LOCUS       NM_001323030            1270 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens IQ motif containing G (IQCG), transcript variant 6,
            mRNA.
ACCESSION   NM_001323030
VERSION     NM_001323030.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Pan,M.M., Zhang,Q.Y., Wang,Y.Y., Liu,P., Ren,R.B., Huang,J.Y.,
            Chen,L.T., Xi,X.D., Chen,Z. and Chen,S.J.
  TITLE     Human NUP98-IQCG fusion protein induces acute myelomonocytic
            leukemia in mice by dysregulating the Hox/Pbx3 pathway
  JOURNAL   Leukemia 30 (7), 1590-1593 (2016)
   PUBMED   26675333
  REMARK    GeneRIF: human NUP98-IQCG fusion protein could induce fatal and
            transplantable acute myelomonocytic leukemia in a mouse model
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Chen,L.T., Liang,W.X., Chen,S., Li,R.K., Tan,J.L., Xu,P.F.,
            Luo,L.F., Wang,L., Yu,S.H., Meng,G., Li,K.K., Liu,T.X., Chen,Z. and
            Chen,S.J.
  TITLE     Functional and molecular features of the calmodulin-interacting
            protein IQCG required for haematopoiesis in zebrafish
  JOURNAL   Nat Commun 5, 3811 (2014)
   PUBMED   24787902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Harris,T.P., Schimenti,K.J., Munroe,R.J. and Schimenti,J.C.
  TITLE     IQ motif-containing G (Iqcg) is required for mouse spermiogenesis
  JOURNAL   G3 (Bethesda) 4 (2), 367-372 (2014)
   PUBMED   24362311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA566107.1 and BC068973.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001323030.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068973.1, BM908080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                DA566107.1         1-40
            41-682              BC068973.1         1-642
            683-1270            BC068973.1         644-1231
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1270
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="IQ motif containing G"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
     exon            1..87
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            88..164
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            165..231
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1156
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="isoform d is encoded by transcript variant 6; IQ
                     domain-containing protein G; dynein regulatory complex
                     subunit 9; dynein regulatory complex protein 9"
                     /codon_start=1
                     /product="dynein regulatory complex protein 9 isoform d"
                     /protein_id="NP_001309959.1"
                     /db_xref="CCDS:CCDS82898.1"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
                     /translation="MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIE
                     IIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLE
                     GTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIM
                     TTETLKKIQIDRQFFSDVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEK
                     GRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQ
                     IAQTQKKCNRTEELLVEEIEVIPGTLAKNPGDGN"
     exon            232..505
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            506..738
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            739..867
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            868..949
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1270
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1251..1256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="hexamer: AATAAA"
     polyA_site      1270
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="major polyA site"
ORIGIN      
        1 agtttacttc ctgcgtcccc ggacgccgta ggtggaaagg cgaaccctga gtggaggatg
       61 ttcccgctgc ctaaagaatg attgactgta tgaggaggac tgcctgcagg aggctttatc
      121 gcccttttag gagaactcgt ttagctgcct cgtgtccgca cctagtaact gcacttttgt
      181 gagattataa atataccacg gagggtaacg aagctacaga agaatggaag aagacagcct
      241 ggaagactca aaccttcctc caaaagtttg gcattctgag atgacggtgt cagtgacagg
      301 cgaaccacct agtaccgtag aagaagaagg aatacctaaa gaaacagaca tagaaatcat
      361 cccagaaatc ccggaaactc tagagccact gtcccttcca gatgtgctga ggatctcggc
      421 agttctggag gacaccacag accagctctc tattctgaac tacatcatgc ccgttcagta
      481 cgaagggaga cagagcatct gcgtgaaaag cagagaaatg aatctagaag gaacgaatct
      541 agacaaactt ccaatggcct caacaatcac aaaaataccc agtccgttaa taactgagga
      601 aggacccaac ttgccagaaa tcagacacag aggccggttc gctgtggagt ttaacaaaat
      661 gcaggatctt gtcttcaaaa aacctacaag gcagaccatc atgactacgg agacactgaa
      721 gaaaattcag attgataggc agtttttcag cgatgtgatt gcagatacca ttaaggagtt
      781 gcaagattcg gccacttaca acagtctcct gcaagctttg agcaaagaga gggaaaacaa
      841 aatgcatttc tatgacatca ttgccaggga ggaaaaagga agaaaacaga taatatcact
      901 tcaaaaacag ctaattaatg tcaaaaagga atggcaattt gaagtccaga gtcagaatga
      961 gtatattgct aacctcaagg accaactgca agagatgaag gcaaaatcca acttggagaa
     1021 tcgctacatg aaaaccaata ccgagctgca gattgcccag acccagaaaa agtgtaacag
     1081 aacagaggaa ctcttggtgg aagagattga ggtaatccct gggacattag ccaagaaccc
     1141 aggagatggc aattgagctg tcactcctga tcccctctca gctaacaaag gagggagaca
     1201 aagatttccc tccatctcta tcggcaacag cccctccact tgaggttgaa aataaaagcc
     1261 taaatgagga
//
