LOCUS       NM_001170738            7087 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens IQ motif and Sec7 domain ArfGEF 3 (IQSEC3), transcript
            variant 1, mRNA.
ACCESSION   NM_001170738
VERSION     NM_001170738.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7087)
  AUTHORS   Kim,D., Jung,H., Shirai,Y., Kim,H., Kim,J., Lim,D., Mori,T.,
            Lee,H., Park,D., Kim,H.Y., Guo,Q., Pang,B., Qiu,W., Cao,X.,
            Kouyama-Suzuki,E., Uemura,T., Kasem,E., Fu,Y., Kim,S., Tokunaga,A.,
            Yoshizawa,T., Suzuki,T., Sakagami,H., Lee,K.J., Ko,J., Tabuchi,K.
            and Um,J.W.
  TITLE     IQSEC3 Deletion Impairs Fear Memory Through Upregulation of
            Ribosomal S6K1 Signaling in the Hippocampus
  JOURNAL   Biol Psychiatry 91 (9), 821-831 (2022)
   PUBMED   35219498
  REMARK    GeneRIF: IQSEC3 Deletion Impairs Fear Memory Through Upregulation
            of Ribosomal S6K1 Signaling in the Hippocampus.
REFERENCE   2  (bases 1 to 7087)
  AUTHORS   Pergande,M., Motameny,S., Ozdemir,O., Kreutzer,M., Wang,H.,
            Daimaguler,H.S., Becker,K., Karakaya,M., Ehrhardt,H., Elcioglu,N.,
            Ostojic,S., Chao,C.M., Kawalia,A., Duman,O., Koy,A., Hahn,A.,
            Reimann,J., Schoner,K., Schanzer,A., Westhoff,J.H.,
            Schwaibold,E.M.C., Cossee,M., Imbert-Bouteille,M., von Pein,H.,
            Haliloglu,G., Topaloglu,H., Altmuller,J., Nurnberg,P., Thiele,H.,
            Heller,R. and Cirak,S.
  TITLE     The genomic and clinical landscape of fetal akinesia
  JOURNAL   Genet Med 22 (3), 511-523 (2020)
   PUBMED   31680123
  REMARK    GeneRIF: The genomic and clinical landscape of fetal akinesia.
            Erratum:[Genet Med. 2020 Aug;22(8):1426-1428. doi:
            10.1038/s41436-020-0839-9.. PMID: 32451403]
REFERENCE   3  (bases 1 to 7087)
  AUTHORS   Kim,S., Kim,H., Park,D., Kim,J., Hong,J., Kim,J.S., Jung,H.,
            Kim,D., Cheong,E., Ko,J. and Um,J.W.
  TITLE     Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases
            Somatostatin Expression in the Hippocampus
  JOURNAL   Cell Rep 30 (6), 1995-2005 (2020)
   PUBMED   32049026
  REMARK    GeneRIF: Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and
            Decreases Somatostatin Expression in the Hippocampus.
            Erratum:[Cell Rep. 2024 May 28;43(5):114254. doi:
            10.1016/j.celrep.2024.114254.. PMID: 38748876]
REFERENCE   4  (bases 1 to 7087)
  AUTHORS   Um,J.W., Choii,G., Park,D., Kim,D., Jeon,S., Kang,H., Mori,T.,
            Papadopoulos,T., Yoo,T., Lee,Y., Kim,E., Tabuchi,K. and Ko,J.
  TITLE     IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts
            with Gephyrin to Promote Inhibitory Synapse Formation
  JOURNAL   J Biol Chem 291 (19), 10119-10130 (2016)
   PUBMED   27002143
  REMARK    GeneRIF: these data reveal that IQSEC3 acts together with gephyrin
            to regulate inhibitory synapse development.
REFERENCE   5  (bases 1 to 7087)
  AUTHORS   Turner,S.T., Bailey,K.R., Schwartz,G.L., Chapman,A.B., Chai,H.S.
            and Boerwinkle,E.
  TITLE     Genomic association analysis identifies multiple loci influencing
            antihypertensive response to an angiotensin II receptor blocker
  JOURNAL   Hypertension 59 (6), 1204-1211 (2012)
   PUBMED   22566498
REFERENCE   6  (bases 1 to 7087)
  AUTHORS   Hattori,Y., Ohta,S., Hamada,K., Yamada-Okabe,H., Kanemura,Y.,
            Matsuzaki,Y., Okano,H., Kawakami,Y. and Toda,M.
