LOCUS       NM_001098629            2899 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens interferon regulatory factor 5 (IRF5), transcript
            variant 5, mRNA.
ACCESSION   NM_001098629 NM_002200
VERSION     NM_001098629.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Lopez-Briceno,I.A., Ramirez-Bello,J., Montufar-Robles,I.,
            Barbosa-Cobos,R.E., Angulo-Ramirez,A.V. and Valencia-Pacheco,G.
  TITLE     IRF5 Variants Are Risk Factors for Systemic Lupus Erythematosus in
            Two Mexican Populations
  JOURNAL   J Clin Rheumatol 30 (7), 283-290 (2024)
   PUBMED   39271190
  REMARK    GeneRIF: IRF5 Variants Are Risk Factors for Systemic Lupus
            Erythematosus in Two Mexican Populations.
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Wang,G., Jing,L., Wang,Y., Mehmood,A., Zhang,H., Guo,R., Zhang,L.
            and Li,B.
  TITLE     Interferon Regulatory Factor 5 Gene Polymorphisms and mRNA
            Expression Levels Are Associated with Neuromyelitis Optica Spectrum
            Disorder
  JOURNAL   Mol Neurobiol 61 (10), 7989-7999 (2024)
   PUBMED   38451436
  REMARK    GeneRIF: Interferon Regulatory Factor 5 Gene Polymorphisms and mRNA
            Expression Levels Are Associated with Neuromyelitis Optica Spectrum
            Disorder.
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Roberts,B.K., Li,D.I., Somerville,C., Matta,B., Jha,V., Steinke,A.,
            Brune,Z., Blanc,L., Soffer,S.Z. and Barnes,B.J.
  TITLE     IRF5 suppresses metastasis through the regulation of tumor-derived
            extracellular vesicles and pre-metastatic niche formation
  JOURNAL   Sci Rep 14 (1), 15557 (2024)
   PUBMED   38969706
  REMARK    GeneRIF: IRF5 suppresses metastasis through the regulation of
            tumor-derived extracellular vesicles and pre-metastatic niche
            formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Hou,P.X., Fan,Q., Zhang,Q., Liu,J.J. and Wu,Q.
  TITLE     M6A-induced transcription factor IRF5 contributes to the
            progression of cervical cancer by upregulating PPP6C
  JOURNAL   Clin Exp Pharmacol Physiol 51 (7), e13868 (2024)
   PUBMED   38745265
  REMARK    GeneRIF: M6A-induced transcription factor IRF5 contributes to the
            progression of cervical cancer by upregulating PPP6C.
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Wang,Y., Liu,Z., Song,S., Wang,J., Jin,C., Jia,L., Ma,Y., Yuan,T.,
            Cai,Z. and Xiang,M.
  TITLE     IRF5 governs macrophage adventitial infiltration to fuel abdominal
            aortic aneurysm formation
  JOURNAL   JCI Insight 9 (3), e171488 (2024)
   PUBMED   38175709
  REMARK    GeneRIF: IRF5 governs macrophage adventitial infiltration to fuel
            abdominal aortic aneurysm formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2899)
  AUTHORS   Barnes,B.J., Kellum,M.J., Field,A.E. and Pitha,P.M.
  TITLE     Multiple regulatory domains of IRF-5 control activation, cellular
            localization, and induction of chemokines that mediate recruitment
            of T lymphocytes
  JOURNAL   Mol Cell Biol 22 (16), 5721-5740 (2002)
   PUBMED   12138184
  REMARK    GeneRIF: this study defines the regulatory phosphorylation sites
            that control the activity of IRF-5 in Newcastle disease
            virus-infected cells and provides further insight into its
            structure and function
REFERENCE   7  (bases 1 to 2899)
  AUTHORS   Nehyba,J., Hrdlickova,R., Burnside,J. and Bose,H.R. Jr.
  TITLE     A novel interferon regulatory factor (IRF), IRF-10, has a unique
            role in immune defense and is induced by the v-Rel oncoprotein
  JOURNAL   Mol Cell Biol 22 (11), 3942-3957 (2002)
   PUBMED   11997525
REFERENCE   8  (bases 1 to 2899)
  AUTHORS   Barnes,B., Lubyova,B. and Pitha,P.M.
