LOCUS       NM_130385               6129 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens inositol 1,4,5-triphosphate receptor associated 1
            (IRAG1), transcript variant 2, mRNA.
ACCESSION   NM_130385 NM_006069
VERSION     NM_130385.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6129)
  AUTHORS   Koehler,K., Hmida,D., Schlossmann,J., Landgraf,D., Reisch,N.,
            Schuelke,M. and Huebner,A.
  TITLE     Homozygous mutation in murine retrovirus integration site 1 gene
            associated with a non-syndromic form of isolated familial achalasia
  JOURNAL   Neurogastroenterol Motil 32 (12), e13923 (2020)
   PUBMED   32573102
  REMARK    GeneRIF: Homozygous mutation in murine retrovirus integration site
            1 gene associated with a non-syndromic form of isolated familial
            achalasia.
REFERENCE   2  (bases 1 to 6129)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6129)
  AUTHORS   Ma,L., Wang,H., Sun,Y., Yang,D., Pu,L. and Zhang,X.
  TITLE     P53-induced MRVI1 mediates carcinogenesis of colorectal cancer
  JOURNAL   Scand J Gastroenterol 55 (7), 824-833 (2020)
   PUBMED   32589066
  REMARK    GeneRIF: P53-induced MRVI1 mediates carcinogenesis of colorectal
            cancer.
REFERENCE   4  (bases 1 to 6129)
  AUTHORS   Zhou,Z., Xu,Y.P., Wang,L.J. and Kong,Y.
  TITLE     miR-940 potentially promotes proliferation and metastasis of
            endometrial carcinoma through regulation of MRVI1
  JOURNAL   Biosci Rep 39 (6) (2019)
   PUBMED   31085718
  REMARK    GeneRIF: forced expression of MRVI1 in miR-940 mimic transfected
            cells abolished the facilitation of miR-940 on cell proliferation,
            migration, and invasion of RL95-2 and KLE cells. In conclusion, our
            study demonstrates that miR-940 might function as a reliable
            diagnostic and prognostic signature in endometrial carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6129)
  AUTHORS   Yaroslavskiy,B.B., Turkova,I., Wang,Y., Robinson,L.J. and
            Blair,H.C.
  TITLE     Functional osteoclast attachment requires
            inositol-1,4,5-trisphosphate receptor-associated cGMP-dependent
            kinase substrate
  JOURNAL   Lab Invest 90 (10), 1533-1542 (2010)
   PUBMED   20567233
  REMARK    GeneRIF: IRAG is required for PKG1beta-regulated cyclic calcium
            release during motility of osteoclasts
REFERENCE   6  (bases 1 to 6129)
  AUTHORS   Fritsch,R.M., Saur,D., Kurjak,M., Oesterle,D., Schlossmann,J.,
            Geiselhoringer,A., Hofmann,F. and Allescher,H.D.
  TITLE     InsP3R-associated cGMP kinase substrate (IRAG) is essential for
            nitric oxide-induced inhibition of calcium signaling in human
            colonic smooth muscle
  JOURNAL   J Biol Chem 279 (13), 12551-12559 (2004)
   PUBMED   14729908
  REMARK    GeneRIF: IRAG appears to be essentially involved in the
            NO/cGK-dependent inhibition of InsP(3)-dependent Ca(2+)-signaling
            in colonic smooth muscle
REFERENCE   7  (bases 1 to 6129)
  AUTHORS   Koller,A., Schlossmann,J., Ashman,K., Uttenweiler-Joseph,S.,
            Ruth,P. and Hofmann,F.
  TITLE     Association of phospholamban with a cGMP kinase signaling complex
  JOURNAL   Biochem Biophys Res Commun 300 (1), 155-160 (2003)
   PUBMED   12480535
REFERENCE   8  (bases 1 to 6129)
  AUTHORS   Ammendola,A., Geiselhoringer,A., Hofmann,F. and Schlossmann,J.
