LOCUS       NM_178229               6013 bp    mRNA    linear   PRI 31-JAN-2025
DEFINITION  Homo sapiens IQ motif containing GTPase activating protein 3
            (IQGAP3), mRNA.
ACCESSION   NM_178229
VERSION     NM_178229.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6013)
  AUTHORS   Tang,M., Zhang,S., Yang,M., Feng,R., Lin,J., Chen,X., Xu,Y., Yu,R.,
            Liao,X., Li,Z., Li,X., Li,M., Zhang,Q., Chen,S., Qian,W., Liu,Y.,
            Song,L. and Li,J.
  TITLE     Infiltrative Vessel Co-optive Growth Pattern Induced by IQGAP3
            Overexpression Promotes Microvascular Invasion in Hepatocellular
            Carcinoma
  JOURNAL   Clin Cancer Res 30 (10), 2206-2224 (2024)
   PUBMED   38470497
  REMARK    GeneRIF: Infiltrative Vessel Co-optive Growth Pattern Induced by
            IQGAP3 Overexpression Promotes Microvascular Invasion in
            Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 6013)
  AUTHORS   Zolotarenko,A. and Bruskin,S.
  TITLE     IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases
  JOURNAL   Int J Mol Sci 25 (8), 4545 (2024)
   PUBMED   38674130
  REMARK    GeneRIF: IQGAP3 Is an Important Mediator of Skin Inflammatory
            Diseases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6013)
  AUTHORS   Su,Z., Wang,Y., Cao,J., Ma,J., Wang,G., Ren,H., Zhang,Y., Sheng,K.,
            Zhu,X. and Wang,Y.
  TITLE     Identification and validation of non-coding RNA-mediated high
            expression of IQGAP3 in poor prognosis of lung adenocarcinoma
  JOURNAL   J Gene Med 26 (1), e3664 (2024)
   PUBMED   38282143
  REMARK    GeneRIF: Identification and validation of non-coding RNA-mediated
            high expression of IQGAP3 in poor prognosis of lung adenocarcinoma.
REFERENCE   4  (bases 1 to 6013)
  AUTHORS   Mei,W., Dong,Y., Gu,Y., Kapoor,A., Lin,X., Su,Y., Vega Neira,S. and
            Tang,D.
  TITLE     IQGAP3 is relevant to prostate cancer: A detailed presentation of
            potential pathomechanisms
  JOURNAL   J Adv Res 54, 195-210 (2023)
   PUBMED   36681115
  REMARK    GeneRIF: IQGAP3 is relevant to prostate cancer: A detailed
            presentation of potential pathomechanisms.
REFERENCE   5  (bases 1 to 6013)
  AUTHORS   Li,W., Wang,Z., Wang,H., Zhang,J., Wang,X., Xing,S. and Chen,S.
  TITLE     IQGAP3 in clear cell renal cell carcinoma contributes to drug
            resistance and genome stability
  JOURNAL   PeerJ 10, e14201 (2022)
   PUBMED   36275458
  REMARK    GeneRIF: IQGAP3 in clear cell renal cell carcinoma contributes to
            drug resistance and genome stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6013)
  AUTHORS   Adachi,M., Kawasaki,A., Nojima,H., Nishida,E. and Tsukita,S.
  TITLE     Involvement of IQGAP family proteins in the regulation of mammalian
            cell cytokinesis
  JOURNAL   Genes Cells 19 (11), 803-820 (2014)
   PUBMED   25229330
  REMARK    GeneRIF: Mammalian IQGAP proteins may play a role in cytokinesis by
            regulating the localization of key cytokinesis regulatory proteins
            to the contractile apparatus during mitosis.
REFERENCE   7  (bases 1 to 6013)
  AUTHORS   Yang,Y., Zhao,W., Xu,Q.W., Wang,X.S., Zhang,Y. and Zhang,J.
  TITLE     IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of
            lung cancer cells
  JOURNAL   PLoS One 9 (5), e97578 (2014)
   PUBMED   24849319
  REMARK    GeneRIF: IQGAP3 may contribute to the pathogenesis of lung cancer
            by modulating EGFR-ERK signaling
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6013)
  AUTHORS   Atcheson,E., Hamilton,E., Pathmanathan,S., Greer,B., Harriott,P.
            and Timson,D.J.
