LOCUS       NM_001145304            4345 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens IQ motif containing N (IQCN), transcript variant 1,
            mRNA.
ACCESSION   NM_001145304
VERSION     NM_001145304.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4345)
  AUTHORS   Li,Q., Wang,Y., Zheng,W., Guo,J., Zhang,S., Gong,F., Lu,G.X.,
            Lin,G. and Dai,J.
  TITLE     Biallelic variants in IQCN cause sperm flagellar assembly defects
            and male infertility
  JOURNAL   Hum Reprod 38 (7), 1390-1398 (2023)
   PUBMED   37140151
  REMARK    GeneRIF: Biallelic variants in IQCN cause sperm flagellar assembly
            defects and male infertility.
REFERENCE   2  (bases 1 to 4345)
  AUTHORS   Wang,Y., Chen,G., Tang,Z., Mei,X., Lin,C., Kang,J., Lian,J., Lu,J.,
            Liu,Y., Lan,F., Huang,W. and Zhang,D.
  TITLE     Loss-of-function mutations in IQCN cause male infertility in humans
            and mice owing to total fertilization failure
  JOURNAL   Mol Hum Reprod 29 (7) (2023)
   PUBMED   37184908
  REMARK    GeneRIF: Loss-of-function mutations in IQCN cause male infertility
            in humans and mice owing to total fertilization failure.
REFERENCE   3  (bases 1 to 4345)
  AUTHORS   Dai,J., Li,Q., Zhou,Q., Zhang,S., Chen,J., Wang,Y., Guo,J., Gu,Y.,
            Gong,F., Tan,Y., Lu,G., Zheng,W. and Lin,G.
  TITLE     IQCN disruption causes fertilization failure and male infertility
            due to manchette assembly defect
  JOURNAL   EMBO Mol Med 14 (12), e16501 (2022)
   PUBMED   36321563
REFERENCE   4  (bases 1 to 4345)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4345)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 4345)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4345)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC403083.1, AC008397.7, BC112932.1 and AL136867.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001145304.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392413.5/ ENSP00000376213.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               DC403083.1         59-314
            257-2901            AC008397.7         34102-36746         c
            2902-3442           BC112932.1         2885-3425
            3443-4345           AL136867.1         2856-3758
FEATURES             Location/Qualifiers
     source          1..4345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4345
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /note="IQ motif containing N"
                     /db_xref="GeneID:80726"
                     /db_xref="HGNC:HGNC:29350"
                     /db_xref="MIM:620160"
     exon            1..50
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /inference="alignment:Splign:2.1.0"
     exon            51..172
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..4263
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /note="isoform a is encoded by transcript variant 1; IQ
                     domain-containing protein N"
                     /codon_start=1
                     /product="IQ domain-containing protein N isoform a"
                     /protein_id="NP_001138776.1"
                     /db_xref="CCDS:CCDS46017.1"
                     /db_xref="GeneID:80726"
                     /db_xref="HGNC:HGNC:29350"
                     /db_xref="MIM:620160"
                     /translation="MTLQGRADLSGNQGNAAGRLATVHEPVVTQWAVHPPAPAHPSLL
                     DKMEKAPPQPQHEGLKSKEHLPQQPAEGKTASRRVPRLRAVVESQAFKNILVDEMDMM
                     HARAATLIQANWRGYWLRQKLISQMMAAKAIQEAWRRFNKRHILHSSKSLVKKTRAEE
                     GDIPYHAPQQVRFQHPEENRLLSPPIMVNKETQFPSCDNLVLCRPQSSPLLQPPAAQG
                     TPEPCVQGPHAARVRGLAFLPHQTVTIRFPCPVSLDAKCQPCLLTRTIRSTCLVHIEG
