LOCUS       NM_001569               3581 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 1 receptor associated kinase 1 (IRAK1),
            transcript variant 1, mRNA.
ACCESSION   NM_001569
VERSION     NM_001569.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3581)
  AUTHORS   Rao,Z., Ao,G., Zhang,Y., Jiang,Z., Li,L. and Hua,Z.
  TITLE     HNRNP I promotes IRAK1 degradation to reduce podocyte apoptosis and
            inflammatory response alleviating renal injury in diabetic
            nephropathy
  JOURNAL   Immunobiology 229 (5), 152835 (2024)
   PUBMED   38986278
  REMARK    GeneRIF: HNRNP I promotes IRAK1 degradation to reduce podocyte
            apoptosis and inflammatory response alleviating renal injury in
            diabetic nephropathy.
REFERENCE   2  (bases 1 to 3581)
  AUTHORS   Chen,J.J., Lu,T.Z., Wang,T., Yan,W.H., Zhong,F.Y., Qu,X.H.,
            Gong,X.C., Li,J.G., Tou,F.F., Jiang,L.P. and Han,X.J.
  TITLE     The m6A reader HNRNPC promotes glioma progression by enhancing the
            stability of IRAK1 mRNA through the MAPK pathway
  JOURNAL   Cell Death Dis 15 (6), 390 (2024)
   PUBMED   38830885
  REMARK    GeneRIF: The m6A reader HNRNPC promotes glioma progression by
            enhancing the stability of IRAK1 mRNA through the MAPK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3581)
  AUTHORS   Zhu,D., Nie,Y., Zhao,Y., Chen,X., Yang,Z. and Yang,Y.
  TITLE     RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung
            Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression
  JOURNAL   Am J Pathol 193 (10), 1603-1617 (2023)
   PUBMED   37717980
  REMARK    GeneRIF: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of
            Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10
            Expression.
REFERENCE   4  (bases 1 to 3581)
  AUTHORS   Zaghloul,H.M., Abdelshafy,S.S., Abdelaleem,E.A., Ali,H.M. and
            Khattab,R.A.M.
  TITLE     Transmembrane Protein 187 (TMEM187) and Interleukin 1 Receptor
            Associated Kinase (IRAK1) gene polymorphism association with
            rheumatoid arthritis susceptibility in Egyptian patients
  JOURNAL   Egypt J Immunol 30 (3), 171-179 (2023)
   PUBMED   37440666
  REMARK    GeneRIF: Transmembrane Protein 187 (TMEM187) and Interleukin 1
            Receptor Associated Kinase (IRAK1) gene polymorphism association
            with rheumatoid arthritis susceptibility in Egyptian patients.
REFERENCE   5  (bases 1 to 3581)
  AUTHORS   Zhou,M., Liu,Y., Xu,H., Chen,X., Zheng,N., Duan,Z., Ge,Y., Li,D.,
            Lin,T., Zeng,R., Chen,Q. and Li,M.
  TITLE     YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes
            Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm
            through Regulating miR-146a/TRAF6 and IRAK1 Axis
  JOURNAL   J Innate Immun 15 (1), 822-835 (2023)
   PUBMED   37903473
  REMARK    GeneRIF: YTHDC1-Modified m6A Methylation of Hsa_circ_0102678
            Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes
            Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis.
REFERENCE   6  (bases 1 to 3581)
  AUTHORS   Muzio,M., Ni,J., Feng,P. and Dixit,V.M.
  TITLE     IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators
            of IL-1 signaling
  JOURNAL   Science 278 (5343), 1612-1615 (1997)
   PUBMED   9374458
REFERENCE   7  (bases 1 to 3581)
  AUTHORS   Huang,J., Gao,X., Li,S. and Cao,Z.
  TITLE     Recruitment of IRAK to the interleukin 1 receptor complex requires
            interleukin 1 receptor accessory protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12829-12832 (1997)
   PUBMED   9371760
REFERENCE   8  (bases 1 to 3581)
  AUTHORS   DiDonato,J.A., Hayakawa,M., Rothwarf,D.M., Zandi,E. and Karin,M.
  TITLE     A cytokine-responsive IkappaB kinase that activates the
            transcription factor NF-kappaB
  JOURNAL   Nature 388 (6642), 548-554 (1997)
   PUBMED   9252186
REFERENCE   9  (bases 1 to 3581)
  AUTHORS   Cao,Z., Xiong,J., Takeuchi,M., Kurama,T. and Goeddel,D.V.
  TITLE     TRAF6 is a signal transducer for interleukin-1
  JOURNAL   Nature 383 (6599), 443-446 (1996)
   PUBMED   8837778
REFERENCE   10 (bases 1 to 3581)
  AUTHORS   Cao,Z., Henzel,W.J. and Gao,X.