  TITLE     IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of
            calmodulin and myosin essential light chain
  JOURNAL   Biosci Rep 31 (5), 371-379 (2011)
   PUBMED   21299499
  REMARK    GeneRIF: The first IQ-motifs from IQGAP2 and IQGAP3 form transient
            interactions with calmodulin in the absence of calcium.
REFERENCE   9  (bases 1 to 6013)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6013)
  AUTHORS   Wang,S., Watanabe,T., Noritake,J., Fukata,M., Yoshimura,T.,
            Itoh,N., Harada,T., Nakagawa,M., Matsuura,Y., Arimura,N. and
            Kaibuchi,K.
  TITLE     IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite
            outgrowth
  JOURNAL   J Cell Sci 120 (Pt 4), 567-577 (2007)
   PUBMED   17244649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365181.24.
            
            On Nov 23, 2018 this sequence version replaced NM_178229.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105103.1, BC131536.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361170.7/ ENSP00000354451.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL365181.24        83630-83702         c
            74-161              AL365181.24        80513-80600         c
            162-318             AL365181.24        77527-77683         c
            319-396             AL365181.24        77164-77241         c
            397-473             AL365181.24        75752-75828         c
            474-541             AL365181.24        74894-74961         c
            542-655             AL365181.24        74690-74803         c
            656-834             AL365181.24        74271-74449         c
            835-913             AL365181.24        73724-73802         c
            914-1077            AL365181.24        72975-73138         c
            1078-1165           AL365181.24        72071-72158         c
            1166-1326           AL365181.24        67670-67830         c
            1327-1484           AL365181.24        65372-65529         c
            1485-1606           AL365181.24        63111-63232         c
            1607-1770           AL365181.24        62842-63005         c
            1771-1861           AL365181.24        61398-61488         c
            1862-2029           AL365181.24        59718-59885         c
            2030-2169           AL365181.24        59485-59624         c
            2170-2340           AL365181.24        59210-59380         c
            2341-2424           AL365181.24        55526-55609         c
            2425-2496           AL365181.24        55289-55360         c
            2497-2566           AL365181.24        55118-55187         c
            2567-2775           AL365181.24        51845-52053         c
            2776-2928           AL365181.24        50975-51127         c
            2929-3092           AL365181.24        50511-50674         c
            3093-3317           AL365181.24        49946-50170         c
            3318-3458           AL365181.24        48318-48458         c
            3459-3543           AL365181.24        46300-46384         c
            3544-3776           AL365181.24        45638-45870         c
            3777-3909           AL365181.24        45146-45278         c
            3910-4012           AL365181.24        44910-45012         c
            4013-4139           AL365181.24        44117-44243         c
            4140-4227           AL365181.24        42297-42384         c
            4228-4440           AL365181.24        41242-41454         c
            4441-4607           AL365181.24        40053-40219         c
            4608-4709           AL365181.24        39646-39747         c
            4710-4818           AL365181.24        39089-39197         c
            4819-6013           AL365181.24        36542-37736         c
FEATURES             Location/Qualifiers
     source          1..6013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6013
                     /gene="IQGAP3"
                     /note="IQ motif containing GTPase activating protein 3"
                     /db_xref="GeneID:128239"
                     /db_xref="HGNC:HGNC:20669"
                     /db_xref="MIM:621092"
     exon            1..73
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..4932
