LOCUS       NM_178827               3034 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens IQ motif and ubiquitin domain containing (IQUB),
            transcript variant 1, mRNA.
ACCESSION   NM_178827
VERSION     NM_178827.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Zhang,Z., Zhou,H., Deng,X., Zhang,R., Qu,R., Mu,J., Liu,R.,
            Zeng,Y., Chen,B., Wang,L., Sang,Q. and Bao,S.
  TITLE     IQUB deficiency causes male infertility by affecting the activity
            of p-ERK1/2/RSPH3
  JOURNAL   Hum Reprod 38 (1), 168-179 (2023)
   PUBMED   36355624
  REMARK    GeneRIF: IQUB deficiency causes male infertility by affecting the
            activity of p-ERK1/2/RSPH3.
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Li,K., Ma,Y.B., Zhang,Z., Tian,Y.H., Xu,X.L., He,Y.Q., Xu,L.,
            Gao,Y., Pan,W.T., Song,W.J., He,X. and Wei,L.
  TITLE     Upregulated IQUB promotes cell proliferation and migration via
            activating Akt/GSK3beta/beta-catenin signaling pathway in breast
            cancer
  JOURNAL   Cancer Med 7 (8), 3875-3888 (2018)
   PUBMED   29968965
  REMARK    GeneRIF: these results indicated that upregulated IQUB promoted
            breast cancer cell proliferation and migration via activating
            Akt/GSK3beta/beta-catenin signaling pathway, which played an
            important part in the tumorigenesis and development of breast
            cancer
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   Cho,K.J., Noh,S.H., Han,S.M., Choi,W.I., Kim,H.Y., Yu,S., Lee,J.S.,
            Rim,J.H., Lee,M.G., Hildebrandt,F. and Gee,H.Y.
  TITLE     ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic
            pre-assembly of dynein arms
  JOURNAL   PLoS Genet 14 (3), e1007316 (2018)
   PUBMED   29601588
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Docherty,S.J., Kovas,Y., Petrill,S.A. and Plomin,R.
  TITLE     Generalist genes analysis of DNA markers associated with
            mathematical ability and disability reveals shared influence across
            ages and abilities
  JOURNAL   BMC Genet 11, 61 (2010)
   PUBMED   20602751
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA112303.1, BC128181.1 and AC073323.5.
            
            On Nov 22, 2018 this sequence version replaced NM_178827.4.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 2, and 5 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.50768.1, BC032838.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324698.11/ ENSP00000324882.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA112303.1         71-102
            33-2529             BC128181.1         1-2497
            2530-3034           AC073323.5         20697-21201         c
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..3034
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /note="IQ motif and ubiquitin domain containing"
                     /db_xref="GeneID:154865"
                     /db_xref="HGNC:HGNC:21995"
                     /db_xref="MIM:620557"
     exon            1..104
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            105..505
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2484
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /note="IQ and ubiquitin-like domain-containing protein"
                     /codon_start=1
                     /product="IQ motif and ubiquitin-like domain-containing
                     protein"
                     /protein_id="NP_849149.3"
                     /db_xref="CCDS:CCDS5787.1"
                     /db_xref="GeneID:154865"
                     /db_xref="HGNC:HGNC:21995"
                     /db_xref="MIM:620557"
                     /translation="MSNQQEKYEAQNIVNSTEESDDAFDTVTIPVPSEEPQESDQTEE
                     HESGIEQFSESHAIHVEEQSDQSFSSLEPDNEQLMEEVISPRQVSYTPQHHEKQYAMQ
                     RPNDDSLAFLDKIKSVKESLQESVEDSLATVKVVLIPVGQEIVIPFKVDTILKYLKDH
                     FSHLLGIPHSVLQIRYSGKILKNNETLVQHGVKPQEIVQVEIFSTNPDLYPVRRIDGL
                     TDVSQIITVTVQTGLDQYQQVPVEIVKSDFHKPFLGGFRHKVTGVEYHNAGTQTVPKR
                     IPERLSIFCRDTQTVFQKKNLQQTTNTTSTQMTNIGVYVSNMTDKLVTPGKYFSAAEY
                     HAQRLKAVIVIQTYYRQWHAKIFVENLRRQKSLRLEWETQQELRKIREKEEWIKLDYH
                     RRHNPKTNEDFEFLYNALEFWRQEELTRINQSFTGAERKAALCELLEKETQIIASIGR
                     HRYIAYMANQEAAIQAFLDKCSAPKIWRTPNGKTIEMDTQFTIRARELQNIYKCIMLK
                     NISQDERLDVLLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKHHNLEGLRKRIAT
                     LFFHYIKTPLFNPEVAKYLKVPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYR
                     CRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENIWA
                     SQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHK
                     IKHKHILAKNYFSQVPVLASFILDDGEIDEIRWKYHSDTTPKIIESQRPPH"
     exon            506..640
