LOCUS       NM_001330452            1670 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens IQ motif containing D (IQCD), transcript variant 1,
            mRNA.
ACCESSION   NM_001330452 XM_005253832
VERSION     NM_001330452.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Gupta,M.K., Jayaram,S., Madugundu,A.K., Chavan,S., Advani,J.,
            Pandey,A., Thongboonkerd,V. and Sirdeshmukh,R.
  TITLE     Chromosome-centric human proteome project: deciphering proteins
            associated with glioma and neurodegenerative disorders on
            chromosome 12
  JOURNAL   J Proteome Res 13 (7), 3178-3190 (2014)
   PUBMED   24804578
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127152.1, BC013151.1, CD358970.1, AC089999.20 and AI638678.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001330452.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.3195.1,
                                           SRR5189667.203401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416617.3/ ENSP00000400669.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK127152.1         1-30
            31-49               BC013151.1         12-30
            50-766              CD358970.1         27-743
            767-920             AC089999.20        43424-43577
            921-1135            AC089999.20        50202-50416
            1136-1226           AI638678.1         459-549             c
            1227-1227           AC089999.20        55126-55126
            1228-1668           AI638678.1         17-457              c
            1669-1670           BC013151.1         1344-1345
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1670
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /note="IQ motif containing D"
                     /db_xref="GeneID:115811"
                     /db_xref="HGNC:HGNC:25168"
     exon            1..98
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /inference="alignment:Splign:2.1.0"
     exon            99..920
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1541
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein D; dynein regulatory complex
                     subunit 10; dynein regulatory complex protein 10"
                     /codon_start=1
                     /product="dynein regulatory complex protein 10 isoform 1"
                     /protein_id="NP_001317381.1"
                     /db_xref="CCDS:CCDS81743.1"
                     /db_xref="GeneID:115811"
                     /db_xref="HGNC:HGNC:25168"
                     /translation="MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKL
                     TTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLL
                     ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLL
                     SNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQ
                     NSNNQQIIDTLEKELAERMKNRNAEVEKENFVIQELKNHLHQVLKFSENSLVRTKQEA
                     EKQQKADFRASQARVAKIQQEILQLQSQFYNLVMENREAEQALRKKKYKVETEIENWI
                     QKYDTEMGEKQEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRME
                     AEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKGKK"
     exon            921..1154
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1226
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1670
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /note="hexamer: ATTAAA"
     polyA_site      1670
                     /gene="IQCD"
                     /gene_synonym="4933433C09Rik; CFAP84; DRC10"
                     /note="major polyA site"
ORIGIN      
        1 agacaccgag tctcgccttc tgagattggc gggtaaccta gcaacgcagg gaccgcggcg
       61 gtaactgtgg ctagggaaac ctggagcggt cagagcagga tggccagaga caataaaagc
      121 acgagaccca agtagtctac cgaagtctcc atctctgtgg acctacagag gcacagaggg
      181 ctgctcacaa gatggcttta gacattctcg ccatggcccc tttgtatcag gcccctgcca
      241 tcaacagaat agggccaaag acagacccat ctaaaaggcc agctgatcca ctaaaaccct
      301 tggttctctc taggaccaaa ctcaccacca ttgaggccaa aaggatcatg tccatcctgg
      361 atgaggcgat ctacaaggtg gagctggtga ccttgctgtc gtatgtggca tccaacagag
      421 aggatatgga ggggatgctg ggggaggacg tcatgagggc agtgagagag catgaggatc
      481 tctgccaggt cctccttgaa aacgtcaggt gcctgaaaga gaaagaaagg caattgcagg
      541 agcagaaaga ggctgaggag gaagggtggc tcagagaccg cctcctttcc atagagctgc
      601 agaaatccag cctctcacca cttatgcagc agatcaaaga ctccaccaag aacgtcctta
      661 gactcttgct cagcaacccc caggctgcta ggctcctgca gatgcagaca cagggtagaa
      721 gtgcagaagc ccagaatttt attgacagcc tgatagagct ccgtggtttc ctgtttgaaa
      781 aactactcac tagtcccatg gaagcgaggg ataaggccca gttcttacag gatatcagta
      841 gacagaatag taataaccaa caaatcattg atactcttga aaaggaattg gcggagagaa
      901 tgaagaacag gaatgcagag gtggaaaagg agaactttgt gatccaagaa ctgaaaaacc
      961 acctgcacca ggtgctcaag ttctcagaga acagcctcgt tcgcactaag caggaggctg
     1021 agaagcagca gaaggccgat ttccgggcat cacaggccag ggtggccaag atccagcagg
     1081 agatcctgca gctgcagtca cagttttaca acctggtcat ggagaaccgg gaggcagagc
     1141 aggcgctgag gaagaagaaa tataaagtgg aaacggaaat cgagaactgg atccagaaat
     1201 atgatacaga gatgggtgag aagcaggagg agttggagga tctggacgct gttcacaggg
     1261 aggagaagat ctcgctggag gagctcaggc ggaggcacaa agtgctggtg ggagagtttg
     1321 cgcagatccg ggaagagcgg gagatcaact ccaagaaaag gatggaggca gagcaggaga
     1381 tggtgcgcat ggtacgggcg gccacgctca tccaggccct atggaagggc tatctggtgc
     1441 gctccctgct cagatccaag aagaagcggg gcaagggcaa agcaaaggac aaggagaagg
     1501 gcaagcagaa aggcaaggag aagggcaagg gcaagaaatg agctctccac ccagcccgct
     1561 cctgaccctt atcttcccag agaccaggcc aggaaggccc gagatggaga gcactaaatt
     1621 cacggctttc atgtttttat ttaataaatt aaaaagtatt tgaagccaca
//