                     /gene="IQGAP3"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP3"
                     /protein_id="NP_839943.3"
                     /db_xref="CCDS:CCDS1144.1"
                     /db_xref="GeneID:128239"
                     /db_xref="HGNC:HGNC:20669"
                     /db_xref="MIM:621092"
                     /translation="MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWM
                     EACLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRH
                     TDNINFWLSAIAHIGLPSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHD
                     LYGKVKFTAEELSNMASELAKYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAV
                     ERGVVEDTLAALQNPSALLENLREPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYD
                     HYLTQAEIQGNINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWY
                     LEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRRV
                     AADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGELGQEELFVAVEMLSAVVLI
                     NRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQERGMGEDFLSWNDLQ
                     ATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYH
                     LLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGK
                     AAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADTAFWVQHDMKDGTAYY
                     FHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQAR
                     LRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQ
                     AWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRR
                     FAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQE
                     VVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAK
                     LIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVT
                     GNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEA
                     QTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRY
                     VAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAP
                     QRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEER
                     FAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT
                     IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQ
                     FHPGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEK
                     QRRVLRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGL
                     STKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIE
                     DLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLF
                     NKAKVNVNLLIFLLNKKFLRK"
     exon            74..161
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            162..318
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..396
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..473
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..541
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..655
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            656..834
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..913
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1077
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1165
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1326
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1484
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1606
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1770
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1861
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2029
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2169
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2340
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2424
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2496
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2566
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2775
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2928
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3092
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3317
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3458
