LOCUS       NM_002460               5314 bp    mRNA    linear   PRI 19-FEB-2025
DEFINITION  Homo sapiens interferon regulatory factor 4 (IRF4), transcript
            variant 1, mRNA.
ACCESSION   NM_002460
VERSION     NM_002460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5314)
  AUTHORS   Elsayed Ramadan Genena,S., Hamouda,M.A.F., Salama,N.M.,
            Zahran,E.S., Abdel Latif,A.A. and Dawood,A.A.
  TITLE     Interferon-induced protein 44 (IFI44) and interferon regulatory
            factor 4 (IRF4) gene expression in rheumatoid arthritis
  JOURNAL   J Immunoassay Immunochem 45 (5), 432-451 (2024)
   PUBMED   39051937
  REMARK    GeneRIF: Interferon-induced protein 44 (IFI44) and interferon
            regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis.
REFERENCE   2  (bases 1 to 5314)
  AUTHORS   Hirsch,T., Neyens,D., Duhamel,C., Bayard,A., Vanhaver,C.,
            Luyckx,M., Sala de Oyanguren,F., Wildmann,C., Dauguet,N.,
            Squifflet,J.L., Montiel,V., Deschamps,M. and van der Bruggen,P.
  TITLE     IRF4 impedes human CD8 T cell function and promotes cell
            proliferation and PD-1 expression
  JOURNAL   Cell Rep 43 (7), 114401 (2024)
   PUBMED   38943641
  REMARK    GeneRIF: IRF4 impedes human CD8 T cell function and promotes cell
            proliferation and PD-1 expression.
REFERENCE   3  (bases 1 to 5314)
  AUTHORS   Maguire,J., Harvey,H., Jones,A., Law,R., Bashir,M., O'Brien,O.,
            Sargent,J., Grant,C. and Flavin,R.
  TITLE     Clinical boundaries in adult cases of large B cell lymphoma with
            IRF4 rearrangement
  JOURNAL   Histopathology 84 (2), 399-401 (2024)
   PUBMED   37876327
  REMARK    GeneRIF: Clinical boundaries in adult cases of large B cell
            lymphoma with IRF4 rearrangement.
REFERENCE   4  (bases 1 to 5314)
  AUTHORS   Schleussner,N., Cauchy,P., Franke,V., Giefing,M., Fornes,O.,
            Vankadari,N., Assi,S.A., Costanza,M., Weniger,M.A., Akalin,A.,
            Anagnostopoulos,I., Bukur,T., Casarotto,M.G., Damm,F., Daumke,O.,
            Edginton-White,B., Gebhardt,J.C.M., Grau,M., Grunwald,S.,
            Hansmann,M.L., Hartmann,S., Huber,L., Kargel,E., Lusatis,S.,
            Noerenberg,D., Obier,N., Pannicke,U., Fischer,A., Reisser,A.,
            Rosenwald,A., Schwarz,K., Sundararaj,S., Weilemann,A., Winkler,W.,
            Xu,W., Lenz,G., Rajewsky,K., Wasserman,W.W., Cockerill,P.N.,
            Scheidereit,C., Siebert,R., Kuppers,R., Grosschedl,R., Janz,M.,
            Bonifer,C. and Mathas,S.
  TITLE     Transcriptional reprogramming by mutated IRF4 in lymphoma
  JOURNAL   Nat Commun 14 (1), 6947 (2023)
   PUBMED   37935654
  REMARK    GeneRIF: Transcriptional reprogramming by mutated IRF4 in lymphoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5314)
  AUTHORS   Thouenon,R. and Kracker,S.
  TITLE     Human inborn errors of immunity associated with IRF4
  JOURNAL   Front Immunol 14, 1236889 (2023)
   PUBMED   37809068
  REMARK    GeneRIF: Human inborn errors of immunity associated with IRF4.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5314)
  AUTHORS   Gupta,S., Jiang,M., Anthony,A. and Pernis,A.B.
  TITLE     Lineage-specific modulation of interleukin 4 signaling by
            interferon regulatory factor 4
  JOURNAL   J Exp Med 190 (12), 1837-1848 (1999)
   PUBMED   10601358
REFERENCE   7  (bases 1 to 5314)
  AUTHORS   Marecki,S., Atchison,M.L. and Fenton,M.J.
  TITLE     Differential expression and distinct functions of IFN regulatory
            factor 4 and IFN consensus sequence binding protein in macrophages
  JOURNAL   J Immunol 163 (5), 2713-2722 (1999)
   PUBMED   10453013
REFERENCE   8  (bases 1 to 5314)
  AUTHORS   Iida,S., Rao,P.H., Butler,M., Corradini,P., Boccadoro,M., Klein,B.,
            Chaganti,R.S. and Dalla-Favera,R.
