LOCUS       NM_032263               2232 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens IQ motif containing G (IQCG), transcript variant 1,
            mRNA.
ACCESSION   NM_032263 NM_025111
VERSION     NM_032263.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Pan,M.M., Zhang,Q.Y., Wang,Y.Y., Liu,P., Ren,R.B., Huang,J.Y.,
            Chen,L.T., Xi,X.D., Chen,Z. and Chen,S.J.
  TITLE     Human NUP98-IQCG fusion protein induces acute myelomonocytic
            leukemia in mice by dysregulating the Hox/Pbx3 pathway
  JOURNAL   Leukemia 30 (7), 1590-1593 (2016)
   PUBMED   26675333
  REMARK    GeneRIF: human NUP98-IQCG fusion protein could induce fatal and
            transplantable acute myelomonocytic leukemia in a mouse model
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Chen,L.T., Liang,W.X., Chen,S., Li,R.K., Tan,J.L., Xu,P.F.,
            Luo,L.F., Wang,L., Yu,S.H., Meng,G., Li,K.K., Liu,T.X., Chen,Z. and
            Chen,S.J.
  TITLE     Functional and molecular features of the calmodulin-interacting
            protein IQCG required for haematopoiesis in zebrafish
  JOURNAL   Nat Commun 5, 3811 (2014)
   PUBMED   24787902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Harris,T.P., Schimenti,K.J., Munroe,R.J. and Schimenti,J.C.
  TITLE     IQ motif-containing G (Iqcg) is required for mouse spermiogenesis
  JOURNAL   G3 (Bethesda) 4 (2), 367-372 (2014)
   PUBMED   24362311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK001737.1, BC016156.1, AL136889.1 and BC004816.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032263.4.
            
            Transcript Variant: Variants 1 through 3 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136889.1, SRR1660807.234043.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265239.11/ ENSP00000265239.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CK001737.1         32-55
            25-1533             BC016156.1         1-1509
            1534-1786           AL136889.1         1546-1798
            1787-2232           BC004816.1         1177-1622
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2232
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="IQ motif containing G"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
     exon            1..147
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            148..338
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            339..405
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1729
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="isoform a is encoded by transcript variant 1; IQ
                     domain-containing protein G; dynein regulatory complex
                     subunit 9; dynein regulatory complex protein 9"
                     /codon_start=1
                     /product="dynein regulatory complex protein 9 isoform a"
                     /protein_id="NP_115639.1"
                     /db_xref="CCDS:CCDS3331.1"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
                     /translation="MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIE
                     IIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLE
                     GTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIM
                     TTETLKKIQIDRQFFSDVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEK
                     GRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQ
                     IAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKY
                     DKDTEMKQNELNALKATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLL
                     ELKSVIKLQAWWRGTMIRREIGGFKMPKDKVDSKDSKGKGKGKDKRRGKKK"
     exon            406..679
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            680..912
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1041
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1123
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1285
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1360
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1492
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1594
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2232
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="major polyA site"
ORIGIN      
        1 agcgggcgtt ggccgtatgt gggtgtcttg aggcagtttt tcagttcttt catttaccaa
       61 agtgacatgc acctactagg tgccaggtgt ttagacgtac atacaaccct ctgcaaaatc
      121 tttcagtgta gtcctctgta tgaaaagttt ccagccaaga attgccactg cacctgagat
      181 aagggggatc ctggccatta aggaaacctt gccttcgaaa ctgagccgtg aggaactata
      241 caaaatggga aattgggaca aatcccagtg gctcatgaca ctaagaagta aaattacgaa
      301 ctcactgagc tggaagtcat tcaacgggaa ttgaataggt aactgcactt ttgtgagatt
      361 ataaatatac cacggagggt aacgaagcta cagaagaatg gaagaagaca gcctggaaga
      421 ctcaaacctt cctccaaaag tttggcattc tgagatgacg gtgtcagtga caggcgaacc
      481 acctagtacc gtagaagaag aaggaatacc taaagaaaca gacatagaaa tcatcccaga
      541 aatcccggaa actctagagc cactgtccct tccagatgtg ctgaggatct cggcagttct
      601 ggaggacacc acagaccagc tctctattct gaactacatc atgcccgttc agtacgaagg
      661 gagacagagc atctgcgtga aaagcagaga aatgaatcta gaaggaacga atctagacaa
      721 acttccaatg gcctcaacaa tcacaaaaat acccagtccg ttaataactg aggaaggacc
      781 caacttgcca gaaatcagac acagaggccg gttcgctgtg gagtttaaca aaatgcagga
      841 tcttgtcttc aaaaaaccta caaggcagac catcatgact acggagacac tgaagaaaat
      901 tcagattgat aggcagtttt tcagcgatgt gattgcagat accattaagg agttgcaaga
      961 ttcggccact tacaacagtc tcctgcaagc tttgagcaaa gagagggaaa acaaaatgca
     1021 tttctatgac atcattgcca gggaggaaaa aggaagaaaa cagataatat cacttcaaaa
     1081 acagctaatt aatgtcaaaa aggaatggca atttgaagtc cagagtcaga atgagtatat
     1141 tgctaacctc aaggaccaac tgcaagagat gaaggcaaaa tccaacttgg agaatcgcta
     1201 catgaaaacc aataccgagc tgcagattgc ccagacccag aaaaagtgta acagaacaga
     1261 ggaactcttg gtggaagaga ttgagaaact caggatgaaa accgaagaag aggcccggac
     1321 tcatacagag attgaaatgt tccttagaaa ggagcagcag aaacttgagg agaggctgga
     1381 gttctggatg gagaaatacg ataaggacac agaaatgaaa cagaatgaac taaatgctct
     1441 caaagccaca aaggccagtg acttagcaca ccttcaagac ctggcaaaga tgataagaga
     1501 gtatgaacag gtcatcattg aagatcgtat agaaaaggag aggagcaaga agaaggtaaa
     1561 acaggatctc ttggaattaa agagcgttat aaagctccag gcctggtggc gaggcactat
     1621 gatacggaga gaaattggtg gtttcaagat gcctaaagac aaagttgata gcaaggattc
     1681 aaaaggcaaa ggtaaaggca aggataagag gagaggcaag aagaagtgac caagttctct
     1741 tttgtgtttt ctgctggtat tctggaggtg ggaaggactt ggagagagtt aagaaacacc
     1801 tggtacctca aagatgactc atctacaggt tgtttcctat tgagactttc ccagggaagc
     1861 ctgatttcac tttgcctgtt aatttcactc tgcctgttag gtgggttttc aaaccctgat
     1921 ttaggattac accattgact tagggcttcc tcataccttg ctgggaagaa gtttctagta
     1981 gtcctgtgaa gattcattct tcttgctctt tctcagcaga acaaaggagt tcactggctt
     2041 agctacagtg acgcattgaa acttgagtaa ttcctgtaat gtcagatttt gattttaccc
     2101 aatttgtctg tagtgaaaaa actcttatga gcaaaagtat tcagtaggaa ttacaatatg
     2161 atgttattag ctgtccagca taatatatac acagcaaagt tttaataaat gttggttcct
     2221 gcctgccttt ta
//
