LOCUS       NM_002198               3554 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens interferon regulatory factor 1 (IRF1), transcript
            variant 1, mRNA.
ACCESSION   NM_002198
VERSION     NM_002198.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Ma,Y., Ye,S., Liu,Y., Zhao,X., Wang,Y. and Wang,Y.
  TITLE     Interferon regulatory factor 1 mediated inhibition of Treg cell
            differentiation induces maternal-fetal immune imbalance in
            preeclampsia
  JOURNAL   Int Immunopharmacol 141, 112988 (2024)
   PUBMED   39213867
  REMARK    GeneRIF: Interferon regulatory factor 1 mediated inhibition of Treg
            cell differentiation induces maternal-fetal immune imbalance in
            preeclampsia.
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
  REMARK    GeneRIF: Opposing tumor-cell-intrinsic and -extrinsic roles of the
            IRF1 transcription factor in antitumor immunity.
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Xian,Y., Wang,X., Yu,Y. and Chen,X.
  TITLE     Transcriptomics confirms IRF1 as a key regulator of pyroptosis in
            diabetic retinopathy
  JOURNAL   Biochem Biophys Res Commun 709, 149760 (2024)
   PUBMED   38554602
  REMARK    GeneRIF: Transcriptomics confirms IRF1 as a key regulator of
            pyroptosis in diabetic retinopathy.
REFERENCE   4  (bases 1 to 3554)
  AUTHORS   Xu,X., Qiao,D. and Brasier,A.R.
  TITLE     Cooperative interaction of interferon regulatory factor -1 and
            bromodomain-containing protein 4 on RNA polymerase activation for
            intrinsic innate immunity
  JOURNAL   Front Immunol 15, 1366235 (2024)
   PUBMED   38601157
  REMARK    GeneRIF: Cooperative interaction of interferon regulatory factor -1
            and bromodomain-containing protein 4 on RNA polymerase activation
            for intrinsic innate immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3554)
  AUTHORS   Recchia Luciani,G., Barilli,A., Visigalli,R., Sala,R., Dall'Asta,V.
            and Rotoli,B.M.
  TITLE     IRF1 Mediates Growth Arrest and the Induction of a Secretory
            Phenotype in Alveolar Epithelial Cells in Response to Inflammatory
            Cytokines IFNgamma/TNFalpha
  JOURNAL   Int J Mol Sci 25 (6), 3463 (2024)
   PUBMED   38542436
  REMARK    GeneRIF: IRF1 Mediates Growth Arrest and the Induction of a
            Secretory Phenotype in Alveolar Epithelial Cells in Response to
            Inflammatory Cytokines IFNgamma/TNFalpha.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3554)
  AUTHORS   Cha,Y., Sims,S.H., Romine,M.F., Kaufmann,M. and Deisseroth,A.B.
  TITLE     Human interferon regulatory factor 1: intron-exon organization
  JOURNAL   DNA Cell Biol 11 (8), 605-611 (1992)
   PUBMED   1382447
REFERENCE   7  (bases 1 to 3554)
  AUTHORS   Itoh,S., Harada,H., Nakamura,Y., White,R. and Taniguchi,T.
  TITLE     Assignment of the human interferon regulatory factor-1 (IRF1) gene
            to chromosome 5q23-q31
  JOURNAL   Genomics 10 (4), 1097-1099 (1991)
   PUBMED   1680796
REFERENCE   8  (bases 1 to 3554)
  AUTHORS   Harada,H., Fujita,T., Miyamoto,M., Kimura,Y., Maruyama,M.,
            Furia,A., Miyata,T. and Taniguchi,T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
REFERENCE   9  (bases 1 to 3554)
  AUTHORS   Maruyama,M., Fujita,T. and Taniguchi,T.
  TITLE     Sequence of a cDNA coding for human IRF-1
  JOURNAL   Nucleic Acids Res 17 (8), 3292 (1989)
   PUBMED   2726461
REFERENCE   10 (bases 1 to 3554)
  AUTHORS   Miyamoto,M., Fujita,T., Kimura,Y., Maruyama,M., Harada,H., Sudo,Y.,
            Miyata,T. and Taniguchi,T.