  TITLE     Deregulation of MUM1/IRF4 by chromosomal translocation in multiple
            myeloma
  JOURNAL   Nat Genet 17 (2), 226-230 (1997)
   PUBMED   9326949
REFERENCE   9  (bases 1 to 5314)
  AUTHORS   Grossman,A., Mittrucker,H.W., Nicholl,J., Suzuki,A., Chung,S.,
            Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P. and Mak,T.W.
  TITLE     Cloning of human lymphocyte-specific interferon regulatory factor
            (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
  JOURNAL   Genomics 37 (2), 229-233 (1996)
   PUBMED   8921401
REFERENCE   10 (bases 1 to 5314)
  AUTHORS   Yamagata,T., Nishida,J., Tanaka,S., Sakai,R., Mitani,K.,
            Yoshida,M., Taniguchi,T., Yazaki,Y. and Hirai,H.
  TITLE     A novel interferon regulatory factor family transcription factor,
            ICSAT/Pip/LSIRF, that negatively regulates the activity of
            interferon-regulated genes
  JOURNAL   Mol Cell Biol 16 (4), 1283-1294 (1996)
   PUBMED   8657101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52682.1, U63738.1, BC015752.1,
            AL589962.3, AL512308.19, BM551611.1, KF458069.1, BG230623.1 and
            AW197089.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002460.3.
            
            Summary: The protein encoded by this gene belongs to the IRF
            (interferon regulatory factor) family of transcription factors,
            characterized by an unique tryptophan pentad repeat DNA-binding
            domain. The IRFs are important in the regulation of interferons in
            response to infection by virus, and in the regulation of
            interferon-inducible genes. This family member is lymphocyte
            specific and negatively regulates Toll-like-receptor (TLR)
            signaling that is central to the activation of innate and adaptive
            immune systems. A chromosomal translocation involving this gene and
            the IgH locus, t(6;14)(p25;q32), may be a cause of multiple
            myeloma. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63738.1, SRR1163658.37149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380956.9/ ENSP00000370343.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               U52682.1           14-124
            112-1012            U63738.1           104-1004
            1013-1516           BC015752.1         973-1476
            1517-1849           AL589962.3         6662-6994
            1850-2575           AL512308.19        101-826
            2576-4287           U52682.1           2584-4295
            4288-4866           BM551611.1         139-717
            4867-4895           KF458069.1         1-29                c
            4896-5196           AL512308.19        3147-3447
            5197-5313           BG230623.1         6-122               c
            5314-5314           AW197089.1         6-6                 c
FEATURES             Location/Qualifiers
     source          1..5314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..5314
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /note="interferon regulatory factor 4"
                     /db_xref="GeneID:3662"
                     /db_xref="HGNC:HGNC:6119"
                     /db_xref="MIM:601900"
     exon            1..58
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            59..329
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1469
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple myeloma oncogene 1; lymphocyte-specific
                     interferon regulatory factor"
                     /codon_start=1
                     /product="interferon regulatory factor 4 isoform 1"
                     /protein_id="NP_002451.2"
                     /db_xref="CCDS:CCDS4469.1"
                     /db_xref="GeneID:3662"
                     /db_xref="HGNC:HGNC:6119"
                     /db_xref="MIM:601900"
                     /translation="MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWEN
                     EEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN
                     KSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPS
                     LPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTG
                     TFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRI
                     SHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRI
                     YWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFP
                     DPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQ
                     E"
     exon            330..516
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            517..605
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            606..750
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            751..858
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1212
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1325
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..5314
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5290..5295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /note="hexamer: AATAAA"
     polyA_site      5314
                     /gene="IRF4"
                     /gene_synonym="IMD131; LSIRF; MUM1; NF-EM5; SHEP8"
                     /note="major polyA site"
ORIGIN      
        1 agtttcaccg ctcgatcttg ggacccaccg ctgccctcag ctccgagtcc agggcgagtg
       61 cagagcagag cgggcggagg accccgggcg cgggcgcgga cggcacgcgg ggcatgaacc
      121 tggagggcgg cggccgaggc ggagagttcg gcatgagcgc ggtgagctgc ggcaacggga
      181 agctccgcca gtggctgatc gaccagatcg acagcggcaa gtaccccggg ctggtgtggg
      241 agaacgagga gaagagcatc ttccgcatcc cctggaagca cgcgggcaag caggactaca
      301 accgcgagga ggacgccgcg ctcttcaagg cttgggcact gtttaaagga aagttccgag
      361 aaggcatcga caagccggac cctcccacct ggaagacgcg cctgcggtgc gctttgaaca
      421 agagcaatga ctttgaggaa ctggttgagc ggagccagct ggacatctca gacccgtaca
      481 aagtgtacag gattgttcct gagggagcca aaaaaggagc caagcagctc accctggagg
      541 acccgcagat gtccatgagc cacccctaca ccatgacaac gccttaccct tcgctcccag
      601 cccagcaggt tcacaactac atgatgccac ccctcgaccg aagctggagg gactacgtcc
      661 cggatcagcc acacccggaa atcccgtacc aatgtcccat gacgtttgga ccccgcggcc
      721 accactggca aggcccagct tgtgaaaatg gttgccaggt gacaggaacc ttttatgctt
      781 gtgccccacc tgagtcccag gctcccggag tccccacaga gccaagcata aggtctgccg
      841 aagccttggc gttctcagac tgccggctgc acatctgcct gtactaccgg gaaatcctcg
      901 tgaaggagct gaccacgtcc agccccgagg gctgccggat ctcccatgga catacgtatg
      961 acgccagcaa cctggaccag gtcctgttcc cctacccaga ggacaatggc cagaggaaaa
     1021 acattgagaa gctgctgagc cacctggaga ggggcgtggt cctctggatg gcccccgacg
     1081 ggctctatgc gaaaagactg tgccagagca ggatctactg ggacgggccc ctggcgctgt
     1141 gcaacgaccg gcccaacaaa ctggagagag accagacctg caagctcttt gacacacagc
     1201 agttcttgtc agagctgcaa gcgtttgctc accacggccg ctccctgcca agattccagg
     1261 tgactctatg ctttggagag gagtttccag accctcagag gcaaagaaag ctcatcacag
     1321 ctcacgtaga acctctgcta gccagacaac tatattattt tgctcaacaa aacagtggac
     1381 atttcctgag gggctacgat ttaccagaac acatcagcaa tccagaagat taccacagat
     1441 ctatccgcca ttcctctatt caagaatgaa aaatgtcaag atgagtggtt ttctttttcc
     1501 tttttttttt tttttttttg atacggggat acggggtctt gctctgtctc ccaggctgga
     1561 gtgcagtgac acaatctcag ctcactgtga cctccgcctc ctgggttcaa gagactctcc
     1621 tgcctcagcc tccctggtag ctgggattac aggtgtgagc cactgcaccc acccaagaca
     1681 agtgattttc attgtaaata tttgacttta gtgaaagcgt ccaattgact gccctcttac
     1741 tgttttgagg aattcagaag tggagatttc agttcagcgg ttgaggagaa ttgcggcgag
     1801 acaagcatgg aaaatcagtg acatctgatt ggcagatgag cttatttcaa aaggaagggt
     1861 ggctttgcat ttcttgtgtt ctgtagactg ccatcattga tgatcactgt gaaaattgac
     1921 caagtgatgt gtttacattt actgaaatgc gctctttaat ttgttgtaga ttaggtcttg
     1981 ctggaagaca gagaaaactt gcctttcagt attgacactg actagagtga tgactgcttg
     2041 taggtatgtc tgtgccattt ctcagggaag taagatgtaa attgaagaag cctcacacgt
     2101 aaaagaaatg tattaatgta tgtaggagct gcagttcttg tggaagacac ttgctgagtg
