LOCUS       XM_011509198            6028 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens IQ motif containing GTPase activating
            protein 3 (IQGAP3), transcript variant X1, mRNA.
ACCESSION   XM_011509198
VERSION     XM_011509198.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011509198.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..6028
                     /gene="IQGAP3"
                     /note="IQ motif containing GTPase activating protein 3;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 18 ESTs, 559 long SRA reads, 4
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 8 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:128239"
                     /db_xref="HGNC:HGNC:20669"
     CDS             37..4947
                     /gene="IQGAP3"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP3
                     isoform X1"
                     /protein_id="XP_011507500.1"
                     /db_xref="GeneID:128239"
                     /db_xref="HGNC:HGNC:20669"
                     /translation="MERRAAGPGWAACECGEDERLTAEEMDEQRRQNVAYQYLCRLEE
                     AKRWMEACLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATG
                     LHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLA
                     PQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIGGILANELSVDEAAVHAAVLA
                     INEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLAQAKMEKAANARNHDDRES
                     QDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRD
                     FADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKA
                     IRRRVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGELGQEELFVAVEMLS
                     AVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQERGMGEDFLS
                     WNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPV
                     APRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQA
                     IKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADTAFWVQHDMKD
                     GTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVI
                     QLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDA
                     IIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPL
                     SVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNR
                     ITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQP
                     IYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQP
                     QDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWI
                     NQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIP
                     YGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGG
                     ALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVP
                     EPEERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDL
                     GELPTIPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLL
                     ADIIQFHPGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLL
                     PLAEKQRRVLRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQA
                     TLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGV
                     LVEIEDLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVA
                     VMKLFNKAKVNVNLLIFLLNKKFLRK"
ORIGIN      
        1 aacggcggga gattcaaacc tggaagaagg aggaacatgg agaggagagc agcgggccca
       61 ggctgggcag cctgtgagtg cggagaggat gaacgcctca cagctgagga gatggatgag
      121 cagaggcggc agaatgttgc ctatcagtac ctgtgccggc tggaggaggc caagcgctgg
      181 atggaggcct gcctgaagga ggagcttcct tccccggtgg agctggagga gagccttcgg
