LOCUS       NM_003870               7205 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens IQ motif containing GTPase activating protein 1
            (IQGAP1), mRNA.
ACCESSION   NM_003870
VERSION     NM_003870.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7205)
  AUTHORS   Pimm,M.L., Haarer,B.K., Nobles,A.D., Haney,L.M., Marcin,A.G.,
            Alcaide Eligio,M. and Henty-Ridilla,J.L.
  TITLE     Coordination of actin plus-end dynamics by IQGAP1, formin, and
            capping protein
  JOURNAL   J Cell Biol 223 (9) (2024)
   PUBMED   38787349
  REMARK    GeneRIF: Coordination of actin plus-end dynamics by IQGAP1, formin,
            and capping protein.
REFERENCE   2  (bases 1 to 7205)
  AUTHORS   Song,C., Wang,G., Liu,M., Han,S., Dong,M., Peng,M., Wang,W.,
            Wang,Y., Xu,Y. and Liu,L.
  TITLE     Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic
            insight into IQGAP1 phosphorylation and pancreatic Cancer
            progression
  JOURNAL   J Transl Med 22 (1), 602 (2024)
   PUBMED   38943117
  REMARK    GeneRIF: Deciphering the SOX4/MAPK1 regulatory axis: a
            phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic
            Cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7205)
  AUTHORS   Sahasrabudhe,D.M., Liesveld,J.L., Minhajuddin,M., Singh,N.A.,
            Nath,S., Kumar,V.M., Balys,M., Evans,A.G., Azadniv,M., Hansen,J.N.,
            Becker,M.W., Sharon,A., Thomas,V.K., Moore,R.G., Khera,M.K.,
            Jordan,C.T. and Singh,R.K.
  TITLE     In silico predicted compound targeting the IQGAP1-GRD domain
            selectively inhibits growth of human acute myeloid leukemia
  JOURNAL   Sci Rep 14 (1), 12868 (2024)
   PUBMED   38834690
  REMARK    GeneRIF: In silico predicted compound targeting the IQGAP1-GRD
            domain selectively inhibits growth of human acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7205)
  AUTHORS   Cerutti,C., Lucotti,S., Menendez,S.T., Reymond,N., Garg,R.,
            Romero,I.A., Muschel,R. and Ridley,A.J.
  TITLE     IQGAP1 and NWASP promote human cancer cell dissemination and
            metastasis by regulating beta1-integrin via FAK and MRTF/SRF
  JOURNAL   Cell Rep 43 (4), 113989 (2024)
   PUBMED   38536816
  REMARK    GeneRIF: IQGAP1 and NWASP promote human cancer cell dissemination
            and metastasis by regulating beta1-integrin via FAK and MRTF/SRF.
REFERENCE   5  (bases 1 to 7205)
  AUTHORS   Huang,Y.T., Hsu,Y.T., Wu,P.Y., Yeh,Y.M., Lin,P.C., Hsu,K.F. and
            Shen,M.R.
  TITLE     Tight junction protein cingulin variant is associated with cancer
            susceptibility by overexpressed IQGAP1 and Rac1-dependent
            epithelial-mesenchymal transition
  JOURNAL   J Exp Clin Cancer Res 43 (1), 65 (2024)
   PUBMED   38424547
  REMARK    GeneRIF: Tight junction protein cingulin variant is associated with
            cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent
            epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7205)
  AUTHORS   Kuroda,S., Fukata,M., Kobayashi,K., Nakafuku,M., Nomura,N.,
            Iwamatsu,A. and Kaibuchi,K.
  TITLE     Identification of IQGAP as a putative target for the small GTPases,
            Cdc42 and Rac1
  JOURNAL   J Biol Chem 271 (38), 23363-23367 (1996)
   PUBMED   8798539
REFERENCE   7  (bases 1 to 7205)
  AUTHORS   McCallum,S.J., Wu,W.J. and Cerione,R.A.
  TITLE     Identification of a putative effector for Cdc42Hs with high
            sequence similarity to the RasGAP-related protein IQGAP1 and a
            Cdc42Hs binding partner with similarity to IQGAP2
  JOURNAL   J Biol Chem 271 (36), 21732-21737 (1996)
   PUBMED   8702968
REFERENCE   8  (bases 1 to 7205)
  AUTHORS   Brill,S., Li,S., Lyman,C.W., Church,D.M., Wasmuth,J.J.,
            Weissbach,L., Bernards,A. and Snijders,A.J.
