LOCUS       NM_001287501            6763 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens IQ motif containing E (IQCE), transcript variant 5,
            mRNA.
ACCESSION   NM_001287501 XM_005249678
VERSION     NM_001287501.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6763)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6763)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6763)
  AUTHORS   Estrada-Cuzcano,A., Etard,C., Delvallee,C., Stoetzel,C.,
            Schaefer,E., Scheidecker,S., Geoffroy,V., Schneider,A., Studer,F.,
            Mattioli,F., Chennen,K., Sigaudy,S., Plassard,D., Poch,O.,
            Piton,A., Strahle,U., Muller,J. and Dollfus,H.
  TITLE     Novel IQCE variations confirm its role in postaxial polydactyly and
            cause ciliary defect phenotype in zebrafish
  JOURNAL   Hum Mutat 41 (1), 240-254 (2020)
   PUBMED   31549751
  REMARK    GeneRIF: Novel IQCE variations confirm its role in postaxial
            polydactyly and cause ciliary defect phenotype in zebrafish.
REFERENCE   4  (bases 1 to 6763)
  AUTHORS   Umair,M., Shah,K., Alhaddad,B., Haack,T.B., Graf,E., Strom,T.M.,
            Meitinger,T. and Ahmad,W.
  TITLE     Exome sequencing revealed a splice site variant in the IQCE gene
            underlying post-axial polydactyly type A restricted to lower limb
  JOURNAL   Eur J Hum Genet 25 (8), 960-965 (2017)
   PUBMED   28488682
  REMARK    GeneRIF: Frameshift and a premature stop codon 22 in IQCE
            completely co-segregated with post-axial polydactyly phenotype
            within the family.
REFERENCE   5  (bases 1 to 6763)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6763)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY029256.1, BC043150.1, AL136792.1 and AL137525.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001287501.1.
            
            Transcript Variant: This variant (5) lacks two alternate exons in
            the 5' coding region and initiates translation at a downstream
            in-frame start codon, compared to variant 1. The encoded isoform
            (5) is shorter at the N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1891848.1,
                                           SRR14372080.2349345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                HY029256.1         11-88
            79-697              BC043150.1         6-624
            698-739             AL136792.1         480-521
            740-2313            BC043150.1         667-2240
            2314-6168           AL137525.1         136-3990
            6169-6231           AL137525.1         3992-4054
            6232-6763           AL137525.1         4056-4587
FEATURES             Location/Qualifiers
     source          1..6763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..6763
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="IQ motif containing E"
                     /db_xref="GeneID:23288"
                     /db_xref="HGNC:HGNC:29171"
                     /db_xref="MIM:617631"
     exon            1..239
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            240..368
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..2197
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="isoform 5 is encoded by transcript variant 5; IQ
                     domain-containing protein E"
                     /codon_start=1
                     /product="IQ domain-containing protein E isoform 5"
                     /protein_id="NP_001274430.1"
                     /db_xref="CCDS:CCDS75560.1"
                     /db_xref="GeneID:23288"
                     /db_xref="HGNC:HGNC:29171"