      241 aatggagtgc tgctggccaa gctaggccac tgttttgcac cctccgtggt tcccttgaag
      301 aagatctacg atgtggagca gctgcggtac caggcaactg gcttacattt ccgtcacaca
      361 gacaacatca acttttggct atctgcaata gcccacatcg gtctgccttc gaccttcttc
      421 ccagagacca cggacatcta tgacaaaaag aacatgcccc gggtagtcta ctgcatccat
      481 gctctcagtc tcttcctctt ccggctggga ttggcccctc agatacatga tctatacggg
      541 aaagtgaaat tcacagctga ggaactcagc aacatggcgt ccgaactggc caaatatggc
      601 ctccagctgc ctgccttcag caagatcggg ggcatcttgg ccaatgagct ctcggtggat
      661 gaggctgcag tccatgcagc tgttcttgcc atcaatgaag cagtggagcg aggggtggtg
      721 gaggacaccc tggctgcctt gcagaatccc agtgctcttc tggagaatct ccgagagcct
      781 ctggcagccg tctaccaaga gatgctggcc caggccaaga tggagaaggc agccaatgcc
      841 aggaaccatg atgacagaga aagccaggac atctatgacc actacctaac tcaggctgaa
      901 atccagggca atatcaacca tgtcaacgtc catggggctc tagaagttgt tgatgatgcc
      961 ctggaaagac agagccctga agccttgctc aaggcccttc aagaccctgc cctggccctg
     1021 cgaggggtga ggagagactt tgctgactgg tacctggagc agctgaactc agacagagag
     1081 cagaaggcac aggagctggg cctggtggag cttctggaaa aggaggaagt ccaggctggt
     1141 gtggctgcag ccaacacaaa gggtgatcag gaacaagcca tgctccacgc tgtgcagcgg
     1201 atcaacaaag ccatccggag gagagtggcg gctgacactg tgaaggagct gatgtgccct
     1261 gaggcccagc tgcctccagt gtaccctgtt gcatcgtcta tgtaccagct ggagctggca
     1321 gtgctccagc agcagcaggg ggagcttggc caggaggagc tcttcgtggc tgtggagatg
     1381 ctctcagctg tggtcctgat taaccgggcc ctggaggccc gggatgccag tggcttctgg
     1441 agcagcctgg tgaaccctgc cacaggcctg gctgaggtgg aaggagaaaa tgcccagcgt
     1501 tacttcgatg ccctgctgaa attgcgacag gagcgtggga tgggtgagga cttcctgagc
     1561 tggaatgacc tgcaggccac cgtgagccag gtcaatgcac agacccagga agagactgac
     1621 cgggtccttg cagtcagcct catcaatgag gctctggaca aaggcagccc tgagaagact
     1681 ctgtctgccc tactgcttcc tgcagctggc ctagatgatg tcagcctccc tgtcgcccct
     1741 cggtaccatc tcctccttgt ggcagccaaa aggcagaagg cccaggtgac aggggatcct
     1801 ggagctgtgc tgtggcttga ggagatccgc cagggagtgg tcagagccaa ccaggacact
     1861 aatacagctc agagaatggc tcttggtgtg gctgccatca atcaagccat caaggagggc
     1921 aaggcagccc agactgagcg ggtgttgagg aaccccgcag tggcccttcg aggggtagtt
     1981 cccgactgtg ccaacggcta ccagcgagcc ctggaaagtg ccatggcaaa gaaacagcgt
     2041 ccagcagaca cagctttctg ggttcaacat gacatgaagg atggcactgc ctactacttc
     2101 catctgcaga ccttccaggg gatctgggag caacctcctg gctgccccct caacacctct
     2161 cacctgaccc gggaggagat ccagtcagct gtcaccaagg tcactgctgc ctatgaccgc
     2221 caacagctct ggaaagccaa cgtcggcttt gttatccagc tccaggcccg cctccgtggc
     2281 ttcctagttc ggcagaagtt tgctgagcat tcccactttc tgaggacctg gctcccagca
     2341 gtcatcaaga tccaggctca ttggcggggt tataggcagc ggaagattta cctggagtgg
     2401 ttgcagtatt ttaaagcaaa cctggatgcc ataatcaaga tccaggcctg ggcccggatg
     2461 tgggcagctc ggaggcaata cctgaggcgt ctgcactact tccagaagaa tgttaactcc
     2521 attgtgaaga tccaggcatt tttccgagcc aggaaagccc aagatgacta caggatatta
     2581 gtgcatgcac cccaccctcc tctcagtgtg gtacgcagat ttgcccatct cttgaatcaa
     2641 agccagcaag acttcttggc tgaggcagag ctgctgaagc tccaggaaga ggtagttagg
     2701 aagatccgat ccaatcagca gctggagcag gacctcaaca tcatggacat caagattggc
     2761 ctgctggtga agaaccggat cactctgcag gaagtggtct cccactgcaa gaagctgacc
     2821 aagaggaata aggaacagct gtcagatatg atggttctgg acaagcagaa gggtttaaag
     2881 tcgctgagca aagagaaacg gcagaaacta gaagcatacc aacacctctt ctacctgctc
     2941 cagactcagc ccatctacct ggccaagctg atctttcaga tgccacagaa caaaaccacc
     3001 aagttcatgg aggcagtgat tttcagcctg tacaactatg cctccagccg ccgagaggcc
     3061 tatctcctgc tccagctgtt caagacagca ctccaggagg aaatcaagtc aaaggtggag
