LOCUS       NM_001571               1595 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens interferon regulatory factor 3 (IRF3), transcript
            variant 1, mRNA.
ACCESSION   NM_001571
VERSION     NM_001571.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Tong,Z., Zou,J.P., Wang,S.Y., Luo,W.W. and Wang,Y.Y.
  TITLE     Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons
            Contributes to Host Defense
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308890 (2024)
   PUBMED   39004913
  REMARK    GeneRIF: Activation of the cGAS-STING-IRF3 Axis by Type I and II
            Interferons Contributes to Host Defense.
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Baraldo,S., Bonato,M., Cassia,S., Casolari,P., De Ferrari,L.,
            Tine,M., Baraldi,F., Bigoni,T., Riccio,A.M., Braido,F., Saetta,M.,
            Papi,A. and Contoli,M.
  TITLE     Expression of human Interferon Regulatory Factor 3 (IRF-3) in
            alveolar macrophages relates to clinical and functional traits in
            COPD
  JOURNAL   Respir Res 25 (1), 315 (2024)
   PUBMED   39160551
  REMARK    GeneRIF: Expression of human Interferon Regulatory Factor 3 (IRF-3)
            in alveolar macrophages relates to clinical and functional traits
            in COPD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Wu,B., Li,D., Bai,H., Mo,R., Li,H., Xie,J., Zhang,X., Yang,Y.,
            Li,H., Idris,A., Li,X. and Feng,R.
  TITLE     Mammalian reovirus micro1 protein attenuates RIG-I and
            MDA5-mediated signaling transduction by blocking IRF3
            phosphorylation and nuclear translocation
  JOURNAL   Mol Immunol 170, 131-143 (2024)
   PUBMED   38663254
  REMARK    GeneRIF: Mammalian reovirus micro1 protein attenuates RIG-I and
            MDA5-mediated signaling transduction by blocking IRF3
            phosphorylation and nuclear translocation.
REFERENCE   4  (bases 1 to 1595)
  AUTHORS   Takahasi,K., Suzuki,N.N., Horiuchi,M., Mori,M., Suhara,W.,
            Okabe,Y., Fukuhara,Y., Terasawa,H., Akira,S., Fujita,T. and
            Inagaki,F.
  TITLE     X-ray crystal structure of IRF-3 and its functional implications
  JOURNAL   Nat Struct Biol 10 (11), 922-927 (2003)
   PUBMED   14555995
REFERENCE   5  (bases 1 to 1595)
  AUTHORS   Lowther,W.J., Moore,P.A., Carter,K.C. and Pitha,P.M.
  TITLE     Cloning and functional analysis of the human IRF-3 promoter
  JOURNAL   DNA Cell Biol 18 (9), 685-692 (1999)
   PUBMED   10492399
REFERENCE   6  (bases 1 to 1595)
  AUTHORS   Bellingham,J., Gregory-Evans,K. and Gregory-Evans,C.Y.
  TITLE     Mapping of human interferon regulatory factor 3 (IRF3) to
            chromosome 19q13.3-13.4 by an intragenic polymorphic marker
  JOURNAL   Ann Hum Genet 62 (Pt 3), 231-234 (1998)
   PUBMED   9803267
REFERENCE   7  (bases 1 to 1595)
  AUTHORS   Lin,R., Heylbroeck,C., Pitha,P.M. and Hiscott,J.
  TITLE     Virus-dependent phosphorylation of the IRF-3 transcription factor
            regulates nuclear translocation, transactivation potential, and
            proteasome-mediated degradation
  JOURNAL   Mol Cell Biol 18 (5), 2986-2996 (1998)
   PUBMED   9566918
REFERENCE   8  (bases 1 to 1595)
  AUTHORS   Weaver,B.K., Kumar,K.P. and Reich,N.C.
  TITLE     Interferon regulatory factor 3 and CREB-binding protein/p300 are
            subunits of double-stranded RNA-activated transcription factor
            DRAF1
  JOURNAL   Mol Cell Biol 18 (3), 1359-1368 (1998)
   PUBMED   9488451
REFERENCE   9  (bases 1 to 1595)
  AUTHORS   Yoneyama,M., Suhara,W., Fukuhara,Y., Fukuda,M., Nishida,E. and
            Fujita,T.
  TITLE     Direct triggering of the type I interferon system by virus
            infection: activation of a transcription factor complex containing
            IRF-3 and CBP/p300
  JOURNAL   EMBO J 17 (4), 1087-1095 (1998)
   PUBMED   9463386
REFERENCE   10 (bases 1 to 1595)
  AUTHORS   Au,W.C., Moore,P.A., Lowther,W., Juang,Y.T. and Pitha,P.M.
  TITLE     Identification of a member of the interferon regulatory factor
            family that binds to the interferon-stimulated response element and
            activates expression of interferon-induced genes
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11657-11661 (1995)
   PUBMED   8524823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA999381.1, AC011495.8 and
            Z56281.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001571.5.