  TITLE     The Ras GTPase-activating-protein-related human protein IQGAP2
            harbors a potential actin binding domain and interacts with
            calmodulin and Rho family GTPases
  JOURNAL   Mol Cell Biol 16 (9), 4869-4878 (1996)
   PUBMED   8756646
REFERENCE   9  (bases 1 to 7205)
  AUTHORS   Hart,M.J., Callow,M.G., Souza,B. and Polakis,P.
  TITLE     IQGAP1, a calmodulin-binding protein with a rasGAP-related domain,
            is a potential effector for cdc42Hs
  JOURNAL   EMBO J 15 (12), 2997-3005 (1996)
   PUBMED   8670801
REFERENCE   10 (bases 1 to 7205)
  AUTHORS   Weissbach,L., Settleman,J., Kalady,M.F., Snijders,A.J.,
            Murthy,A.E., Yan,Y.X. and Bernards,A.
  TITLE     Identification of a human rasGAP-related protein containing
            calmodulin-binding motifs
  JOURNAL   J Biol Chem 269 (32), 20517-20521 (1994)
   PUBMED   8051149
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D29640.1, BC016714.1 and
            AI924000.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003870.3.
            
            Summary: This gene encodes a member of the IQGAP family. The
            protein contains four IQ domains, one calponin homology domain, one
            Ras-GAP domain and one WW domain. It interacts with components of
            the cytoskeleton, with cell adhesion molecules, and with several
            signaling molecules to regulate cell morphology and motility.
            Expression of the protein is upregulated by gene amplification in
            two gastric cancer cell lines. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.72252.1,
                                           SRR1803613.278246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268182.10/ ENSP00000268182.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6355              D29640.1           25-6379
            6356-7141           BC016714.1         294-1079
            7142-7205           AI924000.1         14-77               c
FEATURES             Location/Qualifiers
     source          1..7205
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..7205
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /note="IQ motif containing GTPase activating protein 1"
                     /db_xref="GeneID:8826"
                     /db_xref="HGNC:HGNC:6110"
                     /db_xref="MIM:603379"
     exon            1..155
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..5074
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /note="RasGAP-like with IQ motifs"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP1"
                     /protein_id="NP_003861.1"
                     /db_xref="CCDS:CCDS10362.1"
                     /db_xref="GeneID:8826"
                     /db_xref="HGNC:HGNC:6110"
                     /db_xref="MIM:603379"
                     /translation="MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYL
                     CHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTR
                     YKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLF
                     KLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALH
                     AAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNR
                     TENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALG
                     LRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAV
                     ALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
                     SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQA
                     HAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAA
                     KLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFA
                     LGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNN
                     SKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQ
                     LWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDR
                     LAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYK
                     TLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
                     IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY
                     QHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTAL
                     QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK
                     TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFL
                     SAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPD
                     AFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKF
                     RRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
                     NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAE
                     MDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPD
                     KMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRR
                     YRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMK
                     GKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGV
                     QMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK"
     exon            156..255
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..412
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..490
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..567
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..635
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..928
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1013
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1177
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1262
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1426
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1587
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1712
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1876
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1967
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2135
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2278
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2449
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2533
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2605
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2675
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2884
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3040
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3204
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3429
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3570
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3655
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3888
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4021
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4022..4124
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4260
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4348
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4561
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4728
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4729..4851
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..4960
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..7205
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6496..6501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /note="hexamer: AATAAA"
     polyA_site      6521
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
     regulatory      7186..7191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /note="hexamer: AATAAA"
     polyA_site      7205
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /note="major polyA site"
ORIGIN      
        1 gaccccggca agcccgcgca cttggcagga gctgtagcta ccgccgtccg cgcctccaag
       61 gtttcacggc ttcctcagca gagactcggg ctcgtccgcc atgtccgccg cagacgaggt
      121 tgacgggctg ggcgtggccc ggccgcacta tggctctgtc ctggataatg aaagacttac
      181 tgcagaggag atggatgaaa ggagacgtca gaacgtggct tatgagtacc tttgtcattt
      241 ggaagaagcg aagaggtgga tggaagcatg cctaggggaa gatctgcctc ccaccacaga
      301 actggaggag gggcttagga atggggtcta ccttgccaaa ctggggaact tcttctctcc
      361 caaagtagtg tccctgaaaa aaatctatga tcgagaacag accagataca aggcgactgg
      421 cctccacttt agacacactg ataatgtgat tcagtggttg aatgccatgg atgagattgg
      481 attgcctaag attttttacc cagaaactac agatatctat gatcgaaaga acatgccaag
      541 atgtatctac tgtatccatg cactcagttt gtacctgttc aagctaggcc tggcccctca