  TITLE     IRAK: a kinase associated with the interleukin-1 receptor
  JOURNAL   Science 271 (5252), 1128-1131 (1996)
   PUBMED   8599092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52112.2, L76191.1, BC054000.1,
            BE276817.1 and BC014963.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001569.3.
            
            Summary: This gene encodes the interleukin-1 receptor-associated
            kinase 1, one of two putative serine/threonine kinases that become
            associated with the interleukin-1 receptor (IL1R) upon stimulation.
            This gene is partially responsible for IL1-induced upregulation of
            the transcription factor NF-kappa B. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L76191.1, SRR14038194.2450777.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369980.8/ ENSP00000358997.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                U52112.2           172826-172836       c
            12-572              L76191.1           1-561
            573-1520            BC054000.1         639-1586
            1521-1684           L76191.1           1510-1673
            1685-2098           BE276817.1         177-590
            2099-3581           BC014963.1         1836-3318
FEATURES             Location/Qualifiers
     source          1..3581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3581
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /note="interleukin 1 receptor associated kinase 1"
                     /db_xref="GeneID:3654"
                     /db_xref="HGNC:HGNC:6112"
                     /db_xref="MIM:300283"
     exon            1..226
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2229
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; Pelle
                     homolog"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 1
                     isoform 1"
                     /protein_id="NP_001560.2"
                     /db_xref="CCDS:CCDS14740.1"
                     /db_xref="GeneID:3654"
                     /db_xref="HGNC:HGNC:6112"
                     /db_xref="MIM:300283"
                     /translation="MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQ
                     FAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAW
                     HPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGL
                     VPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKI
                     GEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG
                     YCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP
                     SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLP
                     EEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALR
                     STQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRR
                     PPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAA
                     PSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGD
                     TAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALD
                     SLQLLSSSSLPGLGLEQDRQGPEESDEFQS"
     exon            227..394
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            395..526
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            527..630
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            631..819
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            820..884
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1118
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1326
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1392
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1629
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2020
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2170
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..3581
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3562..3567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /note="hexamer: AATAAA"
     polyA_site      3581
                     /gene="IRAK1"
                     /gene_synonym="IRAK; pelle"
                     /note="major polyA site"
ORIGIN      
        1 gagtcagtgt ccgcggaccc ggccggccca ggcccgcgcc cgccgcggcc ctgagaggcc
       61 ccggcaggtc ccggcccggc ggcggcagcc atggccgggg ggccgggccc gggggagccc