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3543
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3776
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3909
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4012
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4139
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4227
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4440
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4441..4607
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4709
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4818
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..6013
                     /gene="IQGAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5991..5996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQGAP3"
                     /note="hexamer: AATAAA"
     polyA_site      6013
                     /gene="IQGAP3"
                     /note="major polyA site"
ORIGIN      
        1 aacggcggga gattcaaacc tggaagaagg aggaacatgg agaggagagc agcgggccca
       61 ggctgggcag cctatgaacg cctcacagct gaggagatgg atgagcagag gcggcagaat
      121 gttgcctatc agtacctgtg ccggctggag gaggccaagc gctggatgga ggcctgcctg
      181 aaggaggagc ttccttcccc ggtggagctg gaggagagcc ttcggaatgg agtgctgctg
      241 gccaagctag gccactgttt tgcaccctcc gtggttccct tgaagaagat ctacgatgtg
      301 gagcagctgc ggtaccaggc aactggctta catttccgtc acacagacaa catcaacttt
      361 tggctatctg caatagccca catcggtctg ccttcgacct tcttcccaga gaccacggac
      421 atctatgaca aaaagaacat gccccgggta gtctactgca tccatgctct cagtctcttc
      481 ctcttccggc tgggattggc ccctcagata catgatctat acgggaaagt gaaattcaca
      541 gctgaggaac tcagcaacat ggcgtccgaa ctggccaaat atggcctcca gctgcctgcc
      601 ttcagcaaga tcgggggcat cttggccaat gagctctcgg tggatgaggc tgcagtccat
      661 gcagctgttc ttgccatcaa tgaagcagtg gagcgagggg tggtggagga caccctggct
      721 gccttgcaga atcccagtgc tcttctggag aatctccgag agcctctggc agccgtctac
      781 caagagatgc tggcccaggc caagatggag aaggcagcca atgccaggaa ccatgatgac
      841 agagaaagcc aggacatcta tgaccactac ctaactcagg ctgaaatcca gggcaatatc
      901 aaccatgtca acgtccatgg ggctctagaa gttgttgatg atgccctgga aagacagagc
      961 cctgaagcct tgctcaaggc ccttcaagac cctgccctgg ccctgcgagg ggtgaggaga
     1021 gactttgctg actggtacct ggagcagctg aactcagaca gagagcagaa ggcacaggag
     1081 ctgggcctgg tggagcttct ggaaaaggag gaagtccagg ctggtgtggc tgcagccaac
     1141 acaaagggtg atcaggaaca agccatgctc cacgctgtgc agcggatcaa caaagccatc
     1201 cggaggagag tggcggctga cactgtgaag gagctgatgt gccctgaggc ccagctgcct
     1261 ccagtgtacc ctgttgcatc gtctatgtac cagctggagc tggcagtgct ccagcagcag
     1321 cagggggagc ttggccagga ggagctcttc gtggctgtgg agatgctctc agctgtggtc
     1381 ctgattaacc gggccctgga ggcccgggat gccagtggct tctggagcag cctggtgaac
     1441 cctgccacag gcctggctga ggtggaagga gaaaatgccc agcgttactt cgatgccctg
     1501 ctgaaattgc gacaggagcg tgggatgggt gaggacttcc tgagctggaa tgacctgcag
     1561 gccaccgtga gccaggtcaa tgcacagacc caggaagaga ctgaccgggt ccttgcagtc
     1621 agcctcatca atgaggctct ggacaaaggc agccctgaga agactctgtc tgccctactg
     1681 cttcctgcag ctggcctaga tgatgtcagc ctccctgtcg cccctcggta ccatctcctc
     1741 cttgtggcag ccaaaaggca gaaggcccag gtgacagggg atcctggagc tgtgctgtgg
     1801 cttgaggaga tccgccaggg agtggtcaga gccaaccagg acactaatac agctcagaga
     1861 atggctcttg gtgtggctgc catcaatcaa gccatcaagg agggcaaggc agcccagact
     1921 gagcgggtgt tgaggaaccc cgcagtggcc cttcgagggg tagttcccga ctgtgccaac
     1981 ggctaccagc gagccctgga aagtgccatg gcaaagaaac agcgtccagc agacacagct
     2041 ttctgggttc aacatgacat gaaggatggc actgcctact acttccatct gcagaccttc
     2101 caggggatct gggagcaacc tcctggctgc cccctcaaca cctctcacct gacccgggag
     2161 gagatccagt cagctgtcac caaggtcact gctgcctatg accgccaaca gctctggaaa
     2221 gccaacgtcg gctttgttat ccagctccag gcccgcctcc gtggcttcct agttcggcag
     2281 aagtttgctg agcattccca ctttctgagg acctggctcc cagcagtcat caagatccag
     2341 gctcattggc ggggttatag gcagcggaag atttacctgg agtggttgca gtattttaaa
     2401 gcaaacctgg atgccataat caagatccag gcctgggccc ggatgtgggc agctcggagg
     2461 caatacctga ggcgtctgca ctacttccag aagaatgtta actccattgt gaagatccag
     2521 gcatttttcc gagccaggaa agcccaagat gactacagga tattagtgca tgcaccccac
     2581 cctcctctca gtgtggtacg cagatttgcc catctcttga atcaaagcca gcaagacttc
