LOCUS       NM_001570               3431 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2),
            mRNA.
ACCESSION   NM_001570
VERSION     NM_001570.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Ghouri,M., Ismail,M., Zaidi,S.A., Rehman,S., Dahani,A., Saleem,S.
            and Zehra,S.
  TITLE     Multi-locus SNP analyses of interleukin 1 receptor associated
            kinases 2 gene polymorphisms with the susceptibility to rheumatoid
            arthritis
  JOURNAL   PLoS One 17 (5), e0268496 (2022)
   PUBMED   35588430
  REMARK    GeneRIF: Multi-locus SNP analyses of interleukin 1 receptor
            associated kinases 2 gene polymorphisms with the susceptibility to
            rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Shao,S., Tsoi,L.C., Swindell,W.R., Chen,J., Uppala,R., Billi,A.C.,
            Xing,X., Zeng,C., Sarkar,M.K., Wasikowski,R., Jiang,Y., Kirma,J.,
            Sun,J., Plazyo,O., Wang,G., Harms,P.W., Voorhees,J.J., Ward,N.L.,
            Ma,F., Pellegrini,M., Merleev,A., Perez White,B.E., Modlin,R.L.,
            Andersen,B., Maverakis,E., Weidinger,S., Kahlenberg,J.M. and
            Gudjonsson,J.E.
  TITLE     IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification
            of Epidermal Inflammatory Responses
  JOURNAL   J Invest Dermatol 141 (10), 2436-2448 (2021)
   PUBMED   33864770
  REMARK    GeneRIF: IRAK2 Has a Critical Role in Promoting Feed-Forward
            Amplification of Epidermal Inflammatory Responses.
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Joshi,H., Lunz,B., Peters,A., Zolch,M., Berberich,I. and
            Berberich-Siebelt,F.
  TITLE     The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination
            and optimal TLR signaling
  JOURNAL   Mol Immunol 134, 172-182 (2021)
   PUBMED   33799071
  REMARK    GeneRIF: The extreme C-terminus of IRAK2 assures full TRAF6
            ubiquitination and optimal TLR signaling.
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Moncrieffe,M.C., Bollschweiler,D., Li,B., Penczek,P.A., Hopkins,L.,
            Bryant,C.E., Klenerman,D. and Gay,N.J.
  TITLE     MyD88 Death-Domain Oligomerization Determines Myddosome
            Architecture: Implications for Toll-like Receptor Signaling
  JOURNAL   Structure 28 (3), 281-289 (2020)
   PUBMED   31995744
  REMARK    GeneRIF: MyD88 Death-Domain Oligomerization Determines Myddosome
            Architecture: Implications for Toll-like Receptor Signaling.
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Wesche,H., Gao,X., Li,X., Kirschning,C.J., Stark,G.R. and Cao,Z.
  TITLE     IRAK-M is a novel member of the Pelle/interleukin-1
            receptor-associated kinase (IRAK) family
  JOURNAL   J Biol Chem 274 (27), 19403-19410 (1999)
   PUBMED   10383454
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Maschera,B., Ray,K., Burns,K. and Volpe,F.
  TITLE     Overexpression of an enzymically inactive
            interleukin-1-receptor-associated kinase activates nuclear
            factor-kappaB
  JOURNAL   Biochem J 339 (Pt 2) (Pt 2), 227-231 (1999)
   PUBMED   10191251
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Auron,P.E.
  TITLE     The interleukin 1 receptor: ligand interactions and signal
            transduction
  JOURNAL   Cytokine Growth Factor Rev 9 (3-4), 221-237 (1998)
   PUBMED   9918122
  REMARK    Review article
REFERENCE   10 (bases 1 to 3431)
  AUTHORS   Muzio,M., Ni,J., Feng,P. and Dixit,V.M.
  TITLE     IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators
            of IL-1 signaling
  JOURNAL   Science 278 (5343), 1612-1615 (1997)
   PUBMED   9374458
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL538890.3, AF026273.1,
            AL556221.3, AC022384.5, AJ496794.1 and BG682610.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001570.3.
