LOCUS       NM_001197113            2391 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens IQCJ-SCHIP1 readthrough (IQCJ-SCHIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001197113
VERSION     NM_001197113.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Papandreou,M.J., Vacher,H., Fache,M.P., Klingler,E.,
            Rueda-Boroni,F., Ferracci,G., Debarnot,C., Piperoglou,C., Garcia
            Del Cano,G., Goutebroze,L. and Dargent,B.
  TITLE     CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1
            association with AnkG contributes to the maintenance of the axon
            initial segment
  JOURNAL   J Neurochem 134 (3), 527-537 (2015)
   PUBMED   25950943
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Martin,P.M., Carnaud,M., Garcia del Cano,G., Irondelle,M.,
            Irinopoulou,T., Girault,J.A., Dargent,B. and Goutebroze,L.
  TITLE     Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late
            component of nodes of Ranvier and axon initial segments
  JOURNAL   J Neurosci 28 (24), 6111-6117 (2008)
   PUBMED   18550753
REFERENCE   5  (bases 1 to 2391)
  AUTHORS   Kwasnicka-Crawford,D.A., Carson,A.R. and Scherer,S.W.
  TITLE     IQCJ-SCHIP1, a novel fusion transcript encoding a
            calmodulin-binding IQ motif protein
  JOURNAL   Biochem Biophys Res Commun 350 (4), 890-899 (2006)
   PUBMED   17045569
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092997.6, AK096479.1 and
            AC021654.25.
            
            On Aug 13, 2020 this sequence version replaced NM_001197113.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription from the neighboring IQ motif containing J (IQCJ) and
            schwannomin interacting protein 1 (SCHIP1) genes. Alternative
            splicing results in multiple transcript variants that are composed
            of in-frame exons from each individual gene. The resulting fusion
            products are thought to be components of the multimolecular
            complexes of axon initial segments and nodes of Ranvier, and they
            may play a role in calcium-mediated responses. [provided by RefSeq,
            Oct 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096479.1, SRR1803617.206693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 29970, 654502
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC092997.6         68320-68346
            28-802              AK096479.1         1-775
            803-803             AC021654.25        21827-21827
            804-1720            AK096479.1         777-1693
            1721-1721           AC021654.25        149144-149144
            1722-2390           AK096479.1         1695-2363
            2391-2391           AC021654.25        154346-154346
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.32-q25.33"
     gene            1..2391
                     /gene="IQCJ-SCHIP1"
                     /note="IQCJ-SCHIP1 readthrough"
                     /db_xref="GeneID:100505385"
                     /db_xref="HGNC:HGNC:38842"
     exon            1..123
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1806
                     /gene="IQCJ-SCHIP1"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif containing J-schwannomin interacting protein 1
                     read-through transcript; IQ motif containing J-schwannomin
                     interacting protein 1 fusion protein; IQCJ-SCHIP1
                     readthrough transcript protein"
                     /codon_start=1
                     /product="IQCJ-SCHIP1 readthrough transcript protein
                     isoform 1"
                     /protein_id="NP_001184042.1"
                     /db_xref="GeneID:100505385"
                     /db_xref="HGNC:HGNC:38842"
                     /translation="MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQ
                     PLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYRED
                     GMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVY
                     QKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTA
                     MPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAG
                     GLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNE
                     RESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDA
                     DDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAM
                     AKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVN
                     DLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK"
     exon            124..188
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..269
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..405
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1101
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1220
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1338
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1536
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1660
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1754
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2391
                     /gene="IQCJ-SCHIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCJ-SCHIP1"
                     /note="hexamer: AATAAA"
     polyA_site      2391
                     /gene="IQCJ-SCHIP1"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcct cacattcccc cacagtcaca ttgcgctctg tgattctgag gaatacagtg
       61 tgccagcatc cgatccagtc tcctttcacc tgcaggtgtt ccagaaactt caaaatgcgt
      121 ctggaagaac tgaaaagatt gcagaatcct ctagaacaag ttaatgatgg aaaatattca
      181 tttgaaaatc accagctggc catggatgca gagaataata ttgaaaagta tcccctcaat
      241 ctacagccct tggaatcaaa ggtgaaaatc attcagcgag catggcgaga gtacctgcag
      301 cggcaggagc ccctggggaa gaggagcccg tccccaccct ctgtctcctc agagaagctg
      361 agcagctctg tcagcatgaa caccttctcc gacagcagca cacccgatta ccgagaggat
      421 gggatggatc taggcagtga cgccggcagc agcagcagca gcagccgcgc cagttcacag
      481 tccaactcca ccaaagtgac cccttgctcc gagtgcaaat cttcatcgtc gccggggggc
      541 agcctggact tggtgtctgc cctggaggac tatgaggagc ccttcccggt ctaccagaag
      601 aaggtgattg atgagtgggc gccggaggag gacggggagg aggaggaaga ggaggacgag
      661 cgcgaccagc gagggtaccg ggatgaccgc tctccggccc gggaaccggg ggacgtaagc
      721 gccaggaccc gcagcggcgg cggcgggggc aggagcgcca ccaccgccat gccgcccccg
      781 gtgcccaacg gcaacctcca ccagcacgac ccccaggacc tcaggcacaa tggcaacgtg
      841 gtggtggctg gccggccgag ctgttcccgg ggcccccgcc gggcgatcca aaagccccag
      901 ccggctgggg gccggcgcag tggccgcggc ccggcggctg gggggctctg ccttcagccc
      961 ccagacggcg ggacgtgcgt ccccgaagag cccccggtgc cacctatgga ttgggaggcg
     1021 ctggagaagc atctggccgg gctgcagttc cgggagcagg aggtacggaa ccagggccag
     1081 gcgaggacca actccacctc cgcacagaaa aatgagagag agtctatcag acagaagttg
     1141 gcacttggaa gcttctttga tgatggccca ggaatttata ccagctgtag caaaagtggg
     1201 aagccaagcc tttcctcccg actgcagagt gggatgaact tgcagatatg ctttgtcaac
     1261 gacagtggca gtgataagga cagtgatgct gatgacagta agactgaaac cagcttggac
     1321 acccccttgt ctcccatgag caaacagagt tcttcctatt ctgatagaga cactactgaa
     1381 gaggagtctg aatccttgga tgacatggac ttccttacaa ggcaaaagaa attgcaagct
     1441 gaagccaaaa tggcccttgc catggccaaa ccaatggcca aaatgcaagt agaagtggag
     1501 aaacagaaca ggaaaaagtc tcccgtcgct gatcttctgc cacacatgcc tcatataagt
     1561 gaatgcttga tgaaaagaag tttaaaaccc accgacctga gagacatgac tattgggcag
     1621 ctacaagtga tagtcaatga tctccattcc cagatagaaa gcttgaatga agagttggtc
     1681 cagctgcttc tcatccgaga tgagctgcac acagagcagg atgccatgct ggtggacatt
     1741 gaagacttga ccagacatgc tgaaagtcag cagaagcaca tggcagagaa aatgcctgca
     1801 aagtgaaaag aagccattca accagagaac aagctagaat ttattttgct tctgtggttg
     1861 taaaaatgct gttgctaaag gtggcgcaga aacaaatatc agtgttagtc attgataatg
     1921 tctgaagctt aatgtccagt gattggcctt tgcttcttaa tttattttaa ttttttactt
     1981 gtgccactta atatcaggca ttttaataaa atattgttac aaaaaatgta cagtactgac
     2041 accaccacaa atcatggtta ataaaagaga gtagttttaa ctttattttt atttgtttag
     2101 agattttaag ttggaacagt attttcccat tgactacttt tcattcttca ctgtagtttt
     2161 aaagaagaac tgtaaatgac ggtgctatac aagtcaaaaa atacatgcct gcctcgtagt
     2221 gaagttgtag ctctccgtaa tatgtatatt ttactcagtt ttcaacattt tgtgaatgtt
     2281 gactacctga agttcctttt tagatgtgct attaacattc tgttggattc agagggttcc
     2341 ttgaaagttt tatgtataaa tatgtaaaat aaaaattaaa actttgtttc a
//