  TITLE     Identification of a neuron-specific human gene, KIAA1110, that is a
            guanine nucleotide exchange factor for ARF1
  JOURNAL   Biochem Biophys Res Commun 364 (4), 737-742 (2007)
   PUBMED   17981261
  REMARK    GeneRIF: These results suggest that KIAA1110 is expressed
            specifically in mature neurons and may play an important role in
            the secretion pathway as a GEF for ARF1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026369.21 and AC007406.1.
            
            On May 17, 2019 this sequence version replaced NM_001170738.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538872.6/ ENSP00000437554.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               AC026369.21        105863-106532       c
            671-739             AC026369.21        74085-74153         c
            740-1019            AC026369.21        47387-47666         c
            1020-2107           AC026369.21        33945-35032         c
            2108-2269           AC026369.21        32014-32175         c
            2270-2392           AC026369.21        16152-16274         c
            2393-2559           AC026369.21        15605-15771         c
            2560-2699           AC026369.21        11234-11373         c
            2700-2825           AC026369.21        9680-9805           c
            2826-2925           AC026369.21        7766-7865           c
            2926-3087           AC026369.21        7409-7570           c
            3088-3180           AC026369.21        4194-4286           c
            3181-3230           AC026369.21        2138-2187           c
            3231-7087           AC007406.1         1522-5378
FEATURES             Location/Qualifiers
     source          1..7087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..7087
                     /gene="IQSEC3"
                     /note="IQ motif and Sec7 domain ArfGEF 3"
                     /db_xref="GeneID:440073"
                     /db_xref="HGNC:HGNC:29193"
                     /db_xref="MIM:612118"
     exon            1..670
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3665
                     /gene="IQSEC3"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 3; IQ motif and
                     Sec7 domain 3"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 3
                     isoform 1"
                     /protein_id="NP_001164209.1"
                     /db_xref="CCDS:CCDS53728.1"
                     /db_xref="GeneID:440073"
                     /db_xref="HGNC:HGNC:29193"
                     /db_xref="MIM:612118"
                     /translation="MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLD
                     ELSAENRSLWEHQQLLQAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSA
                     AAPHPAPDRPPRQHHGQLLEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCC
                     AAAGALLQHKSPSALGKGVLSRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGG
                     MEDSVVAAAAVAAGRPSAHAPKAQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPA
                     LATALCPHAPAASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKN
                     FEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFA
                     GTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLE
                     AEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVA
                     NCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGA
                     TAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQA
