LOCUS       NM_001111125            6037 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens IQ motif and Sec7 domain ArfGEF 2 (IQSEC2), transcript
            variant 1, mRNA.
ACCESSION   NM_001111125 XM_001714411
VERSION     NM_001111125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6037)
  AUTHORS   Shokhen,M., Walikonis,R., Uversky,V.N., Allbeck,A., Zezelic,C.,
            Feldman,D., Levy,N.S. and Levy,A.P.
  TITLE     Molecular modeling of ARF6 dysregulation caused by mutations in
            IQSEC2
  JOURNAL   J Biomol Struct Dyn 42 (3), 1268-1279 (2024)
   PUBMED   37078745
  REMARK    GeneRIF: Molecular modeling of ARF6 dysregulation caused by
            mutations in IQSEC2.
REFERENCE   2  (bases 1 to 6037)
  AUTHORS   Bai,G., Li,H., Qin,P., Guo,Y., Yang,W., Lian,Y., Ye,F., Chen,J.,
            Wu,M., Huang,R., Li,J., Lu,Y. and Zhang,M.
  TITLE     Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under
            physiological and pathological conditions
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37787765
  REMARK    GeneRIF: Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under
            physiological and pathological conditions.
REFERENCE   3  (bases 1 to 6037)
  AUTHORS   Levy,N.S., Borisov,V., Lache,O. and Levy,A.P.
  TITLE     Molecular Insights into IQSEC2 Disease
  JOURNAL   Int J Mol Sci 24 (5), 4984 (2023)
   PUBMED   36902414
  REMARK    GeneRIF: Molecular Insights into IQSEC2 Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6037)
  AUTHORS   Wang,D.H., Niu,X.Y., Cheng,M.M., Chen,Y., Yang,Y., Yang,X.L.,
            Yang,Z.X. and Zhang,Y.H.
  TITLE     [Genotypes and phenotypes of IQSEC2 gene variants related epilepsy]
  JOURNAL   Zhonghua Er Ke Za Zhi 60 (12), 1317-1321 (2022)
   PUBMED   36444437
  REMARK    GeneRIF: [Genotypes and phenotypes of IQSEC2 gene variants related
            epilepsy].
REFERENCE   5  (bases 1 to 6037)
  AUTHORS   Shoubridge,C., Tarpey,P.S., Abidi,F., Ramsden,S.L.,
            Rujirabanjerd,S., Murphy,J.A., Boyle,J., Shaw,M., Gardner,A.,
            Proos,A., Puusepp,H., Raymond,F.L., Schwartz,C.E., Stevenson,R.E.,
            Turner,G., Field,M., Walikonis,R.S., Harvey,R.J., Hackett,A.,
            Futreal,P.A., Stratton,M.R. and Gecz,J.
  TITLE     Mutations in the guanine nucleotide exchange factor gene IQSEC2
            cause nonsyndromic intellectual disability
  JOURNAL   Nat Genet 42 (6), 486-488 (2010)
   PUBMED   20473311
  REMARK    GeneRIF: Here we show that a mutation of IQSEC2, encoding a guanine
            nucleotide exchange factor for the ADP-ribosylation factor family
            of small GTPases, caused this disorder
REFERENCE   6  (bases 1 to 6037)
  AUTHORS   Murphy,J.A., Jensen,O.N. and Walikonis,R.S.
  TITLE     BRAG1, a Sec7 domain-containing protein, is a component of the
            postsynaptic density of excitatory synapses
  JOURNAL   Brain Res 1120 (1), 35-45 (2006)
   PUBMED   17045249
REFERENCE   7  (bases 1 to 6037)
  AUTHORS   de Vries,B.B., Breedveld,G.J., Deelen,W.H., Breuning,M.H.,
            Niermeijer,M.F. and Heutink,P.
  TITLE     Another family with nonspecific X-linked mental retardation (MRX78)
            maps to Xp11.4-p11.23
  JOURNAL   Am J Med Genet 111 (4), 443-445 (2002)
   PUBMED   12210308
  REMARK    Erratum:[Am J Med Genet. 2002 Dec 15;113(4):391]
REFERENCE   8  (bases 1 to 6037)
  AUTHORS   Gedeon,A., Kerr,B., Mulley,J. and Turner,G.
  TITLE     Pericentromeric genes for non-specific X-linked mental retardation
            (MRX)
  JOURNAL   Am J Med Genet 51 (4), 553-564 (1994)
   PUBMED   7943039
REFERENCE   9  (bases 1 to 6037)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
REFERENCE   10 (bases 1 to 6037)
  AUTHORS   Suthers,G.K., Turner,G. and Mulley,J.C.
