LOCUS       NM_006633               5808 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IQ motif containing GTPase activating protein 2
            (IQGAP2), transcript variant 1, mRNA.
ACCESSION   NM_006633
VERSION     NM_006633.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5808)
  AUTHORS   Lin,K.M., Weng,L.F., Chen,S.J., Lin,S.J. and Tsai,C.H.
  TITLE     Upregulation of IQGAP2 by EBV transactivator Rta and its influence
            on EBV life cycle
  JOURNAL   J Virol 97 (8), e0054023 (2023)
   PUBMED   37504571
  REMARK    GeneRIF: Upregulation of IQGAP2 by EBV transactivator Rta and its
            influence on EBV life cycle.
REFERENCE   2  (bases 1 to 5808)
  AUTHORS   Tang,T., Wang,J., Zhang,L., Cheng,Y., Saleh,L., Gu,Y. and Zhang,H.
  TITLE     IQGAP2 acts as an independent prognostic factor and is related to
            immunosuppression in DLBCL
  JOURNAL   BMC Cancer 21 (1), 603 (2021)
   PUBMED   34034707
  REMARK    GeneRIF: IQGAP2 acts as an independent prognostic factor and is
            related to immunosuppression in DLBCL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5808)
  AUTHORS   Kumar,D., Patel,S.A., Hassan,M.K., Mohapatra,N., Pattanaik,N. and
            Dixit,M.
  TITLE     Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by
            modulating the MEK-ERK and p38 signaling in breast cancer
            irrespective of ER status
  JOURNAL   Cell Death Dis 12 (4), 389 (2021)
   PUBMED   33846302
  REMARK    GeneRIF: Reduced IQGAP2 expression promotes EMT and inhibits
            apoptosis by modulating the MEK-ERK and p38 signaling in breast
            cancer irrespective of ER status.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5808)
  AUTHORS   Li,F., Liu,Z., Zhang,B., Jiang,S., Wang,Q., Du,L., Xue,H.,
            Zhang,Y., Jin,M., Zhu,X., Brown,M.A., Wu,J. and Wang,X.
  TITLE     Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as
            noninvasive biomarkers of primary Sjogren's syndrome
  JOURNAL   Rheumatology (Oxford) 59 (9), 2603-2615 (2020)
   PUBMED   32250392
  REMARK    GeneRIF: Circular RNA sequencing indicates circ-IQGAP2 and
            circ-ZC3H6 as noninvasive biomarkers of primary Sjogren's syndrome.
REFERENCE   5  (bases 1 to 5808)
  AUTHORS   Xu,L., Shao,Y., Ren,L., Liu,X., Li,Y., Xu,J. and Ye,Y.
  TITLE     IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via
            Elevating SHIP2 Phosphatase Activity
  JOURNAL   Int J Mol Sci 21 (6), 1968 (2020)
   PUBMED   32183047
  REMARK    GeneRIF: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer
            Cells via Elevating SHIP2 Phosphatase Activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5808)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 5808)
  AUTHORS   Schmidt,V.A., Scudder,L., Devoe,C.E., Bernards,A., Cupit,L.D. and
            Bahou,W.F.
  TITLE     IQGAP2 functions as a GTP-dependent effector protein in
            thrombin-induced platelet cytoskeletal reorganization
  JOURNAL   Blood 101 (8), 3021-3028 (2003)
   PUBMED   12515716
  REMARK    GeneRIF: The gene for the putative rac1/cdc42 effector protein
            IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 &
            encompassing PAR3. It functions as a GTP-dependent effector protein
            in thrombin-induced platelet cytoskeletal reorganization.
REFERENCE   8  (bases 1 to 5808)
  AUTHORS   Wennerberg,K., Ellerbroek,S.M., Liu,R.Y., Karnoub,A.E., Burridge,K.
            and Der,C.J.
  TITLE     RhoG signals in parallel with Rac1 and Cdc42
  JOURNAL   J Biol Chem 277 (49), 47810-47817 (2002)
   PUBMED   12376551
REFERENCE   9  (bases 1 to 5808)
  AUTHORS   McCallum,S.J., Wu,W.J. and Cerione,R.A.