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            641..802
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..975
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1131
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1342
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1518
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1689
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1866
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2115
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2301
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..3034
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2539..2544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /note="hexamer: AATACA"
     polyA_site      2569
                     /gene="IQUB"
                     /gene_synonym="TRS4"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="IQUB"
                     /gene_synonym="TRS4"
                     /note="major polyA site"
ORIGIN      
        1 gttgctagga tacgaccaac agctgagaac gcggcgagta tggaagctgc gtcttaggag
       61 cctgggaaag cacttcgacg agaatagttt ggtttcgtac acaggaaaat gtctaatcaa
      121 caggagaagt atgaagctca gaatatagtc aattcaacag aagagagtga tgatgctttt
      181 gatactgtca ctattccagt tccctcagaa gagcctcaag agtcagatca aactgaagag
      241 catgaatctg gaatagaaca attcagtgag agccatgcaa tacatgttga ggagcagagt
      301 gaccaaagct tttcaagcct ggaaccagac aatgaacaac tcatggaaga ggttatatca
      361 ccaagacaag tttcatatac tccgcaacat catgaaaagc aatatgcaat gcagaggcca
      421 aatgatgata gtttggcatt tctggataaa ataaagtctg taaaggaatc tttgcaagaa
      481 tcagtggaag attctctagc aacagtaaaa gttgtactta ttccagtggg ccaggaaatt
      541 gtaatacctt ttaaggttga taccattctt aaatatctta aggaccattt ttcacactta
      601 ttaggtatcc cacattctgt actgcagata agatactcag gaaaaattct taaaaataat
      661 gagactctag tacaacatgg agttaagcca caggaaattg tacaagtgga aatcttttct
      721 acaaatccag atctgtatcc agtcagaaga atagatggat taactgatgt ctctcaaatc
      781 ataactgtca ctgtccaaac tggacttgat caataccagc aggtacctgt tgagattgtc
      841 aaatctgact ttcacaaacc atttcttggt ggattcagac ataaagtaac aggagtagag
      901 tatcacaatg ctggaacaca aactgtacct aaaaggattc ccgaaagact cagtatattt
      961 tgtagggata cgcagacagt ttttcagaaa aaaaatctcc aacaaactac aaatacaaca
     1021 tccacacaga tgactaacat tggtgtatat gtatcaaata tgactgataa actggtaaca
     1081 ccaggaaagt atttttcagc agcagaatac catgctcaaa gactaaaggc ggtgatagtg
     1141 atacagactt actacaggca atggcatgct aaaatcttcg tagagaattt aagaagacag
     1201 aaaagcttaa gactggaatg ggaaacacag caagaactaa ggaagataag agaaaaagaa
     1261 gaatggataa aattggacta tcaccggagg cataatccta aaacaaatga agattttgaa
     1321 tttctttata atgcattaga attctggcgg caagaagaac ttacacgtat taaccaatct
     1381 tttactggag ctgaaaggaa agctgctctg tgtgaacttc tggaaaaaga gactcagata
     1441 attgcttcca ttgggagaca tagatacatt gcttatatgg caaatcagga agcagcaata
     1501 caagcttttt tggataagtg ttcagctcca aaaatatgga gaacccctaa tggcaaaaca
     1561 attgagatgg atacgcagtt caccatcaga gccagagagc tgcaaaatat ctataagtgc
     1621 attatgctga aaaatatctc ccaagatgag aggctggatg tgctgttaac tcttaaacac
     1681 actgtaaagg aacatgaatg taaactaact caggaaattc tagaattgat tgacagagag
     1741 gttgacctta tgatgagagg agtcaaacat cataaccttg aaggactcag aaaaagaatt
     1801 gcgacactct tttttcatta tatcaaaaca cctctgttta atcctgaagt tgcaaaatac
     1861 cttaaggtcc ctcaagaccc attgaaattt tataagaaga tttacttttg ccacagttgc
     1921 cagctttatt tgccttctac agaattttct gtatcatcca cctcacgccg catataccgg
     1981 tgtcgtaact gcattaacct tcagaatgag gctcaaaaac gagaatcatt tttgaagtac
     2041 aaatgtttac ttcaacagct ctactataca gaagctgatt atgaagatga ttctaaaatt
     2101 gctttcttga tgcagctaca agacattcag tacctgacag agaacatctg ggcgtcccag
     2161 tcagtcctca gtgcttgcga caatctcagt gatctggtca tggtcagatg gaataaatcc
     2221 ctggagtggt ccccctggaa ctgcattctt cttaccaaag atgaagcagc tgctcatctc
     2281 aagctaacaa gtattgaaga gggatatgaa cgctcattta ttcacaagat caaacacaaa
     2341 catatcctgg ctaagaacta tttttctcag gttccagtgc tggcttcatt tatacttgat
     2401 gatggtgaaa ttgatgagat cagatggaag tatcactcag acacaacacc taagattata
     2461 gaatcccaga ggcctcctca ttaggtgatc caggagtatt tgtttgatga tcggcatttt
     2521 gttcactgct aatagggtaa tacagaggtc acagagtatg gaaatggaat ttaatctgtt
     2581 tattgatttt gttttttgtt tttcatagta ttttgagtta tataaagaga aaacatttct
     2641 atataagtaa gtattctttg ttaggaagtt ggtgctaaat tgaaatgcaa ttttgttact
     2701 gaaattaata ttttggggta aagaaaacat tttaaaatgt gttttcacat taaatttttt
     2761 aaattttttc aagtatatta gagttaaaat ctaacaaaca gccaaataaa aactagacaa
     2821 ctttcaagtt atttatttta gatagaatgt agttatagga agctaatcag tatgtggagg
     2881 ggaggaaaca ttataaagtg ctctttcttg aaaacttctt taagtaggat aaaaaaattt
     2941 atattttagt ataggcattt gaatctttgc agtttatcgt ctgctttcac cttccatcct
     3001 tctcataatc ccaataaaac aacacttgaa acta
//