  TITLE     Molecular determinants of the interaction between the inositol
            1,4,5-trisphosphate receptor-associated cGMP kinase substrate
            (IRAG) and cGMP kinase Ibeta
  JOURNAL   J Biol Chem 276 (26), 24153-24159 (2001)
   PUBMED   11309393
REFERENCE   9  (bases 1 to 6129)
  AUTHORS   Shaughnessy,J.D. Jr., Largaespada,D.A., Tian,E., Fletcher,C.F.,
            Cho,B.C., Vyas,P., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mrvi1, a common MRV integration site in BXH2 myeloid leukemias,
            encodes a protein with homology to a lymphoid-restricted membrane
            protein Jaw1
  JOURNAL   Oncogene 18 (12), 2069-2084 (1999)
   PUBMED   10321731
  REMARK    GeneRIF: Reports use of non-AUG (CUG) translation initiation codon
            in one of the transcript variants of MRVI1 gene in mouse and human.
REFERENCE   10 (bases 1 to 6129)
  AUTHORS   Baltensperger,K., Chiesi,M. and Carafoli,E.
  TITLE     Substrates of cGMP kinase in vascular smooth muscle and their role
            in the relaxation process
  JOURNAL   Biochemistry 29 (41), 9753-9760 (1990)
   PUBMED   2271613
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009532.9.
            
            On Apr 22, 2020 this sequence version replaced NM_130385.3.
            
            Summary: This gene is similar to a putative mouse tumor suppressor
            gene (Mrvi1) that is frequently disrupted by mouse AIDS-related
            virus (MRV). The encoded protein, which is found in the membrane of
            the endoplasmic reticulum, is similar to Jaw1, a
            lymphoid-restricted protein whose expression is down-regulated
            during lymphoid differentiation. This protein is a substrate of
            cGMP-dependent kinase-1 (PKG1) that can function as a regulator of
            IP3-induced calcium release. Studies in mouse suggest that MRV
            integration at Mrvi1 induces myeloid leukemia by altering the
            expression of a gene important for myeloid cell growth and/or
            differentiation, and thus this gene may function as a myeloid
            leukemia tumor suppressor gene. Several alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene, and alternative translation start sites, including a
            non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296336.1, SRR14038193.3155270.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423302.7/ ENSP00000412130.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC009532.9         145162-145381       c
            221-378             AC009532.9         103651-103808       c
            379-482             AC009532.9         85594-85697         c
            483-553             AC009532.9         83617-83687         c
            554-727             AC009532.9         81164-81337         c
            728-805             AC009532.9         80377-80454         c
            806-858             AC009532.9         79599-79651         c
            859-903             AC009532.9         79342-79386         c
            904-1521            AC009532.9         77592-78209         c
            1522-1600           AC009532.9         75404-75482         c
            1601-1724           AC009532.9         61354-61477         c
            1725-1755           AC009532.9         58368-58398         c
            1756-1896           AC009532.9         56031-56171         c
            1897-2028           AC009532.9         54746-54877         c
            2029-2170           AC009532.9         52544-52685         c
            2171-2220           AC009532.9         45772-45821         c
            2221-2328           AC009532.9         45118-45225         c
            2329-2393           AC009532.9         43174-43238         c
            2394-2513           AC009532.9         33493-33612         c
            2514-2648           AC009532.9         32081-32215         c
            2649-6129           AC009532.9         24721-28201         c
