LOCUS       NM_002199               2257 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interferon regulatory factor 2 (IRF2), mRNA.
ACCESSION   NM_002199
VERSION     NM_002199.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Tokumaru,S., Yamamoto,Y., Yoshizawa,K., Soejima,Y., Sanjo,H. and
            Taki,S.
  TITLE     Interferon regulatory factor-2 is required for the establishment of
            the gut intraepithelial T-cell compartment
  JOURNAL   Int Immunol 35 (5), 231-241 (2023)
   PUBMED   36521002
  REMARK    GeneRIF: Interferon regulatory factor-2 is required for the
            establishment of the gut intraepithelial T-cell compartment.
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Persyn,E., Wahlen,S., Kiekens,L., Van Loocke,W., Siwe,H., Van
            Ammel,E., De Vos,Z., Van Nieuwerburgh,F., Matthys,P., Taghon,T.,
            Vandekerckhove,B., Van Vlierberghe,P. and Leclercq,G.
  TITLE     IRF2 is required for development and functional maturation of human
            NK cells
  JOURNAL   Front Immunol 13, 1038821 (2022)
   PUBMED   36544762
  REMARK    GeneRIF: IRF2 is required for development and functional maturation
            of human NK cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   Chen,Y.J., Luo,S.N., Wu,H., Zhang,N.P., Dong,L., Liu,T.T., Liang,L.
            and Shen,X.Z.
  TITLE     IRF-2 inhibits cancer proliferation by promoting AMER-1
            transcription in human gastric cancer
  JOURNAL   J Transl Med 20 (1), 68 (2022)
   PUBMED   35115027
  REMARK    GeneRIF: IRF-2 inhibits cancer proliferation by promoting AMER-1
            transcription in human gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Ren,K., Zhu,Y., Sun,H., Li,S., Duan,X., Li,S., Li,Y., Li,B. and
            Chen,L.
  TITLE     IRF2 inhibits ZIKV replication by promoting FAM111A expression to
            enhance the host restriction effect of RFC3
  JOURNAL   Virol J 18 (1), 256 (2021)
   PUBMED   34930359
  REMARK    GeneRIF: IRF2 inhibits ZIKV replication by promoting FAM111A
            expression to enhance the host restriction effect of RFC3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Ye,G., Wang,P., Xie,Z., Li,J., Zheng,G., Liu,W., Cao,Q., Li,M.,
            Cen,S., Li,Z., Yu,W., Wu,Y. and Shen,H.
  TITLE     IRF2-mediated upregulation of lncRNA HHAS1 facilitates the
            osteogenic differentiation of bone marrow-derived mesenchymal stem
            cells by acting as a competing endogenous RNA
  JOURNAL   Clin Transl Med 11 (6), e429 (2021)
   PUBMED   34185419
  REMARK    GeneRIF: IRF2-mediated upregulation of lncRNA HHAS1 facilitates the
            osteogenic differentiation of bone marrow-derived mesenchymal stem
            cells by acting as a competing endogenous RNA.
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 2257)
  AUTHORS   Harada,H., Takahashi,E., Itoh,S., Harada,K., Hori,T.A. and
            Taniguchi,T.
  TITLE     Structure and regulation of the human interferon regulatory factor
            1 (IRF-1) and IRF-2 genes: implications for a gene network in the
            interferon system
  JOURNAL   Mol Cell Biol 14 (2), 1500-1509 (1994)
   PUBMED   7507207
REFERENCE   8  (bases 1 to 2257)
  AUTHORS   Palombella,V.J. and Maniatis,T.
  TITLE     Inducible processing of interferon regulatory factor-2
  JOURNAL   Mol Cell Biol 12 (8), 3325-3336 (1992)
   PUBMED   1630448
REFERENCE   9  (bases 1 to 2257)
  AUTHORS   Itoh,S., Harada,H., Fujita,T., Mimura,T. and Taniguchi,T.
  TITLE     Sequence of a cDNA coding for human IRF-2
  JOURNAL   Nucleic Acids Res 17 (20), 8372 (1989)
   PUBMED   2813069
REFERENCE   10 (bases 1 to 2257)
  AUTHORS   Harada,H., Fujita,T., Miyamoto,M., Kimura,Y., Maruyama,M.,
            Furia,A., Miyata,T. and Taniguchi,T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP200998.1, AA361545.1,
            BC015803.2 and BQ017798.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002199.3.
