LOCUS       NM_153208               2819 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens IQ motif containing K (IQCK), transcript variant 1,
            mRNA.
ACCESSION   NM_153208 XM_005255108
VERSION     NM_153208.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Mattheisen,M., Samuels,J.F., Wang,Y., Greenberg,B.D., Fyer,A.J.,
            McCracken,J.T., Geller,D.A., Murphy,D.L., Knowles,J.A.,
            Grados,M.A., Riddle,M.A., Rasmussen,S.A., McLaughlin,N.C.,
            Nurmi,E.L., Askland,K.D., Qin,H.D., Cullen,B.A., Piacentini,J.,
            Pauls,D.L., Bienvenu,O.J., Stewart,S.E., Liang,K.Y., Goes,F.S.,
            Maher,B., Pulver,A.E., Shugart,Y.Y., Valle,D., Lange,C. and
            Nestadt,G.
  TITLE     Genome-wide association study in obsessive-compulsive disorder:
            results from the OCGAS
  JOURNAL   Mol Psychiatry 20 (3), 337-344 (2015)
   PUBMED   24821223
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Hinney,A., Albayrak,O., Antel,J., Volckmar,A.L., Sims,R.,
            Chapman,J., Harold,D., Gerrish,A., Heid,I.M., Winkler,T.W.,
            Scherag,A., Wiltfang,J., Williams,J. and Hebebrand,J.
  CONSRTM   GERAD Consortium; IGAP Consortium; GIANT Consortium
  TITLE     Genetic variation at the CELF1 (CUGBP, elav-like family member 1
            gene) locus is genome-wide associated with Alzheimer's disease and
            obesity
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 165B (4), 283-293 (2014)
   PUBMED   24788522
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002550.1, AC027130.5 and
            AC134300.3.
            
            On May 6, 2021 this sequence version replaced NM_153208.2.
            
            Summary: This gene belongs to the IQ motif-containing family of
            proteins. The IQ motif serves as a binding site for different
            EF-hand proteins such as calmodulin. This gene was identified as a
            potential candidate gene for obsessive-compulsive disorder in a
            genome-wide association study. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Feb
            2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 6 both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034823.1, SRR14038195.2428841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695302.1/ ENSP00000511791.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC002550.1         25645-25861         c
            218-282             AC002550.1         13638-13702         c
            283-412             AC002550.1         10305-10434         c
            413-510             AC002550.1         8682-8779           c
            511-563             AC027130.5         21815-21867
            564-641             AC027130.5         22002-22079
            642-726             AC134300.3         154717-154801       c
            727-838             AC134300.3         116502-116613       c
            839-2819            AC134300.3         85172-87152         c
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2819
                     /gene="IQCK"
                     /note="IQ motif containing K"
                     /db_xref="GeneID:124152"
                     /db_xref="HGNC:HGNC:28556"
     exon            1..217
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..900
                     /gene="IQCK"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein K"
                     /codon_start=1
                     /product="IQ domain-containing protein K isoform 1"
                     /protein_id="NP_694940.1"
                     /db_xref="CCDS:CCDS10580.1"
                     /db_xref="GeneID:124152"
                     /db_xref="HGNC:HGNC:28556"
                     /translation="MAAPRQIPSHIVRLKPSCSTDSSFTRTPVPTVSLASRELPVSSW
                     QVTEPSSKNLWEQICKEYEAEQPPFPEGYKVKQEPVITVAPVEEMLFHGFSAEHYFPV
                     SHFTMISRTPCPQDKSETINPKTCSPKEYLETFIFPVLLPGMASLLHQAKKEKCFERK
                     RTKFIACDFLTEWLYNQNPKRAGEPFTEFFSIPFVEERLKQHPRPPIPLSLLLTEEEA
                     ALYIQSFWRACVVRCDPEIQELRQWQKKLREAKHIHQQVKIFWAKQEQKVKCKMEDDA
                     VPAAKMKIPSS"
     exon            218..282
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            283..412
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            413..510
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            511..563
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            564..641
