LOCUS       NM_001363507            2078 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens IQ motif containing M (IQCM), transcript variant 1,
            mRNA.
ACCESSION   NM_001363507 XM_024454307
VERSION     NM_001363507.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
            Mountain,J.L. and Do,C.B.
  TITLE     Novel associations for hypothyroidism include known autoimmune risk
            loci
  JOURNAL   PLoS One 7 (4), e34442 (2012)
   PUBMED   22493691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096756.3, AC093893.2, AC027058.9, AC108168.4 and AC097465.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001363507.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.127254.1,
                                           SRR5189667.228308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636793.2/ ENSP00000490518.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC096756.3         20407-20650         c
            245-282             AC096756.3         20118-20155         c
            283-367             AC093893.2         145766-145850       c
            368-450             AC093893.2         138487-138569       c
            451-715             AC093893.2         136355-136619       c
            716-806             AC093893.2         89489-89579         c
            807-895             AC093893.2         85229-85317         c
            896-1011            AC093893.2         24240-24355         c
            1012-1079           AC027058.9         8354-8421
            1080-1278           AC027058.9         32461-32659
            1279-1423           AC027058.9         43064-43208
            1424-1558           AC027058.9         47762-47896
            1559-1720           AC108168.4         59347-59508         c
            1721-2078           AC097465.2         148217-148574       c
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.23"
     gene            1..2078
                     /gene="IQCM"
                     /note="IQ motif containing M"
                     /db_xref="GeneID:285423"
                     /db_xref="HGNC:HGNC:53443"
     exon            1..244
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            245..282
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            283..367
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1836
                     /gene="IQCM"
                     /note="isoform 1 is encoded by transcript variant 1; iQ
                     domain-containing protein M"
                     /codon_start=1
                     /product="IQ domain-containing protein M isoform 1"
                     /protein_id="NP_001350436.1"
                     /db_xref="CCDS:CCDS87270.1"
                     /db_xref="GeneID:285423"
                     /db_xref="HGNC:HGNC:53443"
                     /translation="MTTEEAMPEKAKCPTLEITKQDFFQEAKTLIAQHYEKINENKVQ
                     GTSINVFRKKHQKPKSGKYIPLEIDKKVTRDVVQEHRAALRRICFPKELSKSEHLQEP
                     PQRISFKEPHIFSRRERCRPIDLITKGQVKLDKIMTIIEPVSKKMETAKQQHFEESRN
                     RMLELLYPFPVHLYLQPGTSNLELLKEPDKAFYDWRGFVLTRSFRLACDSRRVSFSQS
                     SSIFRDYYSKTFKTLIKKERQPIKPEPKSQPRIKGTPNKTDKLDSKVKRIGPHIEIFQ
                     VFRERKKFMITPKLIRMVTVMQAHVRGWLERKRLQRVMTKALDHGPDMKAVINMYGRL
                     IHRVRYRRGLWRTRQILNLAELEEWMDRKKFYEIMFAKREDWPKIERNELPNFFSDCG
                     HFPTQKQVDDTWDLVHQDGKEKYSELIKKSKAIEMLFTLYPPEGAHVPDSTLLKSTWL
                     RPIVNGEEGYRYIVNGHPALKRANIRVVGKLVARSIRERKMRQHYKSCKVE"
     exon            368..450
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            451..715
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            716..806
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            807..895
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1011
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1079
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1278
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1423
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1558
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1720
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..2078
                     /gene="IQCM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaagaca ggcatatgtg agaagaagca atcagaagat tggcaggatt taggaatcta
       61 tttgaaatat tcattaccta ttttgaattg gtcttaaaaa tttaaagaaa tataaagctg
      121 gataattaaa gataaataat aaaggaagaa tacaaggttt ctatgctgtg aagcaactga
      181 gattattatg attttggggc agtgaatttg tttctagaag ttttgttgga actaaggcag
      241 aaaggaagaa gaacaaatga ccttggaatg aaaaacttta aggacttgga gctcacactt
      301 taaaaaagaa gatcattcta actgcccctc atgactactg aagaggctat gcctgaaaaa
      361 gcaaaatgtc ctacattaga gatcaccaag caagactttt ttcaagaagc aaaaactctc
      421 attgcccaac attatgagaa aataaatgag aataaagttc aaggtacttc tataaatgtt
      481 tttagaaaga aacaccaaaa accgaaatct ggcaaataca tacctttgga gattgacaaa
      541 aaggtaacac gtgatgtggt gcaagaacat cgggccgcac tcagaaggat ttgctttccc
      601 aaggagcttt ccaaaagcga gcatcttcag gaacccccac aacgaatctc cttcaaggaa
      661 ccacacattt ttagtagaag agaaagatgc aggcccatag atctaattac aaaaggacaa
      721 gttaaattgg ataaaatcat gactattatt gaaccagtga gtaaaaaaat ggagacagca
      781 aagcaacagc actttgagga gtccagaaac agaatgttgg aattactcta tccctttcct
      841 gtccatcttt acttacaacc tgggacctct aacttggaac ttctgaaaga acctgacaaa
      901 gcattctatg actggagagg atttgtgctg acaaggtctt tccgtttggc ttgtgactcc
      961 cgtcgagtta gtttctctca atcatcatca atatttcggg attattattc taaaaccttt
     1021 aaaaccctta ttaaaaagga gcgacaacct atcaagccag aaccaaaatc acaacccagg
     1081 ataaaaggta ctccaaataa aactgataaa cttgacagta aagttaaaag aattggacca
     1141 cacatagaaa tcttccaagt gttccgagaa agaaaaaaat tcatgattac cccaaaattg
     1201 attagaatgg tcaccgtcat gcaggcacat gtcaggggat ggcttgaacg gaaaagattg
     1261 caaagagtaa tgaccaaggc tttggatcat ggaccagata tgaaagcagt tattaacatg
     1321 tatggcagac taatccaccg tgttagatat cgacgtggtc tttggaggac aagacaaatt
     1381 ctcaacttag cagagctaga ggagtggatg gaccgaaaaa aattctatga aataatgttt
     1441 gctaagaggg aagattggcc aaaaattgaa agaaatgagc tccccaattt cttcagtgac
     1501 tgtggtcatt tcccaactca gaaacaagtt gatgatactt gggacctggt ccatcaagat
     1561 ggcaaagaaa aatattctga actaatcaaa aagtccaaag caattgaaat gttatttaca
     1621 ctctatcctc ctgaaggtgc acatgtgcct gacagtacac tactcaagtc gacttggttg
     1681 agacccatag taaatgggga agaaggttat agatatatag taaatggaca tccagcactc
     1741 aaacgagcta acatccgggt tgttggaaag ttggtggccc gatccataag agaaaggaaa
     1801 atgagacaac attataagtc atgtaaagtt gaatgatgtt tccaacatat tattacctgt
     1861 aatagttaaa cttctctacc caaagagaca agttaacact ggaggtggat caattctgta
     1921 tgagtaggaa gaaaggataa aaatctttga atatagaaag aactttgaca agtttatcta
     1981 taatttctag tatttttgga tgaacaccat tcatttgatc tccttcataa aaaacatctc
     2041 ttttatcata atgaagtaaa cctgcagagt gtcaagta
//