  TITLE     Identification of a putative effector for Cdc42Hs with high
            sequence similarity to the RasGAP-related protein IQGAP1 and a
            Cdc42Hs binding partner with similarity to IQGAP2
  JOURNAL   J Biol Chem 271 (36), 21732-21737 (1996)
   PUBMED   8702968
REFERENCE   10 (bases 1 to 5808)
  AUTHORS   Brill,S., Li,S., Lyman,C.W., Church,D.M., Wasmuth,J.J.,
            Weissbach,L., Bernards,A. and Snijders,A.J.
  TITLE     The Ras GTPase-activating-protein-related human protein IQGAP2
            harbors a potential actin binding domain and interacts with
            calmodulin and Rho family GTPases
  JOURNAL   Mol Cell Biol 16 (9), 4869-4878 (1996)
   PUBMED   8756646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093251.2, AC112173.3,
            AC026725.7, AC026706.5 and AC025188.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_006633.4.
            
            Summary: This gene encodes a member of the IQGAP family. The
            encoded protein contains three IQ domains, one calponin homology
            domain, one Ras-GAP domain and one WW domain. This protein
            interacts with components of the cytoskeleton, with cell adhesion
            molecules, and with several signaling molecules to regulate cell
            morphology and motility. It also acts as a tumor suppressor and has
            been found to play a role in regulating innate antiviral responses.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51903.1, AK291066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274364.11/ ENSP00000274364.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC093251.2         24939-25245         c
            308-407             AC112173.3         55870-55969
            408-564             AC026725.7         37230-37386
            565-642             AC026725.7         45414-45491
            643-719             AC026725.7         50527-50603
            720-787             AC026725.7         63740-63807
            788-901             AC026725.7         64449-64562
            902-1080            AC026725.7         65242-65420
            1081-1168           AC026725.7         67672-67759
            1169-1332           AC026725.7         72273-72436
            1333-1493           AC026725.7         75646-75806
            1494-1618           AC026725.7         81013-81137
            1619-1782           AC026725.7         85854-86017
            1783-1873           AC026706.5         51344-51434         c
            1874-2041           AC026706.5         46818-46985         c
            2042-2184           AC026706.5         41668-41810         c
            2185-2355           AC026706.5         37741-37911         c
            2356-2439           AC026706.5         26011-26094         c
            2440-2511           AC026706.5         24573-24644         c
            2512-2581           AC026706.5         23841-23910         c
            2582-2790           AC026706.5         20177-20385         c
            2791-2940           AC026706.5         13669-13818         c
            2941-3104           AC026706.5         10000-10163         c
            3105-3329           AC026706.5         6861-7085           c
            3330-3470           AC026706.5         5255-5395           c
            3471-3555           AC026706.5         4808-4892           c
            3556-3788           AC026706.5         4135-4367           c
            3789-3921           AC026706.5         1494-1626           c
            3922-4024           AC025188.8         24698-24800
            4025-4166           AC025188.8         25359-25500
            4167-4254           AC025188.8         34938-35025
            4255-4467           AC025188.8         37037-37249
            4468-4628           AC025188.8         39570-39730
            4629-4766           AC025188.8         42659-42796
            4767-4875           AC025188.8         44065-44173
            4876-5808           AC025188.8         48783-49715
FEATURES             Location/Qualifiers
     source          1..5808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..5808
                     /gene="IQGAP2"
