtcagc tccttccaga ctggtgggcg
      601 cagcagccca gcacaggcgt gccgctggtg acggggtaca ccacctacga cgcgcaccat
      661 tcagcattct cccagatggt gatcagcttc tactatgggg gcaagctggt gggccaggcc
      721 accaccacct gccccgaggg ctgccgcctg tccctgagcc agcctgggct gcccggcacc
      781 aagctgtatg ggcccgaggg cctggagctg gtgcgcttcc cgccggccga cgccatcccc
      841 agcgagcgac agaggcaggt gacgcggaag ctgttcgggc acctggagcg cggggtgctg
      901 ctgcacagca gccggcaggg cgtgttcgtc aagcggctgt gccagggccg cgtgttctgc
      961 agcggcaacg ccgtggtgtg caaaggcagg cccaacaagc tggagcgtga tgaggtggtc
     1021 caggtcttcg acaccagcca gttcttccga gagctgcagc agttctataa cagccagggc
     1081 cggcttcctg acggcagggt ggtgctgtgc tttggggaag agtttccgga tatggccccc
     1141 ttgcgctcca aactcattct cgtgcagatt gagcagctgt atgtccggca actggcagaa
     1201 gaggctggga agagctgtgg agccggctct gtgatgcagg cccccgagga gccgccgcca
     1261 gaccaggtct tccggatgtt tccagatatt tgtgcctcac accagagatc atttttcaga
     1321 gaaaaccaac agatcaccgt ctaagtgcgt cgcttgggcg ccccaccccg tctgcgtcct
     1381 gcatccatct ccctgttaca gtggcccgca tcatgattaa agaatgtgga tccctctgtc
     1441 tggggtggga tgccttactt tgcacttaat ttaataaggg cattctcgga ggagtagacg
     1501 tttaatacga agtggcggca tagccctgcc gagatgtcgg tgatggcctg gatgctgtaa
     1561 ccacaacctg tggctaaaaa ttttattttc tatcctttac ccgtcattat cattagttgc
     1621 tatgattctt tctgcatttt cggttaacta tcatttccaa agacttgtca ttcagtaata
     1681 ttagcagata gctgcttcga taaaggaatt tggagtttaa aaatcaactt gtgaaaacaa
     1741 ggttgttttt gtctttatcg tttgttagag ttatagattt atgatttcat aggcttgatt
     1801 ctatgtgaaa tatcttttta cttttatgca ttttaataag atttaaaaat atttagatta
     1861 aagccccctt taatgagtac aagaaaaact cttggcttgt tagaagaaag tatattcttt
     1921 ctagaatttg gtgcaggaat atgtgttcat atccaggcaa acgggtgtgt ttttatcttc
     1981 agacaatgaa accttctcct ctggggcttt gttgccagga agattagaac taaatttatt
     2041 tttttcattt ctgtcatgaa atcattccag atacctcttt tcttctttcc aaatggtttt
     2101 cacatgtgtt tgaaatattt gtacttcgaa ttgtcggatt ttccatgtcc tcctttctcc
     2161 tttgtgccca gcctgagtca gcaccaatcc cgcattcaga acctcccagt gaaagggcag
     2221 ccttcatttt gagaaggtgg aaggtgttag ggtttgggag acagctcatc caatctccca
     2281 agtctcatgg tggatttgtg actgtgagag tttccggttt aaaatctgaa aagccagata
     2341 tgcctgtttc cttttcccag caccatgcct gtggagggga cagtcagacc cagaggtcct
     2401 ttacgtgtgg atggagttca caggcgaata gaggagagga ccaggggacg tggcttgtcc
     2461 cttttgtcca acaaagcatt atatttttaa gaatggcaga cctgtttgct gaagtgttca
     2521 taagataaca ataggcttga atctccaatt caaatgaatg tcaaagcaca tatctttaat
     2581 atgctgaatg aatatttatt tttgtatcca ttaaaacagt atattgatct cttttattct
     2641 ttattaaaat aaaatgctct tttttaaa
//
