LOCUS       NM_001010844            5577 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 1 receptor associated kinase 1 binding
            protein 1 (IRAK1BP1), mRNA.
ACCESSION   NM_001010844 XM_059729
VERSION     NM_001010844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5577)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5577)
  AUTHORS   He,J., Kelly,T.N., Zhao,Q., Li,H., Huang,J., Wang,L., Jaquish,C.E.,
            Sung,Y.J., Shimmin,L.C., Lu,F., Mu,J., Hu,D., Ji,X., Shen,C.,
            Guo,D., Ma,J., Wang,R., Shen,J., Li,S., Chen,J., Mei,H., Chen,C.S.,
            Chen,S., Chen,J., Li,J., Cao,J., Lu,X., Wu,X., Rice,T.K., Gu,C.C.,
            Schwander,K., Hamm,L.L., Liu,D., Rao,D.C., Hixson,J.E. and Gu,D.
  TITLE     Genome-wide association study identifies 8 novel loci associated
            with blood pressure responses to interventions in Han Chinese
  JOURNAL   Circ Cardiovasc Genet 6 (6), 598-607 (2013)
   PUBMED   24165912
REFERENCE   3  (bases 1 to 5577)
  AUTHORS   Luo,Y., Kwon,H.J., Montano,S., Georgiadis,M., Goebl,M.G. and
            Harrington,M.A.
  TITLE     Phosphorylation of SIMPL modulates RelA-associated
            NF-kappaB-dependent transcription
  JOURNAL   Am J Physiol Cell Physiol 292 (3), C1013-C1023 (2007)
   PUBMED   17079333
  REMARK    GeneRIF: Together, these studies reveal that phosphorylation of the
            SIMPL protein plays a critical role in SIMPL regulation by
            affecting both SIMPL subcellular localization and the p65
            coactivator function of SIMPL.
REFERENCE   4  (bases 1 to 5577)
  AUTHORS   Kwon,H.J., Breese,E.H., Vig-Varga,E., Luo,Y., Lee,Y., Goebl,M.G.
            and Harrington,M.A.
  TITLE     Tumor necrosis factor alpha induction of NF-kappaB requires the
            novel coactivator SIMPL
  JOURNAL   Mol Cell Biol 24 (21), 9317-9326 (2004)
   PUBMED   15485901
REFERENCE   5  (bases 1 to 5577)
  AUTHORS   Vig,E., Green,M., Liu,Y., Yu,K.Y., Kwon,H.J., Tian,J., Goebl,M.G.
            and Harrington,M.A.
  TITLE     SIMPL is a tumor necrosis factor-specific regulator of nuclear
            factor-kappaB activity
  JOURNAL   J Biol Chem 276 (11), 7859-7866 (2001)
   PUBMED   11096118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450327.12, BC112253.1 and CB321683.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010844.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.685659.1, BU195215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369940.7/ ENSP00000358956.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AL450327.12        99475-99815
            342-344             AL450327.12        117302-117304
            345-887             BC112253.1         341-883
            888-3114            AL450327.12        130337-132563
            3115-3441           CB321683.1         17-343              c
            3442-5577           AL450327.12        132891-135026
FEATURES             Location/Qualifiers
     source          1..5577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..5577
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="interleukin 1 receptor associated kinase 1 binding
                     protein 1"
                     /db_xref="GeneID:134728"
                     /db_xref="HGNC:HGNC:17368"
                     /db_xref="MIM:615375"
     exon            1..341
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..809
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="ActA binding protein 3; IRAK1-binding protein 1"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase
                     1-binding protein 1"
                     /protein_id="NP_001010844.1"
                     /db_xref="CCDS:CCDS34488.1"
                     /db_xref="GeneID:134728"
                     /db_xref="HGNC:HGNC:17368"
                     /db_xref="MIM:615375"
                     /translation="MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSST
                     QAQTATREVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQ
                     GVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQF
                     YHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDH
                     QSSRLSSSLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL"
     exon            342..407
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /inference="alignment:Splign:2.1.0"
     exon            408..538
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /inference="alignment:Splign:2.1.0"
     exon            539..5577
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="hexamer: AATAAA"
     polyA_site      1061
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="major polyA site"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="hexamer: AATAAA"
     polyA_site      3441
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="major polyA site"
     regulatory      5419..5424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="hexamer: AATAAA"
     polyA_site      5441
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="major polyA site"
     regulatory      5559..5564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
                     /note="hexamer: AACAAA"
     polyA_site      5577
                     /gene="IRAK1BP1"
                     /gene_synonym="AIP70; SIMPL"
ORIGIN      
        1 actatggaaa cccagctgcc atcgctatgt ctctgcaaaa gacccctccg acccgagtgt
       61 tcgtggaact ggttccctgg gctgaccgga gccgggagaa caacctggcc tcagggagag
      121 agacgctacc gggcttacgc caccccctct cctcaacaca agcccaaact gctacccgcg
      181 aggtgcaagt aagcggcacc tcagaagtgt ctgcgggccc tgaccgggcg caggtggtgg
      241 tgcgagtgag cagcaccaag gaggcggcag ccgaggccaa aaagagcgtt tgtcgccgtc
      301 tagattacat cacgcagagc ctccagcagc agggcgtgca ggcagaaaat ataactgtga
      361 caaaggattt taggagagtg gaaaatgctt atcacatgga agcagaggtc tgcattacat
      421 ttactgaatt tggaaaaatg caaaatattt gtaactttct tgttgaaaag ctagatagct
      481 ctgttgtcat cagcccaccc cagttctatc atactccagg ttctgttgag aatcttcgac
      541 ggcaagcctg tcttgttgct gttgagaatg cgtggcgcaa agctcaagaa gtctgtaacc
      601 ttgttggcca aaccttagga aaacctttac taatcaaaga agaagaaaca aaagaatggg
      661 aaggccaaat agatgatcac cagtcatcca gactctcaag ttcattaact gtacaacaaa
      721 aaatcaaaag tgcaacaata catgctgctt caaaagtatt tataactttt gaggtaaagg
      781 gaaaagagaa gagaaaaaag cacctttgaa attccaaaca aattatattg tacttgtatc
      841 tttttaccta tttttatact ttttataatg tttacgtttg tcctgaatat atatatatat
      901 atatatatat atatatatat ggtataggag ataagctatt tctttccaaa atctataaat
      961 ctttgaatat agtcccacag aatacttatg ttcactttct atttttaaaa gactactctg
     1021 aaaaacactc ttggataata aatgtattat gtgcatactt atatactgac agttcataca
     1081 agcacatgtg taatatttct attataagga cagatattga cccttgcatt tcataatttt
     1141 taaagatatt taagctaaaa ttttctcagc cacattttta tataaaacca aattttatgt
     1201 aaaaactagg cttcaataag ttagctaaat tttttaaatt gtaagacaaa atttttatgg
     1261 aaaagaattc ctatatccca tcaaacctaa taattttcca caactaaaaa tgagtataaa
     1321 tacataattt taagtgcatc ctgtcaggtc tgatatttaa ttttacttta gttagaagct
     1381 aagtagttac cctgttactt cttcatggat gctaacagaa gacttgagat tcccagacag
     1441 aaacaaagga ctattactca tggcacaaca aggagcatga gcatcagcac attctcattg
     1501 cttccccttg tcccaggtcc catgggggca aaatgatatg gccatatgca atatggctac
     1561 atatacagca ggcttttgtt gtaggtaaag aatactgagc ttggagggtt cactgctttt
     1621 tatccatgaa cagaagcaaa cctgctcttt gcctcatccc ttatagatgc tcactcaaaa
     1681 ctcaatactg agaaatggcc caggtaaaga acagccaagg tctttcatgc ttgccacacc
     1741 cagcaatatg tttaggaagg tgaagtctac tgagggctat ctcacatcta acagtttctt
     1801 tactaggacc agagaccatt ttggtaagat gcagataaca accccaacct taacaacttc
     1861 acaacatgaa tagaaatagt gataaataat tcatagcttt ttacaaaaga ataatgaggt
     1921 ataataggaa aatgttttga tgccaaaaat aaaagagtta atgtttggat cggactccaa
     1981 cagggctcct tagagtgata caaatacaaa gcaaacgata tgtgtaattt aaaatttcct
     2041 agtgcacatg tttttttatt tttctttttc gagatggagt ctttctctgt cgcccaagct
     2101 ggagtgcagt ggtacgatct cagctcactg caacctctgc ctcctgaatt taagcgattc
     2161 tcctgcctca gcctcccaag tagctgggat tacaggcgtg agccactgca tctggccctg
     2221 tacgcacatt tttaaaaata aaactttaaa aaagaaacag ttgaaactaa ttttaataac
     2281 attttattta accaaatata tcaaaaatat tatttcagca tgtaatcagt attttttaaa
