LOCUS       NM_152397                713 bp    mRNA    linear   PRI 18-MAR-2025
DEFINITION  Homo sapiens IQ motif containing F1 (IQCF1), mRNA.
ACCESSION   NM_152397
VERSION     NM_152397.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 713)
  AUTHORS   Fang,P., Xu,W., Li,D., Zhao,X., Dai,J., Wang,Z., Yan,X., Qin,M.,
            Zhang,Y., Xu,C., Wang,L. and Qiao,Z.
  TITLE     A novel acrosomal protein, IQCF1, involved in sperm capacitation
            and the acrosome reaction
  JOURNAL   Andrology 3 (2), 332-344 (2015)
   PUBMED   25380116
  REMARK    GeneRIF: a newly identified acrosomal protein, IQCF1, is closely
            related to sperm capacitation and AR; in particular, it is involved
            in tyrosine phosphorylation of sperm proteins through interaction
            with CaM
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097636.2 and BC029595.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029595.1, BI551525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310914.10/ ENSP00000307958.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC097636.2         120435-120457       c
            24-306              BC029595.1         6-288
            307-307             AC097636.2         112386-112386       c
            308-713             BC029595.1         290-695
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..713
                     /gene="IQCF1"
                     /note="IQ motif containing F1"
                     /db_xref="GeneID:132141"
                     /db_xref="HGNC:HGNC:28607"
                     /db_xref="MIM:621131"
     exon            1..84
                     /gene="IQCF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..699
                     /gene="IQCF1"
                     /codon_start=1
                     /product="IQ domain-containing protein F1"
                     /protein_id="NP_689610.2"
                     /db_xref="CCDS:CCDS2836.1"
                     /db_xref="GeneID:132141"
                     /db_xref="HGNC:HGNC:28607"
                     /db_xref="MIM:621131"
                     /translation="MEEKQPQKTKEPSKEDEPQQKEMPTHLSLGAESKAEAKTPVLVE
                     TQTVDNANEKSEKPPENQKKLSDKDTVATKIQAWWRGTLVRRALLHAALSACIIQCWW
                     RLILSKILKKRRQAALEAFSRKEWAAVTLQSQARMWRIRRRYCQVLNAVRIIQAYWRC
                     RSCASRGFIKGQYRVTANQLHLQLEILLDSGPCIVTECIPFSIKE"
     exon            85..189
                     /gene="IQCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..252
                     /gene="IQCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..713
                     /gene="IQCF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      687..692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCF1"
                     /note="hexamer: AATAAA"
     polyA_site      713
                     /gene="IQCF1"
                     /note="major polyA site"
ORIGIN      
        1 acccttcctg cctatgctat ggctggatga acacagatgt gaggggattt gaaccatcta
       61 caatcaatcc atatgtgacc aatggaggag aagcagcccc aaaagacgaa ggaaccctca
      121 aaagaagatg agcctcagca gaaggagatg ccaacccatt tgtccttagg agcagagtca
      181 aaggcagagg ctaaaactcc agttctggtt gagacacaga cagtggacaa tgccaatgag
      241 aaatcagaaa aacccccaga aaaccaaaag aagctctctg acaaagatac ggtagccacc
      301 aagatccagg cctggtggcg gggcaccctg gtgcgtcggg cactgttgca cgcagccctc
      361 agtgcctgca tcattcagtg ctggtggcgg ctgatactgt ccaagattct gaagaagagg
      421 cggcaggcag cgctagaggc cttctcccgg aaggagtggg cagcagtcac actgcagtcc
      481 caggcccgca tgtggcgcat ccgcagacgc tattgccagg tgctcaatgc tgttcgcatc
      541 atccaggctt actggaggtg ccgctcctgt gcttcccggg ggttcatcaa gggccagtac
      601 agagtcacag ccaaccagct gcatctccag ctggagatct tgctggactc agggccttgc
      661 attgtgacag agtgtattcc cttctcaata aaggaatgaa gtggtctttt cca
//