                     /note="IQ motif containing GTPase activating protein 2"
                     /db_xref="GeneID:10788"
                     /db_xref="HGNC:HGNC:6111"
                     /db_xref="MIM:605401"
     exon            1..307
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..4989
                     /gene="IQGAP2"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     GTPase-activating-like protein IQGAP2"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP2
                     isoform 1"
                     /protein_id="NP_006624.3"
                     /db_xref="CCDS:CCDS34188.1"
                     /db_xref="GeneID:10788"
                     /db_xref="HGNC:HGNC:6111"
                     /db_xref="MIM:605401"
                     /translation="MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHL
                     EEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKK
                     SGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLG
                     IAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAV
                     IAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSC
                     ISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLP
                     AVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQN
                     QLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEE
                     NDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGD
                     SESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTS
                     NANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVT
                     PESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEA
                     RKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSY
                     LSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDF
                     QEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKK
                     GGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKF
                     MDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFN
                     RGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVT
                     TEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKF
                     PDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQ
                     HAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVS
                     KPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPN
                     DPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
                     EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNL
                     RTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYE
                     EQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLD
                     IDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMK
                     MFDKVKVNVNLLIYLLNKKFYGK"
     exon            308..407
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..564
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..642
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..719
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..787
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..901
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1080
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1168
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1332
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1493
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1618
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1782
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1873
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2041
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2184
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2355
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2439
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2511
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2581
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2790
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2940
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3104