                     MILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDT
                     PIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQA
                     HIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNI
                     KPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSI
                     VGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSS
                     STYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKFVE
                     DLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAKREAALRE
                     RPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLPPPPPTPPG
                     TLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPVKVTHQ
                     PPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV"
     exon            671..739
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1019
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..2107
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2269
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2392
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2559
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2699
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2825
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2925
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3087
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3180
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3230
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..7087
                     /gene="IQSEC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7064..7069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQSEC3"
                     /note="hexamer: ATTATA"
     polyA_site      7087
                     /gene="IQSEC3"
                     /note="major polyA site"
ORIGIN      
        1 aggctgggcc ggtgggagag ggaggcgagc cgaccgctgg gctgctgggc tcccgcgccc
       61 tcgcgctccc cgccgccagc ccaggcgcag gcagggcgca ggcggcggcg ggcggcatgg
      121 agagcctgct ggagaatccg gtgcgcgccg tgctctacct caaggagctc acggccatcg
      181 tgcagaacca gcagagcctc atccacaccc agcgagagcg tatcgacgag ctggagcggc
      241 ggctggacga gctgagcgct gagaaccgca gcctgtggga gcaccagcag ctgctgcaag
      301 cccagcctcc gcccgggctc gtccccccgt catcggcccc gctgccggcc gctccggcca
      361 ccgctcctgc cgccgccgcc agggcccagg aacctctcca ggaccaggga cagcgctcag
      421 cagccgcgcc gcatcccgcg cccgatcggc cgccgcgtca gcaccacgga cagctcctgg
      481 agcagcccca gcggggccct ggcagcaggg ctcacacacc ccagtcgccc cacaagcatc
      541 tggggacaca aggggccgtg actgacaagg agaaggagcg tcccccgagt tgctgcgctg
      601 ctgccggagc cctccttcag cacaaatccc cctccgccct cggcaagggc gtcctgagca
      661 ggagacctga gaatgagacc gtgctgcacc agttctgctg cccagccgcc gacgcctgct
      721 ccgacctggc ctcccaaagt gatggctcct gcacccaggc cggtgggggc atggaggact
      781 ccgtggtggc agcggcggcg gtggcagccg gcagacccag tgcccatgcc ccgaaggctc
      841 aagcccagga gctgcaggag gaggaggagc ggccgggggc aggggctgcc tccccaaggg
      901 ctggccccca gcacaaggcc tcccccggcc ggcagcagcc tgccctggcg acggcgctgt
      961 gcccccacgc ccctgccgcc tccgattacg aactctccct tgacctaaag aataaacaga
     1021 ttgaaatgct agaacataag tacggcggtc acctggtgtc ccggcgcgcc gcttgcacca
     1081 tccaaaccgc cttccgccaa taccagctca gcaagaactt cgagaaaatc cgcaactcgc
     1141 ttctggagag ccgcctgcca cggcggatct ccctgcgcaa ggtgcggtca cccacggccg
     1201 agagcctggc ggccgagaaa gcgctcatgg agggctacgg cctcgtgggg ctgccgctgg
     1261 tgcgctcgcc ctccctgccg cccaccttcg caggcaccct caccgagctg gaggactcct
     1321 tcaccgagca ggtgcaatcc ctggccaagt ccatcgacga cgcgctcagc acgtggagcc