            
            Summary: This gene encodes a member of the interferon regulatory
            transcription factor (IRF) family. The encoded protein is found in
            an inactive cytoplasmic form that upon serine/threonine
            phosphorylation forms a complex with CREBBP. This complex
            translocates to the nucleus and activates the transcription of
            interferons alpha and beta, as well as other interferon-induced
            genes. The protein plays an important role in the innate immune
            response against DNA and RNA viruses. Mutations in this gene are
            associated with Encephalopathy, acute, infection-induced,
            herpes-specific, 7. [provided by RefSeq, Sep 2020].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z56281.1, AK314421.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000377139.8/ ENSP00000366344.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                DA999381.1         19-112
            95-189              AC011495.8         91479-91573         c
            190-1595            Z56281.1           1-1406
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1595
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /note="interferon regulatory factor 3"
                     /db_xref="GeneID:3661"
                     /db_xref="HGNC:HGNC:6118"
                     /db_xref="MIM:603734"
     exon            1..227
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            228..400
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1519
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="interferon regulatory factor 3 isoform 1"
                     /protein_id="NP_001562.1"
                     /db_xref="CCDS:CCDS12775.1"
                     /db_xref="GeneID:3661"
                     /db_xref="HGNC:HGNC:6118"
                     /db_xref="MIM:603734"
                     /translation="MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQ
                     DAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHD
                     PHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSL
                     AVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQ
                     TISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWR
                     AGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTE
                     GSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVD
                     LHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES"
     exon            401..572
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            573..643
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            644..836
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1217
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1333
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1595
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="IRF3"
                     /gene_synonym="IIAE7"
                     /note="major polyA site"
ORIGIN      
        1 ataggggcgg gaacagccca gcgggccgtc ccatcggctt ttgggtctgt tacccaaaga
       61 atgataaagt tggttttatt tcaagaagtc gatcaaaaag aaagccccag cgctctagag
      121 ctcagctgac gggaaagggg gtgcgcagcc tcgagtttga gagctacccg gagctccaag
      181 acaggggtgg gttccagctg cccgcacgcc ccgaccttcc atcgtaggcc ggaccatggg
      241 aaccccaaag ccacggatcc tgccctggct ggtgtcgcag ctggacctgg ggcaactgga
      301 gggcgtggcc tgggtgaaca agagccgcac gcgcttccgc atcccttgga agcacggcct
      361 acggcaggat gcacagcagg aggatttcgg aatcttccag gcctgggccg aggccactgg
      421 tgcatatgtt cccgggaggg ataagccaga cctgccaacc tggaagagga atttccgctc
      481 tgccctcaac cgcaaagaag ggttgcgttt agcagaggac cggagcaagg accctcacga
      541 cccacataaa atctacgagt ttgtgaactc aggagttggg gacttttccc agccagacac
      601 ctctccggac accaatggtg gaggcagtac ttctgatacc caggaagaca ttctggatga
      661 gttactgggt aacatggtgt tggccccact cccagatccg ggacccccaa gcctggctgt
      721 agcccctgag ccctgccctc agcccctgcg gagccccagc ttggacaatc ccactccctt
      781 cccaaacctg gggccctctg agaacccact gaagcggctg ttggtgccgg gggaagagtg
      841 ggagttcgag gtgacagcct tctaccgggg ccgccaagtc ttccagcaga ccatctcctg
      901 cccggagggc ctgcggctgg tggggtccga agtgggagac aggacgctgc ctggatggcc
      961 agtcacactg ccagaccctg gcatgtccct gacagacagg ggagtgatga gctacgtgag
     1021 gcatgtgctg agctgcctgg gtgggggact ggctctctgg cgggccgggc agtggctctg
     1081 ggcccagcgg ctggggcact gccacacata ctgggcagtg agcgaggagc tgctccccaa
     1141 cagcgggcat gggcctgatg gcgaggtccc caaggacaag gaaggaggcg tgtttgacct
     1201 ggggcccttc attgtagatc tgattacctt cacggaagga agcggacgct caccacgcta
     1261 tgccctctgg ttctgtgtgg gggagtcatg gccccaggac cagccgtgga ccaagaggct
     1321 cgtgatggtc aaggttgtgc ccacgtgcct cagggccttg gtagaaatgg cccgggtagg
     1381 gggtgcctcc tccctggaga atactgtgga cctgcacatt tccaacagcc acccactctc
     1441 cctcacctcc gaccagtaca aggcctacct gcaggacttg gtggagggca tggatttcca
     1501 gggccctggg gagagctgag ccctcgctcc tcatggtgtg cctccaaccc ccctgttccc
     1561 caccacctca accaataaac tggttcctgc tatga
//