FEATURES             Location/Qualifiers
     source          1..6129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6129
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /note="inositol 1,4,5-triphosphate receptor associated 1"
                     /db_xref="GeneID:10335"
                     /db_xref="HGNC:HGNC:7237"
                     /db_xref="MIM:604673"
     exon            1..220
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2892
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /note="isoform d is encoded by transcript variant 2;
                     IP3R-associated cGMP kinase substrate; murine retrovirus
                     integration site 1 homolog; JAW1-related protein MRVI1;
                     inositol 1,4,5-triphosphate receptor-associated cGMP
                     kinase substrate; inositol 1,4,5-trisphosphate
                     receptor-associated cGMP kinase substrate"
                     /codon_start=1
                     /product="inositol 1,4,5-triphosphate receptor associated
                     1 isoform d"
                     /protein_id="NP_569056.4"
                     /db_xref="CCDS:CCDS55746.1"
                     /db_xref="GeneID:10335"
                     /db_xref="HGNC:HGNC:7237"
                     /db_xref="MIM:604673"
                     /translation="MVKAPQSEERLARGGKENNSVLACGAQASWSIFGADAAEVPGTR
                     GHSQQEAAMPHIPEDEEPPGEPQAAQSPAGQGPPAAGVSCSPTPTIVLTGDATSPEGE
                     TDKNLANRVHSPHKRLSHRHLKVSTASLTSVDPAGHIIDLVNDQLPDISISEEDKKKN
                     LALLEEAKLVSERFLTRRGRKSRSSPGDSPSAVSPNLSPSASPTSSRSNSLTVPTPPG
                     LDVCSGPPSPLPGAPPQKGDEADVSSPHPGEPNVPKGLADRKQNDQRKVSQGRLAPRP
                     PPVEKSKEIAIEQKENFDPLQYPETTPKGLAPVTNSSGKMALNSPQPGPVESELGKQL
                     LKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRG
                     LSWDSGPEEPGPRLQKVLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQK
                     LTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSELSPAIEEEESKSGLDVMPNIS
                     DVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTE
                     ENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVR
                     QEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARS
                     MSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSESPNGKGSLPVTSA
                     LPALLENGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKEL
                     QDLKEEEEEQKSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIW
                     MMAAVMLVLTVVLGLYNSYNSCAEQADGPLGRSTCSAAQRDSWWSSGLQHEQPTEQ"
     exon            221..378
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..482
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..553
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..727
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..805
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..858
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..903
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1521
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1600
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1724
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1755
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1896
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2028
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2170
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2220
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2328
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2393
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2513
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2648
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..6129
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6110..6115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /note="hexamer: AATAAA"