     2641 ttggctgagg cagagctgct gaagctccag gaagaggtag ttaggaagat ccgatccaat
     2701 cagcagctgg agcaggacct caacatcatg gacatcaaga ttggcctgct ggtgaagaac
     2761 cggatcactc tgcaggaagt ggtctcccac tgcaagaagc tgaccaagag gaataaggaa
     2821 cagctgtcag atatgatggt tctggacaag cagaagggtt taaagtcgct gagcaaagag
     2881 aaacggcaga aactagaagc ataccaacac ctcttctacc tgctccagac tcagcccatc
     2941 tacctggcca agctgatctt tcagatgcca cagaacaaaa ccaccaagtt catggaggca
     3001 gtgattttca gcctgtacaa ctatgcctcc agccgccgag aggcctatct cctgctccag
     3061 ctgttcaaga cagcactcca ggaggaaatc aagtcaaagg tggagcagcc ccaggacgtg
     3121 gtgacaggca acccaacagt ggtgaggctg gtggtgagat tctaccgtaa tgggcgggga
     3181 cagagtgccc tgcaggagat tctgggcaag gttatccagg atgtgctaga agacaaagtg
     3241 ctcagcgtcc acacagaccc tgtccacctc tataagaact ggatcaacca gactgaggcc
     3301 cagacagggc agcgcagcca tctcccatat gatgtcaccc cggagcaggc cttgagccac
     3361 cccgaggtcc agagacgact ggacatcgcc ctacgcaacc tcctcgccat gactgataag
     3421 ttccttttag ccatcacctc atctgtggac caaattccgt atgggatgcg atatgtggcc
     3481 aaagtcctga aggcaactct ggcagagaaa ttccctgacg ccacagacag cgaggtctat
     3541 aaggtggtcg ggaacctcct gtactaccgc ttcctgaacc cagctgtggt ggctcctgac
     3601 gccttcgaca ttgtggccat ggcagctggt ggagccctgg ctgcccccca gcgccatgcc
     3661 ctgggggctg tggctcagct cctacagcac gctgcggctg gcaaggcctt ctctgggcag
     3721 agccagcacc tacgggtcct gaatgactat ctggaggaaa cacacctcaa gttcaggaag
     3781 ttcatccata gagcctgcca ggtgccagag ccagaggagc gttttgcagt ggacgagtac
     3841 tcagacatgg tggctgtggc caaacccatg gtgtacatca ccgtggggga gctggtcaac
     3901 acgcacaggc tgttgctgga gcaccaggac tgcattgccc ctgatcacca agaccccctg
     3961 catgagctcc tggaggatct tggggagctg cccaccatcc ctgaccttat tggtgagagc
     4021 atcgctgcag atgggcacac ggacctgagc aagctagaag tgtccctgac gctgaccaac
     4081 aagtttgaag gactagaggc agatgctgat gactccaaca cccgtagcct gcttctgagc
     4141 accaagcagc tgttggccga tatcatacag ttccatcctg gggacaccct caaggagatc
     4201 ctgtccctct cggcttccag agagcaagaa gcagcccaca agcagctgat gagccgacgc
     4261 caggcctgta cagcccagac accggagcca ctgcgacgac accgctcact gacagctcac
     4321 tccctcctgc cactggcaga gaagcagcgg cgcgtcctgc ggaacctacg ccgacttgaa
     4381 gccctggggt tggtcagcgc cagaaatggc taccaggggc tagtggacga gctggccaag
     4441 gacatccgca accagcacag acacaggcac aggcggaagg cagagctggt gaagctgcag
     4501 gccacattac agggcctgag cactaagacc accttctatg aggagcaggg tgactactac
     4561 agccagtaca tccgggcctg cctggaccac ctggcccccg actccaagag ttctgggaag
     4621 gggaagaagc agccttctct tcattacact gctgctcagc tcctggaaaa gggtgtcttg
     4681 gtggaaattg aagatcttcc cgcctctcac ttcagaaacg tcatctttga catcacgccg
     4741 ggagatgagg caggaaagtt tgaagtaaat gccaagttcc tgggtgtgga catggagcga
     4801 tttcagcttc actatcagga tctcctgcag ctccagtatg agggtgtggc tgtcatgaaa
     4861 ctcttcaaca aggccaaagt caatgtcaac cttctcatct tcctcctcaa caagaagttt
     4921 ttgcggaagt gacagaggca aagggtgcta cccaagcccc tcttacctct ctggatgctt
     4981 tctttaacac taactcacca ctgtgcttcc ctgcagacac ctagagctca ggactgggca
     5041 aggcccaggg attctcaccc cttccccagc tgggaggagc ttgcctgcct ggccacagac
     5101 agtgtatctt ctaattggct aaagtgggcc ttgcccagag tccagctgtg tggcttttat
     5161 catgcatgac aaacccctgg ctttcctgcc agatggtagg acatggacct tgacctggga
     5221 aagccattac tcttgtgtct gctactgccc tcccacagtc accccaatat tacaagcact
     5281 gccccagcgg cttgatttcc cctctgcctt ccttctctct gcactcccac aaagccaggg
     5341 ccaggctccc catccctacc tcccactgca tcagcagtgg gtgttcctgc ccttcctgag
     5401 tctaggcagc tctgctgctg tgatctgcac accctccaac ctgggcaggg actgggggga
     5461 tgcagtgtgt gttagtgccc atgtggcatt gtggcactgt tgccccccat ggcggcatgg
     5521 gcaagatgac cttccattag cttcaagtct tgttctcttg tctgtggtct gtttaatatg
     5581 tgggtcacta gggtatttat tctttctccc atccttacac tctggatcat tgtgcagact
     5641 taatcagggt tttaacgctt tcattttttt tttttttttt ttttttttga gctcaaagag
     5701 agttctcatt ttccctattc aaactaatac ccatgccgtg ttttttacct tggatttaaa
     5761 gtcaccttag gttggggcaa cagattctca ctcatgttta agatcttgtt atttcagctt
     5821 cataagatca aagaggagtc tttccctttt ctcttttacc ctcaggattc tcatccctta
     5881 cagctgactc ttccaggcaa tttccataga tctgcagtcc tgcctctgcc acagtctctc
     5941 tgttgtcccc acatctaccc aacttcctgt actgttgccc ttctgatgtt aataaaagca
     6001 gctgttactc cca
//
