LOCUS       NM_152558               6857 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens IQ motif containing E (IQCE), transcript variant 1,
            mRNA.
ACCESSION   NM_152558 NM_017604
VERSION     NM_152558.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6857)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6857)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6857)
  AUTHORS   Estrada-Cuzcano,A., Etard,C., Delvallee,C., Stoetzel,C.,
            Schaefer,E., Scheidecker,S., Geoffroy,V., Schneider,A., Studer,F.,
            Mattioli,F., Chennen,K., Sigaudy,S., Plassard,D., Poch,O.,
            Piton,A., Strahle,U., Muller,J. and Dollfus,H.
  TITLE     Novel IQCE variations confirm its role in postaxial polydactyly and
            cause ciliary defect phenotype in zebrafish
  JOURNAL   Hum Mutat 41 (1), 240-254 (2020)
   PUBMED   31549751
  REMARK    GeneRIF: Novel IQCE variations confirm its role in postaxial
            polydactyly and cause ciliary defect phenotype in zebrafish.
REFERENCE   4  (bases 1 to 6857)
  AUTHORS   Umair,M., Shah,K., Alhaddad,B., Haack,T.B., Graf,E., Strom,T.M.,
            Meitinger,T. and Ahmad,W.
  TITLE     Exome sequencing revealed a splice site variant in the IQCE gene
            underlying post-axial polydactyly type A restricted to lower limb
  JOURNAL   Eur J Hum Genet 25 (8), 960-965 (2017)
   PUBMED   28488682
  REMARK    GeneRIF: Frameshift and a premature stop codon 22 in IQCE
            completely co-segregated with post-axial polydactyly phenotype
            within the family.
REFERENCE   5  (bases 1 to 6857)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6857)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY029256.1, BC071858.1, AL136792.1 and AL137525.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152558.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071858.1, KJ534872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402050.7/ ENSP00000385597.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                HY029256.1         11-29
            20-904              BC071858.1         1-885
            905-1938            AL136792.1         593-1626
            1939-3035           BC071858.1         1920-3016
            3036-6262           AL137525.1         764-3990
            6263-6325           AL137525.1         3992-4054
            6326-6857           AL137525.1         4056-4587
FEATURES             Location/Qualifiers
     source          1..6857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..6857
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="IQ motif containing E"
                     /db_xref="GeneID:23288"
                     /db_xref="HGNC:HGNC:29171"
                     /db_xref="MIM:617631"
     exon            1..239
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2291
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein E"
                     /codon_start=1
                     /product="IQ domain-containing protein E isoform 1"
                     /protein_id="NP_689771.3"
                     /db_xref="CCDS:CCDS43542.1"
                     /db_xref="GeneID:23288"
                     /db_xref="HGNC:HGNC:29171"
                     /db_xref="MIM:617631"
                     /translation="MFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKPPPTSPK
                     SPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHA
                     WTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQ
                     KSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQR
                     ILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKP
                     LGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEW
                     SKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHER
                     LRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLR
                     EEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLP
                     RPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGHLTRTKLLASK
                     AHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSAT
                     GKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNSDDSDDI
                     VIAPSLPTKNFPV"
     exon            240..287
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            288..333
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            334..462
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            463..597
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            598..668
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            669..782
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            783..833
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            834..904
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            905..977
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1027
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1191
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1247
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1447
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1552
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1643
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1811
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1835
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1946
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2068
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2172
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..6857
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6834..6839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="hexamer: AATAAA"
     polyA_site      6857
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacgcgc atggtcgccc cagggggaac gcaggtcgct tacccggctg ggtaggtcgg
       61 cggcctggtt gccatggcag cggggtcgcg ggccggcgcc agggaaggcc ccgaggctgc
      121 gggcggccag ggctgcccgc ggattcccag acccggacgc ccgagccagc aaccctgagg
      181 ggcggccggg cagcgccgcc accatgttcc tgggcaccgg ggagccggcc ttggacacgg
      241 gagatgacag tctgtctgca gtcacctttg actctgatgt ggagacgaaa gcaaaaagga
      301 aagctttcca caaacctcca cccacatcgc caaagtcacc ttatctctct aagccgagaa
      361 aagtggcctc ctggaggtcc ctcaggacgg cagggagcat gcctctgggc ggccgagcgt
      421 ccctgacccc gcagaagctg tggctgggaa ccgcaaagcc aggaagtctg acccaggccc
      481 tgaactcacc cctcacctgg gagcatgcgt ggactggcgt ccccggcggc actcctgact
      541 gtctgacaga caccttcaga gtgaagaggc cacatctcag gcgctctgcc agcaacggtc
      601 atgtccctgg gactcctgtc tacagagaaa aagaagatat gtatgacgag attattgagt
      661 taaagaagtc attgcacgtg cagaagagcg acgtggacct gatgagaacg aagctccggc
      721 gcctggagga ggaaaacagc aggaaggacc ggcagataga gcagctcctg gatcccagcc
      781 gcggcacgga ttttgttcgg actctggcag agaaaaggcc cgatgccagt tgggtcatta
      841 acgggctgaa gcagaggatc ctgaagctgg aacagcagtg caaggagaag gacggcacca
      901 tcagcaaact ccagaccgat atgaagacta ccaacctgga agagatgcgg atcgccatgg
      961 agacatacta cgaggaggtg catcgtctcc agaccctctt ggcaagttct gaaaccaccg
     1021 gaaagaagcc cctgggggag aagaagacgg gcgccaaaag gcagaagaag atgggcagtg
     1081 ccctcctgag cttgtcccgg agtgtccagg agctcacgga agagaaccag agcctgaagg