                     /db_xref="MIM:617631"
                     /translation="MPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGG
                     TPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLM
                     RTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQ
                     CKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTG
                     AKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLR
                     RIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRD
                     LKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLT
                     SKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCS
                     DGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPP
                     SVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTA
                     ASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNSDDSDDIVIAPSLP
                     TKNFPV"
     exon            369..503
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            504..574
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            575..688
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            689..739
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            740..810
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            884..933
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1097
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1153
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1353
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1458
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1549
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1717
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1741
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1852
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1974
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2078
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..6763
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6740..6745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="hexamer: AATAAA"
     polyA_site      6763
                     /gene="IQCE"
                     /gene_synonym="1700028P05Rik; PAPA7"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacgcgc atggtcgccc cagggggaac gcaggtcgct tacccggctg ggtaggtcgg
       61 cggcctggtt gccatggcag cggggtcgcg ggccggcgcc agggaaggcc ccgaggctgc
      121 gggcggccag ggctgcccgc ggattcccag acccggacgc ccgagccagc aaccctgagg
      181 ggcggccggg cagcgccgcc accatgttcc tgggcaccgg ggagccggcc ttggacacga
      241 gtcaccttat ctctctaagc cgagaaaagt ggcctcctgg aggtccctca ggacggcagg
      301 gagcatgcct ctgggcggcc gagcgtccct gaccccgcag aagctgtggc tgggaaccgc
      361 aaagccagga agtctgaccc aggccctgaa ctcacccctc acctgggagc atgcgtggac
      421 tggcgtcccc ggcggcactc ctgactgtct gacagacacc ttcagagtga agaggccaca
      481 tctcaggcgc tctgccagca acggtcatgt ccctgggact cctgtctaca gagaaaaaga
      541 agatatgtat gacgagatta ttgagttaaa gaagtcattg cacgtgcaga agagcgacgt
      601 ggacctgatg agaacgaagc tccggcgcct ggaggaggaa aacagcagga aggaccggca
      661 gatagagcag ctcctggatc ccagccgcgg cacggatttt gttcggactc tggcagagaa
      721 aaggcccgat gccagttggg tcattaacgg gctgaagcag aggatcctga agctggaaca
      781 gcagtgcaag gagaaggacg gcaccatcag caaactccag accgatatga agactaccaa
      841 cctggaagag atgcggatcg ccatggagac atactacgag gaggtgcatc gtctccagac
      901 cctcttggca agttctgaaa ccaccggaaa gaagcccctg ggggagaaga agacgggcgc
      961 caaaaggcag aagaagatgg gcagtgccct cctgagcttg tcccggagtg tccaggagct