            
            Summary: IRAK2 encodes the interleukin-1 receptor-associated kinase
            2, one of two putative serine/threonine kinases that become
            associated with the interleukin-1 receptor (IL1R) upon stimulation.
            IRAK2 is reported to participate in the IL1-induced upregulation of
            NF-kappaB. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.88999.1,
                                           SRR1660805.220225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256458.5/ ENSP00000256458.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL538890.3         55-81
            28-284              AF026273.1         1-257
            285-434             AL556221.3         231-380
            435-1328            AF026273.1         408-1301
            1329-1509           AC022384.5         113681-113861
            1510-2376           AJ496794.1         1474-2340
            2377-2718           BG682610.1         305-646
            2719-3429           AJ496794.1         2700-3410
            3430-3431           AC022384.5         122946-122947
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..3431
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /note="interleukin 1 receptor associated kinase 2"
                     /db_xref="GeneID:3656"
                     /db_xref="HGNC:HGNC:6113"
                     /db_xref="MIM:603304"
     exon            1..130
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1914
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase-like 2"
                     /protein_id="NP_001561.3"
                     /db_xref="CCDS:CCDS33697.1"
                     /db_xref="GeneID:3656"
                     /db_xref="HGNC:HGNC:6113"
                     /db_xref="MIM:603304"
                     /translation="MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRK
                     IKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCP
                     IPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEED
                     APHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQ
                     GTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFC
                     AARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS
                     NVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQL
                     TKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVM
                     AKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRET
                     LLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLR
                     VIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFG
                     P"
     exon            131..313
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..460
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..564
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..759
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..824
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..939
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1049
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1245
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1308
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1509
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1801
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..3431
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3407..3412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="IRAK2"
                     /gene_synonym="IRAK-2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtcccg cgccggagcc ggccccgtag cgtgccatgg cctgctacat ctaccagctg
       61 ccctcctggg tgctggacga cctgtgccgc aacatggacg cgctcagcga gtgggactgg
      121 atggagttcg cctcctacgt gatcacagac ctgacccagc tgcggaagat caagtccatg
      181 gagcgggtgc agggtgtgag catcacgcgg gagctgctgt ggtggtgggg catgcggcag
      241 gccaccgtcc agcaacttgt ggacctcctg tgccgcctgg agctctaccg ggctgcccag