     1381 tcaagaccat gtgctccctg cgggagagtg gcgcttacca gctccaccag gccctgcagg
     1441 cggccgcggg gcccccaggc ctggaggccg aggggcgggc gccggagagc gcgggccccg
     1501 ggcccgggga tgacgccgcg gagacccccg gcctgccccc ggcccacagc gggaccctca
     1561 tgatggcttt ccgggacgtc acggtgcaga tcgccaacca gaacatatcc gtctcctcct
     1621 ccacggctct gtcggtggcc aactgcctgg gcgctcagac ggtccaggcc cccgcagagc
     1681 ccgcggcggg caaggccgag cagggcgaga cctctgggcg ggaggccccg gaagcccccg
     1741 ccgtgggccg ggaggacgcg tcagccgagg actcatgcgc agaggctgcg gctagtgggg
     1801 cggcggatgg ggccacagcc cccaaaacag aggaggaaga ggaggaggag gagacggcgg
     1861 aggtggggag aggggccgag gccgaggcag gcgacttgga gcagctgagc agcagcagca
     1921 cgtccaccaa gtccgccaag tcaggctcgg aggcgtcggc ctccgcctcc aaggacgccc
     1981 tgcaggccat gatcctgagc ctgccgcgct accactgcga gaacccagcc agctgcaagt
     2041 cgcccacgct ctccaccgac accctgcgca agcggctcta ccgcatcggc ctcaacctct
     2101 tcaacataaa ccccgacaag ggcatccagt tcctgatctc acgcggcttc atcccggaca
     2161 cccccatcgg tgtggcccat ttcctcctcc agcgaaaggg cctcagccgc cagatgattg
     2221 gagagttcct gggcaacagc aagaagcagt tcaaccgcga cgtgctggac tgcgtggtgg
     2281 acgagatgga cttctccagc atggagctgg acgaggccct gcgcaagttc caggcacaca
     2341 tccgtgtgca gggggaggct cagaaggtgg agcggctcat tgaggccttc agccagcgct
     2401 actgcatgtg caaccccgaa gtggttcagc agttccacaa ccccgacacc atcttcatcc
     2461 tcgccttcgc catcatcctc ctcaacaccg acatgtacag ccccaacatc aagcctgacc
     2521 ggaagatgat gctggaggac ttcatccgaa accttcgagg tgtggacgat ggcgctgaca
     2581 tccccaggga gctggtggta ggcatctatg agaggataca gcagaaggag ctcaagtcca
     2641 atgaggacca cgtcacgtac gtcaccaagg tggagaagtc cattgtgggc atgaagacag
     2701 tgctgtccgt gccccaccgc cgcctggtgt gctgcagccg gctcttcgag gtgacggatg
     2761 tgaacaagct gcagaagcag gcagcgcatc agagggaggt gttcctcttc aatgacctgc
     2821 tggtgattct caaactttgc ccgaagaaga agagctcctc cacgtacacc ttttgcaagt
     2881 cagttggcct gctgggcatg cagttccagc tctttgagaa cgagtattac tctcatggca
     2941 tcacactggt gaccccgctc tcgggctccg agaagaagca ggtgctgcat ttctgtgccc
     3001 tgggctcgga cgagatgcag aagttcgtgg aggacctgaa ggagtccatt gctgaggtga
     3061 cggagctgga gcagatccga atagagtggg agctggagaa gcagcaggga acaaagacac
     3121 tctccttcaa gccctgcgga gcccaggggg acccacagtc aaagcaagga tcgccgacag
     3181 ccaaaaggga agccgcgctc agggagaggc cggcggagag cacggtggag gtgtcaattc
     3241 acaacaggct tcaaacgtcc cagcacaact ccgggctggg ggccgagagg ggagcgccgg
     3301 tgccgccgcc agacctgcag cctagccccc cgagacagca gaccccacca ctgccgccgc
     3361 cgccacccac gcccccgggc accctggtgc agtgccagca aattgtcaag gtcattgtcc
     3421 tggacaagcc ctgcctggcc cgcatggagc ccctgctgag ccaggctctc tcctgctaca
     3481 cctcgtcgtc ctctgactcc tgcggctcca cacccctggg cggtcccggc tctccggtca
     3541 aggtcaccca ccagcctccg ctgcccccgc ccccaccccc ctacaaccac cctcaccagt
     3601 tctgtccccc aggctccctg ctgcacgggc accgctactc cagtggctca aggagcctgg
     3661 tgtagactct gccccaccac cctgctgtcc tgggagggct ggccactggg gggcctgggc
     3721 tgcccctcca ctgctcccca taccctggca cgatgcgttc ctggtcactg atcaccatca
     3781 ttttgggaag agaatcccaa tccctggcac ctgggtttgc ctcatccaac catccttccc
     3841 tttctcagct gcaccccctc tgcagatctg aagacacacc tcactctccc agggccctac
     3901 acagccagac ccggcgaggc ctcctcttcc cctggccacc actttccccc attggaccat
     3961 ggactgaaga aaacgagctg agggtctaac gagcttgcag gctttgagtc tgttagtgcc
     4021 cggggcctcg ggccttgggc agcagcatga ggctgggccg gccggcagtg gagcactaga
     4081 cagagtggct ggctcgcagc ccagaactag tgcctctgta gctgcactga ggggaggagg
     4141 gttggtccca cccctggagg gacaggtggg aggagtgagg agggggcttt ttctgccacc
     4201 cccgccccca agcctgaaac tctcaggagt ctacttcttg gtccccaggg acattggctg