     1021 cacggaagag aaccagagcc tgaaggagga cctggaccgc gtgctgagca cctccccaac
     1081 catctccaag acacagggtt atgtggagtg gagcaagccc cggctgctga ggcgcattgt
     1141 ggagctggag aagaaactaa gtgtgatgga gagctcaaaa tcacacgccg cagagccagt
     1201 cagatcacac ccgccagcct gccttgcatc cagctctgcg ctgcacagac agccacgagg
     1261 ggaccgcaac aaggaccacg agcgtctccg aggggctgtg agagacctga aggaagagcg
     1321 gaccgcgctg caggagcagc tgctgcagag agatttggag gtgaagcagc tcctgcaggc
     1381 gaaggccgac ctggagaagg agctggagtg cgcgagggag ggcgaggagg agaggagaga
     1441 gcgagaggag gttttgagag aggagattca gacacttacc agcaagctcc aagaattgca
     1501 agaaatgaag aaagaagaga aagaggattg cccggaagtt cctcataagg cccaagagct
     1561 cccagctccc actcccagca gcaggcactg cgagcaagac tggccgccgg attccagcga
     1621 ggaggggctc ccgcggcccc gctccccctg ctctgatggg agaagagacg ccgcggccag
     1681 agtcctgcag gcccagtgga aggtgtacaa gcacaagaaa aaaaaggctg ttctggatga
     1741 ggcggctgtg gtgcttcagg cagctttcag gggacatctc acgcggacaa agctcttagc
     1801 aagcaaagca catggctcag agccacccag cgtgccaggc ctcccagacc agagctctcc
     1861 tgtgccccgc gttccgagcc ccatcgccca ggccacgggc agccctgtgc aggaggaggc
     1921 catcgtcatc atccagtccg ctctgcgggc acacctggcc cgggccaggc acagtgctac
     1981 cggtaaaaga accaccaccg cagcttctac caggaggaga tcggcttcag ccacacacgg
     2041 ggacgcctcc tccccaccct tcctcgcagc tcttcctgac ccctctccct cagggccaca
     2101 ggccttggca cctctacctg gggatgacgt caactccgat gattccgacg atattgtcat
     2161 tgcaccgtct ctgcccacga agaactttcc agtttaggtc cccgtcactg tctccacgcc
     2221 gtgatggcag cgctgccgag gacataggaa ccacgactgg aaagataatt tatcgtgtta
     2281 ggagaagaac gatgatacct acttaacacc tcagcatctg cgtcgtgtct ctttgtgctt
     2341 ttgtttgtgg aaggagaccc aaatgccttt actttattct ctggggaggg ccagcggctc
     2401 gcatccccct catctccagc tgcagctcgg atggtggatt ttcagtgcca acagacacat
     2461 ctgccgtgaa ctcgcagatg ccagggagcc ctgtagtgac acgttctctg acagcacctt
     2521 gccgcctgcc cacgaccttg accgtgagga gctgctatcc gcaaccagcg ccgacaccat
     2581 gccccctctt cctggtgaca ccctcaacaa ccaggatttg ctcgatctca gcccagcagg
     2641 ccaggcagac acaccccgct gtgccttagg aaggtgtgag accggcttcc cccatcccca
     2701 cagcaaaaca cggcctgtcc caagccagtg aggagctaaa gacacccagg tccccaaatg
     2761 atcttactcc atgccccacc cgctcacacc gtcctttccc gtcacccttg ctatcccctg
     2821 gagcactgcc ctccagagct gcccttccca ggaaggaatt tggttggatt ctgtcactgt
     2881 ggagaccaag attttttaaa attcccaatt acaaaagcag catcacactt gcttctgaga
     2941 acagcagggt gatgtctgtt cccaagctgg tggcgggagc cttagcctgt gtggggccac
     3001 ccggggaaga ggaggagagg agggtgagga ggcaggctcg ccgttccaag ggacagcata
     3061 ggctcgtggt ggggcgtgtt gcatctggtg tctgggacag tccccgtcac cccatgtgtg
     3121 cggcctctgc actcccaagc tccatggctg ggctgggctg ggctgggctg ggctgggccg
     3181 ggcgtgcgga gcctgtggag ccagcagctg cagaggccta ggagggagtt cctgggggaa
     3241 gcgcacagtg tccagtgccc atctcttgct tgtgtgtgag attagccctt gctggggcgt
     3301 caagaggaag agccttagac ctgggcgggc cttcaggggc atctagaccc ctgcacagcc
     3361 caggcctggt gtctgcattt ccacagcacc cctgtgggga ctcctgccgg ggctggccgc
     3421 tgtctcagga gagacccaat ggttagaaag ccccttttta cacagctgac agcttctccc
     3481 aaggcttccg tccacgggga caggcttaac ccctgggcgc cttttctgca gcatggcggc
     3541 cttctgagtc acctaagctg agcctgggtc attctctgtg gcggtcagaa ggccgatggc
     3601 cccaacacag tggcttgtga aagggagaga ggaggctctg catgtccacc tgctctatgg
     3661 gaggaggaca caggtgtccc cagcccagcc tgttctctcc cagtcactca gggatggggc
     3721 cacccaaagt gcaggacccg ccccaccctg cggttcgaag cctggcccct gtctccactt
     3781 agcttctgtt tctgcagtgg gtggaagcga gtcagcgggg ggcctggctt gtgtacgtgt
     3841 tttccttatt tggtctgtgg gttgccaagt ccattttttt ttccactgaa ctggctggta