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3329
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3470
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3555
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3788
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3921
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4024
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4166
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4254
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4467
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4468..4628
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4766
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..4875
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4876..5808
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5784..5789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQGAP2"
                     /note="hexamer: AATAAA"
     polyA_site      5808
                     /gene="IQGAP2"
                     /note="major polyA site"
ORIGIN      
        1 aaacctgctg cgggaggcgg cggcgaccgg ccagggagcg agggaggaga gttcactttt
       61 acttcagtgt cagcgcgcgg cggccgtggc tggctctggc gagagagcac cgagggagtg
      121 ggtcgcagat cttcgggcgg ctaggggaaa tcggcgagag gcgggatccg agcgcgccgg
      181 cggggcgcag agcccgcgag cctggccagc gagggtagcc gcggggggcg cgccccgggc
      241 gggcccccgg agacgcgcag gatgccacac gaagagctgc cgtcgctgca gagaccccgc
      301 tatggctcta ttgtggacga tgaaaggctc tctgcagagg agatggatga gaggaggcgg
      361 cagaacattg cttatgaata tctgtgccac ttagaggaag ccaaaaggtg gatggaagtt
      421 tgcttagttg aagaattgcc accaaccact gaattggaag aagggctccg gaatggagtt
      481 taccttgcaa agttagccaa gttctttgcc ccgaaaatgg tatcagagaa aaagatctat
      541 gatgtggaac aaacacgtta taagaagtct ggccttcatt ttcgacacac agataatacc
      601 gtccagtggt taagagcgat ggagtctatt ggtctaccca agatatttta tccagaaaca
      661 acagatgtct atgatcggaa aaacatacca agaatgatat attgcattca cgcactgagt
      721 ttgtatctgt tcaaactagg aatagcaccc cagatccagg atttgttggg caaagtagac
      781 ttcacagagg aggaaatcag taatatgaga aaagaacttg agaaatatgg aatacagatg
      841 ccatctttca gcaaaatagg tggtattctg gccaatgaac tgtccgtgga tgaagctgca
      901 ttacatgctg cagttatagc cattaatgaa gcagttgaaa aaggaatagc agagcaaacc
      961 gttgtaacac taagaaaccc aaatgcggtt ttaactttag tggatgacaa ccttgcacca
     1021 gaatatcaga aagaactctg ggatgccaaa aagaaaaaag aggaaaatgc aagactgaag
     1081 aatagctgta tttcagaaga agaaagagat gcttatgaag aactgctgac acaagcagaa
     1141 atccaaggca atattaataa agtcaacagg caggctgcag tggaccatat caatgctgtc
     1201 attccggaag gtgaccccga gaatacgctg cttgcactga agaaaccaga ggcccagctg
     1261 cctgctgttt atccctttgc tgctgccatg tatcagaacg aacttttcaa cctccagaaa
     1321 cagaacacca tgaactactt ggcccacgag gagcttttga ttgctgtgga aatgttgtct
     1381 gctgttgctt tactaaacca ggccttggaa agcaacgatc ttgtgtctgt gcagaatcaa
     1441 ctcagaagcc ccgcaatagg cttaaacaat ctggacaagg catatgtgga acgttatgca
     1501 aacacactac tctctgttaa actagaagtt ttatcccaag ggcaagataa cttaagctgg
     1561 aatgaaattc agaattgtat tgatatggtt aatgctcaaa ttcaagaaga aaatgaccga
     1621 gttgtagctg tagggtacat caatgaagct attgatgaag ggaatccttt gaggacttta
     1681 gaaactttgc tcctacctac tgcgaatatt agtgatgtgg acccagccca tgcccagcac
     1741 taccaggatg ttttatacca tgctaaatca cagaaactcg gagactctga gagtgtttcc
     1801 aaagtgcttt ggctggatga gatacagcaa gccgtcgatg atgccaacgt ggacaaggac
     1861 agagcaaaac aatgggttac tctggtggtt gatgttaatc agtgtttgga aggaaaaaaa
     1921 tcaagtgata ttttgtctgt attgaagtct tccacttcta atgcaaatga cataatcccg
     1981 gagtgtgctg acaaatacta tgatgccctt gtgaaggcaa aagagctcaa atctgaaaga
     2041 gtgtctagtg acggttcatg gctcaaactc aacctgcaca aaaaatatga ctactattac
     2101 aacactgatt caaaagagag ttcctgggtc acacctgaat catgcttgta taaagaatca
     2161 tggctcacag gaaaagaaat cgaggacatt attgaggaag tcacagtagg ttacattcgt
     2221 gagaatatat ggtctgcttc agaagagttg cttcttcgct ttcaagccac aagctcagga
     2281 cccatcctta gggaagagtt tgaagctaga aaatcatttt tgcatgaaca agaagagaat
     2341 gtggtcaaaa tacaggcttt ttggaaagga tataaacaac ggaaggagta tatgcacagg
     2401 cggcaaacgt tcattgataa tactgattct attgtgaaga ttcagtcctg gttccgaatg
     2461 gcaactgcaa gaaagagcta tctttcaaga ctacagtatt tcagagatca taataatgaa
