LOCUS       NM_001285460            5444 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IQ motif containing GTPase activating protein 2
            (IQGAP2), transcript variant 2, mRNA.
ACCESSION   NM_001285460 XM_005248412
VERSION     NM_001285460.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5444)
  AUTHORS   Lin,K.M., Weng,L.F., Chen,S.J., Lin,S.J. and Tsai,C.H.
  TITLE     Upregulation of IQGAP2 by EBV transactivator Rta and its influence
            on EBV life cycle
  JOURNAL   J Virol 97 (8), e0054023 (2023)
   PUBMED   37504571
  REMARK    GeneRIF: Upregulation of IQGAP2 by EBV transactivator Rta and its
            influence on EBV life cycle.
REFERENCE   2  (bases 1 to 5444)
  AUTHORS   Tang,T., Wang,J., Zhang,L., Cheng,Y., Saleh,L., Gu,Y. and Zhang,H.
  TITLE     IQGAP2 acts as an independent prognostic factor and is related to
            immunosuppression in DLBCL
  JOURNAL   BMC Cancer 21 (1), 603 (2021)
   PUBMED   34034707
  REMARK    GeneRIF: IQGAP2 acts as an independent prognostic factor and is
            related to immunosuppression in DLBCL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5444)
  AUTHORS   Kumar,D., Patel,S.A., Hassan,M.K., Mohapatra,N., Pattanaik,N. and
            Dixit,M.
  TITLE     Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by
            modulating the MEK-ERK and p38 signaling in breast cancer
            irrespective of ER status
  JOURNAL   Cell Death Dis 12 (4), 389 (2021)
   PUBMED   33846302
  REMARK    GeneRIF: Reduced IQGAP2 expression promotes EMT and inhibits
            apoptosis by modulating the MEK-ERK and p38 signaling in breast
            cancer irrespective of ER status.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5444)
  AUTHORS   Li,F., Liu,Z., Zhang,B., Jiang,S., Wang,Q., Du,L., Xue,H.,
            Zhang,Y., Jin,M., Zhu,X., Brown,M.A., Wu,J. and Wang,X.
  TITLE     Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as
            noninvasive biomarkers of primary Sjogren's syndrome
  JOURNAL   Rheumatology (Oxford) 59 (9), 2603-2615 (2020)
   PUBMED   32250392
  REMARK    GeneRIF: Circular RNA sequencing indicates circ-IQGAP2 and
            circ-ZC3H6 as noninvasive biomarkers of primary Sjogren's syndrome.
REFERENCE   5  (bases 1 to 5444)
  AUTHORS   Xu,L., Shao,Y., Ren,L., Liu,X., Li,Y., Xu,J. and Ye,Y.
  TITLE     IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via
            Elevating SHIP2 Phosphatase Activity
  JOURNAL   Int J Mol Sci 21 (6), 1968 (2020)
   PUBMED   32183047
  REMARK    GeneRIF: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer
            Cells via Elevating SHIP2 Phosphatase Activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5444)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 5444)
  AUTHORS   Schmidt,V.A., Scudder,L., Devoe,C.E., Bernards,A., Cupit,L.D. and
            Bahou,W.F.
  TITLE     IQGAP2 functions as a GTP-dependent effector protein in
            thrombin-induced platelet cytoskeletal reorganization
  JOURNAL   Blood 101 (8), 3021-3028 (2003)
   PUBMED   12515716
  REMARK    GeneRIF: The gene for the putative rac1/cdc42 effector protein
            IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 &
            encompassing PAR3. It functions as a GTP-dependent effector protein
            in thrombin-induced platelet cytoskeletal reorganization.
REFERENCE   8  (bases 1 to 5444)
  AUTHORS   Wennerberg,K., Ellerbroek,S.M., Liu,R.Y., Karnoub,A.E., Burridge,K.
            and Der,C.J.