     3901 acttgatgga ctgtgtaact gacacaggcc ctctttagac ccctgccttc accccacccg
     3961 cccgggtcca ctccctgggg cgctgtccca agccatccct gcttgccagc tcaaagcttc
     4021 aggtcctagg agccagtcca cctcgaaagc cctgagaaag tgagacacct gcacattcgc
     4081 tgggggagac cctccgttct cttgtggcag ctgctcccac ttgttaaacc aagctgtttc
     4141 tgcgggacgt gctcactctt gggaaccagt ggcctagagc tttgggttac aggcatggag
     4201 agggctttcc tgcctcaggc ttggaggcca atgttccata cataaaccgc catgtcctct
     4261 ggtgcagctg ggctgctctt ttaaaagcca gcatccatct tgaagctcgc tgggtaaatg
     4321 gcaatgcatt ctcaagccag tgtcttcagc tgatgcccag tgtccagtgc tggtcaccag
     4381 tcccctttgc tgggtacagc ctgcctggct gttctgtggt cctggaacgc tgcagtgtgg
     4441 ttttgttcca tggagacagt accaagcgga gaggcctcct tgcccacggc cccagggcct
     4501 gggggccagg ggttctggcc ctgcggggac ttaggcagga ggggaagaga agcccatgga
     4561 gccatgggag gggtgagctg tgggcggggc ctagtcatgg gaggggtgag ctgtgggcgg
     4621 ggcgagctgt gggtggggcc tagccatggg agaggtgagc tgtgaatggg gctagctatg
     4681 ggtggggtga gctgtggaca gggcctagcc atgggaaagg tgagctgtgg gcggggccta
     4741 gtcacgggag aggtgagctg tgggcggggc ctagtcatgg gaggggtgag ctgtggatgg
     4801 ggcctagcca tgggaggggt gagctgtgag tggggctgag ccatgggagc agcaagctgg
     4861 tggagtgggc tgggcggagc tgtgggggct gctggcaggg cctaggaaag tagacaactc
     4921 ccgggggaga cgaagtagag agtgagtccc caagaaaggg actcctgccc cagcgtcaag
     4981 tgccaaagca ggccccatct accacttcag ggtcgacgtt ggtggcaggt gttgttcacg
     5041 gtgtactgat tgtcactgca acacctccac atcaccttga acttcaagaa cagcagcaaa
     5101 gctgtatctg ctatcagagg ctgttaggta gtccagcttt aaaataacac actctttctc
     5161 tatcccatgc cctttaaaca agcagccaca ggagatgtca gtctccaggg cctggcccca
     5221 ctgtgttgac agcagtcacg tctgttgagc tgacactgct gaggctgaag ctggccccgt
     5281 gcaggtggct ggtgagccac aggtgcagta cccggaggtg tgctctcccc tagaggcctg
     5341 tccccaactc ctcccctaga ggcctattcc cgctgctcac agacctcagc agaggcacca
     5401 gctggagggc tccagggaca tccttggaga tacaggaggc tttcctggca cagggcacag
     5461 ctcttaggag gcctttgtag gacgctgtct ccccagcgtg tcctgctcat ccaggatggg
     5521 gagaaagagg aggaggcccc aggctcagaa gccagggaca gactgccgac gattaccaaa
     5581 ctgaatccag gcagtgccat gaccctgggt gtcccttggt tcacatcacc caccagacag
     5641 ctgcggagag agtgcaggga ggggctggga ccaaacaggc cagaaaccag cagaaaagag
     5701 gcagaagtga ggtgggtgtg cctggggcac gaagccagcg ccggggggat ttcagtggag
     5761 ccttacagcc aggctccgtg cggactgtga tgccagagag gcgtgcagcc tctgggcaag
     5821 tcgggagagg gcttgggtgg tccccacaag gcagaagagg tggaagggcc agagaagacc
     5881 accaagacca ccgttcccgc aggcctgggg tgagtgacct gactgagact agcgggcaga
     5941 gccaagcagg gctaaactcc aacccagggc ccggtgttgg acaaagtagc tttttctttg
     6001 ctcgtttgtc tgtgtattaa gaagagacta aaatagccaa acgacgctgg tcgcatgcgc
     6061 tggctgtggt ctgtctgctg aatgtctatt tttgtctcct gacgagacgt gaggaccatg
     6121 cccttgatcc ctccgatgga ccagaaaccc ccttccttgc aaaaaaaagg caattgaatt
     6181 aggaaaagat agcccaacct agctcagatc caccaagata agcacagcaa agcttggctg
     6241 catttttgag gaataaaaac ctgcagaaag caccgataac cttcaagatc tgaatgagat
     6301 tctattataa cccgtctaaa cgattgcaaa attcctcctt tggttttgga agcagcgttt
     6361 gctctcccgt ggctcggatt ctctgaggac cagggagttg acacacaaac cccgccatgg
     6421 gtccgagcca gctatttctc aaggctccca cctcgccaag ctcccaaggg cctgctggca
     6481 gtgcctacgc tgtgccaact accctgtctg gtacagacca cggctgggta agcaccctta
     6541 aaagcaacag aaatgacgtc tggaagctga aatgtgaaac tgtcaagatg gcttaggaga
     6601 ggaaggagtg gacccgctgg tctttggcat tttgtattta gaattattct aactttatac
     6661 ataatgtata ggccgatctt ttggaaggga taaggttttc attcttgtgc aactcattat
     6721 tctcattatt ggccttttaa ataaaaagtt gttttgcagt gtg
//
