LOCUS       XM_005268945            4860 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens interleukin 1 receptor associated kinase 4
            (IRAK4), transcript variant X4, mRNA.
ACCESSION   XM_005268945
VERSION     XM_005268945.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005268945.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..4860
                     /gene="IRAK4"
                     /gene_synonym="IMD67; IPD1; IRAK-4; NY-REN-64; REN64"
                     /note="interleukin 1 receptor associated kinase 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 12 ESTs, 329 long SRA reads, 7 Proteins, and
                     91% coverage of the annotated genomic feature by RNAseq
                     alignments, including 56 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:51135"
                     /db_xref="HGNC:HGNC:17967"
                     /db_xref="MIM:606883"
     CDS             652..2034
                     /gene="IRAK4"
                     /gene_synonym="IMD67; IPD1; IRAK-4; NY-REN-64; REN64"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 4
                     isoform X1"
                     /protein_id="XP_005269002.1"
                     /db_xref="GeneID:51135"
                     /db_xref="HGNC:HGNC:17967"
                     /db_xref="MIM:606883"
                     /translation="MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSG
                     DDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLP
                     DAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEV
                     SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAM
                     VDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC
                     LDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR
                     ASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHRE
                     PQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKV
                     QQLLQEMTAS"
ORIGIN      
        1 cttcgcggcg cttcctagtt cggctggttc ttctgtcgcc ggcttcagca gcccgcgccc
       61 gggcaggtaa ggcattcccc gccttaatgc ctcggtcaaa cgtcgtccga ggtccgcttc
      121 caggcctcgg cacctctgcc ccagggttgc tggggtcggc tgcggaacgg aaatctcttt
      181 atcatccgtg agaaaagtta gagaggaagt gggttccttt gacagagctt actccagaag
      241 aaagacttgg gtaggtcccc ggtaatcaag aagttcgtcg gccctgagga agagcctgag
      301 gcttggaggg acgtcaccca gctgttctgg ggcgcagtcg gacctcaagt ttctcacctc
      361 tcaggccctg gattccgtga acccgactgc gaaatgaagt ctcttttccc cagaaccagg
      421 aagtcaggcc agcacctgac agatgcctgt ggcgccagca gctcgctgag cctccacacg
      481 attgtaattc gcttgtttct ccggcctcca agcttccagg gaattagaaa gtggaggcgg
      541 cttatgggat cagatgagta cattcgcaga tgggggaaaa aagtgtacct gtcagcttgg
      601 aagccagagg gagacaaagg gataaaagca aaccctgtcc aggaatagaa gatgaacaaa
      661 cccataacac catcaacata tgtgcgctgc ctcaatgttg gactaattag gaagctgtca
      721 gattttattg atcctcaaga aggatggaag aagttagctg tagctattaa aaaaccatct
      781 ggtgatgata gatacaatca gtttcacata aggagatttg aagcattact tcaaactgga
      841 aaaagtccca cttctgaatt actgtttgac tggggcacca caaattgcac agttggtgat
      901 cttgtggatc ttttgatcca aaatgaattt tttgctcctg cgagtctttt gctcccagat
      961 gctgttccca aaactgctaa tacactacct tctaaagaag ctataacagt tcagcaaaaa
     1021 cagatgcctt tctgtgacaa agacaggaca ttgatgacac ctgtgcagaa tcttgaacaa
     1081 agctatatgc cacctgactc ctcaagtcca gaaaataaaa gtttagaagt tagtgataca
     1141 cgttttcaca gtttttcatt ttatgaattg aagaatgtca caaataactt tgatgaacga
     1201 cccatttctg ttggtggtaa taaaatggga gagggaggat ttggagttgt atataaaggc
     1261 tacgtaaata acacaactgt ggcagtgaag aagcttgcag caatggttga cattactact
     1321 gaagaactga aacagcagtt tgatcaagaa ataaaagtaa tggcaaagtg tcaacatgaa
     1381 aacttagtag aactacttgg tttctcaagt gatggagatg acctctgctt agtatatgtt
     1441 tacatgccta atggttcatt gctagacaga ctctcttgct tggatggtac tccaccactt
     1501 tcttggcaca tgagatgcaa gattgctcag ggtgcagcta atggcatcaa ttttctacat
     1561 gaaaatcatc atattcatag agatattaaa agtgcaaata tcttactgga tgaagctttt
