LOCUS       NM_015649               2534 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens interferon regulatory factor 2 binding protein 1
            (IRF2BP1), mRNA.
ACCESSION   NM_015649
VERSION     NM_015649.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Barysch,S.V., Stankovic-Valentin,N., Miedema,T., Karaca,S.,
            Doppel,J., Nait Achour,T., Vasudeva,A., Wolf,L., Sticht,C.,
            Urlaub,H. and Melchior,F.
  TITLE     Transient deSUMOylation of IRF2BP proteins controls early
            transcription in EGFR signaling
  JOURNAL   EMBO Rep 22 (3), e49651 (2021)
   PUBMED   33480129
  REMARK    GeneRIF: Transient deSUMOylation of IRF2BP proteins controls early
            transcription in EGFR signaling.
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Kimura,M.
  TITLE     IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor
            of ATF2-dependent transcription
  JOURNAL   FEBS Lett 582 (19), 2833-2837 (2008)
   PUBMED   18671972
  REMARK    GeneRIF: IRF2-BP1 is a JDP2-binding protein enhancing the
            polyubiquitination of JDP2 and represses ATF2-mediated
            transcriptional activation from a CRE-containing promoter.
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Faresse,N., Colland,F., Ferrand,N., Prunier,C., Bourgeade,M.F. and
            Atfi,A.
  TITLE     Identification of PCTA, a TGIF antagonist that promotes PML
            function in TGF-beta signalling
  JOURNAL   EMBO J 27 (13), 1804-1815 (2008)
   PUBMED   18511908
  REMARK    GeneRIF: PCTA (IRF2BP1) defines a new component of the TGF-beta
            signalling pathway that functions to facilitate Smad2
            phosphorylation through controlling the accumulation of cPML into
            the cytoplasm, and consequently, the assembly of Smad2-receptor
            complex.
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Peng,Y.B., Yerle,M. and Liu,B.
  TITLE     Mapping of nine porcine interferon regulatory factor genes
  JOURNAL   Anim Genet 37 (6), 600-601 (2006)
   PUBMED   17121613
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Childs,K.S. and Goodbourn,S.
  TITLE     Identification of novel co-repressor molecules for Interferon
            Regulatory Factor-2
  JOURNAL   Nucleic Acids Res 31 (12), 3016-3026 (2003)
   PUBMED   12799427
  REMARK    GeneRIF: Identification of IRF-2 binding protein 1 and IRF-2
            binding protein 2 as co-repressor molecules for interferon
            regulatory factor-2.
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Odendahl,M., Jacobi,A., Hansen,A., Feist,E., Hiepe,F.,
            Burmester,G.R., Lipsky,P.E., Radbruch,A. and Dorner,T.
  TITLE     Disturbed peripheral B lymphocyte homeostasis in systemic lupus
            erythematosus
  JOURNAL   J Immunol 165 (10), 5970-5979 (2000)
   PUBMED   11067960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA791039.1 and AY278022.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015649.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC039002.1, AY278022.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302165.5/ ENSP00000307265.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA791039.1         30-49
            21-2534             AY278022.1         1-2514
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2534
                     /gene="IRF2BP1"
                     /note="interferon regulatory factor 2 binding protein 1"
                     /db_xref="GeneID:26145"
                     /db_xref="HGNC:HGNC:21728"
                     /db_xref="MIM:615331"
     exon            1..2534
                     /gene="IRF2BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..2122
                     /gene="IRF2BP1"
                     /EC_number="2.3.2.27"
                     /note="IRF-2-binding protein 1; probable E3
                     ubiquitin-protein ligase IRF2BP1; probable RING-type E3
                     ubiquitin transferase IRF2BP1"
                     /codon_start=1
                     /product="interferon regulatory factor 2-binding protein
                     1"
                     /protein_id="NP_056464.1"
                     /db_xref="CCDS:CCDS12678.1"
                     /db_xref="GeneID:26145"
                     /db_xref="HGNC:HGNC:21728"
