LOCUS       NM_024726               3215 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens IQ motif containing with AAA domain 1 (IQCA1),
            transcript variant 1, mRNA.
ACCESSION   NM_024726
VERSION     NM_024726.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Bower,R., Tritschler,D., Vanderwaal,K., Perrone,C.A., Mueller,J.,
            Fox,L., Sale,W.S. and Porter,M.E.
  TITLE     The N-DRC forms a conserved biochemical complex that maintains
            outer doublet alignment and limits microtubule sliding in motile
            axonemes
  JOURNAL   Mol Biol Cell 24 (8), 1134-1152 (2013)
   PUBMED   23427265
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Snider,J., Thibault,G. and Houry,W.A.
  TITLE     The AAA+ superfamily of functionally diverse proteins
  JOURNAL   Genome Biol 9 (4), 216 (2008)
   PUBMED   18466635
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD688750.1 and BC043504.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024726.4.
            
            Summary: The protein encoded by this gene is a member of the
            ATPases Associated with diverse cellular Activities (AAA)
            superfamily. Members of this superfamily, found in all organisms,
            participate in a large number of cellular processes and contain the
            ATPase module consisting of an alpha-beta-alpha core domain and the
            Walker A and B motifs of the P-loop NTPases. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043504.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409907.8/ ENSP00000387347.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CD688750.1         94-120
            28-3215             BC043504.1         1-3188
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.2-q37.3"
     gene            1..3215
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /note="IQ motif containing with AAA domain 1"
                     /db_xref="GeneID:79781"
                     /db_xref="HGNC:HGNC:26195"
     exon            1..220
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2678
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     and AAA domain-containing protein 1; dynein regulatory
                     complex subunit 11; dynein regulatory complex protein 11"
                     /codon_start=1
                     /product="dynein regulatory complex protein 11 isoform 1"
                     /protein_id="NP_079002.3"
                     /db_xref="CCDS:CCDS46549.1"
                     /db_xref="GeneID:79781"
                     /db_xref="HGNC:HGNC:26195"
                     /translation="MSNAMYNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLAT
                     FYVKYVQIFRNLENVYDQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFD
                     DILQDLKLAPQQLDIPIPKYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIP
                     FDEAVKLIQIAERARQGRLRALFMKQIYLQEYRAKQSKMLGKKVTDTWAAALRIQKVW
                     RRFHQRKETEKLREEEMIFLGMNPPPLFNEVSATVIQAEKVDRLRNEVQIKHEEDYRE
                     ALVTIKNDLKLIEGVDIKENLQDQIRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKT
                     IQQVIEDIIANQEEEEKNKKKKKKKEKQPKKAKKQKKGTKEKNKEEDEKWKMSPSLFL
                     PAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIRIQVDELMRQELKN
                     LKLAVDRERERPVKAGKKKDKKGKKGKKKEKKAKKDKDLTADRTIESLYKELVEEGLL
                     IQALKVNLSDYIGEYSYLGTTLRQVSIEPMPSLLDVRQLITLYGIWPLGSAAVHEKAP
                     LVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVFKV
                     ARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTR
                     RPFDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIERNGGVLTSALNVSCLAKVTDG
                     FTQGHIVEVVKGVLTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEEESFKNWYAKTP
                     LGKKRALAITGGSTEKAKDKGKRK"
     exon            221..545
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            546..665
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            666..857
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            858..929
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1135
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1220
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1343
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1419
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1526
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1622
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1687
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1770
