LOCUS       NM_001323027            2370 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens IQ motif containing G (IQCG), transcript variant 3,
            mRNA.
ACCESSION   NM_001323027
VERSION     NM_001323027.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Pan,M.M., Zhang,Q.Y., Wang,Y.Y., Liu,P., Ren,R.B., Huang,J.Y.,
            Chen,L.T., Xi,X.D., Chen,Z. and Chen,S.J.
  TITLE     Human NUP98-IQCG fusion protein induces acute myelomonocytic
            leukemia in mice by dysregulating the Hox/Pbx3 pathway
  JOURNAL   Leukemia 30 (7), 1590-1593 (2016)
   PUBMED   26675333
  REMARK    GeneRIF: human NUP98-IQCG fusion protein could induce fatal and
            transplantable acute myelomonocytic leukemia in a mouse model
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Chen,L.T., Liang,W.X., Chen,S., Li,R.K., Tan,J.L., Xu,P.F.,
            Luo,L.F., Wang,L., Yu,S.H., Meng,G., Li,K.K., Liu,T.X., Chen,Z. and
            Chen,S.J.
  TITLE     Functional and molecular features of the calmodulin-interacting
            protein IQCG required for haematopoiesis in zebrafish
  JOURNAL   Nat Commun 5, 3811 (2014)
   PUBMED   24787902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Harris,T.P., Schimenti,K.J., Munroe,R.J. and Schimenti,J.C.
  TITLE     IQ motif-containing G (Iqcg) is required for mouse spermiogenesis
  JOURNAL   G3 (Bethesda) 4 (2), 367-372 (2014)
   PUBMED   24362311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135893.2 and BC004816.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001323027.1.
            
            Transcript Variant: Variants 1 through 3 encode the same isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.512447.1,
                                           SRR1803612.63777.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AC135893.2         67637-68112         c
            477-543             AC135893.2         63807-63873         c
            544-817             AC135893.2         61965-62238         c
            818-1050            AC135893.2         56735-56967         c
            1051-1179           AC135893.2         50361-50489         c
            1180-1261           AC135893.2         44211-44292         c
            1262-1423           AC135893.2         32068-32229         c
            1424-1498           AC135893.2         30862-30936         c
            1499-1630           AC135893.2         10815-10946         c
            1631-1732           AC135893.2         9633-9734           c
            1733-2355           AC135893.2         7279-7901           c
            2356-2370           BC004816.1         1608-1622
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2370
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="IQ motif containing G"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
     exon            1..476
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            477..543
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..1867
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="isoform a is encoded by transcript variant 3; IQ
                     domain-containing protein G; dynein regulatory complex
                     subunit 9; dynein regulatory complex protein 9"
                     /codon_start=1
                     /product="dynein regulatory complex protein 9 isoform a"
                     /protein_id="NP_001309956.1"
                     /db_xref="CCDS:CCDS3331.1"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
                     /translation="MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIE
                     IIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLE
                     GTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIM
                     TTETLKKIQIDRQFFSDVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEK
                     GRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQ
                     IAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKY
                     DKDTEMKQNELNALKATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLL
                     ELKSVIKLQAWWRGTMIRREIGGFKMPKDKVDSKDSKGKGKGKDKRRGKKK"
     exon            544..817
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1050
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1179
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1261
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1423
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1498
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1630
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1732
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..2370
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="major polyA site"
ORIGIN      
        1 agtttacttc ctgcgtcccc ggacgccgta ggtggaaagg cgaaccctga gtggaggatg
       61 ttcccgctgc ctaaagaatg attgactgta agattgattt gccaacagtg gggtgctttt
      121 ctctcgatac acacagcaat agacagaacg gaaattctgg gatcctaatc tagcatggaa
      181 gagaaaggcc gggagcacga aggcagcagg acctcttcct tctctttttt ctttttctat
      241 acttcttttc tcccctctac ttatttatct ctttcaagaa atgagactgg gcacagtggc
      301 tcacgcctgt aaacccagct ctttgggaag ccgaggcggg aggatcgctt gaggccagga
      361 gttcgagacc agcctgggca acatagtgag accacctccc ccaacctcta caaaagaaaa
      421 aaaaaatgaa tgaaatgact taagttctta cctccattct tctttttgga tccgaggtaa
      481 ctgcactttt gtgagattat aaatatacca cggagggtaa cgaagctaca gaagaatgga
      541 agaagacagc ctggaagact caaaccttcc tccaaaagtt tggcattctg agatgacggt
      601 gtcagtgaca ggcgaaccac ctagtaccgt agaagaagaa ggaataccta aagaaacaga
      661 catagaaatc atcccagaaa tcccggaaac tctagagcca ctgtcccttc cagatgtgct
      721 gaggatctcg gcagttctgg aggacaccac agaccagctc tctattctga actacatcat
      781 gcccgttcag tacgaaggga gacagagcat ctgcgtgaaa agcagagaaa tgaatctaga
      841 aggaacgaat ctagacaaac ttccaatggc ctcaacaatc acaaaaatac ccagtccgtt
      901 aataactgag gaaggaccca acttgccaga aatcagacac agaggccggt tcgctgtgga
      961 gtttaacaaa atgcaggatc ttgtcttcaa aaaacctaca aggcagacca tcatgactac
     1021 ggagacactg aagaaaattc agattgatag gcagtttttc agcgatgtga ttgcagatac
     1081 cattaaggag ttgcaagatt cggccactta caacagtctc ctgcaagctt tgagcaaaga
     1141 gagggaaaac aaaatgcatt tctatgacat cattgccagg gaggaaaaag gaagaaaaca
     1201 gataatatca cttcaaaaac agctaattaa tgtcaaaaag gaatggcaat ttgaagtcca
     1261 gagtcagaat gagtatattg ctaacctcaa ggaccaactg caagagatga aggcaaaatc
     1321 caacttggag aatcgctaca tgaaaaccaa taccgagctg cagattgccc agacccagaa
     1381 aaagtgtaac agaacagagg aactcttggt ggaagagatt gagaaactca ggatgaaaac
     1441 cgaagaagag gcccggactc atacagagat tgaaatgttc cttagaaagg agcagcagaa
     1501 acttgaggag aggctggagt tctggatgga gaaatacgat aaggacacag aaatgaaaca
     1561 gaatgaacta aatgctctca aagccacaaa ggccagtgac ttagcacacc ttcaagacct
     1621 ggcaaagatg ataagagagt atgaacaggt catcattgaa gatcgtatag aaaaggagag
     1681 gagcaagaag aaggtaaaac aggatctctt ggaattaaag agcgttataa agctccaggc
     1741 ctggtggcga ggcactatga tacggagaga aattggtggt ttcaagatgc ctaaagacaa
     1801 agttgatagc aaggattcaa aaggcaaagg taaaggcaag gataagagga gaggcaagaa
     1861 gaagtgacca agttctcttt tgtgttttct gctggtattc tggaggtggg aaggacttgg
     1921 agagagttaa gaaacacctg gtacctcaaa gatgactcat ctacaggttg tttcctattg
     1981 agactttccc agggaagcct gatttcactt tgcctgttaa tttcactctg cctgttaggt
     2041 gggttttcaa accctgattt aggattacac cattgactta gggcttcctc ataccttgct
     2101 gggaagaagt ttctagtagt cctgtgaaga ttcattcttc ttgctctttc tcagcagaac
     2161 aaaggagttc actggcttag ctacagtgac gcattgaaac ttgagtaatt cctgtaatgt
     2221 cagattttga ttttacccaa tttgtctgta gtgaaaaaac tcttatgagc aaaagtattc
     2281 agtaggaatt acaatatgat gttattagct gtccagcata atatatacac agcaaagttt
     2341 taataaatgt tggttcctgc ctgcctttta
//