      121 gcagcccccg gcgcccagca cttcttgtac gaggtgccgc cctgggtcat gtgccgcttc
      181 tacaaagtga tggacgccct ggagcccgcc gactggtgcc agttcgccgc cctgatcgtg
      241 cgcgaccaga ccgagctgcg gctgtgcgag cgctccgggc agcgcacggc cagcgtcctg
      301 tggccctgga tcaaccgcaa cgcccgtgtg gccgacctcg tgcacatcct cacgcacctg
      361 cagctgctcc gtgcgcggga catcatcaca gcctggcacc ctcccgcccc gcttccgtcc
      421 ccaggcacca ctgccccgag gcccagcagc atccctgcac ccgccgaggc cgaggcctgg
      481 agcccccgga agttgccatc ctcagcctcc accttcctct ccccagcttt tccaggctcc
      541 cagacccatt cagggcctga gctcggcctg gtcccaagcc ctgcttccct gtggcctcca
      601 ccgccatctc cagccccttc ttctaccaag ccaggcccag agagctcagt gtccctcctg
      661 cagggagccc gcccctttcc gttttgctgg cccctctgtg agatttcccg gggcacccac
      721 aacttctcgg aggagctcaa gatcggggag ggtggctttg ggtgcgtgta ccgggcggtg
      781 atgaggaaca cggtgtatgc tgtgaagagg ctgaaggaga acgctgacct ggagtggact
      841 gcagtgaagc agagcttcct gaccgaggtg gagcagctgt ccaggtttcg tcacccaaac
      901 attgtggact ttgctggcta ctgtgctcag aacggcttct actgcctggt gtacggcttc
      961 ctgcccaacg gctccctgga ggaccgtctc cactgccaga cccaggcctg cccacctctc
     1021 tcctggcctc agcgactgga catccttctg ggtacagccc gggcaattca gtttctacat
     1081 caggacagcc ccagcctcat ccatggagac atcaagagtt ccaacgtcct tctggatgag
     1141 aggctgacac ccaagctggg agactttggc ctggcccggt tcagccgctt tgccgggtcc
     1201 agccccagcc agagcagcat ggtggcccgg acacagacag tgcggggcac cctggcctac
     1261 ctgcccgagg agtacatcaa gacgggaagg ctggctgtgg acacggacac cttcagcttt
     1321 ggggtggtag tgctagagac cttggctggt cagagggctg tgaagacgca cggtgccagg
     1381 accaagtatc tgaaagacct ggtggaagag gaggctgagg aggctggagt ggctttgaga
     1441 agcacccaga gcacactgca agcaggtctg gctgcagatg cctgggctgc tcccatcgcc
     1501 atgcagatct acaagaagca cctggacccc aggcccgggc cctgcccacc tgagctgggc
     1561 ctgggcctgg gccagctggc ctgctgctgc ctgcaccgcc gggccaaaag gaggcctcct
     1621 atgacccagg tgtacgagag gctagagaag ctgcaggcag tggtggcggg ggtgcccggg
     1681 cattcggagg ccgccagctg catcccccct tccccgcagg agaactccta cgtgtccagc
     1741 actggcagag cccacagtgg ggctgctcca tggcagcccc tggcagcgcc atcaggagcc
     1801 agtgcccagg cagcagagca gctgcagaga ggccccaacc agcccgtgga gagtgacgag
     1861 agcctaggcg gcctctctgc tgccctgcgc tcctggcact tgactccaag ctgccctctg
     1921 gacccagcac ccctcaggga ggccggctgt cctcaggggg acacggcagg agaatcgagc
     1981 tgggggagtg gcccaggatc ccggcccaca gccgtggaag gactggccct tggcagctct
     2041 gcatcatcgt cgtcagagcc accgcagatt atcatcaacc ctgcccgaca gaagatggtc
     2101 cagaagctgg ccctgtacga ggatggggcc ctggacagcc tgcagctgct gtcgtccagc
     2161 tccctcccag gcttgggcct ggaacaggac aggcaggggc ccgaagaaag tgatgaattt
     2221 cagagctgat gtgttcacct gggcagatcc cccaaatccg gaagtcaaag ttctcatggt
     2281 cagaagttct catggtgcac gagtcctcag cactctgccg gcagtggggg tgggggccca
     2341 tgcccgcggg ggagagaagg aggtggccct gctgttctag gctctgtggg cataggcagg
     2401 cagagtggaa ccctgcctcc atgccagcat ctgggggcaa ggaaggctgg catcatccag
     2461 tgaggaggct ggcgcatgtt gggaggctgc tggctgcaca gacccgtgag gggaggagag
     2521 gggctgctgt gcaggggtgt ggagtaggga gctggctccc ctgagagcca tgcagggcgt
     2581 ctgcagccca ggcctctggc agcagctctt tgcccatctc tttggacagt ggccaccctg
     2641 cacaatgggg ccgacgaggc ctagggccct cctacctgct tacaatttgg aaaagtgtgg
     2701 ccgggtgcgg tggctcacgc ctgtaatccc agcactttgg gaggccaagg caggaggatc
     2761 gctggagccc agtaggtcaa gaccagccag ggcaacatga tgagaccctg tctctgccaa
     2821 aaaatttttt aaactattag cctggcgtgg tagcgcacgc ctgtggtccc agctgctggg
     2881 gaggctgaag taggaggatc atttatgctt gggaggtcga ggctgcagtg agtcatgatt
     2941 gtatgactgc actccagcct gggtgacaga gcaagaccct gtttcaaaaa gaaaaaccct
     3001 gggaaaagtg aagtatggct gtaagtctca tggttcagtc ctagcaagaa gcgagaattc
     3061 tgagatcctc cagaaagtcg agcagcaccc acctccaacc tcgggccagt gtcttcaggc
     3121 tttactgggg acctgcgagc tggcctaatg tggtggcctg caagccaggc catccctggg
     3181 cgccacagac gagctccgag ccaggtcagg cttcggaggc cacaagctca gcctcaggcc
     3241 caggcactga ttgtggcaga ggggccacta cccaaggtct agctaggccc aagacctagt
     3301 tacccagaca gtgagaagcc cctggaaggc agaaaagttg ggagcatggc agacagggaa
     3361 gggaaacatt ttcagggaaa agacatgtat cacatgtctt cagaagcaag tcaggtttca
     3421 tgtaaccgag tgtcctcttg cgtgtccaaa agtagcccag ggctgtagca caggcttcac
     3481 agtgattttg tgttcagccg tgagtcacac tacatgcccc cgtgaagctg ggcattggtg
     3541 acgtccaggt tgtccttgag taataaaaac gtatgttgca a
//
