LOCUS       NM_001134435            1981 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens IQ motif containing G (IQCG), transcript variant 2,
            mRNA.
ACCESSION   NM_001134435
VERSION     NM_001134435.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Pan,M.M., Zhang,Q.Y., Wang,Y.Y., Liu,P., Ren,R.B., Huang,J.Y.,
            Chen,L.T., Xi,X.D., Chen,Z. and Chen,S.J.
  TITLE     Human NUP98-IQCG fusion protein induces acute myelomonocytic
            leukemia in mice by dysregulating the Hox/Pbx3 pathway
  JOURNAL   Leukemia 30 (7), 1590-1593 (2016)
   PUBMED   26675333
  REMARK    GeneRIF: human NUP98-IQCG fusion protein could induce fatal and
            transplantable acute myelomonocytic leukemia in a mouse model
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Chen,L.T., Liang,W.X., Chen,S., Li,R.K., Tan,J.L., Xu,P.F.,
            Luo,L.F., Wang,L., Yu,S.H., Meng,G., Li,K.K., Liu,T.X., Chen,Z. and
            Chen,S.J.
  TITLE     Functional and molecular features of the calmodulin-interacting
            protein IQCG required for haematopoiesis in zebrafish
  JOURNAL   Nat Commun 5, 3811 (2014)
   PUBMED   24787902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Harris,T.P., Schimenti,K.J., Munroe,R.J. and Schimenti,J.C.
  TITLE     IQ motif-containing G (Iqcg) is required for mouse spermiogenesis
  JOURNAL   G3 (Bethesda) 4 (2), 367-372 (2014)
   PUBMED   24362311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA566107.1, CR533515.1 and AK027224.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001134435.2.
            
            Transcript Variant: Variants 1 through 3 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027224.1, SRR14038191.2293460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               DA566107.1         1-146
            147-1521            CR533515.1         1-1375
            1522-1981           AK027224.1         1520-1979
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1981
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="IQ motif containing G"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
     exon            1..87
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            88..154
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1478
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="isoform a is encoded by transcript variant 2; IQ
                     domain-containing protein G; dynein regulatory complex
                     subunit 9; dynein regulatory complex protein 9"
                     /codon_start=1
                     /product="dynein regulatory complex protein 9 isoform a"
                     /protein_id="NP_001127907.1"
                     /db_xref="CCDS:CCDS3331.1"
                     /db_xref="GeneID:84223"
                     /db_xref="HGNC:HGNC:25251"
                     /db_xref="MIM:612477"
                     /translation="MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIE
                     IIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLE
                     GTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIM
                     TTETLKKIQIDRQFFSDVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEK
                     GRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQ
                     IAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKY
                     DKDTEMKQNELNALKATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLL
                     ELKSVIKLQAWWRGTMIRREIGGFKMPKDKVDSKDSKGKGKGKDKRRGKKK"
     exon            155..428
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            429..661
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            662..790
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            791..872
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1034
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1109
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1241
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1343
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1981
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="hexamer: AATAAA"
     polyA_site      1981
                     /gene="IQCG"
                     /gene_synonym="CFAP122; DRC9"
                     /note="major polyA site"
ORIGIN      
        1 agtttacttc ctgcgtcccc ggacgccgta ggtggaaagg cgaaccctga gtggaggatg
       61 ttcccgctgc ctaaagaatg attgactgta actgcacttt tgtgagatta taaatatacc
      121 acggagggta acgaagctac agaagaatgg aagaagacag cctggaagac tcaaaccttc
      181 ctccaaaagt ttggcattct gagatgacgg tgtcagtgac aggcgaacca cctagtaccg
      241 tagaagaaga aggaatacct aaagaaacag acatagaaat catcccagaa atcccggaaa
      301 ctctagagcc actgtccctt ccagatgtgc tgaggatctc ggcagttctg gaggacacca
      361 cagaccagct ctctattctg aactacatca tgcccgttca gtacgaaggg agacagagca
      421 tctgcgtgaa aagcagagaa atgaatctag aaggaacgaa tctagacaaa cttccaatgg
      481 cctcaacaat cacaaaaata cccagtccgt taataactga ggaaggaccc aacttgccag
      541 aaatcagaca cagaggccgg ttcgctgtgg agtttaacaa aatgcaggat cttgtcttca
      601 aaaaacctac aaggcagacc atcatgacta cggagacact gaagaaaatt cagattgata
      661 ggcagttttt cagcgatgtg attgcagata ccattaagga gttgcaagat tcggccactt
      721 acaacagtct cctgcaagct ttgagcaaag agagggaaaa caaaatgcat ttctatgaca
      781 tcattgccag ggaggaaaaa ggaagaaaac agataatatc acttcaaaaa cagctaatta
      841 atgtcaaaaa ggaatggcaa tttgaagtcc agagtcagaa tgagtatatt gctaacctca
      901 aggaccaact gcaagagatg aaggcaaaat ccaacttgga gaatcgctac atgaaaacca
      961 ataccgagct gcagattgcc cagacccaga aaaagtgtaa cagaacagag gaactcttgg
     1021 tggaagagat tgagaaactc aggatgaaaa ccgaagaaga ggcccggact catacagaga
     1081 ttgaaatgtt ccttagaaag gagcagcaga aacttgagga gaggctggag ttctggatgg
     1141 agaaatacga taaggacaca gaaatgaaac agaatgaact aaatgctctc aaagccacaa
     1201 aggccagtga cttagcacac cttcaagacc tggcaaagat gataagagag tatgaacagg
     1261 tcatcattga agatcgtata gaaaaggaga ggagcaagaa gaaggtaaaa caggatctct
     1321 tggaattaaa gagcgttata aagctccagg cctggtggcg aggcactatg atacggagag
     1381 aaattggtgg tttcaagatg cctaaagaca aagttgatag caaggattca aaaggcaaag
     1441 gtaaaggcaa ggataagagg agaggcaaga agaagtgacc aagttctctt ttgtgttttc
     1501 tgctggtatt ctggaggtgg gaaggacttg gagagagtta agaaacacct ggtacctcaa
     1561 agatgactca tctacaggtt gtttcctatt gagactttcc cagggaagcc tgatttcact
     1621 ttgcctgtta atttcactct gcctgttagg tgggttttca aaccctgatt taggattaca
     1681 ccattgactt agggcttcct cataccttgc tgggaagaag tttctagtag tcctgtgaag
     1741 attcattctt cttgctcttt ctcagcagaa caaaggagtt cactggctta gctacagtga
     1801 cgcattgaaa cttgagtaat tcctgtaatg tcagattttg attttaccca atttgtctgt
     1861 agtgaaaaaa ctcttatgag caaaagtatt cagtaggaat tacaatatga tgttattagc
     1921 tgtccagcat aatatataca cagcaaagtt ttaataaatg ttggttcctg cctgcctttt
     1981 a
//