     2161 aaggaaatga atctttgact gaagccgtgc ctgtagcctt ggggaggccc atcccccacc
     2221 tgccagcggt ttcctggtgt gggtccctct gccccgccct ccttcccatt ggctttctct
     2281 ccttggcctt tcctggaagc cagttagtaa acttcctatt ttcttgagtc aaaaaacatg
     2341 agcgctactc ttggatggga catttttgtc tgtcctacaa tctagtaatg tctaagtaat
     2401 ggttaagttt tcttgtttct gcatcttttt gaccctcatt ctttagagat gctaaaattc
     2461 ttcgcataaa gaagaagaaa ttaaggaaca taaatcttaa tacttgaact gttgcccttc
     2521 tgtccaagta cttaactatc tgttcccttc ctctgtgcca cgctcctctg tttgtttggc
     2581 tgtccagcga tcagccatgg cgacactaaa ggaggaggag ccggggactc ccaggctgga
     2641 gagcactgcc aggacccacc actggaagca ggatggagct gactacggaa ctgcacactc
     2701 agtgggctgt ttctgcttat ttcatctgtt ctatgcttcc tcgtgccaat tatagtttga
     2761 cagggcctta aaattacttg gctttttcca aatgcttcta tttatagaat cccaaagacc
     2821 tccacttgct taagtatacc tatcacttac atttttgtgg ttttgagaaa gtacagcagt
     2881 agactggggc gtcacctcca ggccgtttct catactacag gatatttact attactccca
     2941 ggatcagcag aagattgcgt agctctcaaa tgtgtgttcc tgcttttcta atggatattt
     3001 taaattcatt caacaagcac ctagtaagtg cctgctgtat ccctacatta cacagttcag
     3061 cctttatcaa gcttagtgag cagtgagcac tgaaacatta ttttttaatg tttaaaaagt
     3121 ttctaatatt aaagtcagaa tattaataca attaatatta atattaacta cagaaaagac
     3181 aaacagtaga gaacagcaaa aaaataaaaa ggatctcctt ttttcccagc ccaaattctc
     3241 ctctctaaaa gtgtccacaa gaaggggtgt ttattcttcc aacacatttc acttttctgt
     3301 aaatatacat aaacttaaaa agaaaacctc atggagtcat cttgcacaca ctttcatgca
     3361 gtgctctttg tagctaacag tgaagattta cctcgttctg ctcagaggcc ttgctgtgga
     3421 gctccactgc catgtaccca gtagggtttg acatttcatt agccatgcaa catggatatg
     3481 tattgggcag cagactgtgt ttcgtgaact gcagtgatgt atacatctta tagatgcaaa
     3541 gtattttggg gtatattatc ctaagggaag ataaagatga tattaagaac tgctgtttca
     3601 cggggccctt acctgtgacc ctctttgctg aagaatattt aaccccacac agcacttcaa
     3661 agaagctgtc ttggaagtct gtctcaggag caccctgtct tcttaattct ccaagcggat
     3721 gctccatttc aattgctttg tgacttcttc ttctttgttt ttttaaatat tatgctgctt
     3781 taacagtgga gctgaatttt ctggaaaatg cttcttggct ggggccacta cctcctttcc
     3841 tatctttaca tctatgtgta tgttgacttt ttaaaattct gagtgatcca gggtatgacc
     3901 tagggaatga actagctatg aaatactcag ggttaggaat cctagcactt gtctcaggac
     3961 tctgaaaagg aacggcttcc tcattccttg tcttgataaa gtggaattgg caaactagaa
     4021 tttagtttgt actcagtgga cagtgctgtt gaagatttga ggacttgtta aagagcactg
     4081 ggtcatatgg aaaaaatgta tgtgtctccc aggtgcattt cttggtttat gtcttgttct
     4141 tgagattttg tatatttagg aaaacctcaa gcagtaatta atatctcctg gaacactata
     4201 gagaaccaag tgaccgactc atttacaact gaaacctagg aagcccctga gtcctgagcg
     4261 aaaacaggag agttagtcgc cctacagaaa acccagctag actattgggt atgaactaaa
     4321 aagagactgt gccatggtga gaaaaatgta aaatcctaca gtgaaatgag cagcccttac
     4381 agtattgtta ccaccaaggg caggtaggta ttagtgtttg aaaaagctgg tctttgagcg
     4441 agggcataaa tacagctagc cccaggggtg gaacaactct gggagtcttg ggtactcgca
     4501 cctcttggct ttgttgatgc tccgccagga aggccacttg tgtgtgcgtg tcagttactt
     4561 ttttagtaac aattcagatc cagtgtaaac ttccgttcat tgctctccag tcacatgccc
     4621 ccacttcccc acaggtgaaa gtttttctga aagtgttggg attggttaag gtctttattt
     4681 gtattacgta tctccccaag tcctctgtgg ccagctgcat ctgtctgaat ggtgcgtgaa
     4741 ggctctcaga ccttacacac cattttgtaa gttatgtttt acatgccccg tttttgagac
     4801 tgatctcgat gcaggtggat ctccttgaga tcctgatagc ctgttacagg aatgaagtaa
     4861 aggtcagttt ttttttgtat tgattttcac agctttgagg aacatgcata agaaatgtag
     4921 ctgaagtaga ggggacgtga gagaagggcc aggccggcag gccaaccctc ctccaatgga
     4981 aattcccgtg ttgcttcaaa ctgagacaga tgggacttaa caggcaatgg ggtccacttc
     5041 cccctcttca gcatcccccg taccccactt tctgctgaaa gaactgccag caggtaggac
     5101 cccagaggcc cccaaatgaa agcttgaatt tcccctactg gctctgcgtt ttgctgagat
     5161 ctgtaggaaa ggatgcttca caaactgagg tagataatgc tatgctgtcg ttggtataca
     5221 tcatgaattt ttatgtaaat tgctctgcaa agcaaattga tatgtttgat aaatttatgt
     5281 ttttaggtaa ataaaaactt ttaaaaattt gtta
//