  TITLE     Regulated expression of a gene encoding a nuclear factor, IRF-1,
            that specifically binds to IFN-beta gene regulatory elements
  JOURNAL   Cell 54 (6), 903-913 (1988)
   PUBMED   3409321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314025.1, BC009483.2,
            AC116366.2 and AA402319.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002198.2.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator and tumor suppressor, serving as an activator of genes
            involved in both innate and acquired immune responses. The encoded
            protein activates the transcription of genes involved in the body's
            response to viruses and bacteria, playing a role in cell
            proliferation, apoptosis, the immune response, and DNA damage
            response. This protein represses the transcription of several other
            genes. As a tumor suppressor, it both suppresses tumor cell growth
            and stimulates an immune response against tumor cells. Defects in
            this gene have been associated with gastric cancer, myelogenous
            leukemia, and lung cancer. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.593112.1, AK314025.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245414.9/ ENSP00000245414.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1212              AK314025.1         1-1212
            1213-2025           BC009483.2         1182-1994
            2026-3145           AC116366.2         93575-94694         c
            3146-3554           AA402319.1         1-409
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..3554
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="interferon regulatory factor 1"
                     /db_xref="GeneID:3659"
                     /db_xref="HGNC:HGNC:6116"
                     /db_xref="MIM:147575"
     exon            1..229
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            230..321
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1212
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="interferon regulatory factor 1 isoform 1"
                     /protein_id="NP_002189.1"
                     /db_xref="CCDS:CCDS4155.1"
                     /db_xref="GeneID:3659"
                     /db_xref="HGNC:HGNC:6116"
                     /db_xref="MIM:147575"
                     /translation="MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKH
                     GWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKG
                     SSAVRVYRMLPPLTKNQRKERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDD
                     HSSYTVPGYMQDLEVEQALTPALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMP
                     STSEATTDEDEEGKLPEDIMKLLEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKE
                     EPEIDSPGGDIGLSLQRVFTDLKNMDATWLDSLLTPVRLPSIQAIPCAP"
     exon            322..421
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            422..598
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            599..648
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            649..778
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            779..901
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            902..951
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1087
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..3554
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="hexamer: AGTAAA"
     polyA_site      2105
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="major polyA site"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="IRF1"
                     /gene_synonym="IMD117; IRF-1; MAR"
                     /note="major polyA site"
ORIGIN      
        1 agagctcgcc actccttagt cgaggcaaga cgtgcgcccg agccccgccg aaccgaggcc
       61 acccggagcc gtgcccagtc cacgccggcc gtgcccggcg gccttaagaa cccggcaacc
      121 tctgccttct tccctcttcc actcggagtc gcgctccgcg cgccctcact gcagcccctg
      181 cgtcgccggg accctcgcgc gcgaccgccg aatcgctcct gcagcagagc caacatgccc
      241 atcactcgga tgcgcatgag accctggcta gagatgcaga ttaattccaa ccaaatcccg
