LOCUS       NM_001572               1923 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens interferon regulatory factor 7 (IRF7), transcript
            variant a, mRNA.
ACCESSION   NM_001572
VERSION     NM_001572.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Zhan,T., Zou,Y., Han,Z., Tian,X., Chen,M., Liu,J., Yang,X., Zhu,Q.,
            Liu,M., Chen,W., Chen,M., Huang,X., Tan,J., Liu,W. and Tian,X.
  TITLE     Single-cell sequencing combined with spatial transcriptomics
            reveals that the IRF7 gene in M1 macrophages inhibits the
            occurrence of pancreatic cancer by regulating lipid
            metabolism-related mechanisms
  JOURNAL   Clin Transl Med 14 (8), e1799 (2024)
   PUBMED   39118300
  REMARK    GeneRIF: Single-cell sequencing combined with spatial
            transcriptomics reveals that the IRF7 gene in M1 macrophages
            inhibits the occurrence of pancreatic cancer by regulating lipid
            metabolism-related mechanisms.
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Fan,S., Popli,S., Chakravarty,S., Chakravarti,R. and
            Chattopadhyay,S.
  TITLE     Non-transcriptional IRF7 interacts with NF-kappaB to inhibit viral
            inflammation
  JOURNAL   J Biol Chem 300 (4), 107200 (2024)
   PUBMED   38508315
  REMARK    GeneRIF: Non-transcriptional IRF7 interacts with NF-kappaB to
            inhibit viral inflammation.
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Ma,W., Huang,G., Wang,Z., Wang,L. and Gao,Q.
  TITLE     IRF7: role and regulation in immunity and autoimmunity
  JOURNAL   Front Immunol 14, 1236923 (2023)
   PUBMED   37638030
  REMARK    GeneRIF: IRF7: role and regulation in immunity and autoimmunity.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Qing,F. and Liu,Z.
  TITLE     Interferon regulatory factor 7 in inflammation, cancer and
            infection
  JOURNAL   Front Immunol 14, 1190841 (2023)
   PUBMED   37251373
  REMARK    GeneRIF: Interferon regulatory factor 7 in inflammation, cancer and
            infection.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Ohtani,F., Miyazaki,D., Shimizu,Y., Haruki,T., Yamagami,S. and
            Inoue,Y.
  TITLE     Role of interferon regulatory factor 7 in corneal endothelial cells
            after HSV-1 infection
  JOURNAL   Sci Rep 11 (1), 16487 (2021)
   PUBMED   34389779
  REMARK    GeneRIF: Role of interferon regulatory factor 7 in corneal
            endothelial cells after HSV-1 infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Lu,R., Au,W.C., Yeow,W.S., Hageman,N. and Pitha,P.M.
  TITLE     Regulation of the promoter activity of interferon regulatory
            factor-7 gene. Activation by interferon snd silencing by
            hypermethylation
  JOURNAL   J Biol Chem 275 (41), 31805-31812 (2000)
   PUBMED   10924517
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Au,W.C., Moore,P.A., LaFleur,D.W., Tombal,B. and Pitha,P.M.
  TITLE     Characterization of the interferon regulatory factor-7 and its
            potential role in the transcription activation of interferon A
            genes
  JOURNAL   J Biol Chem 273 (44), 29210-29217 (1998)
   PUBMED   9786932
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Pitha,P.M., Au,W.C., Lowther,W., Juang,Y.T., Schafer,S.L.,
            Burysek,L., Hiscott,J. and Moore,P.A.
  TITLE     Role of the interferon regulatory factors (IRFs) in virus-mediated
            signaling and regulation of cell growth
  JOURNAL   Biochimie 80 (8-9), 651-658 (1998)
   PUBMED   9865487
  REMARK    Review article
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Wathelet,M.G., Lin,C.H., Parekh,B.S., Ronco,L.V., Howley,P.M. and
            Maniatis,T.
  TITLE     Virus infection induces the assembly of coordinately activated
            transcription factors on the IFN-beta enhancer in vivo
  JOURNAL   Mol Cell 1 (4), 507-518 (1998)
   PUBMED   9660935
  REMARK    Erratum:[Mol Cell 1999 Jun;3(6):813]
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Zhang,L. and Pagano,J.S.
  TITLE     IRF-7, a new interferon regulatory factor associated with
            Epstein-Barr virus latency
  JOURNAL   Mol Cell Biol 17 (10), 5748-5757 (1997)
   PUBMED   9315633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM849172.1, U73036.1, U53830.1,
            AF076494.1 and U53831.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 19, 2018 this sequence version replaced NM_001572.4.
            
            Summary: This gene encodes interferon regulatory factor 7, a member
            of the interferon regulatory transcription factor (IRF) family. It
            has been shown to play a role in the transcriptional activation of
            virus-inducible cellular genes, including interferon beta chain
            genes. Inducible expression of IRF7 is largely restricted to
            lymphoid tissue. The encoded protein plays an important role in the
            innate immune response against DNA and RNA viruses. [provided by
            RefSeq, Jul 2021].