  TITLE     A non-syndromal form of X-linked mental retardation (XLMR) is
            linked to DXS14
  JOURNAL   Am J Med Genet 30 (1-2), 485-491 (1988)
   PUBMED   3177466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245102.1, AB011094.1 and
            AL139396.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001111125.2.
            
            Summary: This gene encodes a guanine nucleotide exchange factor for
            the ARF family of small GTP-binding proteins. The encoded protein
            is a component of the postsynaptic density at excitatory synapses,
            and may play a critical role in cytoskeletal and synaptic
            organization through the activation of selected ARF substrates
            including ARF1 and ARF6. Mutations in this gene have been
            implicated in nonsyndromic X-linked cognitive disability.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642864.1/ ENSP00000495726.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC245102.1         168819-168844       c
            27-4629             AB011094.1         1-4603
            4630-4630           AL139396.18        120822-120822       c
            4631-6037           AB011094.1         4604-6010
FEATURES             Location/Qualifiers
     source          1..6037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..6037
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /note="IQ motif and Sec7 domain ArfGEF 2"
                     /db_xref="GeneID:23096"
                     /db_xref="HGNC:HGNC:29059"
                     /db_xref="MIM:300522"
     exon            1..934
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..4694
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 2; brefeldin A
                     resistant Arf-guanine nucleotide exchange factor 1b;
                     brefeldin A resistant Arf-guanine nucleotide exchange
                     factor 1c; IQ motif and Sec7 domain 2"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001104595.1"
                     /db_xref="CCDS:CCDS48130.1"
                     /db_xref="GeneID:23096"
                     /db_xref="HGNC:HGNC:29059"
                     /db_xref="MIM:300522"
                     /translation="MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRI
                     EELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHREL
                     RESQFHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLH
                     HENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAG
                     GGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPP
                     SSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKV
                     EMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
                     SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTS
                     GEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
                     SATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDG
                     SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEAD
                     GCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLG
                     KCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRH
                     SWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGL
                     SRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERL
                     IEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKN
                     LRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRL
                     VCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEM
                     HMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
                     YRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRD
                     LSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSF
                     LGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQS
                     KLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
                     HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
                     PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPS
                     YPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV"
     exon            935..964
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1226