  TITLE     On the role of IRF in host defense
  JOURNAL   J Interferon Cytokine Res 22 (1), 59-71 (2002)
   PUBMED   11846976
  REMARK    Review article
REFERENCE   9  (bases 1 to 2899)
  AUTHORS   Barnes,B.J., Moore,P.A. and Pitha,P.M.
  TITLE     Virus-specific activation of a novel interferon regulatory factor,
            IRF-5, results in the induction of distinct interferon alpha genes
  JOURNAL   J Biol Chem 276 (26), 23382-23390 (2001)
   PUBMED   11303025
REFERENCE   10 (bases 1 to 2899)
  AUTHORS   Pitha,P.M., Au,W.C., Lowther,W., Juang,Y.T., Schafer,S.L.,
            Burysek,L., Hiscott,J. and Moore,P.A.
  TITLE     Role of the interferon regulatory factors (IRFs) in virus-mediated
            signaling and regulation of cell growth
  JOURNAL   Biochimie 80 (8-9), 651-658 (1998)
   PUBMED   9865487
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025594.5, AK293654.1,
            AY693665.1, BC004139.2, U51127.1, AL713733.1 and CA444548.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001098629.2.
            
            Summary: This gene encodes a member of the interferon regulatory
            factor (IRF) family, a group of transcription factors with diverse
            roles, including virus-mediated activation of interferon, and
            modulation of cell growth, differentiation, apoptosis, and immune
            system activity. Members of the IRF family are characterized by a
            conserved N-terminal DNA-binding domain containing tryptophan (W)
            repeats. Alternative promoter use and alternative splicing result
            in multiple transcript variants, and a 30-nt indel polymorphism
            (SNP rs60344245) can result in loss of a 10-aa segment. [provided
            by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 9. Variants 5 and 9 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.567972.1,
                                           SRR1163658.486675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357234.10/ ENSP00000349770.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC025594.5         127078-127087
            11-13               AK293654.1         1-3
            14-682              AY693665.1         1-669
            683-1806            BC004139.2         541-1664
            1807-2233           U51127.1           1746-2172
            2234-2896           AL713733.1         266-928
            2897-2899           CA444548.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..2899
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /note="interferon regulatory factor 5"
                     /db_xref="GeneID:3663"
                     /db_xref="HGNC:HGNC:6120"
                     /db_xref="MIM:607218"
     exon            1..123
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            124..329
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1679
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /note="isoform d is encoded by transcript variant 5"
                     /codon_start=1
                     /product="interferon regulatory factor 5 isoform d"
                     /protein_id="NP_001092099.1"
                     /db_xref="CCDS:CCDS43645.1"
                     /db_xref="GeneID:3663"
                     /db_xref="HGNC:HGNC:6120"
                     /db_xref="MIM:607218"
                     /translation="MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFC
                     IPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRL
                     IYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLT
                     DAVQSGPHMTPYSLLKEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAP
                     PPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRP
                     PRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLL
                     DVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFL
                     NELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGEL
                     SWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPM
                     HPAGMQ"
     exon            330..519
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            520..581
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            582..615