  TITLE     RhoG signals in parallel with Rac1 and Cdc42
  JOURNAL   J Biol Chem 277 (49), 47810-47817 (2002)
   PUBMED   12376551
REFERENCE   9  (bases 1 to 5444)
  AUTHORS   McCallum,S.J., Wu,W.J. and Cerione,R.A.
  TITLE     Identification of a putative effector for Cdc42Hs with high
            sequence similarity to the RasGAP-related protein IQGAP1 and a
            Cdc42Hs binding partner with similarity to IQGAP2
  JOURNAL   J Biol Chem 271 (36), 21732-21737 (1996)
   PUBMED   8702968
REFERENCE   10 (bases 1 to 5444)
  AUTHORS   Brill,S., Li,S., Lyman,C.W., Church,D.M., Wasmuth,J.J.,
            Weissbach,L., Bernards,A. and Snijders,A.J.
  TITLE     The Ras GTPase-activating-protein-related human protein IQGAP2
            harbors a potential actin binding domain and interacts with
            calmodulin and Rho family GTPases
  JOURNAL   Mol Cell Biol 16 (9), 4869-4878 (1996)
   PUBMED   8756646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026725.7, AC026706.5 and
            AC025188.8.
            
            On Aug 14, 2020 this sequence version replaced NM_001285460.1.
            
            Summary: This gene encodes a member of the IQGAP family. The
            encoded protein contains three IQ domains, one calponin homology
            domain, one Ras-GAP domain and one WW domain. This protein
            interacts with components of the cytoskeleton, with cell adhesion
            molecules, and with several signaling molecules to regulate cell
            morphology and motility. It also acts as a tumor suppressor and has
            been found to play a role in regulating innate antiviral responses.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and initiates translation from an in-frame downstream
            start codon compared to variant 1. The resulting isoform (2) has a
            shorter N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038194.2258606.1, SRR14372080.746898.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2148093, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC026725.7         22243-22285
            44-200              AC026725.7         37230-37386
            201-278             AC026725.7         45414-45491
            279-355             AC026725.7         50527-50603
            356-423             AC026725.7         63740-63807
            424-537             AC026725.7         64449-64562
            538-716             AC026725.7         65242-65420
            717-804             AC026725.7         67672-67759
            805-968             AC026725.7         72273-72436
            969-1129            AC026725.7         75646-75806
            1130-1254           AC026725.7         81013-81137
            1255-1418           AC026725.7         85854-86017
            1419-1509           AC026706.5         51344-51434         c
            1510-1677           AC026706.5         46818-46985         c
            1678-1820           AC026706.5         41668-41810         c
            1821-1991           AC026706.5         37741-37911         c
            1992-2075           AC026706.5         26011-26094         c
            2076-2147           AC026706.5         24573-24644         c
            2148-2217           AC026706.5         23841-23910         c
            2218-2426           AC026706.5         20177-20385         c
            2427-2576           AC026706.5         13669-13818         c
            2577-2740           AC026706.5         10000-10163         c
            2741-2965           AC026706.5         6861-7085           c
            2966-3106           AC026706.5         5255-5395           c
            3107-3191           AC026706.5         4808-4892           c
            3192-3424           AC026706.5         4135-4367           c
            3425-3557           AC026706.5         1494-1626           c
            3558-3660           AC025188.8         24698-24800
            3661-3802           AC025188.8         25359-25500
            3803-3890           AC025188.8         34938-35025
            3891-4103           AC025188.8         37037-37249
            4104-4264           AC025188.8         39570-39730