     polyA_site      6129
                     /gene="IRAG1"
                     /gene_synonym="IRAG; JAW1L; MRVI1"
                     /note="major polyA site"
ORIGIN      
        1 gccattatcc cccgagccag gccggagtgg ggctcccaga ggagctctcg gctctaagtc
       61 ccagcccctc tcagaggagg cgtgcggccg aggttctgca gccagaggct tctcggctct
      121 gagctccgga gccagatgta acattgacct taaatggtaa aagctcccca gagtgaagag
      181 aggctggcca gaggaggaaa ggagaataac tcagttttag cctgtggagc ccaggcctct
      241 tggagcatct ttggggctga cgcagcggag gttccgggca cacgtggcca ctcccagcag
      301 gaggctgcca tgccccacat tcccgaggac gaggagcccc ccggagagcc acaggcagcc
      361 cagagccctg ccggccaagg tcctcctgcc gcaggagtat cttgcagtcc aactcccacg
      421 attgtcctga ctggggatgc cacttcacca gaaggagaaa ccgacaaaaa cctggccaac
      481 agagttcaca gtccccacaa gaggctttct caccgacact tgaaggtgtc cactgcctcc
      541 ctgacatctg tggaccccgc ggggcacatc attgacctgg tgaatgacca gctgccagac
      601 atcagcatct cagaggagga caagaagaaa aacctggcgc tgctggaaga agccaagttg
      661 gtgagtgagc gattcctgac ccgccgtggg aggaagtcca ggagcagccc cggagactcc
      721 ccatcagctg tttccccgaa cctcagcccc agcgcttctc ctacatcctc tcggagcaac
      781 tcacttacag tccccacccc gccaggtttg gatgtgtgca gtggcccgcc atcccctctg
      841 cctggagcac caccacagaa gggggatgag gccgacgtct cttcacctca ccctggcgag
      901 cctaacgtcc ccaaagggct agctgacagg aagcagaatg accagaggaa agtgtctcag
      961 ggcaggctgg ctcctcgtcc tcctccagtt gagaagtcca aagagattgc aatagaacaa
     1021 aaggaaaact tcgatcccct ccagtacccc gagaccacac ccaaaggcct agctcctgtt
     1081 acaaacagca gtgggaaaat ggccctgaac agccctcagc ctggccccgt ggagagcgag
     1141 ctggggaagc agctcttgaa aacgggctgg gagggcagcc ctctgccgag aagtccaacc
     1201 caggatgcgg caggagtggg tcccccagcc tcccagggga gaggcccagc tggagagccg
     1261 atggggcccg aggctggctc caaagctgag cttccaccca ctgtgtcccg gcccccgctg
     1321 ctgcgagggc tctcctggga cagtggccct gaagaacctg gcccccggct gcagaaagtg
     1381 cttgccaagc tgccactggc agaggaagaa aagcgttttg caggcaaggc cggcggcaag
     1441 ctggccaagg cccctggtct caaagacttt cagatacaag tgcagcccgt gcggatgcag
     1501 aaactgacca agctccgaga ggagcacatc ctgatgagaa atcagaactt agtggggctc
     1561 aagcttccag accttagtga agcagctgag caggaaaaag ggcttccttc tgaactctcc
     1621 ccagctattg aggaagaaga gtcaaagagt ggcttagatg tcatgcctaa tatttctgat
     1681 gtgctgctgc gcaaactgcg ggtccacagg agtctccctg gaagtgcccc tccactcact
     1741 gaaaaggaag ttgagaacgt gtttgtgcaa ctgtccttgg cctttagaaa tgacagctac
     1801 actctggaat ctagaattaa ccaggctgaa agggaacgca acctgacaga ggagaacact
     1861 gagaaagaac tggaaaactt caaagcttcc attacgtcct cagcttcact ctggcaccac
     1921 tgtgagcacc gggaaaccta ccagaagttg ctggaggaca tcgctgtcct gcaccgcctg
     1981 gctgcccgcc tctccagccg agctgaggtg gtaggcgccg tccgccagga aaagcgcatg
     2041 tcgaaagcaa cggaagtgat gatgcagtat gtggagaatc taaagaggac gtatgagaag
     2101 gaccatgcgg agctcatgga gtttaaaaag cttgcaaatc agaattcaag ccgcagctgt
     2161 ggcccctctg aagatggggt ccctcgcacg gcacggtcca tgtccctcac gctgggaaag
     2221 aatatgcctc gccggagggt cagcgttgct gtggttccta agtttaatgc cctgaatctg
     2281 cctggccaaa ctcccagctc atcatccatt ccctccttac cagccttgtc ggaatcaccc
     2341 aatgggaaag gcagcctacc tgtcacttca gcactgcctg cacttttgga aaatggaaag
     2401 acaaatgggg acccagattg tgaagcctct gctcctgcgc tgaccctgag ctgcctggag
     2461 gagcttagtc aggagaccaa ggccaggatg gaggaagaag cctacagcaa gggattccaa
     2521 gaaggtctaa agaagaccaa agaacttcaa gacctgaagg aggaggagga agaacagaag
     2581 agtgagagtc ctgaggaacc tgaagaggta gaagaaactg aggaagagga aaagggccca
     2641 agaagcagca aacttgaaga attggtccat ttcttacaag tcatgtatcc caaactgtgt
     2701 cagcactggc aagtgatctg gatgatggct gcagtgatgc tggtcttgac tgttgtgctg
     2761 gggctctaca attcctataa ctcttgtgca gagcaggctg atgggcccct tggaagatcc
     2821 acttgctcgg cagcccagag ggactcctgg tggagctcag gactccagca tgagcagcct
     2881 acagagcagt aggaaacctc acacctagcc agtgccctgc tctgagacac tcagactacc
     2941 accctttccc caagtataac gtcaggccca agtgtggaca cactgccgcc catcccatca
