LOCUS       NM_001042706            1469 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IQ motif containing J (IQCJ), transcript variant 2,
            mRNA.
ACCESSION   NM_001042706
VERSION     NM_001042706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1469)
  AUTHORS   Vallee Marcotte,B., Guenard,F., Cormier,H., Lemieux,S., Couture,P.,
            Rudkowska,I. and Vohl,M.C.
  TITLE     Plasma Triglyceride Levels May Be Modulated by Gene Expression of
            IQCJ, NXPH1, PHF17 and MYB in Humans
  JOURNAL   Int J Mol Sci 18 (2), 257 (2017)
   PUBMED   28134766
  REMARK    GeneRIF: A genome-wide association study (GWAS) identified loci
            associated with the plasma triglyceride (TG) response to omega-3
            fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1469)
  AUTHORS   Vallee Marcotte,B., Cormier,H., Guenard,F., Rudkowska,I.,
            Lemieux,S., Couture,P. and Vohl,M.C.
  TITLE     Novel Genetic Loci Associated with the Plasma Triglyceride Response
            to an Omega-3 Fatty Acid Supplementation
  JOURNAL   J Nutrigenet Nutrigenomics 9 (1), 1-11 (2016)
   PUBMED   27160456
  REMARK    GeneRIF: identification of SNPs within the IQCJ, NXPH1, PHF17 and
            MYB genes partly explaining the large interindividual variability
            observed in plasma triglyceride levels in response to an n-3 fatty
            acid supplementation
REFERENCE   3  (bases 1 to 1469)
  AUTHORS   Martin,P.M., Carnaud,M., Garcia del Cano,G., Irondelle,M.,
            Irinopoulou,T., Girault,J.A., Dargent,B. and Goutebroze,L.
  TITLE     Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late
            component of nodes of Ranvier and axon initial segments
  JOURNAL   J Neurosci 28 (24), 6111-6117 (2008)
   PUBMED   18550753
REFERENCE   4  (bases 1 to 1469)
  AUTHORS   Kwasnicka-Crawford,D.A., Carson,A.R. and Scherer,S.W.
  TITLE     IQCJ-SCHIP1, a novel fusion transcript encoding a
            calmodulin-binding IQ motif protein
  JOURNAL   Biochem Biophys Res Commun 350 (4), 890-899 (2006)
   PUBMED   17045569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA305468.1 and DQ309554.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001042706.2.
            
            Transcript Variant: This variant (2) uses an alternate 3' exon and
            thereby differs in the 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (CaMBPv2) has a distinct and shorter
            C-terminus, compared to isoform CaMBPv1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ309554.1, DA178041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397832.7/ ENSP00000380932.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA305468.1         72-80
            10-1469             DQ309554.1         1-1460
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.32"
     gene            1..1469
                     /gene="IQCJ"
                     /note="IQ motif containing J"
                     /db_xref="GeneID:654502"
                     /db_xref="HGNC:HGNC:32406"
                     /db_xref="MIM:611622"
     exon            1..123
                     /gene="IQCJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..453
                     /gene="IQCJ"
                     /note="isoform CaMBPv2 is encoded by transcript variant 2;
                     IQ domain-containing protein J; calmodulin binding
                     protein"
                     /codon_start=1
                     /product="IQ domain-containing protein J isoform CaMBPv2"
                     /protein_id="NP_001036171.1"
                     /db_xref="CCDS:CCDS46947.1"
                     /db_xref="GeneID:654502"
                     /db_xref="HGNC:HGNC:32406"
                     /db_xref="MIM:611622"
                     /translation="MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQ
                     PLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPVSVMF
                     LFLCPDLTFN"
     exon            124..188
                     /gene="IQCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            189..269
                     /gene="IQCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            270..1469
                     /gene="IQCJ"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcgcct cacattcccc cacagtcaca ttgcgctctg tgattctgag gaatacagtg
       61 tgccagcatc cgatccagtc tcctttcacc tgcaggtgtt ccagaaactt caaaatgcgt
      121 ctggaagaac tgaaaagatt gcagaatcct ctagaacaag ttaatgatgg aaaatattca
      181 tttgaaaatc accagctggc catggatgca gagaataata ttgaaaagta tcccctcaat
      241 ctacagccct tggaatcaaa ggtgaaaatc attcagcgag catggcgaga gtacctgcag
      301 cggcaggagc ccctggggaa gaggagcccg tccccaccct ctgtctcctc agagaagctg
      361 agcagctctg tcagcatgaa caccttctcc gacagcagca cacccgtgag tgtcatgttt
      421 ctttttctat gtcctgactt gacattcaac tgaaagccta gactttggtt ctaagagaga
      481 aatcttggga tgtgagcagg tggtttgtga cagtgaagat ctatgtagct tatttgctac
      541 ccaggaaccc atggtgagag ttttgtcacc tcaaaataaa gacacaattc ataagcacaa
      601 agtgaacttt atcaagtctg gagaaaatag attgcattta tgtgttctca tttctctatt
      661 atggaggtat cttttttgct tttctttata atagcatatt tcttttagta tgtgctgtgt
      721 gtttctttta ttgtgtggtg ctaatatgat agaagataag attggttata aggagtagaa
      781 agagaacttt taccagaaga attgaaagtg gtcacacact caggggttgc aacttaaatg
      841 tctccagggg ccaggtaagt caccctcatg actgaggtgg ctgagctgtg cccctggcta
      901 cacggagaac atagacctca cctgaagggc agcgcacttg gctcctgaca atgtgacacc
      961 atgtggcgat acaggcaggc atggccaaat gtgattttct ttcttcagga catgtcagaa
     1021 atctgcattt ttaagtgtta gcagccagta agaaaattta aaaggtaaag taagcatgcc
     1081 tacagaccac aattgaccta caggccacca gtttaagaaa tctgagatag agagttaagg
     1141 aataagggaa tctgctggaa gtctttattt ttaaaaaaca ccaaaagtgg gaagaaatca
     1201 gtgatgaggg atttatgaac caggattttg tggatttaag cattgtgata atttgtaacc
     1261 agtcactgaa atgctgaaaa gttagagaaa tgaagtaatt acacaagtat attacttcca
     1321 aaaatttttc ttttactttt ggttatcatg tttattctgt ggtaaaaagg tttcccaaca
     1381 ctcaacgcaa tgtattcttt ttgggatcag gtaaaagtta ctgtatttga aatgttttca
     1441 gatggttgca ttgcatattc ttcaataaa
//