            4265-4402           AC025188.8         42659-42796
            4403-4511           AC025188.8         44065-44173
            4512-5444           AC025188.8         48783-49715
FEATURES             Location/Qualifiers
     source          1..5444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..5444
                     /gene="IQGAP2"
                     /note="IQ motif containing GTPase activating protein 2"
                     /db_xref="GeneID:10788"
                     /db_xref="HGNC:HGNC:6111"
                     /db_xref="MIM:605401"
     exon            1..43
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            44..200
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..4625
                     /gene="IQGAP2"
                     /note="isoform 2 is encoded by transcript variant 2; ras
                     GTPase-activating-like protein IQGAP2"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP2
                     isoform 2"
                     /protein_id="NP_001272389.2"
                     /db_xref="CCDS:CCDS75262.1"
                     /db_xref="GeneID:10788"
                     /db_xref="HGNC:HGNC:6111"
                     /db_xref="MIM:605401"
                     /translation="MEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYD
                     VEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHAL
                     SLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVD
                     EAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEE
                     NARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLAL
                     KKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALES
                     NDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDM
                     VNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYH
                     AKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDIL
                     SVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTD
                     SKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGP
                     ILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFR
                     MATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYL
                     LDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISH
                     SKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQM
                     PQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTV
                     IKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEA
                     SKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
                     KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNL
                     GSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDK
                     YTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFL
                     GEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIR
                     NQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQK
                     KRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNAL
                     NKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKL
                     HEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQ
                     YEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK"
     exon            201..278
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..355
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..423
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..537
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..716
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..804
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..968
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1129
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1254
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1418
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1509
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1677
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1820
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1991