     3001 ggtcatgagg aagggttctt ttaacactcg gcacttctgt gggagctatt catacacagt
     3061 gacttgatgt tcttggagga tcaacaaaac tgccctggga aagcatccag tggatgaaga
     3121 agtcaccttc accaaggaac tctattggaa gggaaggtct cctgccccta gctcaggtgg
     3181 ctggggagaa ctaaaacacc ttcactggtg gttgggggta aggagcgggg cacgggggag
     3241 gaggaggtag ggggcagtaa aaaacttact ctcttttttc ctctctgtaa ttggttatca
     3301 ggaagaattt gcttaatgac taacacccta agcatcagac ctggaatttg gagttgcaaa
     3361 gtgactatct tcccatttcc catctcattt tcaataactt cagcctccca ttctttcctt
     3421 tggaatgaga gtttcttttt acagaagtag gaaaggcttc tcagaaaaaa aaaaaaaagt
     3481 ataggctgaa tttagctcag tgcttgaaat gggaagatat gaattattat atacgcatct
     3541 gtccacacat acacacatac tgttgtgtac acacacacaa catgcctgtg cacagagcca
     3601 acaacccttc aaaagtgtgc tctgggtgtg tacctctgga taaataagat gcatgccaag
     3661 ccaacccaca gattttcacc agtgtggggc agtcaccagg cacctgttca atgagctgtc
     3721 cacatggatt gaagatgttt taaaaacaca gaaaactcat ggcttcaatg gcagacttac
     3781 tagtctccat ttcaaatgcc aactctgagc tgctgtacag cacaatctat tccctattct
     3841 ctctttgaaa acagttaacc cacctcacag gtgaatgagg agagaagatg tgctttctgc
     3901 ttcagtctct tactctgtgt gtgaccacat gcaagagtaa acttgcacct cagtgcttca
     3961 gttcaaatgg ggtttccaac cccagtataa ttaggggtgt ttcagagcat ccccagttat
     4021 ttagcacaac actgaaggag cacatcccct ctccattttg acttctctcc ccacttttac
     4081 agccactgcc ttcatcagtt ttgtagaggt ttgatttcca tgtgggtttt gttgtcattg
     4141 ttttgcattt ttgttttgtt attgatattg tttgctttca ttgctaaaac tcatatacga
     4201 cttactatga gccaagcact gttctcagta ttacataggt atgaattcat ttaagtcctg
     4261 aagaaaaaga aaaaaaaata cgaagtggat attacccttc ccattttcaa ataaggaaac
     4321 tgaagcacaa aaagaacaag taacttgaca aggacacccc ggtagtaaat catggggctg
     4381 gagctcaacc ccagggtagg ctggctccag agctgtgctc tccttgactc ttctgatggt
     4441 ctcctagctg gaagcctcac atttcagtct cattccccca agtggcccat cagctactcc
     4501 atctctggct ccccaactaa acagtttctc tcatagtgct ggacctccac tcactagttt
     4561 tttttccagc tgttcttctc ttttcttcag gtcactcttc tcgaccgagt gcaaaaatta
     4621 tcccctccat accagctttg atgaccttcc ttccatactc ctcaccagac acaacataat
     4681 aggtcacaca ctcctctgtg ctttctggca cgttttaaac attattatta ttgaccttta
     4741 cctatagtat accatggcct atttatgtat ccatctcccc tagcattttt cctcaaagac
     4801 aagaaccatg tcttacccat ctcttgggta agtgcctagc atggtggctg acgcttggga
     4861 gggtgtcatt aaatgttgct caaaagaaca agcaaacatt taaggtggtg gagagcagcc
     4921 tggggacagc tgacatgctg catgcttctc agtaccagca ccatcacaat gcaaaaagca
     4981 acatctttct taacctcagc ttattctgtt tttcagtcta ctctgtgaga gagcaggaat
     5041 gagaccagac tagcaacacc attgccaagc tcaaggactg ggctcaatgc agtcactcct
     5101 tcagagagac cccccacccc aagcatgccc cactttaaaa tagcatgttt attgaagggg
     5161 gcatccttta cagtagctag aaaatgactg aggcccaagc cagggttgat caaggatgtg
     5221 ccattaaggt aaagagttac agagcagggc agagggactc tgggggcaga agtggatgat
     5281 ttgcccggcc tcttccaggg ggtctggata caactgaagg agctttagct acatgaggcc
     5341 ctcagagcca aagacaggat gcaaatagag ttctagagag tggccgtgga agcagaactc
     5401 caggtgggga atgttcaatc tctgcctccc ttaaagcagg gccaggctca gctggcccca
     5461 ttgttcactt ggtcacaagt ttcctacctt tgtttctgga tgagtcaaag gccaggaagg
     5521 cagttatgga gagctcctgc acctccagct gccccacaga aaagcctgca agagtacttc
     5581 caggcacagg ccctctccca ccctattcca tttgtaagca agggaggtcg aggaaaagga
     5641 catctccaaa agggagcata agaatagcca tatatacagg ggctgaaaaa gtgctcatga
     5701 gtccatcttt tctggaaagc aaagaccagc ctgaagcagt gggagctgct gcccaagcgg
     5761 tagtgaactg gagagaaaca ggccctggat tttcagtgag gatgtggatc tgaagagtcc
     5821 cccaaatgcc tctgaagtct gacatctctg cttagcccta ggagtctggt tccctgcctt
     5881 cagttgcaga gtgatgtgtt tgtgtcattg ttgatgtcac ctcctaaaaa gaccttcact
     5941 ttctggctgc cacaaagcca tatgtgttgc tccccatata cagcctgaca gagtaaatgg
     6001 agaggaagtg ctggatttgt gtatcactgg ctatcagttc ctcatgttgt taagcctcac
     6061 acaggtgtgc tagcattgaa ctgtagagtg tcacatacct gagtttgaaa ataaaagcac
     6121 atttccaaa
//
