LOCUS       NM_018134               2012 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens IQ motif containing C (IQCC), transcript variant 2,
            mRNA.
ACCESSION   NM_018134
VERSION     NM_018134.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK223272.1, AL049795.21 and DB324323.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018134.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region compared to variant 1. The encoded
            isoform (2) is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001409.1, AK223272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291358.11/ ENSP00000291358.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               AK223272.1         25-660
            637-637             AL049795.21        96635-96635
            638-1594            AK223272.1         662-1618
            1595-1595           AL049795.21        97593-97593
            1596-2012           DB324323.1         6-422               c
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2012
                     /gene="IQCC"
                     /note="IQ motif containing C"
                     /db_xref="GeneID:55721"
                     /db_xref="HGNC:HGNC:25545"
     exon            1..53
                     /gene="IQCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1412
                     /gene="IQCC"
                     /note="isoform 2 is encoded by transcript variant 2; IQ
                     domain-containing protein C"
                     /codon_start=1
                     /product="IQ domain-containing protein C isoform 2"
                     /protein_id="NP_060604.2"
                     /db_xref="CCDS:CCDS355.1"
                     /db_xref="GeneID:55721"
                     /db_xref="HGNC:HGNC:25545"
                     /translation="MEPELLVRKVSALQACVRGFLVRRQFQSLRAEYEAIVREVEGDL
                     GTLQWTEGRIPRPRFLPEKAKSHQTWKAGDRVANPEQGLWNHFPCEESEGEATWEEMV
                     LKKSGESSANQGSLCRDHSSWLQMKQNRKPSQEKTRDTTRMENPEATDQRLPHSQPQL
                     QELQYHRSHLAMELLWLQQAINSRKEYLLLKQTLRSPEAGPIREEPRVFLEHGEQACE
                     RDQSQPSAPLEDQSYRDRTTGELEQEDDSCHRVKSPHRSPGSLATTQKNIAGAKCREP
                     CYSKSGPPSSIPSNSQALGDRLTKGPDDGRQTFGGTCLLQMKILEDQTPRGLKPRNHC
                     PRKSRTQLSALYEDSNIKEMSPRKLDHKEPDCRTVRTQELGLSEDHIIWDGTLGGPEH
                     SVLDLWRTKPPKGQAPTDRSSRDGTSNEPSHEGQKKQRTIPWRSKSPEILSSTKAGCT
                     GEEQWRGRPWKTEPPG"
     exon            54..197
                     /gene="IQCC"
                     /inference="alignment:Splign:2.1.0"
     exon            198..450
                     /gene="IQCC"
                     /inference="alignment:Splign:2.1.0"
     exon            451..569
                     /gene="IQCC"
                     /inference="alignment:Splign:2.1.0"
     exon            570..2012
                     /gene="IQCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCC"
                     /note="hexamer: AATAAA"
     polyA_site      2012
                     /gene="IQCC"
                     /note="major polyA site"
ORIGIN      
        1 agttggcgcc catggagcca gagctgctgg ttcggaaggt gtctgcattg caggcctgcg
       61 tccggggctt cttggtccga cgccagttcc agagcctgcg agctgagtat gaggcgattg
      121 tacgagaggt cgagggcgac ctgggcacgc ttcagtggac cgagggccgc attcccaggc
      181 cgcgattcct cccagagaag gcaaaatccc atcagacctg gaaagcagga gacagggtag
      241 caaatccaga gcaggggctg tggaaccact tcccatgtga agagtctgag ggagaggcca
      301 cctgggagga gatggtgctg aagaagtcag gagagagctc agcaaatcaa ggaagcctct
      361 gcagagatca cagctcctgg cttcagatga agcagaacag gaaacccagc caagagaaga
      421 ccagagacac gacaaggatg gagaatccag aagccacaga tcaaagactg ccccacagcc
      481 aacctcagct tcaagagctt cagtaccacc gcagccactt ggccatggaa ttgctgtggc
      541 tgcaacaggc catcaatagc cgtaaggagt acctacttct taaacaaaca ctgagatccc
      601 cagaggcggg cccgatcaga gaggaacccc gcgtgttcct agaacatggg gaacaggcct
      661 gtgagaggga ccagtcacaa ccaagcgcac cactggagga ccagtcctac agagacagga
      721 ccactggaga gctagaacag gaggatgact cctgtcacag ggtcaaatca ccccacagat
      781 ccccaggaag tttggccact acacaaaaaa acattgctgg ggctaagtgc agagaaccat
      841 gctacagcaa gtctggacca ccgtcgtcta taccatcaaa cagccaggcc ttgggggaca
      901 ggctcaccaa agggccagac gatggaagac agacctttgg agggacctgc ctgctgcaga
      961 tgaaaatcct ggaggaccag acccccagag gtttaaaacc taggaaccat tgtcccagga
     1021 agtccaggac acagctgtct gcactctatg aggactcaaa tattaaggag atgtctccca
     1081 gaaaactaga ccacaaagag cctgactgcc gaacagtcag gacacaagag ttgggcctct
     1141 cagaggacca catcatctgg gatggtacct tgggggggcc agagcatagt gtcctcgatc
     1201 tctggaggac taaaccaccc aaaggccagg cccccactga tagaagctcc agagatggaa
     1261 cctccaatga gcctagtcat gaaggacaga aaaagcagag gactatacca tggagatcaa
     1321 agtcacctga gattctgtct tctacaaagg caggctgtac aggagaggaa cagtggaggg
     1381 gcaggccatg gaaaacagaa ccacctggct agaccctagg aagccaggag aggatcaggt
     1441 tccaaagggg aatgctatga aagggcagtg agacaagacc tcatcctacc tccctgacca
     1501 gctctggctt ctgctcctgc ccctggccat tggtgactag tggggccaag agaagctgga
     1561 gcagagagct ggcatgagta tagggaagga ggaaggacac attttcaatc ctctgcctgt
     1621 agctcaatcc aaatttgtgg ataaggggcc gggtgcagtg gctcacacct gtaatcccag
     1681 cactttggga ggccaaggtg agtggatcac ctgaggtcag aagtttgaga ccagcctgac
     1741 caacatggtg aaatgaaacc ccatctcaac taaaaatata aaaattagcc aggcgtggtg
     1801 gtgcatgcct gtagtcccag ttactcggga ggctgagaca ggagaatcgc ttgaacccag
     1861 gagatggaga ttgcagtagg ccaagatgat gccactgcac tccagcctgg gctacagagc
     1921 gagacacggt ctcaaaaaac aaatgtgtgg ctaaggagtt acctggggga agtagaatga
     1981 gaggtctgtt gggaataaag gtttttctta ga
//