      601 gattcaagac ctatatggaa aggttgactt cacagaagaa gaaatcaaca acatgaagac
      661 tgagttggag aagtatggca tccagatgcc tgcctttagc aagattgggg gcatcttggc
      721 taatgaactg tcagtggatg aagccgcatt acatgctgct gttattgcta ttaatgaagc
      781 tattgaccgt agaattccag ccgacacatt tgcagctttg aaaaatccga atgccatgct
      841 tgtaaatctt gaagagccct tggcatccac ttaccaggat atactttacc aggctaagca
      901 ggacaaaatg acaaatgcta aaaacaggac agaaaactca gagagagaaa gagatgttta
      961 tgaggagctg ctcacgcaag ctgaaattca aggcaatata aacaaagtca atacattttc
     1021 tgcattagca aatatcgacc tggctttaga acaaggagat gcactggcct tgttcagggc
     1081 tctgcagtca ccagccctgg ggcttcgagg actgcagcaa cagaatagcg actggtactt
     1141 gaagcagctc ctgagtgata aacagcagaa gagacagagt ggtcagactg accccctgca
     1201 gaaggaggag ctgcagtctg gagtggatgc tgcaaacagt gctgcccagc aatatcagag
     1261 aagattggca gcagtagcac tgattaatgc tgcaatccag aagggtgttg ctgagaagac
     1321 tgttttggaa ctgatgaatc ccgaagccca gctgccccag gtgtatccat ttgccgccga
     1381 tctctatcag aaggagctgg ctaccctgca gcgacaaagt cctgaacata atctcaccca
     1441 cccagagctc tctgtcgcag tggagatgtt gtcatcggtg gccctgatca acagggcatt
     1501 ggaatcagga gatgtgaata cagtgtggaa gcaattgagc agttcagtta ctggtcttac
     1561 caatattgag gaagaaaact gtcagaggta tctcgatgag ttgatgaaac tgaaggctca
     1621 ggcacatgca gagaataatg aattcattac atggaatgat atccaagctt gcgtggacca
     1681 tgtgaacctg gtggtgcaag aggaacatga gaggatttta gccattggtt taattaatga
     1741 agccctggat gaaggtgatg cccaaaagac tctgcaggcc ctacagattc ctgcagctaa
     1801 acttgaggga gtccttgcag aagtggccca gcattaccaa gacacgctga ttagagcgaa
     1861 gagagagaaa gcccaggaaa tccaggatga gtcagctgtg ttatggttgg atgaaattca
     1921 aggtggaatc tggcagtcca acaaagacac ccaagaagca cagaagtttg ccttaggaat
     1981 ctttgccatt aatgaggcag tagaaagtgg tgatgttggc aaaacactga gtgcccttcg
     2041 ctcccctgat gttggcttgt atggagtcat ccctgagtgt ggtgaaactt accacagtga
     2101 tcttgctgaa gccaagaaga aaaaactggc agtaggagat aataacagca agtgggtgaa
     2161 gcactgggta aaaggtggat attattatta ccacaatctg gagacccagg aaggaggatg
     2221 ggatgaacct ccaaattttg tgcaaaattc tatgcagctt tctcgggagg agatccagag
     2281 ttctatctct ggggtgactg ccgcatataa ccgagaacag ctgtggctgg ccaatgaagg
     2341 cctgatcacc aggctgcagg ctcgctgccg tggatactta gttcgacagg aattccgatc
     2401 caggatgaat ttcctgaaga aacaaatccc tgccatcacc tgcattcagt cacagtggag
     2461 aggatacaag cagaagaagg catatcaaga tcggttagct tacctgcgct cccacaaaga
     2521 tgaagttgta aagattcagt ccctggcaag gatgcaccaa gctcgaaagc gctatcgaga
     2581 tcgcctgcag tacttccggg accatataaa tgacattatc aaaatccagg cttttattcg
     2641 ggcaaacaaa gctcgggatg actacaagac tctcatcaat gctgaggatc ctcctatggt
     2701 tgtggtccga aaatttgtcc acctgctgga ccaaagtgac caggattttc aggaggagct
     2761 tgaccttatg aagatgcggg aagaggttat caccctcatt cgttctaacc agcagctgga
     2821 gaatgacctc aatctcatgg atatcaaaat tggactgcta gtgaaaaata agattacgtt
     2881 gcaggatgtg gtttcccaca gtaaaaaact taccaaaaaa aataaggaac agttgtctga
     2941 tatgatgatg ataaataaac agaagggagg tctcaaggct ttgagcaagg agaagagaga
     3001 gaagttggaa gcttaccagc acctgtttta tttattgcaa accaatccca cctatctggc
     3061 caagctcatt tttcagatgc cccagaacaa gtccaccaag ttcatggact ctgtaatctt
     3121 cacactctac aactacgcgt ccaaccagcg agaggagtac ctgctcctgc ggctctttaa
     3181 gacagcactc caagaggaaa tcaagtcgaa ggtagatcag attcaagaga ttgtgacagg
     3241 aaatcctacg gttattaaaa tggttgtaag tttcaaccgt ggtgcccgtg gccagaatgc
     3301 cctgagacag atcttggccc cagtcgtgaa ggaaattatg gatgacaaat ctctcaacat
     3361 caaaactgac cctgtggata tttacaaatc ttgggttaat cagatggagt ctcagacagg
     3421 agaggcaagc aaactgccct atgatgtgac ccctgagcag gcgctagctc atgaagaagt
     3481 gaagacacgg ctagacagct ccatcaggaa catgcgggct gtgacagaca agtttctctc
     3541 agccattgtc agctctgtgg acaaaatccc ttatgggatg cgcttcattg ccaaagtgct
     3601 gaaggactcg ttgcatgaga agttccctga tgctggtgag gatgagctgc tgaagattat
     3661 tggtaacttg ctttattatc gatacatgaa tccagccatt gttgctcctg atgcctttga
     3721 catcattgac ctgtcagcag gaggccagct taccacagac caacgccgaa atctgggctc
     3781 cattgcaaaa atgcttcagc atgctgcttc caataagatg tttctgggag ataatgccca
     3841 cttaagcatc attaatgaat atctttccca gtcctaccag aaattcagac ggtttttcca