     1141 aggacctgga ccgcgtgctg agcacctccc caaccatctc caagacacag ggttatgtgg
     1201 agtggagcaa gccccggctg ctgaggcgca ttgtggagct ggagaagaaa ctaagtgtga
     1261 tggagagctc aaaatcacac gccgcagagc cagtcagatc acacccgcca gcctgccttg
     1321 catccagctc tgcgctgcac agacagccac gaggggaccg caacaaggac cacgagcgtc
     1381 tccgaggggc tgtgagagac ctgaaggaag agcggaccgc gctgcaggag cagctgctgc
     1441 agagagattt ggaggtgaag cagctcctgc aggcgaaggc cgacctggag aaggagctgg
     1501 agtgcgcgag ggagggcgag gaggagagga gagagcgaga ggaggttttg agagaggaga
     1561 ttcagacact taccagcaag ctccaagaat tgcaagaaat gaagaaagaa gagaaagagg
     1621 attgcccgga agttcctcat aaggcccaag agctcccagc tcccactccc agcagcaggc
     1681 actgcgagca agactggccg ccggattcca gcgaggaggg gctcccgcgg ccccgctccc
     1741 cctgctctga tgggagaaga gacgccgcgg ccagagtcct gcaggcccag tggaaggtgt
     1801 acaagcacaa gaaaaaaaag gctgttctgg atgaggcggc tgtggtgctt caggcagctt
     1861 tcaggggaca tctcacgcgg acaaagctct tagcaagcaa agcacatggc tcagagccac
     1921 ccagcgtgcc aggcctccca gaccagagct ctcctgtgcc ccgcgttccg agccccatcg
     1981 cccaggccac gggcagccct gtgcaggagg aggccatcgt catcatccag tccgctctgc
     2041 gggcacacct ggcccgggcc aggcacagtg ctaccggtaa aagaaccacc accgcagctt
     2101 ctaccaggag gagatcggct tcagccacac acggggacgc ctcctcccca cccttcctcg
     2161 cagctcttcc tgacccctct ccctcagggc cacaggcctt ggcacctcta cctggggatg
     2221 acgtcaactc cgatgattcc gacgatattg tcattgcacc gtctctgccc acgaagaact
     2281 ttccagttta ggtccccgtc actgtctcca cgccgtgatg gcagcgctgc cgaggacata
     2341 ggaaccacga ctggaaagat aatttatcgt gttaggagaa gaacgatgat acctacttaa
     2401 cacctcagca tctgcgtcgt gtctctttgt gcttttgttt gtggaaggag acccaaatgc
     2461 ctttacttta ttctctgggg agggccagcg gctcgcatcc ccctcatctc cagctgcagc
     2521 tcggatggtg gattttcagt gccaacagac acatctgccg tgaactcgca gatgccaggg
     2581 agccctgtag tgacacgttc tctgacagca ccttgccgcc tgcccacgac cttgaccgtg
     2641 aggagctgct atccgcaacc agcgccgaca ccatgccccc tcttcctggt gacaccctca
     2701 acaaccagga tttgctcgat ctcagcccag caggccaggc agacacaccc cgctgtgcct
     2761 taggaaggtg tgagaccggc ttcccccatc cccacagcaa aacacggcct gtcccaagcc
     2821 agtgaggagc taaagacacc caggtcccca aatgatctta ctccatgccc cacccgctca
     2881 caccgtcctt tcccgtcacc cttgctatcc cctggagcac tgccctccag agctgccctt
     2941 cccaggaagg aatttggttg gattctgtca ctgtggagac caagattttt taaaattccc
     3001 aattacaaaa gcagcatcac acttgcttct gagaacagca gggtgatgtc tgttcccaag
     3061 ctggtggcgg gagccttagc ctgtgtgggg ccacccgggg aagaggagga gaggagggtg
     3121 aggaggcagg ctcgccgttc caagggacag cataggctcg tggtggggcg tgttgcatct
     3181 ggtgtctggg acagtccccg tcaccccatg tgtgcggcct ctgcactccc aagctccatg
     3241 gctgggctgg gctgggctgg gctgggctgg gccgggcgtg cggagcctgt ggagccagca
     3301 gctgcagagg cctaggaggg agttcctggg ggaagcgcac agtgtccagt gcccatctct
     3361 tgcttgtgtg tgagattagc ccttgctggg gcgtcaagag gaagagcctt agacctgggc
     3421 gggccttcag gggcatctag acccctgcac agcccaggcc tggtgtctgc atttccacag
     3481 cacccctgtg gggactcctg ccggggctgg ccgctgtctc aggagagacc caatggttag
     3541 aaagcccctt tttacacagc tgacagcttc tcccaaggct tccgtccacg gggacaggct
     3601 taacccctgg gcgccttttc tgcagcatgg cggccttctg agtcacctaa gctgagcctg
     3661 ggtcattctc tgtggcggtc agaaggccga tggccccaac acagtggctt gtgaaaggga
     3721 gagaggaggc tctgcatgtc cacctgctct atgggaggag gacacaggtg tccccagccc
     3781 agcctgttct ctcccagtca ctcagggatg gggccaccca aagtgcagga cccgccccac
     3841 cctgcggttc gaagcctggc ccctgtctcc acttagcttc tgtttctgca gtgggtggaa
     3901 gcgagtcagc ggggggcctg gcttgtgtac gtgttttcct tatttggtct gtgggttgcc
     3961 aagtccattt ttttttccac tgaactggct ggtaacttga tggactgtgt aactgacaca