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2075
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2147
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2217
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2426
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2576
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2740
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2965
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3106
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3191
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3424
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3557
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3660
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3802
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3890
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4103
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4264
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4402
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4511
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..5444
                     /gene="IQGAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5420..5425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQGAP2"
                     /note="hexamer: AATAAA"
     polyA_site      5444
                     /gene="IQGAP2"
                     /note="major polyA site"
ORIGIN      
        1 agaagaggga agtcaagtgt aggaaggagt tgtggcaatt taagtggatg gaagtttgct
       61 tagttgaaga attgccacca accactgaat tggaagaagg gctccggaat ggagtttacc
      121 ttgcaaagtt agccaagttc tttgccccga aaatggtatc agagaaaaag atctatgatg
      181 tggaacaaac acgttataag aagtctggcc ttcattttcg acacacagat aataccgtcc
      241 agtggttaag agcgatggag tctattggtc tacccaagat attttatcca gaaacaacag
      301 atgtctatga tcggaaaaac ataccaagaa tgatatattg cattcacgca ctgagtttgt
      361 atctgttcaa actaggaata gcaccccaga tccaggattt gttgggcaaa gtagacttca
      421 cagaggagga aatcagtaat atgagaaaag aacttgagaa atatggaata cagatgccat
      481 ctttcagcaa aataggtggt attctggcca atgaactgtc cgtggatgaa gctgcattac
      541 atgctgcagt tatagccatt aatgaagcag ttgaaaaagg aatagcagag caaaccgttg
      601 taacactaag aaacccaaat gcggttttaa ctttagtgga tgacaacctt gcaccagaat
      661 atcagaaaga actctgggat gccaaaaaga aaaaagagga aaatgcaaga ctgaagaata
      721 gctgtatttc agaagaagaa agagatgctt atgaagaact gctgacacaa gcagaaatcc
      781 aaggcaatat taataaagtc aacaggcagg ctgcagtgga ccatatcaat gctgtcattc
      841 cggaaggtga ccccgagaat acgctgcttg cactgaagaa accagaggcc cagctgcctg
      901 ctgtttatcc ctttgctgct gccatgtatc agaacgaact tttcaacctc cagaaacaga
      961 acaccatgaa ctacttggcc cacgaggagc ttttgattgc tgtggaaatg ttgtctgctg
     1021 ttgctttact aaaccaggcc ttggaaagca acgatcttgt gtctgtgcag aatcaactca
     1081 gaagccccgc aataggctta aacaatctgg acaaggcata tgtggaacgt tatgcaaaca
     1141 cactactctc tgttaaacta gaagttttat cccaagggca agataactta agctggaatg
     1201 aaattcagaa ttgtattgat atggttaatg ctcaaattca agaagaaaat gaccgagttg
     1261 tagctgtagg gtacatcaat gaagctattg atgaagggaa tcctttgagg actttagaaa
     1321 ctttgctcct acctactgcg aatattagtg atgtggaccc agcccatgcc cagcactacc
     1381 aggatgtttt ataccatgct aaatcacaga aactcggaga ctctgagagt gtttccaaag
     1441 tgctttggct ggatgagata cagcaagccg tcgatgatgc caacgtggac aaggacagag
     1501 caaaacaatg ggttactctg gtggttgatg ttaatcagtg tttggaagga aaaaaatcaa
     1561 gtgatatttt gtctgtattg aagtcttcca cttctaatgc aaatgacata atcccggagt
     1621 gtgctgacaa atactatgat gcccttgtga aggcaaaaga gctcaaatct gaaagagtgt
     1681 ctagtgacgg ttcatggctc aaactcaacc tgcacaaaaa atatgactac tattacaaca
     1741 ctgattcaaa agagagttcc tgggtcacac ctgaatcatg cttgtataaa gaatcatggc
     1801 tcacaggaaa agaaatcgag gacattattg aggaagtcac agtaggttac attcgtgaga
     1861 atatatggtc tgcttcagaa gagttgcttc ttcgctttca agccacaagc tcaggaccca
     1921 tccttaggga agagtttgaa gctagaaaat catttttgca tgaacaagaa gagaatgtgg
     1981 tcaaaataca ggctttttgg aaaggatata aacaacggaa ggagtatatg cacaggcggc
     2041 aaacgttcat tgataatact gattctattg tgaagattca gtcctggttc cgaatggcaa
     2101 ctgcaagaaa gagctatctt tcaagactac agtatttcag agatcataat aatgaaattg