     3901 aactgcttgt gatgtcccag agcttcagga taaatttaat gtggatgagt actctgattt
     3961 agtaaccctc accaaaccag taatctacat ttccattggt gaaatcatca acacccacac
     4021 tctcctgttg gatcaccagg atgccattgc tccggagcac aatgatccaa tccacgaact
     4081 gctggacgac ctcggcgagg tgcccaccat cgagtccctg ataggggaaa gctctggcaa
     4141 tttaaatgac ccaaataagg aggcactggc taagacggaa gtgtctctca ccctgaccaa
     4201 caagttcgac gtgcctggag atgagaatgc agaaatggat gctcgaacca tcttactgaa
     4261 tacaaaacgt ttaattgtgg atgtcatccg gttccagcca ggagagacct tgactgaaat
     4321 cctagaaaca ccagccacca gtgaacagga agcagaacat cagagagcca tgcagagacg
     4381 tgctatccgt gatgccaaaa cacctgacaa gatgaaaaag tcaaaatctg taaaggaaga
     4441 cagcaacctc actcttcaag agaagaaaga gaagatccag acaggtttaa agaagctaac
     4501 agagcttgga accgtggacc caaagaacaa ataccaggaa ctgatcaacg acattgccag
     4561 ggatattcgg aatcagcgga ggtaccgaca gaggagaaag gccgaactag tgaaactgca
     4621 acagacatac gctgctctga actctaaggc caccttttat ggggagcagg tggattacta
     4681 taaaagctat atcaaaacct gcttggataa cttagccagc aagggcaaag tctccaaaaa
     4741 gcctagggaa atgaaaggaa agaaaagcaa aaagatttct ctgaaatata cagcagcaag
     4801 actacatgaa aaaggagttc ttctggaaat tgaggacctg caagtgaatc agtttaaaaa
     4861 tgttatattt gaaatcagtc caacagaaga agttggagac ttcgaagtga aagccaaatt
     4921 catgggagtt caaatggaga cttttatgtt acattatcag gacctgctgc agctacagta
     4981 tgaaggagtt gcagtcatga aattatttga tagagctaaa gtaaatgtca acctcctgat
     5041 cttccttctc aacaaaaagt tctacgggaa gtaattgatc gtttgctgcc agcccagaag
     5101 gatgaaggaa agaagcacct cacagctcct ttctaggtcc ttctttcctc attggaagca
     5161 aagacctagc caacaacagc acctcaatct gatacactcc cgatgccaca tttttaactc
     5221 ctctcgctct gatgggacat ttgttaccct tttttcatag tgaaattgtg tttcaggctt
     5281 agtctgacct ttctggtttc ttcattttct tccattactt aggaaagagt ggaaactcca
     5341 ctaaaatttc tctgtgttgt tacagtctta gaggttgcag tactatattg taagctttgg
     5401 tgtttgttta attagcaata gggatggtag gattcaaatg tgtgtcattt agaagtggaa
     5461 gctattagca ccaatgacat aaatacatac aagacacaca actaaaatgt catgttatta
     5521 acagttatta ggttgtcatt taaaaataaa gttcctttat atttctgtcc catcaggaaa
     5581 actgaaggat atggggaatc attggttatc ttccattgtg tttttcttta tggacaggag
     5641 ctaatggaag tgacagtcat gttcaaagga agcatttcta gaaaaaagga gataatgttt
     5701 ttaaatttca ttatcaaact tgggcaattc tgtttgtgta actccccgac tagtggatgg
     5761 gagagtccca ttgctaaaat tcagctactc agataaattc agaatgggtc aaggcacctg
     5821 cctgtttttg ttggtgcaca gagattgact tgattcagag agacaattca ctccatccct
     5881 atggcagagg aatgggttag ccctaatgta gaatgtcatt gtttttaaaa ctgttttata
     5941 tcttaagagt gccttattaa agtatagatg tatgtcttaa aatgtgggtg ataggaattt
     6001 taaagattta tataatgcat caaaagcctt agaataagaa aagctttttt taaattgctt
     6061 tatctgtata tctgaactct tgaaacttat agctaaaaca ctaggattta tctgcagtgt
     6121 tcagggagat aattctgcct ttaattgtct aaaacaaaaa caaaaccagc caacctatgt
     6181 tacacgtgag attaaaacca attttttccc cattttttct ccttttttct cttgctgccc
     6241 acattgtgcc tttattttat gagccccagt tttctgggct tagtttaaaa aaaaaatcaa
     6301 gtctaaacat tgcatttaga aagcttttgt tcttggataa aaagtcatac actttaaaaa
     6361 aaaaaaaaac tttttccagg aaaatatatt gaaatcatgc tgctgagcct ctattttctt
     6421 tctttgatgt tttgattcag tattctttta tcataaattt ttagcattta aaaattcact
     6481 gatgtacatt aagccaataa actgctttaa tgaataacaa actatgtagt gtgtccctat
     6541 tataaatgca ttggagaagt atttttatga gactctttac tcaggtgcat ggttacagcc
     6601 cacagggagg catggagtgc catggaagga ttcgccacta cccagacctt gttttttgtt
     6661 gtattttgga agacaggttt tttaaagaaa cattttcctc agattaaaag atgatgctat
     6721 tacaactagc attgcctcaa aaactgggac caaccaaagt gtgtcaaccc tgtttcctta
     6781 aaagaggcta tgaatcccaa aggccacatc caagacaggc aataatgagc agagtttaca
     6841 gctcctttaa taaaatgtgt cagtaatttt aaggtttata gttccctcaa cacaattgct
     6901 aatgcagaat agtgtaaaat gcgcttcaag aatgttgatg atgatgatat agaattgtgg
     6961 ctttagtagc acagaggatg ccccaacaaa ctcatggcgt tgaaaccaca cagttctcat
     7021 tactgttatt tattagctgt agcattctct gtctcctctc tctcctcctt tgaccttctc
     7081 ctcgaccagc catcatgaca tttaccatga atttacttcc tcccaagagt ttggactgcc
     7141 cgtcagattg ttgctgcaca tagttgcctt tgtatctctg tatgaaataa aaggtcattt
     7201 gttca
//