            
            Transcript Variant: This variant (a) has an alternate exon
            structure in the 5' coding region, resulting in the use of an
            alternate start codon compared to variant d. The resulting isoform
            (a) is shorter and has a distinct N-terminus compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53830.1, U73036.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000525445.6/ ENSP00000434009.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BM849172.1         50-72
            24-29               U73036.1           12-17
            30-795              U53830.1           1-766
            796-855             AF076494.1         849-908
            856-1919            U53830.1           827-1890
            1920-1923           U53831.1           1804-1807
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1923
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /note="interferon regulatory factor 7"
                     /db_xref="GeneID:3665"
                     /db_xref="HGNC:HGNC:6122"
                     /db_xref="MIM:605047"
     exon            1..38
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            39..341
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1833
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /note="isoform a is encoded by transcript variant a;
                     interferon regulatory factor-7H"
                     /codon_start=1
                     /product="interferon regulatory factor 7 isoform a"
                     /protein_id="NP_001563.2"
                     /db_xref="CCDS:CCDS7703.1"
                     /db_xref="GeneID:3665"
                     /db_xref="HGNC:HGNC:6122"
                     /db_xref="MIM:605047"
                     /translation="MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPW
                     KHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRST
                     RRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLA
                     HTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGL
                     PLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPS
                     ACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSP
                     AELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTP
                     ACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVL
                     VKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA"
     exon            342..504
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            505..715
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            716..774
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1000
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1087
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1168
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1558
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1677
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1923
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /note="hexamer: AATAAA"
     polyA_site      1923
                     /gene="IRF7"
                     /gene_synonym="IMD39; IRF-7; IRF-7H; IRF7A; IRF7B; IRF7C;
                     IRF7H"
                     /note="major polyA site"
ORIGIN      
        1 gagacgaaac ttcccgtccc ggcggctctg gcacccaggg tccggcctgc gccttcccgc
       61 caggcctgga cactggttca acacctgtga cttcatgtgt gcgcgccggc cacacctgca
      121 gtcacacctg tagccccctc tgccaagaga tccataccga ggcagcgtcg gtggctacaa
      181 gccctcagtc cacacctgtg gacacctgtg acacctggcc acacgacctg tggccgcggc
      241 ctggcgtctg ctgcgacagg agcccttacc tcccctgtta taacacctga ccgccaccta
      301 actgcccctg cagaaggagc aatggccttg gctcctgaga gggcagcccc acgcgtgctg
      361 ttcggagagt ggctccttgg agagatcagc agcggctgct atgaggggct gcagtggctg
      421 gacgaggccc gcacctgttt ccgcgtgccc tggaagcact tcgcgcgcaa ggacctgagc
      481 gaggccgacg cgcgcatctt caaggcctgg gctgtggccc gcggcaggtg gccgcctagc
      541 agcaggggag gtggcccgcc ccccgaggct gagactgcgg agcgcgccgg ctggaaaacc
      601 aacttccgct gcgcactgcg cagcacgcgt cgcttcgtga tgctgcggga taactcgggg
      661 gacccggccg acccgcacaa ggtgtacgcg ctcagccggg agctgtgctg gcgagaaggc
      721 ccaggcacgg accagactga ggcagaggcc cccgcagctg tcccaccacc acagggtggg
      781 cccccagggc cattcctggc acacacacat gctggactcc aagccccagg ccccctccct
      841 gccccagctg gtgacaaggg ggacctcctg ctccaggcag tgcaacagag ctgcctggca
      901 gaccatctgc tgacagcgtc atggggggca gatccagtcc caaccaaggc tcctggagag
      961 ggacaagaag ggcttcccct gactggggcc tgtgctggag gcccagggct ccctgctggg
     1021 gagctgtacg ggtgggcagt agagacgacc cccagccccg ggccccagcc cgcggcacta
     1081 acgacaggcg aggccgcggc cccagagtcc ccgcaccagg cagagccgta cctgtcaccc
     1141 tccccaagcg cctgcaccgc ggtgcaagag cccagcccag gggcgctgga cgtgaccatc
     1201 atgtacaagg gccgcacggt gctgcagaag gtggtgggac acccgagctg cacgttccta
     1261 tacggccccc cagacccagc tgtccgggcc acagaccccc agcaggtagc attccccagc
     1321 cctgccgagc tcccggacca gaagcagctg cgctacacgg aggaactgct gcggcacgtg
     1381 gcccctgggt tgcacctgga gcttcggggg ccacagctgt gggcccggcg catgggcaag
     1441 tgcaaggtgt actgggaggt gggcggaccc ccaggctccg ccagcccctc caccccagcc
     1501 tgcctgctgc ctcggaactg tgacaccccc atcttcgact tcagagtctt cttccaagag
     1561 ctggtggaat tccgggcacg gcagcgccgt ggctccccac gctataccat ctacctgggc
     1621 ttcgggcagg acctgtcagc tgggaggccc aaggagaaga gcctggtcct ggtgaagctg
     1681 gaaccctggc tgtgccgagt gcacctagag ggcacgcagc gtgagggtgt gtcttccctg
     1741 gatagcagca gcctcagcct ctgcctgtcc agcgccaaca gcctctatga cgacatcgag
     1801 tgcttcctta tggagctgga gcagcccgcc tagaacccag tctaatgaga actccagaaa
     1861 gctggagcag cccacctaga gctggccgcg gccgcccagt ctaataaaaa gaactccaga
     1921 aca
//