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1878
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2078
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2165
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2343
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2582
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..3215
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="IQCA1"
                     /gene_synonym="4930465P12Rik; DRC11; IQCA"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgctccg tgcctgcgaa gcaaacccgg cctcaccttt tcctgcccga agcagaagat
       61 tctcgcagtc ctggtttctc cctccagaag accccccacc caaatcctct gtagctcctg
      121 gtagtgccct gacccctgct gccaccgtcc ttcagagagc aacggaagag cttcccggag
      181 ggcgaggaaa agagggaaag tagccagcaa tgtcgaacgc aatgtataat aagatgtggc
      241 atcagaccca agaagccctc ggtgctttac tcgataaaga gcctcagaag atgattgaac
      301 cacaaagaaa tcaggttttc atctttcaaa cattagccac cttctacgta aagtatgtgc
      361 agatctttag aaacctagag aatgtctacg accagttcgt ccacccccag aaacgaatac
      421 tgatcaggaa agtcctggac ggggtgatgg gccgcatcct ggagctgaag aacgagatgg
      481 tggagctgga actcacggag ttccattatt tcgatgatat cctgcaggat ctcaagctgg
      541 ccccccaaca attagatatt cccataccca agtatttttt gaaggagaag ttggaagtaa
      601 taaaaggaag agagaaaatt cttgctcaaa tattagcgga cagcggaata gatacatctg
      661 acatgaaata ccctgtaaag agtatccctt tcgatgaggc tgttaaatta atccagattg
      721 ctgagagggc acggcaaggt cgcctaaggg ctttattcat gaagcaaatc tatctgcaag
      781 aatatagagc aaagcaatcc aagatgcttg gcaagaaagt gacagatacc tgggctgctg
      841 cactccgcat tcagaaggtt tggcgacgtt tccatcaacg taaggaaact gaaaaactga
      901 gagaagagga gatgatcttc ctgggtatga atccacctcc tctctttaat gaagtcagtg
      961 ctacagtaat ccaggctgaa aaggtggacc gcctgcggaa tgaggtgcag ataaagcatg
     1021 aagaggacta cagggaagcc ctggttacca tcaagaatga cctaaagttg atagaaggcg
     1081 tggatatcaa ggagaacctt caagaccaga tccggcattg gttcatcgaa tgcagaaatt
     1141 taaccgggac atttcctgac taccctgacg ttgaagaagg agggtcagct attatttttt
     1201 ctgacaagac catacaacag gttattgagg atatcatagc aaaccaagag gaagaagaaa
     1261 aaaacaaaaa gaagaagaag aaaaaggaaa aacaacccaa gaaagccaaa aaacaaaaga
     1321 aaggaacaaa ggagaaaaat aaggaagaag acgaaaaatg gaaaatgtca ccaagtcttt
     1381 ttcttcctgc aatgaaggaa ggatgtaacg catacaaaga aatctggatg aaaaaagatg
     1441 agtcttggaa tttctctcag gactatgatc cagaactgat caaagaggag aaacgaaaag
     1501 aattacagtc agagatcagg atacaggttg atgagttgat gagacaggaa cttaaaaact
     1561 taaagctagc tgtggacaga gaaagggagc gcccagtgaa agcaggaaag aaaaaggaca
     1621 agaaaggaaa gaaaggcaaa aagaaagaga agaaggcaaa gaaggataaa gatctgacag
     1681 ctgacaggac catcgagtct ctgtataagg aactggtgga agaaggatta ctgatccagg
     1741 ctctgaaagt caacctctct gattacattg gtgagtacag ctacctgggg actactcttc
     1801 gccaggtgtc catagaaccc atgccctccc tcctggatgt cagacagctc atcacattgt
     1861 acggaatctg gccattaggt tctgcagcag tgcatgagaa agctcctttg gtgaaatcgc
     1921 tactgttagc cgggccgtct ggggtaggga agaaaatgct ggtccatgcc atctgcaccg
     1981 aaacgggagc caacctcttc aacttgtcct cctctaacat tgctgggaaa taccctggca
     2041 aaaatggcct ccaaatgatg ctgcatgcag tcttcaaggt ggctcgacag ctccagccct
     2101 ccgtggtgtg gattgaagac acagaaaaaa ccttctacaa aaaagttccc aacgcagaaa
     2161 agatgaatga acctaaacgc ctgaaaaaac accttcccca aatcctgaaa ctcctgaaac
     2221 cagatgaccg gattctgatt gtggggacca cacggcgtcc cttcgatgct gaactccaat
     2281 ctttctgcaa agtttaccag aaaattattt tggtgcccag accagactat gcttccagat
     2341 acgttctgtg gaagcaaatc attgaacgca atggaggagt cctcaccagt gccttgaatg
     2401 tcagctgcct ggcgaaggtc actgacggct tcacccaagg acatatagtc gaagtggtta
     2461 aaggcgtgct cacagatcag agaatccggc ggcaaattca taaacctctc actgcagttg
     2521 agtttattac ggcgataacc agcatgaatc cagtgtacaa agaggaagaa gagagcttta
     2581 agaactggta tgccaaaact cctctgggta aaaaacgtgc cttggcgata acaggaggca
     2641 gcacagaaaa ggcaaaggac aaagggaaaa ggaaataaaa gaaagagaaa aaggcaaaaa
     2701 agaaaaagta atgcctttct gaagaaccat gcttgagtct ctctgggatg gagaggaccc
     2761 caactcgcca aagaaaagat tcaccattgc ccgcctgaag aagccctcag gggaaggaac
     2821 ttagcagtgt gcaggtgagc tgatgccgca aacccgctaa ccactgcatg tgctgttatg
     2881 cctttcccag gctggacacc tagctgggtg ttcatcataa ctttccacag ctttaatcca
     2941 cgccaagttt gtatataact gaaattcact cttgacaccc tccacagtct ttccaagttg
     3001 gactcttcct ctcatcagta ctagttgtca aatttaaaat gtgacagtta aagaatattc
     3061 tagtttgaca attagtaagc aatgagtata tcatcagtac actagctttt tattaatcca
     3121 tgtacactgt atagtatctt gcatctattt taataaatta attctttgct ctagtaatag
     3181 attttatata atgaaataaa ggtgttgtcc ttgaa
//