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            616..921
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1314
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1433
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2899
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /note="hexamer: AATGAA"
     polyA_site      2249
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /note="hexamer: AATAAA"
     polyA_site      2899
                     /gene="IRF5"
                     /gene_synonym="SLEB10"
                     /note="major polyA site"
ORIGIN      
        1 aagacgcgga agtgcccggc aggttggcgg accggcggga ggcgcagcct gggcagagct
       61 cagcttggtc ccgccgcccg gccggtgctc cctggcgcag ccacgcaggc gcaccgcaga
      121 cagacccctc tgccatgaac cagtccatcc cagtggctcc caccccaccc cgccgcgtgc
      181 ggctgaagcc ctggctggtg gcccaggtga acagctgcca gtacccaggg cttcaatggg
      241 tcaacgggga aaagaaatta ttctgcatcc cctggaggca tgccacaagg catggtccca
      301 gccaggacgg agataacacc atcttcaagg cctgggccaa ggagacaggg aaatacaccg
      361 aaggcgtgga tgaagccgat ccggccaagt ggaaggccaa cctgcgctgt gcccttaaca
      421 agagccggga cttccgcctc atctacgacg ggccccggga catgccacct cagccctaca
      481 agatctacga ggtctgctcc aatggccctg ctcccacaga ctcccagccc cctgaggatt
      541 actcttttgg tgcaggagag gaggaggaag aagaggaaga gctgcagagg atgttgccaa
      601 gcctgagcct cacagatgca gtgcagtctg gcccccacat gacaccctat tctttactca
      661 aagaggatgt caagtggccg cccactctgc agccgcccac tctgcggccg cctactctgc
      721 agccgcccac tctgcagccg cccgtggtgc tgggtccccc tgctccagac cccagccccc
      781 tggctcctcc ccctggcaac cctgctggct tcagggagct tctctctgag gtcctggagc
      841 ctgggcccct gcctgccagc ctgccccctg caggcgaaca gctcctgcca gacctgctga
      901 tcagccccca catgctgcct ctgaccgacc tggagatcaa gtttcagtac cgggggcggc
      961 caccccgggc cctcaccatc agcaaccccc atggctgccg gctcttctac agccagctgg
     1021 aggccaccca ggagcaggtg gaactcttcg gccccataag cctggagcaa gtgcgcttcc
     1081 ccagccctga ggacatcccc agtgacaagc agcgcttcta cacgaaccag ctgctggatg
     1141 tcctggaccg cgggctcatc ctccagctac agggccagga cctttatgcc atccgcctgt
     1201 gtcagtgcaa ggtgttctgg agcgggcctt gtgcctcagc ccatgactca tgccccaacc
     1261 ccatccagcg ggaggtcaag accaagcttt tcagcctgga gcattttctc aatgagctca
     1321 tcctgttcca aaagggccag accaacaccc caccaccctt cgagatcttc ttctgctttg
     1381 gggaagaatg gcctgaccgc aaaccccgag agaagaagct cattactgta caggtggtgc
     1441 ctgtagcagc tcgactgctg ctggagatgt tctcagggga gctatcttgg tcagctgata
     1501 gtatccggct acagatctca aacccagacc tcaaagaccg catggtggag caattcaagg
     1561 agctccatca catctggcag tcccagcagc ggttgcagcc tgtggcccag gcccctcctg
     1621 gagcaggcct tggtgttggc caggggccct ggcctatgca cccagctggc atgcaataac
     1681 aaggctgcag acggtgactg gccctggctt cctgggtggc ggtgcggact gatgtggaga
     1741 tgtgacagcc ccgatgagca cctggctggc tgcagggtcc tacctctggg tttcctggaa
     1801 gtggatttgg gccaagaagg agagggagaa aggcccgagc ccctgccttc ccgggccttt
     1861 ctctcctggg ctgtctctgg tctggtcagc ctggctctcg ggaaattcag ccatgagcag
     1921 ggaaagaact ctcccaaccc tggggcctag ctgtatagga ggaattgcct aagggtggcc
     1981 cactcttgtg attgccccat ttcctctggc aacaaaagcc agagtgttgt gggccaagtc
     2041 cccccacagg gcctctgcag ggcatggccc tgatttccct ggtttgagac tcacttcctc
     2101 atctccctgt cctctgagat aatatgagtg agcacttagg tatcatatca gatgctcaag
     2161 gctggcagct acccccttct tgagagtcca agaacctgga gcagaaataa tttttatgta
     2221 tttttggatt aatgaatgtt aaaaacagac tcagctgttt ctttcctttt actactacca
     2281 gttgctccca tgctgctcca ccaggccctg tttcggatgc caactggccc actccccaag
     2341 cacttgcccc cagcttgcga ccattggcac tgggagggcc tggcttctgg gctgatgggt
     2401 cagttgggcc ttcataaaca ctcacctggc tggctttgcc ttccaggagg aagctggctg
     2461 aagcaagggt gtggaatttt aaatgtgtgc acagtctgga aaactgtcag aatcagtttt
     2521 cccataaaag ggtgggctag cattgcagct gcatttggga ccattcaaat ctgtcactct
     2581 cttgtgtata ttcctgtgct attaaatata tcagggcagt gcatgtaaat catcctgata
     2641 tatttaatat atttattata ttgtcccccg aggtggggac agtgagtgag ttctcttagt
     2701 ccccccagag ctggttgtta aagagcctgg cacctacccg ctctcacttc atctgtgtca
     2761 tctctgcaca ctccagccca ctttctgcct tcagccattg agtggaagct gccccaggcc
     2821 cttaccaggt gcagatgccc aatcttgatg cccagccatc agaactgtga gccaaataaa
     2881 cctttttctg tataaatta
//