      301 atcatcctga actggaaacc ggctcctgaa atcaggtgtc ccattccagc cttccctgac
      361 tctgtgaagc cagaaaagcc tttggcagct tctgtaagaa aggctgagga tgaacaggaa
      421 gaggggcagc ctgtgaggat ggccaccttt ccaggcccag ggtcctctcc agccagagcc
      481 caccagccgg cctttctcca gcctcctgaa gaagatgccc ctcattcctt gagaagcgac
      541 ctccccactt cgtctgattc aaaggacttc agcacctcca ttcctaagca ggaaaaactt
      601 ttgagcttgg ctggagacag ccttttctgg agtgaggcag acgtggtcca ggcaaccgat
      661 gacttcaatc aaaaccgcaa aatcagccag gggacctttg ctgacgtcta cagagggcac
      721 aggcacggga agccattcgt cttcaagaag ctcagagaga cagcctgttc aagtccagga
      781 tcaatcgaaa gattcttcca ggcagagttg cagatttgtc ttagatgctg ccaccccaat
      841 gtcttacctg tgctgggctt ctgtgctgca agacagtttc acagcttcat ctacccctac
      901 atggcaaatg gttccctaca ggacagactg cagggtcagg gtggctcgga ccccctcccc
      961 tggccccagc gtgtcagcat ctgctcaggg ctgctctgtg ccgtcgagta cctgcatggt
     1021 ctggagatca tccacagcaa cgtcaagagc tctaatgtct tgctggacca aaatctcacc
     1081 cccaaacttg ctcacccaat ggctcatctg tgtcctgtca acaaaaggtc aaaatacacc
     1141 atgatgaaga ctcacctgct ccggacgtca gccgcgtatc tgccagagga tttcatccgg
     1201 gtggggcagc tgacaaagcg agtggacatc ttcagctgtg gaatagtgtt ggccgaggtc
     1261 ctcacgggca tccctgcaat ggataacaac cgaagcccgg tttacctgaa ggacttactc
     1321 ctcagtgata ttccaagcag caccgcctcg ctctgctcca ggaagacggg cgtggagaac
     1381 gtgatggcaa aggagatctg ccagaagtac ctggagaagg gcgcagggag gcttccggag
     1441 gactgcgccg aggccctggc cacggctgcc tgcctgtgcc tgcggaggcg taacaccagc
     1501 ctgcaggagg tgtgtggctc tgtggctgct gtggaagagc ggctccgagg tcgggagacg
     1561 ttgctccctt ggagtgggct ttctgagggt acaggctctt cttccaacac cccagaggaa
     1621 acagacgacg ttgacaattc cagccttgat gcctcctcct ccatgagtgt ggcaccctgg
     1681 gcaggggctg ccaccccact tctccccaca gagaatgggg aaggaaggct gcgggtcatc
     1741 gtgggaaggg aggctgactc ctcctctgag gcctgtgttg gcctggagcc tccccaggat
     1801 gttacagaaa cttcgtggca aattgagatc aatgaggcca aaaggaaact gatggagaat
     1861 attctgctct acaaagagga aaaagtggac agcattgagc tctttggccc ctgatgaccg
     1921 gaacacagct gaggaccctt gtcctcagtt ggaaagatga gcatcagatc aagaaaaagg
     1981 tctgaggcag aatccaagat ctgccaggaa acacacaaca aaacatctgc tgtcctgggt
     2041 gggagggaaa cttcatttca ctggaatgag ttgggagaga aaggccctca gcttttagag
     2101 acacaaaaat ccatgaagtc tcttcctttc tgggctttgt tagtcagagc aggggatcag
     2161 aggagactga agcagaaacc ctgcacacgg gcccaggatg tggctgattt tgtggttccg
     2221 gggagtatgt gatgataatc acccccagca gattccatta cctcagcagc tcttgttccc
     2281 ccgccactgg cagttctgca atgccatagc attttccaga gctaagatct ctgggttgta
     2341 tttgctgaca gcctgcaagc ttgcatgctc tgaaagattt tttttagttt ttaatttttt
     2401 tgtagagatg gggtctcgct ttgttggcgc aatcctccca cctcagactc ccaaagtgct
     2461 ggaattacag ttgggagcca ctgtgcctgg cctggaagac tttcaacttg tgtctcagtg
     2521 cagttcttga ctcacctctc tgggcctcag gttctacaaa tgccagacac ctagcgaaga
     2581 gctctgcagg ctttccactg cctgtattgg aaatcttgca attcacataa ttattcagtc
     2641 actgcctggt acctttatct tcccatccca ctaatgttag tgttttttaa tggagctttt
     2701 attctgagaa tatgtgtttg tctgtttgtt tgttttttga gacagagtct cactttgtca
     2761 cccaggctgg agtgcagtgg cacgatctca gctcactgca agctctgcct ctcaggttca
     2821 agtgattctc ctgcctcagc ctcctgagta gatgggactg taggcacctg ccactatgcc
     2881 tggctaattt ttgtgttttt agtagagaca gggtttcacc atattggcca ggctggtctc
     2941 gaactactga cctcgtgatc tgcccgcctt ggcctatcaa agtgttggga ttacaggctt
     3001 gagccaccgc acccggccga gaatatgtgt tgttatttat gactggatta tgaagaatca
     3061 ggagaatgca tttcatgtct gattctgctg ctaattaagt caatcattta atttttggga
     3121 cctcagtttc tttgtaagta aaataacacc tgcttgttct tcatccctgg gctgttggga
     3181 ggaacagatg agacagtggc tatagaagca cttggaaaat gcacttgtcc tgttttgtaa
     3241 aataaaaagg tattaaatgt gtatttctgc catgtaccta atgattattc agtgcgtata
     3301 tatctgaaaa gtcatgttgc aaatctttct gtgaaacaga tgctatttta aattcactgg
     3361 gagaaatatc ctatttaaag taatctatag taatttcttt ttatataata aaaatatatt
     3421 tgtaaagtcg a
//