     1621 actgctaaaa tatctgactt tggccttgca cgggcttctg agaagtttgc ccagacagtc
     1681 atgactagca gaattgtggg aacaacagct tatatggcac cagaagcttt gcgtggagaa
     1741 ataacaccca aatctgatat ttacagcttt ggtgtggttt tactagaaat aataactgga
     1801 cttccagctg tggatgaaca ccgtgaacct cagttattgc tagatattaa agaagaaatt
     1861 gaagatgaag aaaagacaat tgaagattat attgataaaa agatgaatga tgctgattcc
     1921 acttcagttg aagctatgta ctctgttgct agtcaatgtc tgcatgaaaa gaaaaataag
     1981 agaccagaca ttaagaaggt tcaacagctg ctgcaagaga tgacagcttc ttaaaacttt
     2041 attggaaaag actcttgact ttttatatac acctatctca accatttttt taactgattt
     2101 ttttcctaaa tattcttctt tacctttaac aaggcatagg ctgttgcagg acagtggtta
     2161 ttaaagcatg ggttgaactt ccaaaatata aaaatagagc caccatatca acacttagcc
     2221 ctacccatta gtatcacccc cagttcttac agtaatccct gagaaatctc cttcaagcat
     2281 caccaaacac agtttgaaaa ttacagggtt agcaaaaaga gcctgggctg tatgtagggt
     2341 ggaaacactc tgatctgaag cccagctgac tccactacta atttgctgta aagctttgga
     2401 catacactta gctgctgtga gccactaata acattgggct aatatctgct gtgcttctct
     2461 gacaggtagt catgaaaatc aaatgatgca aaatatatac aagcactttg taaattgtaa
     2521 aatgatacaa aatttaaagt ttatagagcc agttacaaaa tcctattagt catatattta
     2581 tagattgtgt tcacagcaat catttaacca caaataaaat atcccttgat gatactgcca
     2641 taatgatatg tccattatta gattatgtta catgacaaag ttgaaggaat ttggcagatg
     2701 cagttaaggt tcctaaacaa ctcactttga gactgttgaa agggcctgac ctaatcaagt
     2761 gaacccttgc aagaagaatt ctccttgtaa gccttgaaga agtatgtgag agggccacat
     2821 tggctaaaac ctaaaggtgg cctctaggag atgagaccta ccttccagtt gtcagcaagc
     2881 aggaaaaaaa aattgggacc tcagttgcaa ccacaaggaa ctgaattctg ccaaaaatct
     2941 gagtcagctt agaagagtac tccaagcttc agatgataac cacagcctgg gctgacacct
     3001 ggatttcagc tttgcatgat cctcagtatg agaatctatc tgttctgtgc tggacttcta
     3061 atatatagaa ctgtgagata atgggtcaca ttggctggat gtggtggctc atacctgtaa
     3121 atcccagcac tttgggaggc cgaggcaggc agatcacctg aggtcaagag ttcaagaccg
     3181 gcctggccaa catggtgaaa ccccgtctct actaaaaata caaaaattag acgagcgtgg
     3241 tggtggacac ctgtagtccc agctacttgg gaggctgagg caggagacta gctggaacca
     3301 gggaggtaga ggttgcagtg agctgagatc gtgccactgc actccagcct gggtgacaga
     3361 gtgagactcc atcataaata aataaataaa taaatgggtc acattaagcc tttaagtttg
     3421 tggtaattta ttattcagta atagaaaaca aatacagata ctctcccatg atgtttttcc
     3481 catgatgatt tcccatgata tttacaggtt ttgcccacat ttgaggggta tgtggaaatt
     3541 atacagagca tgtacagcgg gaggcttata gtgtacgtac tgaaatgtgg ggttggagcc
     3601 ccaacacaga gaccccagca ggacactgcc tagtagagct atgggaaggg tgctgccacc
     3661 ctccagactt gagaattgta gagccaccag cagcttgcac tctgagcttg gaaaagccac
     3721 aggcactcaa cttcaaccat gagggaagcc acgcaccctg caaagccaca ggagtggagc
     3781 tgcccacggc ctcgagggcc caccccttgc accagtgtgc caggatgtgg gacatggaat
     3841 caaggaatat gttagggctt tttttttttt ttttttgaga cggagtcttg ctctgttgcc
     3901 caggctggag tgcagtggca cgatctcggc tcactgcaag ctctgcctcc caggttcacg
     3961 ccattcccct gcctcagcct ccccagtagc tgggactaca ggtgcccgcc accatgccca
     4021 gctaattttt tttgtatttt tagtagagat ggggtttcac tgtgttagcc aggatggtct
     4081 tgatctcctg acctcgtgat cacccgcctc ggcctcccaa agtgccagta tttaaagttt
     4141 aatgtcttcc cagctgggtt tcagacttgc caggatcctg ttgccccttt ctttagccaa
     4201 tttctccctt ttgggacaag aatgttttac ttattgcctg taccaccaac tgtatcttgg
     4261 aaataaataa cttatatttt atttcagagg ctcataggcg gcaggaactt accttgagtc
     4321 tcaaatgaga cttaggactt ttgagtgatg ctagaatgag ttaagacttt gggaagggat
     4381 gattatattt tgcaatgtga gaaagacatt agatttgggg ggctgggggt agaatgacat
     4441 tgtttagatg tttgtctcct tcaaatttca tgtttaaatg taatccccag tgttgggggt
     4501 ggaggtgggg cctgatggga agtgtttggg tcatggtgga tgatccctca tgaatggctt
     4561 agagccactg gtgatgagtg agttctcact cagttcgtgt gagatctggt ggcttaaaag
     4621 agtctgctcc ccctttgcct tccattgtga ttgtaacctt cctggggcct tcatcaaagg
     4681 ccaggcaaat attggtgccg tgctagtatg gcctgcagaa ccgtaagcca aaacaaacct
     4741 tttttcttta taaattaccc agcctcagtt attcctttat agtgatgcaa aacgggctaa
     4801 ctatataaat ttgtaatttt taagttatag attgttttta ttaaacactt atgaatactg
//