     2341 ttgagatatt tgttttatct tcaaaattca gtgtatattt ttacataata gcacatctca
     2401 attcacatgc taaattttca tcagaaatat tttatctgta tttaaatttc ctaaaatgta
     2461 cagttgaaaa aaagagattc acatacccag gttgttctag catgcctaaa aaatcttgta
     2521 actggatcaa gtatcagttt ttaaattagt taaaattaaa taaaatttaa aatttagttc
     2581 ctcagtcaca ctagccatat ttcaagtact tgaaggccac aaatggcttg agactacctt
     2641 gctgaacaga ccaaggtcaa acactgagat aataatgatt cttaaggcca tttgaaagtt
     2701 aacagcaagt atgtattact gctatctaca gtaagaatta cattttatct acaggcaatc
     2761 ataagccatg tctgttatgc agcataggct ttccattctc tatacatcta ggtcatagag
     2821 tttttccatt gataaatctg gatgtttata taccaacagt actttcttac aacatattcc
     2881 agtatatagt gtccagcttc acccactttt taaagtggcc ctgaaacaat tttattcatc
     2941 ttattggagt gttgctgtag gggaagagta gaagctaaga agagtttgag ttcaacacca
     3001 ttatatccaa atcctgacct tactactgga atgtaagctc cttgaaagtg gagatcttgt
     3061 ctgtcttgtt cacagttgtg ttcccagccc cagaggtagt ctcagggcca atatcaagta
     3121 tgctctcaaa tatttgctgg gaaaatttac tagctggata aaaggcaagt tactttaatc
     3181 tctttaatct tcctttgtcc ttacaaatga aagagactaa tagtacttaa ccttgcagtg
     3241 ttattataag gattaaagtt gataaatata tgatcatgag aacaattgct agcacataac
     3301 ggtcactctg aaaatagtag ctgatatatc agctgcattg tttgattatt gttggctcaa
     3361 ttaaaagttg gcttttccaa atcctccatt aggaagaatt tttaaatagc catattgaaa
     3421 ataaagttgt cagaaaacca atgtaacata tgttgaattt ttattaccaa aaagaagtta
     3481 ctatccagtt gtacagaaaa gtagaatgag gttgtgcatc aagaaaaaaa ttgttcgttc
     3541 tcaacaaaaa tttaatcaca tgggtagttt tttttttttt agctatgggt tcatgctgta
     3601 tttggttgca tcatatttga taaagaagct tccaacttag catgaaatac ctaaagacaa
     3661 tttttttttt aagttagtag gcacttttta gaatttccag gaacttttaa agatgttgtc
     3721 tccaaaaaaa acaaaaaaat cctgtaaagt atacaatcct acatttttct atagaagagc
     3781 ttagggaaga aatcattcaa agattggaaa gacttatgtg tagtattctg tatactaaag
     3841 ggtatcaaat ttagttgtca gttgatagca atttaatttc ttgatacatg gcatacactg
     3901 gaatcttatg atgaattatt taggggacct gtgccacaaa gtctactaga ataaacctat
     3961 cctaaactta atcctgttag aatttccttc ttttgaactc tgtttaaaaa aaaaaaaatc
     4021 tttccagaaa gtaggaagtt ataatttcta ttttctgaaa gacaaacaaa aattctaaat
     4081 aggatatttg aaacagaccc actgtatcct aaatggaagt gctattaaaa ggaaatgcta
     4141 ttaaaataag atttcatata ttactgataa ttcataatga attttaggat tccattcaat
     4201 tacatactaa aaattacatt ttttatagtg gcaatgtact tttatcagta ttcttatttg
     4261 acggtcaatt tgagttcagt gtaaacaaat aggacttaga aaaataattt gtaactcaag
     4321 atgctgtacc tcatcctata attgttgttt tgtaatattc cttctcagga atatgggcta
     4381 aggatatctc aactctgtca gatttgttga taagaattta atagtaagga gttcttatag
     4441 cctataaaaa gcatgaatta tgagatcaaa tgtgggagtt actatatgat tatctgcatt
     4501 acaaaatgaa agcaaatgct ttatttattc caacaaaaaa agacctatat aaattagttt
     4561 aagctaacat ttagacattt actattacat atatggtatt tgcaaccaaa tcactgagtt
     4621 tgttgttgtc gttgtttgag gctgttgctc tgtcacccag gatggagtgc aagtagctca
     4681 atcatagctt actgcagcct aaaaactcct gggctgaaga aatcctctca cctcagcctt
     4741 ttaagtagct gaaacattag gtgcacacca ccaggcctgg ctaatttttt attagtgata
     4801 aggtcttgct atgttgccca ggctggtctc aaactcctgg cttcaagcag tcctgcctca
     4861 gcttcccaga gtgctggact acaggcttga gccactgcac ccagccccaa atagcttcta
     4921 ctcataacct agtgtggcct aaatttattt aaaatgcccg ggtaggccag gcacgttggc
     4981 tcacgcctgt aatcccagca cttgggaggc cgaggtaggc agatcacttg aggtcaggag
     5041 ttcgagacca acctggccaa tatattgaaa ccctgtctct tctaaaaata cagaagttac
     5101 tcaggcgtgg tggcgtgtga ctgtaatctc agctaccggg gaggctgaag cagaagaaac
     5161 gctcgaacct gggaggcaga gcttacagtg agccgagatc gcaccactgc acttcagcct
     5221 gggtgacaaa gtgagactcc atctacatac atacatacat acatacatac atacatacat
     5281 acatacatac atacataaaa tgcccagtat cttacaagac tgtagttcac agtgggtaat
     5341 tcaaatcaga cactgctctt caagagaggt aatattaata gaaatctttc aagaaggatt
     5401 gttttctact attaaaacaa taaaactctt ataaacctgt ttatcagaag gatatttctg
     5461 tttcagcaac tcctggaatc cttcttcaac atcccaacca acaattactc ccagatagcc
     5521 atgtcacctg tgaattatca tgaatcccac atcaaatgaa caaatactgc ctctgga
//
