LOCUS       NM_001031715            4253 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IQ motif containing H (IQCH), transcript variant 1,
            mRNA.
ACCESSION   NM_001031715
VERSION     NM_001031715.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4253)
  AUTHORS   Navarrete-Lopez,P., Lombo,M., Maroto,M., Pericuesta,E.,
            Fernandez-Gonzalez,R., Ramos-Ibeas,P., Parra,M.T., Viera,A.,
            Suja,J.A. and Gutierrez-Adan,A.
  TITLE     An ancient testis-specific IQ motif-containing H gene regulates
            specific transcript isoform expression during spermatogenesis
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36975404
REFERENCE   2  (bases 1 to 4253)
  AUTHORS   Yin,L.L., Li,J.M., Zhou,Z.M. and Sha,J.H.
  TITLE     Identification of a novel testis-specific gene and its potential
            roles in testis development/spermatogenesis
  JOURNAL   Asian J Androl 7 (2), 127-137 (2005)
   PUBMED   15897968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110292.6, AC106000.6 and AC016355.8.
            
            On May 17, 2019 this sequence version replaced NM_001031715.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014282.2, BC048964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335894.9/ ENSP00000336861.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC110292.6         147064-147225       c
            163-285             AC110292.6         140617-140739       c
            286-380             AC110292.6         138795-138889       c
            381-498             AC110292.6         122499-122616       c
            499-619             AC110292.6         64916-65036         c
            620-748             AC110292.6         57820-57948         c
            749-825             AC110292.6         44590-44666         c
            826-864             AC110292.6         42126-42164         c
            865-1416            AC110292.6         29349-29900         c
            1417-1483           AC110292.6         28578-28644         c
            1484-1567           AC110292.6         16992-17075         c
            1568-1743           AC110292.6         13005-13180         c
            1744-2016           AC110292.6         6448-6720           c
            2017-2208           AC110292.6         1706-1897           c
            2209-2329           AC106000.6         41856-41976         c
            2330-2616           AC106000.6         37330-37616         c
            2617-2787           AC016355.8         123136-123306       c
            2788-2910           AC016355.8         112615-112737       c
            2911-2972           AC016355.8         98369-98430         c
            2973-3081           AC016355.8         94067-94175         c
            3082-4253           AC016355.8         86629-87800         c
FEATURES             Location/Qualifiers
     source          1..4253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..4253
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="IQ motif containing H"
                     /db_xref="GeneID:64799"
                     /db_xref="HGNC:HGNC:25721"
                     /db_xref="MIM:612523"
     exon            1..162
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..3195
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein H; testis development protein
                     NYD-SP5"
                     /codon_start=1
                     /product="IQ domain-containing protein H isoform 1"
                     /protein_id="NP_001026885.2"
                     /db_xref="CCDS:CCDS32273.1"
                     /db_xref="GeneID:64799"
                     /db_xref="HGNC:HGNC:25721"
                     /db_xref="MIM:612523"
                     /translation="MAQNTENHDPVGSILIQIHEDLYQLKEKLTKFSPEEKGETLDIQ
                     SLETAIKRTEVGLRIHIEKYLNVVNQNVLTTSVNDESLYTPQASKWLLPTVIDQKSFI
                     FPQESEGTFWQPQRQHSSSLPVFPRAKIKVSKLIKGSNISSLTVLPSSHCTDPYFTPI
                     PVLQADAHKGILSMIERGLIPPTARITFQNPPITPRAAPLHSFDEARKIPTVATFTIP