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1628
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2524
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2686
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2809
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2976
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3116
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3242
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3342
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3504
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3678
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3728
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..6037
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6018..6023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /note="hexamer: CATAAA"
     polyA_site      6037
                     /gene="IQSEC2"
                     /gene_synonym="BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78;
                     XLID1"
                     /note="major polyA site"
ORIGIN      
        1 agtggctgtg gtggtggtgg tggcggcggc agcctcagct cctgctcccc gtgccgccgg
       61 ccccagcgct gtctcccggg ccccctaggg cccccgggcc ctcaagcccg gtgcgcgccc
      121 tcgcgtcccg ccggccccct cccccggctg ggcccggggg agggtggcgc cgtgagagag
      181 cggggacagg gctctcctgc ccgttcccct gcccctgggc cgccaggatg gaggcggggt
      241 cggggccccc gggcggcccg ggatccgaga gcccaaatcg ggccgtggag tacctgctgg
      301 agctgaacaa catcatcgag agccagcagc agctgctgga aacccagcgg cggcgcatcg
      361 aggagctgga gggccagctg gaccagctca cccaggagaa ccgcgacctg cgagaggaga
      421 gccagctgca ccgcggggag ctgcaccggg acccccacgg cgcgcgggat agcccgggcc
      481 gcgagagcca gtaccagaac ctgcgcgaga cccagttcca ccaccgcgag ctgcgggaga
      541 gccagttcca ccaggcggcc cgggacgtgg gctacccgaa ccgggaaggc gcctaccaga
      601 atcgggaggc tgtgtatcgg gacaaggagc gggacgcctc ctacccgctc caggacacta
      661 ccggttacac agcccgcgag cgtgacgtgg cccagtgcca cctgcaccac gagaacccag
      721 ccctgggtcg cgagcgtggc gggcgggagg ccgggccggc gcacccgggc cgcgagaagg
      781 aagcgggcta ttcggcggcg gtgggcgtgg ggccgcggcc accgcgggag cggggccagc
      841 tgagccgtgg cgcatccagg agctccagtc ccggcgccgg cggaggccac agcaccagta
      901 ccagcaccag cccggccacg accctccaga gaaaatctga tggtgagaat tccagaacag
      961 tcagtgtgga gggtgatgcc ccaggcagtg acctgagcac agcggttgat agtcctggga
     1021 gccaaccccc ctaccggctg agccagctgc ccccctccag cagccacatg gggggccccc
     1081 ctgctggagt gggccttccc tgggctcagc gggcacgcct ccagccagcc agtgtcgccc
     1141 tgaggaagca ggaggaggag gagataaagc gctccaaggc cctatcggac agctatgaac
     1201 tctccacaga cctgcaggac aagaaggtgg aaatgctgga gaggaagtat gggggctcct
     1261 tcctgagccg cagggctgcc aggaccatcc agacagcctt ccgccagtac cgcatgaaca
     1321 agaactttga gcggctacgc agctcagcct cagagagccg catgtcccgc cgcatcatcc
     1381 tttccaacat gcggatgcag ttctcctttg aggagtatga gaaggcacag aaccccgcgt
     1441 acttcgaggg caagcctgcc tcgctggacg agggtgccat ggctggtgcc cggagccacc
     1501 ggcttgaacg ggggctccca tatggaggct cctgtggtgg gggcatcgat ggtggtggaa
     1561 gctccgtcac cacatctgga gagttttcta atgacatcac agaacttgag gactccttct
     1621 ccaaacaggt aaagtctctg gctgaatcca tcgacgaagc cctgaactgc cacccgtcag
     1681 ggcccatgtc tgaggagcca gggtcagccc agctggagaa gcgggagtca aaggaacagc
     1741 aagaggacag ctcagccaca tccttcagtg atcttcccct ctacctggat gacacagttc
     1801 cccaacaatc ccctgagcga ctgcccagca cagaaccccc accccagggc cggcccgagt
     1861 tctgggcgcc agcccctctc ccgccagttc ctccaccagt gccatcagga acccgggaag
     1921 acggtagccg tgaggaaggc actcgcaggg gtcccgggtg cttggagtgc cgggatttcc
     1981 ggctgcgggc tgcccacctt cccctgctta ccattgagcc tcctagtgac agctccgtgg
     2041 acctgagtga ccgctcagat cgcggctctg tccaccgcca gctggtgtat gaggctgatg
     2101 gctgcagccc ccatgggacc ctgaagcaca aggggccacc aggcagggcc ccgatcccac
     2161 accgccacta cccagcccct gaaggcccag ccccagcccc accagggccc ctgccaccag
     2221 cccccaacag tggcactggg cccagtggtg tggctggggg tcggaggttg gggaagtgcg
     2281 aggcagcagg cgagaactct gatggtggag ataacgagag ccttgagagc tccagcaatt
     2341 ccaatgagac catcaactgc agctccggct cctcttctcg ggacagtcta agggagcctc
     2401 cggctaccgg cctgtgcaag cagacttacc agcgggagac aaggcatagc tgggactcgc
     2461 cagctttcaa caatgatgtg gtccagaggc ggcactaccg aatcggcctc aacctcttca
     2521 acaagaagcc agagaagggt atccagtatc tgatcgagcg gggcttcctg tcagacacac