     2161 tgaaaataca gtcactgttg agagcgaaca aagctagaga tgactacaaa acattggttg
     2221 gctctgaaaa cccaccatta acagtaattc gcaaatttgt atacctgctg gaccaaagtg
     2281 atttggattt ccaggaggaa ctagaggttg cacgattaag ggaagaagta gtgaccaaga
     2341 tcagggccaa tcaacagctg gaaaaagacc tgaacctgat ggacatcaag attggactgc
     2401 tggtgaagaa caggatcaca ctagaggatg taatttcaca tagtaaaaag ctgaacaaga
     2461 aaaaaggagg agaaatggaa atactgaata acaccgacaa ccaaggaata aaaagtttga
     2521 gtaaggagag gagaaaaaca ctagaaacat atcagcagct gttttacctt ttacagacca
     2581 accctttata cttggctaag ctgattttcc agatgccaca gaacaagtcc actaaattta
     2641 tggatactgt tattttcaca ctatataatt atgcctctaa tcagcgagaa gaatatctac
     2701 ttctcaagct ttttaaaact gctctggagg aagaaataaa atcaaaagtg gaccaggtac
     2761 aggacatagt tactggtaac cctacagtca tcaagatggt cgtcagcttc aatagaggtg
     2821 cccggggaca gaacaccctg cgccaactcc tggctccagt ggtaaaagag atcatcgacg
     2881 acaagtcgct gattatcaac acaaaccctg tagaggtgta caaggcttgg gtgaaccaac
     2941 tagaaacaca gactggagag gccagcaagt tgccttatga tgtgaccaca gaacaagctc
     3001 taacataccc agaagtgaaa aataaactgg aggcttccat tgagaacctg agaagggtca
     3061 ccgacaaagt cctgaattct atcatttctt cccttgatct actgccttat ggattgaggt
     3121 atatagccaa agtactgaag aattcgatcc atgagaaatt ccccgatgca acagaagatg
     3181 agctattaaa gattgttgga aacctcctgt actatcggta catgaatcca gccattgtag
     3241 ctccagatgg ctttgatatc atcgacatga cagctggagg tcagataaat tctgaccaaa
     3301 ggagaaactt aggatcagtg gccaaggttc ttcagcacgc agcctccaac aagctgtttg
     3361 aaggagaaaa tgagcatctc tcatctatga acaattattt atcagagacg tatcaggaat
     3421 tcaggaaata tttcaaagaa gcatgtaatg tccctgagcc agaagagaag tttaatatgg
     3481 acaaatacac agacctggtg acagtcagca aaccagtcat ttatatttca attgaagaaa
     3541 tcatcagcac acactcactc ctgttggaac accaggatgc aattgcccct gagaaaaatg
     3601 acttactgag tgaattgctg gggtcgctgg gagaggtgcc aaccgtggaa tcttttcttg
     3661 gggaaggagc agttgacccc aatgacccta acaaggcaaa tacactaagt cagctttcaa
     3721 agaccgagat ttctcttgtc ttgacaagca aatatgacat agaggacggt gaagctatag
     3781 atagccgaag cctcatgata aagaccaaga agctgataat tgatgtgatc cggaaccagc
     3841 cagggaacac attgacagaa atcttagaga caccagcaac tgcgcaacag gaggtagacc
     3901 atgccacgga catggtgagc cgtgcaatga tagattccag gactccagaa gaaatgaagc
     3961 atagccaatc tatgattgaa gatgcacagc tgcctcttga gcagaagaag aggaaaatcc
     4021 agaggaatct tcggacgttg gaacagactg gacacgtgtc atccgaaaat aaataccaag
     4081 acattctcaa tgagattgcc aaggatattc gaaatcaaag aatctatcgt aagcttcgaa
     4141 aagctgaatt ggcaaaactt cagcagaccc tgaatgcact taacaagaag gcagcatttt
     4201 atgaagagca aatcaattat tatgacacct acataaagac ttgtttagac aacttaaaaa
     4261 gaaaaaatac tcggagatca attaaactag atggaaaagg agaacccaaa ggggcgaaga
     4321 gagcgaagcc agtgaagtac actgcagcaa agctgcatga gaaaggtgtc ctgctagata
     4381 tagatgatct tcaaacaaac cagtttaaga atgttacatt tgatatcata gctactgaag
     4441 atgtaggcat tttcgatgta agatcaaaat tccttggtgt tgagatggaa aaggtgcaac
     4501 tcaatattca ggatttactt cagatgcaat atgaaggagt agctgtaatg aaaatgtttg
     4561 ataaggttaa agtgaatgta aaccttctca tatacctgct gaacaagaag ttctatggaa
     4621 agtgaagtgc ctacagaaat ttcttggatt ctgtatcatc tggattagga aatgaatttg
     4681 tttaatattt ttgtttttaa acatgattga aatcactgct tataaatgtg tgattttttt
     4741 aaaacgacca aaactgttct gaagaatgta cccaggtgcc tttttgctaa tttgatacta
     4801 taatagaatg agacataaaa tgaattaatg gaaacatatc cacactgtac tgtgatatag
     4861 gtactctgat ttaaaacttt ggacatcctg tgatctgttt taaagttggg gggtgggaaa
     4921 tttagctgac tagggacaaa catgtaaacc tattttccta tgaaaaaaat tttaaatgtc
     4981 ccacttgaat aacgtaattc ttcatagttt ttttaatcta tggataaatg gaaacctaat
     5041 tatttgtaat gaattattta gacagttcta agccctgtct tctgggagtt atcaatttta
     5101 aagagaactt ttgtgcaatt caaatgaagt ttttataagt aattgaaaat gacaacacaa
     5161 taacactttc tgtataaaag tatatatttt atgtgattta ttcctactaa atgaaagtgc
     5221 actactgcct catgtaaaga ctcttgcacg cagagccttt aagtgactaa ggaacaacat
     5281 agatagtgag catagtcccc acctccaccc ctcacaattt atttgaatac ttcaattgtg
     5341 cctctcaatt ttttgtaatg ctaaaaaatc agtatctaga tggtttttaa atgtattctc
     5401 tggaaattgt tttatgtaaa ataaatgtta cttaattcca ttaa
//