     2521 attgtgaaaa tacagtcact gttgagagcg aacaaagcta gagatgacta caaaacattg
     2581 gttggctctg aaaacccacc attaacagta attcgcaaat ttgtatacct gctggaccaa
     2641 agtgatttgg atttccagga ggaactagag gttgcacgat taagggaaga agtagtgacc
     2701 aagatcaggg ccaatcaaca gctggaaaaa gacctgaacc tgatggacat caagattgga
     2761 ctgctggtga agaacaggat cacactagag gatgtaattt cacatagtaa aaagctgaac
     2821 aagaaaaaag gaggagaaat ggaaatactg aataacaccg acaaccaagg aataaaaagt
     2881 ttgagtaagg agaggagaaa aacactagaa acatatcagc agctgtttta ccttttacag
     2941 accaaccctt tatacttggc taagctgatt ttccagatgc cacagaacaa gtccactaaa
     3001 tttatggata ctgttatttt cacactatat aattatgcct ctaatcagcg agaagaatat
     3061 ctacttctca agctttttaa aactgctctg gaggaagaaa taaaatcaaa agtggaccag
     3121 gtacaggaca tagttactgg taaccctaca gtcatcaaga tggtcgtcag cttcaataga
     3181 ggtgcccggg gacagaacac cctgcgccaa ctcctggctc cagtggtaaa agagatcatc
     3241 gacgacaagt cgctgattat caacacaaac cctgtagagg tgtacaaggc ttgggtgaac
     3301 caactagaaa cacagactgg agaggccagc aagttgcctt atgatgtgac cacagaacaa
     3361 gctctaacat acccagaagt gaaaaataaa ctggaggctt ccattgagaa cctgagaagg
     3421 gtcaccgaca aagtcctgaa ttctatcatt tcttcccttg atctactgcc ttatggattg
     3481 aggtatatag ccaaagtact gaagaattcg atccatgaga aattccccga tgcaacagaa
     3541 gatgagctat taaagattgt tggaaacctc ctgtactatc ggtacatgaa tccagccatt
     3601 gtagctccag atggctttga tatcatcgac atgacagctg gaggtcagat aaattctgac
     3661 caaaggagaa acttaggatc agtggccaag gttcttcagc acgcagcctc caacaagctg
     3721 tttgaaggag aaaatgagca tctctcatct atgaacaatt atttatcaga gacgtatcag
     3781 gaattcagga aatatttcaa agaagcatgt aatgtccctg agccagaaga gaagtttaat
     3841 atggacaaat acacagacct ggtgacagtc agcaaaccag tcatttatat ttcaattgaa
     3901 gaaatcatca gcacacactc actcctgttg gaacaccagg atgcaattgc ccctgagaaa
     3961 aatgacttac tgagtgaatt gctggggtcg ctgggagagg tgccaaccgt ggaatctttt
     4021 cttggggaag gagcagttga ccccaatgac cctaacaagg caaatacact aagtcagctt
     4081 tcaaagaccg agatttctct tgtcttgaca agcaaatatg acatagagga cggtgaagct
     4141 atagatagcc gaagcctcat gataaagacc aagaagctga taattgatgt gatccggaac
     4201 cagccaggga acacattgac agaaatctta gagacaccag caactgcgca acaggaggta
     4261 gaccatgcca cggacatggt gagccgtgca atgatagatt ccaggactcc agaagaaatg
     4321 aagcatagcc aatctatgat tgaagatgca cagctgcctc ttgagcagaa gaagaggaaa
     4381 atccagagga atcttcggac gttggaacag actggacacg tgtcatccga aaataaatac
     4441 caagacattc tcaatgagat tgccaaggat attcgaaatc aaagaatcta tcgtaagctt
     4501 cgaaaagctg aattggcaaa acttcagcag accctgaatg cacttaacaa gaaggcagca
     4561 ttttatgaag agcaaatcaa ttattatgac acctacataa agacttgttt agacaactta
     4621 aaaagaaaaa atactcggag atcaattaaa ctagatggaa aaggagaacc caaaggggcg
     4681 aagagagcga agccagtgaa gtacactgca gcaaagctgc atgagaaagg tgtcctgcta
     4741 gatatagatg atcttcaaac aaaccagttt aagaatgtta catttgatat catagctact
     4801 gaagatgtag gcattttcga tgtaagatca aaattccttg gtgttgagat ggaaaaggtg
     4861 caactcaata ttcaggattt acttcagatg caatatgaag gagtagctgt aatgaaaatg
     4921 tttgataagg ttaaagtgaa tgtaaacctt ctcatatacc tgctgaacaa gaagttctat
     4981 ggaaagtgaa gtgcctacag aaatttcttg gattctgtat catctggatt aggaaatgaa
     5041 tttgtttaat atttttgttt ttaaacatga ttgaaatcac tgcttataaa tgtgtgattt
     5101 ttttaaaacg accaaaactg ttctgaagaa tgtacccagg tgcctttttg ctaatttgat
     5161 actataatag aatgagacat aaaatgaatt aatggaaaca tatccacact gtactgtgat
     5221 ataggtactc tgatttaaaa ctttggacat cctgtgatct gttttaaagt tggggggtgg
     5281 gaaatttagc tgactaggga caaacatgta aacctatttt cctatgaaaa aaattttaaa
     5341 tgtcccactt gaataacgta attcttcata gtttttttaa tctatggata aatggaaacc
     5401 taattatttg taatgaatta tttagacagt tctaagccct gtcttctggg agttatcaat
     5461 tttaaagaga acttttgtgc aattcaaatg aagtttttat aagtaattga aaatgacaac
     5521 acaataacac tttctgtata aaagtatata ttttatgtga tttattccta ctaaatgaaa
     5581 gtgcactact gcctcatgta aagactcttg cacgcagagc ctttaagtga ctaaggaaca
     5641 acatagatag tgagcatagt ccccacctcc acccctcaca atttatttga atacttcaat
     5701 tgtgcctctc aattttttgt aatgctaaaa aatcagtatc tagatggttt ttaaatgtat
     5761 tctctggaaa ttgttttatg taaaataaat gttacttaat tccattaa
//