                     REPPPSPAEVKFFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFLIYDGV
                     IDNTAPDFLAFKEHFSLAWGGIFSLLEHVEKFLRNYAIPEVKIKGNNLVALLPEFELT
                     NKLTRYDLLSVLEDPAHVQMLINLPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFY
                     RQQKWASGVIAIAWLLYCHKTRLKKILKESRQRHLENFRIRAKHLAANWNRIRTSRRT
                     IIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDANVNVIYICSHHMNDELVLYYK
                     KILSLHAAVKSGNLEDRSDLQDRFKIITPEAVNIFPKHHMCLATHLMYSPKAIKRIKN
                     LIRGTEAYIVSGLLHRDDLAVADMLDIPILGSEPELAHLYSTKSGGKRVFDSANVAVP
                     PGIYDIYSQQQMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVL
                     KESSRYGLEDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQG
                     GVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVDPQV
                     LTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTL
                     YLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLV
                     FHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLF
                     IIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSKDDKNLSKPKK"
     exon            163..285
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            286..380
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            381..498
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..619
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            620..748
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            749..825
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            826..864
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1416
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1483
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1567
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1743
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2016
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2208
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2329
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2616
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2787
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2910
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..2972
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3081
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..4253
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3611..3616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="major polyA site"
     regulatory      4228..4233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="hexamer: AATAAA"
     polyA_site      4253
                     /gene="IQCH"
                     /gene_synonym="NYDSP5"
                     /note="major polyA site"
ORIGIN      
        1 ggaacaggcc aggtcgcgcg cggtgttgcc atggggacga gcggctccgg ctgaaggttt
       61 ccgtgcttgg aaaccgcgcc tccgcggagg tagccgttcc ctgacctagc catggcacag
      121 aacactgaaa accacgaccc tgtcggatcc atcttaatcc agatccatga agacctttat
      181 cagttaaagg agaaattaac aaaattctca cctgaggaaa aaggagagac tctagacatt
      241 cagagtcttg aaacagcaat caaaaggact gaagtggggt taagaattca cattgagaag
      301 tatttaaatg ttgtaaacca gaatgtatta acgacttctg ttaatgatga gagcttatat
      361 actccccagg cttccaaatg gttacttcca actgtaattg atcagaaatc atttattttc
      421 cctcaggaat ctgagggtac attttggcaa ccccaaagac agcacagttc atctctgcct
      481 gtctttccaa gagcaaagat aaaggtttcg aagttaatca aagggtctaa catatccagc
      541 ctcacggttc tgccatcttc tcattgcaca gatccctatt tcactcctat accagtctta
      601 caagcagatg cccacaaagg gattttaagt atgatagaac gagggctgat tccaccaaca
      661 gcaaggatta cctttcagaa tccacccatt acacccagag cagctcctct gcatagtttt
      721 gatgaagcac gtaagattcc aactgtagcc actttcacta tacctcggga accacctcca
      781 tctccagcag aagtgaagtt ctttcccaag aaacaaagat caaaggggaa aagcagaagg
      841 tcaagaggac atcatgatag gaaggccatg aaagtcaaaa cacctttgag agccctgaaa
      901 tcactgtggg attatgactt tttaatttat gatggtgtca tagacaatac agccccagac
      961 ttcttagcat tcaaggaaca ttttagctta gcttggggag gtattttttc tctcttggaa