                     DSVKTKRVSARTNKARAPETPLSRRYDQAVTRPSRAQTQGPVKAETPKAPFQICPGPM
                     ITKTLLQTYPVVSVTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAQMYPGPTVTKTAP
                     HTCPMPTMTKIQVHPTASRTGTPRQTCPATITAKNRPQVSLLASIMKSLPQVCPGPAM
                     AKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQTRLPAMITKTPAQL
                     RSVATILKTLCLASPTVANVKAPPQVAVAAGTPNTSGSIHENPPKAKATVNVKQAAKV
                     VKASSPSYLAEGKIRCLAQPHPGTGVPRAAAELPLEAEKIKTGTQKQAKTDMAFKTSV
                     AVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTNASSQRHPPCLSQRP
                     LAAPLTKASSQGHLPTELTKTPSLAHLDTCLSKMHSQTHLATGAVKVQSQAPLATCLT
                     KTQSRGQPITDITTCLIPAHQAADLSSNTHSQVLLTGSKVSNHACQRLGGLSAPPWAK
                     PEDRQTQPQPHGHVPGKTTQGGPCPAACEVQGMLVPPMAPTGHSTCNVESWGDNGATR
                     AQPSMPGQAVPCQEDTVGSLLASLCAEVAGVLASQEDLRTLLAKALSQGEVWAALNQA
                     LSKEVLGATVTKALPQSMLSMALVKALSWSELRLTLSRALSRGELRAELTKVMQGKLA
                     EVLSKALTEEEWVALSQALCQGELGALLSQSWCRVALRTGTILPKAASKSTGSGVTKT
                     PALVKVACRRSPSAAWGPSLGPVRPQTSKGPADAGVVGGQSWNRAWEPARGAASWDTW
                     RNKAVVPPRRSGEPMVSMQAAEEIRILAVITIQAGVRGYLARRRIRLWHRGAMVIQAT
                     WRGYRVRRNLAHLCRATTTIQSAWRGYSTRRDQARHWQMLHPVTWVELGSRAGVMSDR
                     SWFQDGRARTVSDHRCFQSCQAHACSVCHSLSSRIGSPPSVVMLVGSSPRTCHTCGRT
                     QPTRVVQGMGQGTEGPGAVSWASAYQLAALSPRQPHRQDKAATAIQSAWRGFKIRQQM
                     RQQQMAAKIVQATWRGHHTRSCLKNTEALLGPADPSASSRHMHWPGI"
     exon            173..3336
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..4345
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4325..4330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /note="hexamer: AATAAA"
     polyA_site      4345
                     /gene="IQCN"
                     /gene_synonym="KIAA1683; SPGF78"
                     /note="major polyA site"
ORIGIN      
        1 agggctccaa gactggccgt tcagactgct aggtttagct tcaggggcag cccagggcag
       61 tgttgctgca tattgcatgg atgaaaggct gaaggctgcc tcctcttgca ggctggcttc
      121 tgagattgca ccttcttctc ctgctactcc tccaaatcta tgacccttca aggcagagct
      181 gacctgtccg gtaatcaagg caatgcagcc ggccgcctag ctacagttca cgagccagtt
      241 gtcacccagt gggcggtgca tcctccagcc cccgctcacc ccagtctcct ggacaaaatg
      301 gagaaagcgc ctccacagcc ccagcacgag ggcctcaagt ccaaggagca tcttccgcaa
      361 cagcctgccg aaggcaagac ggcgtcccgc cgcgtcccac gcctccgggc tgtggtcgag
      421 agccaggcct tcaagaacat cctggtagac gagatggaca tgatgcacgc ccgtgcagcc
      481 acgctcatcc aagccaactg gaggggctat tggctccggc agaagctgat ttcccagatg
      541 atggcggcca aggccatcca ggaggcctgg cggcgcttca acaagagaca catccttcac
      601 tccagcaagt cgttggtaaa gaaaacgagg gcggaggagg gggacatacc ttatcacgcc
      661 ccacagcagg tgcgcttcca gcatccggaa gagaaccgcc ttctgtcccc gcccatcatg
      721 gtgaacaagg agacccagtt cccttcctgt gacaatctgg tcctctgcag accccagtcg
      781 tcccccctcc tgcagccccc agcagctcag ggtaccccag agccctgtgt gcagggtcct
      841 catgctgcca gagtccgggg gctggccttc ctgccacacc agacggtcac catcagattt
      901 ccctgcccag tgagtctgga cgcaaaatgc cagccatgcc tgctgaccag aaccatcaga
      961 agcacctgcc tcgtccacat agagggtgac tcagtgaaga ccaaacgtgt aagtgcccgg
     1021 accaacaaag ccagggctcc ggagacacca ttgtccagaa ggtatgacca ggcagttacg
     1081 agaccatcca gagcccaaac ccagggccct gtgaaagcag agacccccaa agcccccttc
     1141 cagatatgtc cagggcccat gatcaccaag actctactcc agacatatcc agtggtctcc
     1201 gtgaccctgc cacagacata tccagcgtcc acgatgacca ccaccccacc caagactagc
     1261 ccagttccca aagtaacaat aatcaagacc ccagcccaga tgtatccggg gcccacagtg
     1321 accaaaactg cacctcacac atgccccatg cccacaatga ccaagatcca ggtacacccc