                     /db_xref="MIM:615331"
                     /translation="MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADR
                     IELLIDAARQLKRSHVLPEGRSPGPPALKHPATKDLAAAAAQGPQLPPPQAQPQPSGT
                     GGGVSGQDRYDRATSSGRLPLPSPALEYTLGSRLANGLGREEAVAEGARRALLGSMPG
                     LMPPGLLAAAVSGLGSRGLTLAPGLSPARPLFGSDFEKEKQQRNADCLAELNEAMRGR
                     AEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFT
                     EYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELL
                     TDGVRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGEAA
                     GKMTTEEQQQRHWVAPGGPYSAETPGVPSPIAALKNVAEALGHSPKDPGGGGGPVRAG
                     GASPAASSTAQPPTQHRLVARNGEAEVSPTAGAEAVSGGGSGTGATPGAPLCCTLCRE
                     RLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQG
                     EIATILAGDIKVKKERDP"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF2BP1"
                     /note="hexamer: AATAAA"
     polyA_site      2534
                     /gene="IRF2BP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagaag gaggtggagg cggcggcggc cgttgcagcg gcggcggcga gagcggcggg
       61 agcccgaggc ggcggcgctc gcggcccatc gtggggcccg agctgtgcgc ctcggctcgg
      121 agcccggacc gggcgggggc gccgacgtgc ctcagcctgc cttcgcgagg gaggcgggag
      181 tgagcagaaa ggcttagggc ccagggggcg gggaaggggg gccgggcctg gatccggcgg
      241 ggaggccgag ccggaggccg gaccgtggct cgcgctgtcc ccgggacgcg gatcgaacgt
      301 tggcggcgcg gatcgcacgt cggcggccgg tggaacgcgg gagctgggcg gcgcgcggac
      361 tggggccatg gcgtctgtgc aggcgtcccg ccgccagtgg tgctacctgt gcgacctgcc
      421 caagatgccg tgggccatgg tgtgggactt cagcgaggcc gtgtgtcgcg gctgcgtgaa
      481 cttcgagggc gcggaccgca tcgaactgct catcgatgcc gcccgccagc tcaagcgcag
      541 ccacgtgctc cccgagggcc gctcgcccgg gcccccggcc cttaagcacc cggccaccaa
      601 ggacctggcg gcggcagccg cacaggggcc ccagctgccg cccccgcagg cccagcccca
      661 gccgtcaggg accggcggcg gcgtgtcggg ccaggaccgc tatgacaggg ccacatcatc
      721 aggccgcctc cccctgccct cgcccgccct ggagtacact ctggggtccc gcctggccaa
      781 tgggctgggc cgtgaggagg ccgtggctga gggggcgcga agggccttgc ttggctccat
      841 gcctggcttg atgccccctg ggctgctggc agctgcagtg tctggcctgg gaagccgagg
      901 cctgacgctg gcacccggct tgagtcctgc ccgtcccctc ttcggctccg atttcgagaa
      961 agagaagcag cagaggaatg cggactgtct ggcagaactg aacgaggcca tgcgaggccg
     1021 ggcagaggaa tggcacgggc gccccaaagc agtgcgggaa cagctactgg cgctgtccgc
     1081 ctgcgccccg ttcaatgtgc gcttcaagaa ggatcacggg ctggtggggc gagtgttcgc
     1141 cttcgatgct actgcccgtc ctccaggata cgagttcgag ctgaagctct tcaccgaata
     1201 cccctgtggt tccggcaatg tgtacgccgg cgtcctggca gtggctcgcc agatgttcca
     1261 cgatgctctg cgggagccgg gcaaggcact ggcttcttcg ggcttcaagt acctcgaata
     1321 tgaacgccgg catggatcag gagaatggcg gcagctgggc gagctgctta ccgacggcgt
     1381 ccgcagcttc cgcgagccag ctcccgcgga ggccctgccc cagcagtacc cagagccggc
     1441 ccctgcggct ctctgtggcc cacccccgcg agccccatcc cggaacctgg cgcccacgcc
     1501 gcgccgtcgc aaggcatccc ccgagccgga gggcgaggcg gctgggaaga tgaccaccga
     1561 ggagcagcag caacggcact gggtggcacc cggcggcccg tactccgctg agacccctgg
     1621 tgtgccctcg cccattgccg ccctgaagaa tgtggccgaa gccctgggcc actcacccaa
     1681 ggaccctggc ggaggcgggg ggcctgtgcg tgcagggggc gccagccctg cagcctcctc
     1741 cacggcccag ccgccaaccc agcatcgcct tgtggcccgc aacggcgaag cagaagtcag
     1801 tcccacagcg ggggccgaag ctgtcagcgg gggtggcagc ggcactgggg cgacccctgg
     1861 ggcccccctg tgctgtaccc tgtgcaggga gcggctagaa gacacccact tcgtccagtg
     1921 cccctcggtg cccggacaca agttctgctt tccctgctcc cgggagttca tcaaggcgca
     1981 gggcccggcc ggggaggtgt actgcccgag cggagacaag tgcccgctgg tcggctcctc
     2041 cgtgccctgg gccttcatgc agggcgagat cgccaccatc cttgctggag acatcaaagt
     2101 taagaaagaa cgggacccct aggctaccac tgcctccagg ctactgccct ctgccccttt
     2161 gccacccacc gctgccgcgg ataaattatt ccctccccga cccagcccag tgccacctct
     2221 atctgtgtac atactccctt cttccaccca gatgggtccc ctggggtaga tgcattgtgg
     2281 gtggggggag aaagcttgtg gctcctgtcc gagggggtgt ttggggtccc ttggcccctc
     2341 cagtttccct ctgtcctcct tggcttggct ttgctgctgc ttgtagttgg gggagaggtg
     2401 cccccctcct ccttgagaag ggacctcctg aaaactcgct ctttataaac gaggcaaaag
     2461 catttaattc ccaccccccc accccccgct cccttctgct ccttcaataa accgaaagat
     2521 gggttttttt tttc
//