     1021 cacgtcgaga agtttctcag gaactatgct ataccagaag tcaaaataaa agggaataat
     1081 ttggtggccc tccttccaga gtttgagctg acgaataaac ttaccagata tgaccttctc
     1141 tcagtgttag aggacccagc tcatgtccaa atgctgataa atcttccagg gcaaaggtac
     1201 aagggccaag atggaaattc ggaggccgcc atgaagatcc aagccacatg gaaatgctac
     1261 aaagcaagaa aattcttcct cttttatcgc cagcagaagt gggcatcagg tgtgattgcc
     1321 attgcttggc tgttatattg ccataagact cgactaaaga agatactaaa ggaatcacgt
     1381 cagagacacc tggagaattt tcgcattcga gccaagcatc tggcagccaa ctggaatcgc
     1441 atcaggacct ccaggaggac tattatccat atcccatcat tagggtattc ccagcctgtg
     1501 agagaacata ttgccgattt caacacacag cagaacatgc agctggggag gctgtgtgac
     1561 atcttagatg ccaatgtgaa tgtcatctac atctgctccc atcatatgaa tgacgagtta
     1621 gtgctgtatt acaaaaaaat cctaagtcta catgcagccg tcaaatctgg gaaccttgag
     1681 gacagaagtg acctgcagga caggttcaaa attatcacac ctgaagctgt aaacatcttc
     1741 cctaagcatc atatgtgcct ggccactcac ctgatgtaca gtcccaaggc aatcaaaaga
     1801 ataaaaaatc tcatccgagg aacagaggcc tacatcgtca gcgggctcct ccacagagat
     1861 gatttagctg tggccgatat gttagacata cccatcctgg gctctgagcc tgaactagct
     1921 catctttata gtaccaaatc tggaggcaaa cgtgtctttg acagtgccaa tgtggcagtt
     1981 cctcctggaa tatatgatat ttatagtcag caacagatga tagagcagct gagtcagctg
     2041 ataactgatc acctgcaaat acagcgttgg ctctttaaaa tggactctga gttccgagga
     2101 aatgggactg cattttgtga tattccttcc tacctaaagt gctacaaatg ggtgctaaag
     2161 gagagtagca gatatggcct tgaagactgg agaaagaaat gggcacaaga gccagctttg
     2221 gtgaagatct ctgaggagct ggcgggcatt ttagcacagc acgcacagcc agtcaatgag
     2281 aaacggttcc cgacgtggag gaaattcctc caaacatttc tcagtcaagg gggtgtgatc
     2341 gaagcattcc cacctgcaga caatgtcacc aacctcacag tggacatgct gatagagccc
     2401 aacgggaaaa tcagcgtgct gtcgacaggg gaccagcttc atgctgaaag ccccttcatc
     2461 tcctctggta ccaccgtgcc tcagacctca gtggatcccc aagttctcac ttatttgtgc
     2521 ctccaaattg gaaaagcctg cagaatgaga gatgtggttg gttacttttc gatagatctg
     2581 gtgactttta tagatccaag caccttggaa caacaggtgt gggcaaccgg ccttaacctc
     2641 gcatatagtg accagctggc cctgactcaa ctcaccttat acctgacaaa cggccatctg
     2701 gattgcagtt tgagcaccct ggaagtgccc cgctttgttc caaaggaaag gaagaaaacc
     2761 aaatgcatga gtgcgctgtc aatgccgatg ctggcaacca gtcgctatgc agtgatgacc
     2821 acccagctaa gacacagcaa tctctcactg gttttccact atgtttttct ccagatctgt
     2881 agggcccatg gcattggcta tgatgttgag gaaaggcaag gaactgtttt tatattatat
     2941 gagcacctga agagacacaa gttgggaatg ttaacaatcg gcgaggatct ccagggggtc
     3001 ctcatgacct ttgctcgcca tctcttcatc atccatcaag aaatatcagc acctaatatg
     3061 caaggcgaga ccaattttaa gaccaccatt gctgatattg aaactattct aagagtaaca
     3121 aaggaaaaca aaatgagatt tgaagaggag caacagtcca aagatgataa aaacctctct
     3181 aaacccaaga aatgatcctg gaatacagta cataacaatt tggatcccag tctggaataa
     3241 aaagggcaat ttttttttct gttagaaata aaagccaggg gaaattggtt tgctttgtgt
     3301 gctaggaggt gaatcagaac agattataat gaaatgctct ttttaaaaca ttgtttatta
     3361 agtgatctta ttttatttat taaaccaaaa cttatttgtg ttttcatttg agagtgttga
     3421 acaatccctt cttcttctca aactcagaaa aaagtaatct gataaaagaa gaaagttaaa
     3481 agtcttactg atatcacctc cgcatttact tcctcatagg cctcaggatt atgtagcttt
     3541 tattttttat gttttataaa gttttctcct atttctaata gtccatcgat cttctgcatt
     3601 tataggtttg aataaaggct taagaattgc tatttgtcaa aacacaaatg cctttttttc
     3661 aaagcttcaa attatattga aattatattt atatgaattt ttaagtgact atcattcatc
     3721 gtgtttttgt tataccaagc cactattgtc tgctattgtt gccatttttc aaaaagtagg
     3781 ataagccagc atctagttaa ccaaagcatc agaatgtatc taggtggcag tatctgctct
     3841 tagtttaaga tggagtgtag ctcgagctct gtagcttgaa taaacatttg tattctctag
     3901 ttctccattt aatacagcag taggattttt tcaagtttag ttcaacatta tactaccttt
     3961 aaaaaggcag actgttaaga ttgtagtagt gctgactcta actttcagca ttcacttcat
     4021 aattgtccaa aaatatttcc acatcagtga gctttactga agggtgaaat aaaagcaaat
     4081 tacaacacca aaaccattat tgttttaaag aatgaccttt atgtctataa aaatatttta
     4141 gtgtattggg gaaaggaata ggatttttac ctgtggaatt tcaataattt gttaactgtg
     4201 attcagccac aggctaagag tttctgtaat aaaattaaca tttgtgtgtg tca
//