     4261 tcctgaccat gtccttcccc ctcctcccag ggcctctgct tcctcaggag ctgcccagac
     4321 tccagaaaag cctggaaaaa gggaggcggg aaggggagca ctttcggctt tctataggtc
     4381 agtccagcag ggccacggga tcgcgaggtc atgtatctgc aaaatgcacc tttttaaaga
     4441 gtgtcttagt tccccagccc cagctaatac ccggccaatg ccgtgtacgc accggcatgt
     4501 gcacgcaaac acgcatgaga accaggccat tccttccgct gtggaagcag aactggagac
     4561 ggggcaggaa tgtgcccagc agagatgggg ctcagcccga ggcagggctc cctcctgcat
     4621 gaggctcggc ccgaggcagg gctccctcct gcatgagtct gtggcctcca ggagggactt
     4681 gggtgcagat gtaagcaaga aaaaccgggg ctccagaggc atgtgcattt cccctgcgcc
     4741 cctcagcctt taaatattcc ctcctcctag aaggttctag acccccccct tccagcaggg
     4801 gtgcccaaga gtccctggac cctcaaaatt gcaaaggaga cccaagcggg gctcgctgac
     4861 ctcccagggc ccagcaagat gggatagcca gccttaggtg gccccacgag cccaagcctg
     4921 gggaagggcc cctccccagc cagacgagag gcagccaccc cagagaccac aggagccgta
     4981 ccatggcctg cgcagtcagg ccctatcagg atgtgtctgt cccaagcctg gccaggctcc
     5041 agtcctgtgc cagtagctca ctgctgtcct atgtgcaggt cccccaacac ttggagcctg
     5101 tggttaaggc ctcctgggag aggcagtgag catgagtcaa aggtgacatg gacttgaatc
     5161 tccccacccc gccccgcctg cagtagccgg gccaggtagg aggcaaggat cattccctgc
     5221 tcccagaggt tccagatgac ctagtttcgt tttgtgtgtg tgtgtgtgtg gtcacccaga
     5281 cgtcactgtg atatcaccta gtgaatctat ttctggccct gtcttcgtcg gcccagtttc
     5341 tgtaacttgc agccaatttg ccctctcccc tgtggctgcc agcccatctg cccctctgtg
     5401 tccttgctgc cctggccctc ctctgttttc tgtaacagat gctccagtca ttgcctttca
     5461 gagtggagca gatgacagat ggggtgcacg cattcagaca cctctgatgc ccttagccag
     5521 ggcagggatc gtccttaaag tgaaggcctg gacaggagga gtcagggact tgggaggagg
     5581 tggagctgtg gggatgggag tggaggaatc aaaatgaggg aagctgaaaa tagaatgaaa
     5641 acgatgacta agaggcaggg agtgcgaggt atgggggaat aggaactatg agctaaatat
     5701 acttatgggg tgggggccgt gggggccagg gacactctcc cagacagccc tgacccgcca
     5761 ggcaggaccc cgtcccctgc tcacacagct cttcaaactt accaaggaca ggcaggaccc
     5821 cgtcccctgc tcacacagct cttcaagctt accaaggaca ggcagaaccc cgtcccctgc
     5881 tcacacagct cttcaagctt accaaggaca ggcaggaccc cgtcccctgc tcacacagct
     5941 cttcaaactt accaagtgcc ctctcccctg ttgagggcac agcaacccca ggccctccct
     6001 cccacctcag ctgaagcccc aatcttccaa atcggaacca gcaagtctta gggctggcac
     6061 gcatctgggc ctctagctga gaacccggac tctcaggcac ctcagtgccc ctgccccagg
     6121 gcagaggccc accccgtggg ttggtgcagt ggctgccctg ggctccacgg gcagcacagg
     6181 gagtctgtcc aggaagcagc ccagccgggg tcagtattcc gtggagccag tcctgagctg
     6241 ggaggggcat ttaacacccc tgagggcctg gggcaggaca cagctggccc tcctcattgt
     6301 caggggaagc aagtgcccaa catctgtaac ctcccttccc tgctcagtcc ccaggccaag
     6361 gttgggaccc ctctccatcc ctgtccccag agcctagacc tcagggacct aggaaaagcc
     6421 tcctgctccc tccccacggc agcagacagg gcagggcctc cagcccccag agggccggtg
     6481 gggggtgctc tcgggccttc ctgctctcct aaggttgcgg ggacagtaga gtgctgagcc
     6541 ccagacccag tcaccccaag atggccccac tctatccact ctctagacct ttgggaaatc
     6601 tgggtccctc tcctgatttg atccattcgg ccccaactcc agagtcggga atgggagatg
     6661 aaactagttt tccacccact tttggacaag tcccacccct agatctgaag caagctctac
     6721 cagcagcgtg tcctggaagc ctgcctgcct gcctgcccgt ctgcacaggt gtcttgatcc
     6781 agccctgcgt cttcgagccc ctgtgccacc ggtccccacg gcccgccagg agtctctttg
     6841 tacccactag gcttccctga tgaccatctg tctgtccgtc cctgtttttg ctgtacataa
     6901 ctcctgctgc accctctccc cgcacacccg tcacccatga gagagagaaa cctctctagg
     6961 gaaaggcagg gtggctgcac ccagcaacta atccaaatgg caaatatttt gtaacaaaat
     7021 agcccagagg tattttatct gttcaattca tagagtttta gagattatat tgaaagatgt
     7081 cacttga
//