     3121 cagccccagg acgtggtgac aggcaaccca acagtggtga ggctggtggt gagattctac
     3181 cgtaatgggc ggggacagag tgccctgcag gagattctgg gcaaggttat ccaggatgtg
     3241 ctagaagaca aagtgctcag cgtccacaca gaccctgtcc acctctataa gaactggatc
     3301 aaccagactg aggcccagac agggcagcgc agccatctcc catatgatgt caccccggag
     3361 caggccttga gccaccccga ggtccagaga cgactggaca tcgccctacg caacctcctc
     3421 gccatgactg ataagttcct tttagccatc acctcatctg tggaccaaat tccgtatggg
     3481 atgcgatatg tggccaaagt cctgaaggca actctggcag agaaattccc tgacgccaca
     3541 gacagcgagg tctataaggt ggtcgggaac ctcctgtact accgcttcct gaacccagct
     3601 gtggtggctc ctgacgcctt cgacattgtg gccatggcag ctggtggagc cctggctgcc
     3661 ccccagcgcc atgccctggg ggctgtggct cagctcctac agcacgctgc ggctggcaag
     3721 gccttctctg ggcagagcca gcacctacgg gtcctgaatg actatctgga ggaaacacac
     3781 ctcaagttca ggaagttcat ccatagagcc tgccaggtgc cagagccaga ggagcgtttt
     3841 gcagtggacg agtactcaga catggtggct gtggccaaac ccatggtgta catcaccgtg
     3901 ggggagctgg tcaacacgca caggctgttg ctggagcacc aggactgcat tgcccctgat
     3961 caccaagacc ccctgcatga gctcctggag gatcttgggg agctgcccac catccctgac
     4021 cttattggtg agagcatcgc tgcagatggg cacacggacc tgagcaagct agaagtgtcc
     4081 ctgacgctga ccaacaagtt tgaaggacta gaggcagatg ctgatgactc caacacccgt
     4141 agcctgcttc tgagcaccaa gcagctgttg gccgatatca tacagttcca tcctggggac
     4201 accctcaagg agatcctgtc cctctcggct tccagagagc aagaagcagc ccacaagcag
     4261 ctgatgagcc gacgccaggc ctgtacagcc cagacaccgg agccactgcg acgacaccgc
     4321 tcactgacag ctcactccct cctgccactg gcagagaagc agcggcgcgt cctgcggaac
     4381 ctacgccgac ttgaagccct ggggttggtc agcgccagaa atggctacca ggggctagtg
     4441 gacgagctgg ccaaggacat ccgcaaccag cacagacaca ggcacaggcg gaaggcagag
     4501 ctggtgaagc tgcaggccac attacagggc ctgagcacta agaccacctt ctatgaggag
     4561 cagggtgact actacagcca gtacatccgg gcctgcctgg accacctggc ccccgactcc
     4621 aagagttctg ggaaggggaa gaagcagcct tctcttcatt acactgctgc tcagctcctg
     4681 gaaaagggtg tcttggtgga aattgaagat cttcccgcct ctcacttcag aaacgtcatc
     4741 tttgacatca cgccgggaga tgaggcagga aagtttgaag taaatgccaa gttcctgggt
     4801 gtggacatgg agcgatttca gcttcactat caggatctcc tgcagctcca gtatgagggt
     4861 gtggctgtca tgaaactctt caacaaggcc aaagtcaatg tcaaccttct catcttcctc
     4921 ctcaacaaga agtttttgcg gaagtgacag aggcaaaggg tgctacccaa gcccctctta
     4981 cctctctgga tgctttcttt aacactaact caccactgtg cttccctgca gacacctaga
     5041 gctcaggact gggcaaggcc cagggattct caccccttcc ccagctggga ggagcttgcc
     5101 tgcctggcca cagacagtgt atcttctaat tggctaaagt gggccttgcc cagagtccag
     5161 ctgtgtggct tttatcatgc atgacaaacc cctggctttc ctgccagatg gtaggacatg
     5221 gaccttgacc tgggaaagcc attactcttg tgtctgctac tgccctccca cagtcacccc
     5281 aatattacaa gcactgcccc agcggcttga tttcccctct gccttccttc tctctgcact
     5341 cccacaaagc cagggccagg ctccccatcc ctacctccca ctgcatcagc agtgggtgtt
     5401 cctgcccttc ctgagtctag gcagctctgc tgctgtgatc tgcacaccct ccaacctggg
     5461 cagggactgg ggggatgcag tgtgtgttag tgcccatgtg gcattgtggc actgttgccc
     5521 cccatggcgg catgggcaag atgaccttcc attagcttca agtcttgttc tcttgtctgt
     5581 ggtctgttta atatgtgggt cactagggta tttattcttt ctcccatcct tacactctgg
     5641 atcattgtgc agacttaatc agggttttaa cgctttcatt tttttttttt tttttttttt
     5701 tttgagctca aagagagttc tcattttccc tattcaaact aatacccatg ccgtgttttt
     5761 taccttggat ttaaagtcac cttaggttgg ggcaacagat tctcactcat gtttaagatc
     5821 ttgttatttc agcttcataa gatcaaagag gagtctttcc cttttctctt ttaccctcag
     5881 gattctcatc ccttacagct gactcttcca ggcaatttcc atagatctgc agtcctgcct
     5941 ctgccacagt ctctctgttg tccccacatc tacccaactt cctgtactgt tgcccttctg
     6001 atgttaataa aagcagctgt tactccca
//