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            642..726
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            727..838
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     exon            839..2819
                     /gene="IQCK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCK"
                     /note="hexamer: AATAAA"
     polyA_site      1716
                     /gene="IQCK"
                     /note="major polyA site"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCK"
                     /note="hexamer: AATATA"
     polyA_site      1891
                     /gene="IQCK"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCK"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="IQCK"
     regulatory      2798..2803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCK"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="IQCK"
ORIGIN      
        1 cttccggcga acgcggttac cgtggaaacc gcggccatgg cggcaccgcg gcaaatcccc
       61 agccacatag tgcgcctcaa gcccagctgc tctacagact cgtcgttcac ccggacgccg
      121 gtgcccaccg tgtctctcgc gtcccgcgag ctgcctgtct cgtcgtggca ggtcaccgag
      181 ccgtcaagca agaatctgtg ggagcagatc tgcaaggagt atgaagctga gcagcctccc
      241 tttccagaag gatataaagt caaacaggag cctgtgatta cggttgcgcc agtagaggaa
      301 atgctttttc atggcttcag tgcagagcac tattttccgg tttcccattt caccatgatc
      361 tcacgtacac cctgtcctca agataaatcg gaaacaatca acccaaaaac atgttctccc
      421 aaagaatatt tggaaacttt catctttcct gttctgcttc ccggaatggc tagcctgctt
      481 caccaagcga agaaagaaaa atgttttgag aggaaaagaa ccaaattcat tgcctgtgat
      541 tttctgactg agtggttata caaccaaaat ccaaagaggg caggggagcc attcacagaa
      601 tttttctcca ttccatttgt ggaggagcgg ctaaagcaac acccacggcc gccaatccca
      661 ctctcgctcc tgctgacaga agaggaagca gccctctaca ttcaatcctt ctggagagcc
      721 tgtgtggttc gctgtgatcc tgagattcaa gaactgcgtc agtggcagaa gaaacttcgc
      781 gaggccaagc acattcacca gcaagtcaaa attttctggg ccaagcaaga acaaaaagtg
      841 aaatgcaaaa tggaggacga tgcagtacct gcagccaaga tgaaaattcc atcatcttaa
      901 ccatagctaa gacgtatctt tgcccattcg agcacaagtt accttgtgca aggaaaatgt
      961 ccaaatgatg ctctctctct tgtgatttct ttaacaagac ttggaacatg tgcaaatgga
     1021 atcttttctg tacaagatag gattcattgc aaacaagctt taatgcaaat agtttagaaa
     1081 agaaaggacc agtcttcact ttctgcatta tccccacatt ttattcattc atccagatta
     1141 cttcttcagt gcctcaggag tattcttcta caccagctgc tgttaaaatg tacaatgaac
     1201 tctagtccca aggaatacag aagtgctctt attaccagtt ttcccacttg tggccgcctt
     1261 tgcaaagatc catattctaa tttaagtccc caacctctga atttggtttt aagtttacct
     1321 agtgactgac tactctcttt ataaaaaaga ccttatactt aatgatcatt tccaaaggag
     1381 accactcctt aacttttact gcaaacccaa caagatgaga cacttaaacc cagacagatg
     1441 taacaaagga tttttgttgt ctaagtccca aagtattata tagaaagttc ctgcttttat
     1501 gggtaaactt attaccttaa tatgttctgt ggtttgctgt taaccaagat tctcccattt
     1561 aaaatgccac agaccgaccc tcaaggcaga tccgaaagcc tagtagttag ttgcactggg
     1621 ttgttttgac aagctaccac acgtcttaag taaatagtaa agcctttatt tttgtgttaa
     1681 gaacagcatt ttgaaaataa aacctatctg cccatggttt acagcctttt aaatttgtaa
     1741 tatttatata gtcgtttatg gtacatattg attgtcttga aatttcttta acttcttttt
     1801 tataagtatg caacagtcag ccgggggaag ataaaggtac attataaaac acacattaat
     1861 gcatttaata aatatatatt atctatcaaa agtgagcctt agctcttcat cagttaataa
     1921 aaagcacctg ctgagaactc ctgtaagctg gtatcatcat tgcatcattg gattataaaa
     1981 gccacaatgc tccctttcaa cttggggttt ggcctgaggc gttcaactca gccttggcca
     2041 accgagacca ccacccgagt tcacccttgt tcagtgggtc ctgacggcat ctgggctaaa
     2101 aaaaaaaaaa aaaaaaagca ctgggcgccc agcttccaac aaccagatct tcaactctgg
     2161 aatccctgga gatgcacaga acttcccagt ttgtaagctg tcagagctga ctcccttctc
     2221 ttcccaccct ccacctccag tggggagaaa tccaggctag aatgacaatt ttctattaaa
     2281 aggggggaca agagtggctg ttatagaccc aaagcgattt taataaccag acacggaaca
     2341 atttgtgctt acaatgagag attttgatca cagatgctct cctcccgggt cgttttcccc
     2401 aaacgagtct tgtttacaca cgcagatctt aaacagaggt gccatttaat tttgtcttta
     2461 aaccttgctc cacggggggc agctggctgc tacagtctct tggcaaagat gtctcttgat
     2521 acttttcagg tgtagtcatt agaaaaagaa cagctctctc ccttctcctc tcactcccgc
     2581 ctccgccccc attatgaagg cgttcagccc actctcaacc ttaaaagcca aaataaaaca
     2641 aaaccctaag tgcgataaca tatcagattt aaaagggggg aaaaaggtct cattaaatga
     2701 ggcttcccat ggctcaaaga tggctctgtt cttatgctgg ggaagcacga ctttccatgg
     2761 cagccatttg tgctgtgctc accttatatg cttggacaat aaagaactta gaaaacgaa
//