     1381 acagcctcca gaactggcac cccacggcag acatgccctg cgaccatcac ggcaaagaac
     1441 cgacctcagg tttcccttct ggcttccatc atgaagagcc tgccccaggt atgcccgggg
     1501 cctgcgatgg caaagacccc accccagatg cacccggtca ccaccccagc caaaaaccca
     1561 ttgcaaacat gtctgtcagc cacaatgtcc aagacttcat cccagaggag cccagttggg
     1621 gtgaccaagc cctcacccca gacccgcctg ccagccatga taaccaagac cccagcccag
     1681 ttacgctcgg tggccaccat cctcaagact ctgtgtctgg cctctccaac agtggcaaat
     1741 gtcaaggctc caccccaagt ggcggtagca gccggaactc ccaacacctc aggctccatc
     1801 catgagaacc cacccaaggc caaggccacc gtgaatgtga agcaggctgc aaaggtggtg
     1861 aaagcctcat ccccctccta tttggctgag gggaagatca ggtgcctggc tcaaccacat
     1921 ccgggaactg gggtccccag ggctgcagct gagcttcctt tggaagccga gaaaatcaag
     1981 actggcaccc agaaacaggc gaaaacagac atggcattta agaccagtgt ggcagtggaa
     2041 atggctgggg ctccatcctg gacaaaagtt gctgaggaag gggacaagcc acctcacgtg
     2101 tatgtgcctg tagacatggc tgtcaccctg ccccggggac agctggctgc cccactgacc
     2161 aatgcctcat cccagagaca tccaccctgc ctgtcccaga gaccactggc cgccccgctg
     2221 accaaggcct catctcaggg acatctgccc actgagctga ccaagacccc atccctggcc
     2281 catctggaca cctgtctgag caagatgcat tcccagacac atctggccac aggtgccgtg
     2341 aaggtccagt cccaagcgcc tctagccacc tgtctgacca agacgcagtc ccgggggcag
     2401 ccgatcacag acataaccac gtgcctcatc ccagcgcacc aggctgctga tctcagcagc
     2461 aacacccact cccaggtgct cctaacaggg tccaaggtgt ccaaccacgc ctgccagcgc
     2521 ctcggtggcc tcagcgcccc accctgggcc aagccagagg acagacagac ccagccacag
     2581 ccccacggac acgtgccggg gaagaccact caggggggac catgcccggc agcctgtgag
     2641 gtccagggta tgctggtgcc gccgatggca cccaccggcc attccacatg caacgttgag
     2701 tcctggggag acaacggagc cacacgtgcc cagccatcaa tgcccggcca ggcggtgccc
     2761 tgccaggagg acacggtagg ctccctgctg gcctccttgt gtgctgaagt agctggtgtg
     2821 ctggcatccc aggaggatct ccgcactctg ttggccaaag ccctctccca gggagaagtc
     2881 tgggcagctc tgaaccaggc cctgtccaag gaggtcctgg gtgccactgt caccaaagcc
     2941 ctgccccaga gcatgctgag catggcgctg gtgaaggcgc tgtcctggag tgagctgcgc
     3001 ctgaccctgt cccgagccct gtcccggggc gagctgcggg cggaactcac caaggtcatg
     3061 cagggtaaat tggccgaggt gcttagcaag gctttgacgg aggaggagtg ggtggctctg
     3121 agccaggccc tgtgtcaggg tgagctgggt gctctcctga gccagtcttg gtgtcgggtg
     3181 gccctgagga ctggaaccat cctccccaag gccgcctcga aatcaacagg aagcggggtg
     3241 actaagacgc cggccctggt gaaggtggcc tgcaggagga gtccatcggc cgcatggggg
     3301 ccctccctgg gccccgtgag accacagacc agcaagggcc ccgcggacgc tggtgtggtt
     3361 ggtggccaat cgtggaaccg cgcatgggag ccagccaggg gtgctgcgtc ctgggacacc
     3421 tggcgcaaca aggcggtggt gcctcccagg cggtccgggg agccaatggt gtccatgcag
     3481 gctgcagagg agatccgcat cctcgcagtg atcactatcc aggcgggcgt ccgtggctac
     3541 ctggcgcgtc gcaggatccg gctgtggcac cggggggcca tggtcatcca agctacttgg
     3601 cgcggctacc gtgtgcggcg gaacctggca cacctctgca gagccaccac gaccatccag
     3661 tctgcctggc gcggctacag cacccgccgg gaccaagccc ggcactggca gatgctccac
     3721 cccgtcacgt gggtggagct gggcagccgg gccggggtca tgtctgaccg aagctggttc
     3781 caggatggca gagccaggac agtatctgac catcgctgct tccagtcctg ccaggcacac
     3841 gcttgcagcg tctgccactc cctgagctcc aggatcggga gcccgcccag cgtggtgatg
     3901 ctagtgggct ccagccctcg cacctgtcat acctgtggac gcacacagcc cacccgtgtg
     3961 gtgcagggca tgggccaggg cactgagggc cccggggcag tgtcttgggc ctccgcctac
     4021 cagctggctg ccctgagtcc caggcagccg catcgccagg acaaagcggc cacagccatc
     4081 cagtccgcct ggaggggctt taagatccgc cagcagatga ggcagcagca aatggcagcg
     4141 aagatagttc aagccacctg gcgaggccac catacccgga gctgtctgaa gaacacagag
     4201 gcgctcttgg gaccagcaga cccctcggcc agctcacggc acatgcattg gcctggcatc
     4261 taggaccctg gctccctgca gtggggactt cgtgggaggc actcatggct ctctgggtct
     4321 aatgaataaa gtcctccaca gccta
//