     4021 ggccctcttt agacccctgc cttcacccca cccgcccggg tccactccct ggggcgctgt
     4081 cccaagccat ccctgcttgc cagctcaaag cttcaggtcc taggagccag tccacctcga
     4141 aagccctgag aaagtgagac acctgcacat tcgctggggg agaccctccg ttctcttgtg
     4201 gcagctgctc ccacttgtta aaccaagctg tttctgcggg acgtgctcac tcttgggaac
     4261 cagtggccta gagctttggg ttacaggcat ggagagggct ttcctgcctc aggcttggag
     4321 gccaatgttc catacataaa ccgccatgtc ctctggtgca gctgggctgc tcttttaaaa
     4381 gccagcatcc atcttgaagc tcgctgggta aatggcaatg cattctcaag ccagtgtctt
     4441 cagctgatgc ccagtgtcca gtgctggtca ccagtcccct ttgctgggta cagcctgcct
     4501 ggctgttctg tggtcctgga acgctgcagt gtggttttgt tccatggaga cagtaccaag
     4561 cggagaggcc tccttgccca cggccccagg gcctgggggc caggggttct ggccctgcgg
     4621 ggacttaggc aggaggggaa gagaagccca tggagccatg ggaggggtga gctgtgggcg
     4681 gggcctagtc atgggagggg tgagctgtgg gcggggcgag ctgtgggtgg ggcctagcca
     4741 tgggagaggt gagctgtgaa tggggctagc tatgggtggg gtgagctgtg gacagggcct
     4801 agccatggga aaggtgagct gtgggcgggg cctagtcacg ggagaggtga gctgtgggcg
     4861 gggcctagtc atgggagggg tgagctgtgg atggggccta gccatgggag gggtgagctg
     4921 tgagtggggc tgagccatgg gagcagcaag ctggtggagt gggctgggcg gagctgtggg
     4981 ggctgctggc agggcctagg aaagtagaca actcccgggg gagacgaagt agagagtgag
     5041 tccccaagaa agggactcct gccccagcgt caagtgccaa agcaggcccc atctaccact
     5101 tcagggtcga cgttggtggc aggtgttgtt cacggtgtac tgattgtcac tgcaacacct
     5161 ccacatcacc ttgaacttca agaacagcag caaagctgta tctgctatca gaggctgtta
     5221 ggtagtccag ctttaaaata acacactctt tctctatccc atgcccttta aacaagcagc
     5281 cacaggagat gtcagtctcc agggcctggc cccactgtgt tgacagcagt cacgtctgtt
     5341 gagctgacac tgctgaggct gaagctggcc ccgtgcaggt ggctggtgag ccacaggtgc
     5401 agtacccgga ggtgtgctct cccctagagg cctgtcccca actcctcccc tagaggccta
     5461 ttcccgctgc tcacagacct cagcagaggc accagctgga gggctccagg gacatccttg
     5521 gagatacagg aggctttcct ggcacagggc acagctctta ggaggccttt gtaggacgct
     5581 gtctccccag cgtgtcctgc tcatccagga tggggagaaa gaggaggagg ccccaggctc
     5641 agaagccagg gacagactgc cgacgattac caaactgaat ccaggcagtg ccatgaccct
     5701 gggtgtccct tggttcacat cacccaccag acagctgcgg agagagtgca gggaggggct
     5761 gggaccaaac aggccagaaa ccagcagaaa agaggcagaa gtgaggtggg tgtgcctggg
     5821 gcacgaagcc agcgccgggg ggatttcagt ggagccttac agccaggctc cgtgcggact
     5881 gtgatgccag agaggcgtgc agcctctggg caagtcggga gagggcttgg gtggtcccca
     5941 caaggcagaa gaggtggaag ggccagagaa gaccaccaag accaccgttc ccgcaggcct
     6001 ggggtgagtg acctgactga gactagcggg cagagccaag cagggctaaa ctccaaccca
     6061 gggcccggtg ttggacaaag tagctttttc tttgctcgtt tgtctgtgta ttaagaagag
     6121 actaaaatag ccaaacgacg ctggtcgcat gcgctggctg tggtctgtct gctgaatgtc
     6181 tatttttgtc tcctgacgag acgtgaggac catgcccttg atccctccga tggaccagaa
     6241 acccccttcc ttgcaaaaaa aaggcaattg aattaggaaa agatagccca acctagctca
     6301 gatccaccaa gataagcaca gcaaagcttg gctgcatttt tgaggaataa aaacctgcag
     6361 aaagcaccga taaccttcaa gatctgaatg agattctatt ataacccgtc taaacgattg
     6421 caaaattcct cctttggttt tggaagcagc gtttgctctc ccgtggctcg gattctctga
     6481 ggaccaggga gttgacacac aaaccccgcc atgggtccga gccagctatt tctcaaggct
     6541 cccacctcgc caagctccca agggcctgct ggcagtgcct acgctgtgcc aactaccctg
     6601 tctggtacag accacggctg ggtaagcacc cttaaaagca acagaaatga cgtctggaag
     6661 ctgaaatgtg aaactgtcaa gatggcttag gagaggaagg agtggacccg ctggtctttg
     6721 gcattttgta tttagaatta ttctaacttt atacataatg tataggccga tcttttggaa
     6781 gggataaggt tttcattctt gtgcaactca ttattctcat tattggcctt ttaaataaaa
     6841 agttgttttg cagtgtg
//