     2581 cggtgggagt ggctcacttc atcctggagc ggaaaggcct cagccggcag atgatagggg
     2641 aattcctagg gaaccggcag aagcagttca acagagacgt gttggactgt gtggtggatg
     2701 agatggactt ctcctccatg gatctggatg atgcgctccg gaagttccag tcccatatcc
     2761 gggttcaggg tgaggcccag aaagtggagc gactcatcga agccttcagc cagcggtact
     2821 gtgtctgtaa cccagccctc gtgcgccagt tccggaaccc agacaccatc ttcatccttg
     2881 cttttgccat catcctcctc aataccgaca tgtacagtcc cagcgtcaaa gctgaacgaa
     2941 agatgaaact agatgacttc atcaagaacc tgagaggggt tgacaatggt gaagacatcc
     3001 cccgagacct cctggtgggc atctaccagc gcatccaggg gcgtgaactg cggaccaacg
     3061 atgaccatgt gtcccaggtg caggctgtgg agcgcatgat tgttggaaag aaaccagtcc
     3121 tgtctctccc tcaccgtcga ctggtttgct gctgccagct ctacgaggtg ccagatccaa
     3181 accgccccca gaggctaggg ttgcatcagc gggaggtctt cctcttcaat gatctccttg
     3241 tggtcaccaa aattttccag aagaagaaga tcttggtgac gtacagtttc cgtcagtctt
     3301 tccccctcgt ggaaatgcac atgcagctct tccagaattc atattaccag tttgggatca
     3361 agttgctgtc tgcagtacct ggtggggagc gaaaagtcct catcatcttc aatgccccca
     3421 gcctccagga ccggctgcgc tttacatccg acctgcgcga gtccattgcg gaggtgcagg
     3481 agatggagaa ataccgtgtg gagtcggagc tggagaagca gaaaggtatg atgcggccta
     3541 acgcctcaca gcctggaggg gccaaggact cagtgaatgg gacgatggcc cgcagtagcc
     3601 tggaggacac ttacggggca ggcgatgggc tcaaacgggg cgcactcagc agttccctgc
     3661 gagacctctc tgatgcaggg aagcgggggc ggcgtaacag cgtgggatcg ctggacagca
     3721 ccatcgaagg gtctgttatt agcagtccac gccctcacca gaggatgcca cctccgcccc
     3781 cacccccgcc gccagaggag tacaagagcc agaggcccgt ctccaactcc tcatccttcc
     3841 tgggctccct atttggaagc aagcggggca aggggccctt ccagatgcca ccaccgccaa
     3901 caggccaggc ctctgcctcc tcttcatctg cttcttccac gcaccaccac caccaccacc
     3961 accatcatgg ccatagccac ggtggcctgg gggtgctgcc tgatgggcag tccaagctcc
     4021 aggccctgca tgcccagtat tgccaaggac cgggccctgc cccgccaccc tacctcccac
     4081 cccagcagcc ctctcttccc ccacctcccc agcagccccc acccttgccc cagctgggct
     4141 ccattccacc gcctcccgcc tcagccccac ctgtggggcc acatcgccac ttccacgccc
     4201 atggcccagt cccagggccc caacactata ccttgggccg gccaggcagg gcacccagac
     4261 ggggggctgg aggacaccct cagtttgctc cacatggccg ccaccccctg caccagccca
     4321 catccccact gcccctgtac agtcctgccc cccagcaccc tccagcccac aaacagggcc
     4381 ctaagcactt catcttcagc caccacccac agatgatgcc agcagcaggc gcggctgggg
     4441 gccctggatc ccggccacca gggggctcct actcccaccc ccaccacccc cagtcaccat
     4501 tgtcaccaca ctcacccatc ccaccccacc cctcctatcc acccctcccc ccaccctccc
     4561 ctcacacccc gcactcaccc cttccaccca cctcccccca tggcccgctg cacgcctctg
     4621 ggccccctgg cacagccaac ccccccagtg caaaccccaa ggccaagcca agccggatca
     4681 gcaccgtggt ctgatgaatg gagagagtga gctggggaac aggaaagtct ggggagccac
     4741 aggagaggga ccttgcaccc tctttgcttc ctcggttttt tcaaaaatat atatacacat
     4801 agcaatgtcc tcctccccat gtcctccctg ccttgggacc cgtcctctca cccccagcag
     4861 ttgccatggg gtttccttcc agattcgagg atccttgcca cttgaagcct ggactcaggg
     4921 tgctccagcg ctggggagtg gtgagggcct tccagagatc ctcgtactct ttctcccgtc
     4981 ttcttcttcc ccacttttcc ctggaggtct agctctgtgg cctcagacct ctgggcctgt
     5041 gtgagctctc tgtgagctct ggctggcgga gaagggcagg tgtccggagc tgtcggggtg
     5101 aaggcttccc tggggctcct ctggccgtgt ggggctagga gagcgctctg tagagttgtg
     5161 gccaaacttc agctggcttg gccctctctc tgacctcagg gcctggccac acacttccat
     5221 gtgtcttttt gcctgctgga ggacacggac cattgatgca cttggtgggt gggaccctgc
     5281 ttgtgttggc cccacgtggg gcagtgcttc ctctctcgag ccagtctatg ccctttctcc
     5341 agtaggcccc agcccagacc tcttcggctt caggaacttg cctcgccctg caacgttctt
     5401 atcctgatca aagtccagac aggttttggg gggggctcag gtctgggatg agaagggcac
     5461 tgccctccct cacccatatt gcatgccccc ccgccattcc cttacaccta ccccacctac
     5521 aactgaagac aatgcacttt acagatatca cccacacaca cctcgctggg gcaggggcac
     5581 ccagcatcag ccctggggag agaggctccc aaagggccac catgagccca agatatcctt
     5641 cctgaggcag agattgaagc catcagagct ggggttggga gccagaatgc ctgagtcctt
     5701 ctgtccgtca gaatctccgc tgcctctcca gcccttttgc agccctgttt atttattata
     5761 aatatatttt ttacaagccc cagctcctct tcttgccccg catatccagc tcctcactca
     5821 gctcctgcct ccctctcccc tctccaccat gggctgcagt atagacagac agatggaccc
     5881 tggctgtacg aagggccagg gccactgggg cttgggggcg ggggagggtg gcagtgggag
     5941 gggctgtatg gagaggagct ggggttcagg cattgtcttt tttcctcctt gtatataaga
     6001 atgtatattt gatgcctcat aaaagacctt gtgctca
//