            
            Summary: IRF2 encodes interferon regulatory factor 2, a member of
            the interferon regulatory transcription factor (IRF) family. IRF2
            competitively inhibits the IRF1-mediated transcriptional activation
            of interferons alpha and beta, and presumably other genes that
            employ IRF1 for transcription activation. However, IRF2 also
            functions as a transcriptional activator of histone H4. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.764367.1,
                                           SRR1660809.207099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393593.8/ ENSP00000377218.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               BP200998.1         23-131
            110-309             AA361545.1         68-267
            310-1774            BC015803.2         139-1603
            1775-2257           BQ017798.1         24-506              c
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..2257
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /note="interferon regulatory factor 2"
                     /db_xref="GeneID:3660"
                     /db_xref="HGNC:HGNC:6117"
                     /db_xref="MIM:147576"
     exon            1..172
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..265
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1228
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /codon_start=1
                     /product="interferon regulatory factor 2"
                     /protein_id="NP_002190.2"
                     /db_xref="CCDS:CCDS3835.1"
                     /db_xref="GeneID:3660"
                     /db_xref="HGNC:HGNC:6117"
                     /db_xref="MIM:147576"
                     /translation="MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARH
                     GWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKG
                     NNAFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAV
                     LTSTIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSE
                     LYPLQISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPG
                     MASFVTSNKPDLQVTIKEESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASV
                     IKKTSDITQARVKSC"
     exon            266..365
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..542
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..589
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..707
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..872
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..919
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..2257
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /note="hexamer: AATATA"
     polyA_site      2091
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /note="hexamer: AATAAA"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /note="hexamer: AATGAA"
     polyA_site      2251
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
     polyA_site      2257
                     /gene="IRF2"
                     /gene_synonym="IRF-2"
                     /note="major polyA site"
ORIGIN      
        1 ctctccttgt tttgctttcg atctggactg ttctcaggca agccggggag taacttttag
       61 ttttgctcct gcgattattc aactgacggg ctttcatttc catttcacat accctagcaa
      121 cacttatacc ttgcggaatt gtattggtag cgtgaaaaaa gcacactgag agggcaccat
      181 gccggtggaa aggatgcgca tgcgcccgtg gctggaggag cagataaact ccaacacgat
      241 cccggggctc aagtggctta acaaggaaaa gaagattttt cagatcccct ggatgcatgc
      301 ggctagacat gggtgggatg tggaaaaaga tgcaccactc tttagaaact gggcaatcca
      361 tacaggaaag catcaaccag gagtagataa acctgatccc aaaacatgga aggcgaattt
      421 cagatgcgcc atgaattcct tgcctgatat tgaagaagtc aaggataaaa gcataaagaa
      481 aggaaataat gccttcaggg tctaccgaat gctgccccta tcagaacggc cttctaagaa
      541 aggaaagaaa ccaaagacag aaaaagaaga caaagttaag cacatcaagc aagaaccagt
      601 tgagtcatct ctggggctta gtaatggagt aagtgatctt tctcctgagt atgcggtcct
      661 gacttcaact ataaaaaatg aagtggatag tacggtgaac atcatagttg taggacagtc
      721 ccatctggac agcaacattg agaatcaaga gattgtcacc aatccgccag acatttgcca
      781 agttgtagag gtgaccactg agagcgacga gcagccggtc agcatgagcg agctctaccc
      841 tctgcagatc tcccccgtgt cttcctatgc agaaagcgaa acgactgata gtgtgcccag
      901 cgatgaagag agtgccgagg ggcggccaca ctggcggaag aggaatattg aaggcaaaca
      961 gtacctcagc aacatgggga ctcgaggctc ctacctgctg cccggcatgg cgtccttcgt
     1021 cacttccaac aaaccggacc tccaggtcac catcaaagag gagagcaatc cggtgcctta
     1081 caacagctcc tggccccctt ttcaagacct ccccctttct tcctccatga ccccagcatc
     1141 cagcagcagt cggccagacc gggagacccg ggccagcgtc atcaagaaaa catcggatat
     1201 cacccaggcc cgcgtcaaga gctgttaagc ctctgactct ccgcggtggt tgttggggct
     1261 tcttggcttt gttttgttgt ttgtttgtat tttatttttt tctctctgac acctatttta
     1321 gacaaatcta agggaaaaag ccttgacaat agaacattga ttgctgtgtc caactccagt
     1381 actggagctt ctctttaact caggactcca gcccattggt agacgtgtgt ttctagagcc
     1441 tgctggatct cccagggcta ctcactcaag ttcaaggacc aacaagggca gtggaggtgc
     1501 tgcattgcct gcggtcaagg ccagcaaggt ggagtggatg cctcagaacg gacgagataa
     1561 tgtgaactag ctggaatttt ttattcttgt gaatatgtac ataggcagca ctagcgacat
     1621 tgcagtctgc ttctgcacct tatcttaaag cacttacaga taggccttct tgtgatcttg
     1681 ctctatctca cagcacactc agcaccccct tctctgccca ttccccagcc tctcttccta
     1741 tcccatccca tcccatccca tcccatccca tcccatcccg ctcttttcct acttttcctt
     1801 ccctcaaagc ttccattcca catccggagg agaagaagga aatgaatttc tctacagatg
     1861 tcccattttc agactgcttt aaaaaaaatc cttctaatct gctatgcttg aatgccacgc
     1921 ggtacaaagg aaaaagtatc atggaaatat tatgcaaatt cccagatttg aagacaaaaa
     1981 tactctaatt ctaaccagag caagcttttt tattttttat acaggggaat attttattca
     2041 aggtaaaatt ctaaataaaa tataattgtt ttttatcttt tctacagcaa atttataatt
     2101 ttaagattcc ttttcttgtt tatcagcagt tgttattaca tccttgtggc acattttttt
     2161 ttttaatttt gtaaaggtga aaaaagcttt tatgagctca tgtagcaatc agattttcct
     2221 gtggattgat aataaatgaa tatgatatat agttaaa
//