      301 gggctcatct ggattaataa agaggagatg atcttccaga tcccatggaa gcatgctgcc
      361 aagcatggct gggacatcaa caaggatgcc tgtttgttcc ggagctgggc cattcacaca
      421 ggccgataca aagcagggga aaaggagcca gatcccaaga cgtggaaggc caactttcgc
      481 tgtgccatga actccctgcc agatatcgag gaggtgaaag accagagcag gaacaagggc
      541 agctcagctg tgcgagtgta ccggatgctt ccacctctca ccaagaacca gagaaaagaa
      601 agaaagtcga agtccagccg agatgctaag agcaaggcca agaggaagtc atgtggggat
      661 tccagccctg ataccttctc tgatggactc agcagctcca ctctgcctga tgaccacagc
      721 agctacacag ttccaggcta catgcaggac ttggaggtgg agcaggccct gactccagca
      781 ctgtcgccat gtgctgtcag cagcactctc cccgactggc acatcccagt ggaagttgtg
      841 ccggacagca ccagtgatct gtacaacttc caggtgtcac ccatgccctc cacctctgaa
      901 gctacaacag atgaggatga ggaagggaaa ttacctgagg acatcatgaa gctcttggag
      961 cagtcggagt ggcagccaac aaacgtggat gggaaggggt acctactcaa tgaacctgga
     1021 gtccagccca cctctgtcta tggagacttt agctgtaagg aggagccaga aattgacagc
     1081 ccaggggggg atattgggct gagtctacag cgtgtcttca cagatctgaa gaacatggat
     1141 gccacctggc tggacagcct gctgacccca gtccggttgc cctccatcca ggccattccc
     1201 tgtgcaccgt agcagggccc ctgggcccct cttattcctc taggcaagca ggacctggca
     1261 tcatggtgga tatggtgcag agaagctgga cttctgtggg cccctcaaca gccaagtgtg
     1321 accccactgc caagtgggga tggggcctcc ctccttgggt cattgacctc tcagggcctg
     1381 gcaggccagt gtctgggttt ttcttgtggt gtaaagctgg ccctgcctcc tgggaagatg
     1441 aggttctgag accagtgtat caggtcaggg acttggacag gagtcagtgt ctggcttttt
     1501 cctctgagcc cagctgcctg gagagggtct cgctgtcact ggctggctcc taggggaaca
     1561 gaccagtgac cccagaaaag cataacacca atcccagggc tggctctgca ctaagagaaa
     1621 attgcactaa atgaatctcg ttcccaaaga actaccccct tttcagctga gccctgggga
     1681 ctgttccaaa gccagtgaaa tgtgaaggaa agtggggtcc ttcggggcga tgctccctca
     1741 gcctcagagg agctctaccc tgctccctgc tttggctgag gggcttggga aaaaaacttg
     1801 gcactttttc gtgtggatct tgccacattt ctgatcagag gtgtacacta acatttcccc
     1861 cgagctcttg gcctttgcat ttatttatac agtgccttgc tcggcgccca ccaccccctc
     1921 aagccccagc agccctcaac aggcccaggg agggaagtgt gagcgccttg gtatgactta
     1981 aaattggaaa tgtcatctaa ccattaagtc atgtgtgaac acataaggac gtgtgtaaat
     2041 atgtacattt gtctttttat aaaaagtaaa ttgtttataa ggggtgtggc ctttttagag
     2101 agaaatttaa cttgtagatg attttacttt ttatggaaac actgatggac ttattattgg
     2161 catcccgcct gaacttgact ttggggtgaa cagggacatg catctattat aaaatccttt
     2221 cggccaggcg cggtggctca cacctgtaat cccagcactt tgggaggccg agatgggtgg
     2281 atcacctgag gtcaggagtt cgagaccagc ctggtgaaac tccatttcta ctaaaaatgc
     2341 aaaaattagc tgggcgtggt tgcgggtgct tgtaatccca gctactcagg aggctgaggc
     2401 aagagaatcg cttgaacctg ggaggtggag gttgcagtga gccgagaaca tgccattgca
     2461 ctccagcccg ggcaccaaaa aaaaaaaaaa aaaaaaaaac ctttcatttg gccgggcatg
     2521 gtggcttatg cctgtaatcc tggcactttg ggaggccaag gtgggcagat cacctgaggt
     2581 caggagtttg agaccagcct ggccaacatg gtgaaacctc atctctacta aaaatacaaa
     2641 aattaggccg ggcacggtgg ctcacgcctg taatcccagc actttgggag gcagaggcgg
     2701 gcggatcacg aggtcaggag atcaagacca tcctggctaa cacggtgaaa ccccgtctct
     2761 actaaaaata taaaaaatta gccgggccta gtggcgggtg cctgtagtcc cagctactcg
     2821 ggaggctgag gcaggagaat ggcatgaacc ccggaggcag agcttgcagt gagccgagat
     2881 tgcaccactg cactacagcc tgggcgacag agcgagactc cgtctcaaaa aaaaaaaaaa
     2941 aaattagccg ggcctggtgg cgggcgcctg taatcccagc tactgtggag gctgaagcac
     3001 aagaatcact tgaacccggg agatggaggt tgcagtgagc tgagactgtg ccactgcact
     3061 ccagcctggg tgacaagagt gagactttgt ctcaaaaaaa aaaaaatcct tttgtttatg
     3121 ttcacataga caatggcaga aggaggggac attcctgtca taggaacatg cttatataaa
     3181 catagtcacc tgtccttgac tatcaccagg gctgtcagtt gattctgggc tcctggggcc
     3241 caaggagtgt taagttttga ggcatgtgcc ataggtgatg tgtcctgcta acacacagat
     3301 gctgctccaa aaagtcagtt gatatgacac agtcacagac agaacagtca gcagcccaag
     3361 aaaggtcctc acggctgctg tgctgggtag cacttgccat ccagtttcta gagtgatgaa
     3421 atgctctgtc tgtaccgttc aatacagtag gcactggcac tagccacatg tgccagctaa
     3481 gcacttgaaa tgtggccagt gcaataagga attgaacttt taattgcatt taataaactg
     3541 tatgtaaata gtca
//
