LOCUS       NM_001381874            1805 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens IQ motif and ankyrin repeat containing 1 (IQANK1),
            transcript variant 1, mRNA.
ACCESSION   NM_001381874
VERSION     NM_001381874.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Wang,R., Yu,X., Ye,H., Ao,M., Xi,M. and Hou,M.
  TITLE     LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by
            promoting DNMT1-mediated CDO1 promoter hypermethylation
  JOURNAL   J Biol Chem 300 (9), 107680 (2024)
   PUBMED   39159808
  REMARK    GeneRIF: LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial
            cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Luo,X.J., Lu,Y.X., Wang,Y., Huang,R., Liu,J., Jin,Y., Liu,Z.K.,
            Liu,Z.X., Huang,Q.T., Pu,H.Y., Zeng,Z.L., Xu,R., Zhao,Q. and
            Wu,Q.N.
  TITLE     M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer
            progression through PTBP1
  JOURNAL   Cancer Lett 598, 217085 (2024)
   PUBMED   38964733
  REMARK    GeneRIF: M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer
            progression through PTBP1.
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Liu,N., Zhang,C. and Zhang,L.
  TITLE     WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates
            the Development of Gastric Cancer
  JOURNAL   Mol Biotechnol 66 (8), 1883-1893 (2024)
   PUBMED   37477820
  REMARK    GeneRIF: WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1
            Accelerates the Development of Gastric Cancer.
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Wang,S., Han,C., Liu,T., Ma,Z., Qiu,M., Wang,J., You,Q., Zheng,X.,
            Xu,W., Xia,W., Xu,Y., Hu,J., Xu,L. and Yin,R.
  TITLE     FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target
            of lung adenocarcinoma
  JOURNAL   Clin Transl Med 11 (2), e316 (2021)
   PUBMED   33634993
  REMARK    GeneRIF: FAM83H-AS1 is a noncoding oncogenic driver and therapeutic
            target of lung adenocarcinoma.
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Wu,H., Cao,F., Zhou,W., Wang,G., Liu,G., Xia,T., Liu,M., Mi,B. and
            Liu,Y.
  TITLE     Long Noncoding RNA FAM83H-AS1 Modulates SpA-Inhibited Osteogenic
            Differentiation in Human Bone Mesenchymal Stem Cells
  JOURNAL   Mol Cell Biol 40 (5), e00362-19 (2020)
   PUBMED   31871129
  REMARK    GeneRIF: FAM83H-AS1 role in the osteogenic differentiation of the
            bone mesenchymal stem cells.FAM83H-AS1 negatively regulated
            microRNA 541-3p and WNT3A.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Zhang,J., Feng,S., Su,W., Bai,S., Xiao,L., Wang,L., Thomas,D.G.,
            Lin,J., Reddy,R.M., Carrott,P.W., Lynch,W.R., Chang,A.C.,
            Beer,D.G., Guo,Y.M. and Chen,G.
  TITLE     Overexpression of FAM83H-AS1 indicates poor patient survival and
            knockdown impairs cell proliferation and invasion via MET/EGFR
            signaling in lung cancer
  JOURNAL   Sci Rep 7, 42819 (2017)
   PUBMED   28198463
  REMARK    GeneRIF: Results showed that FAM83H-AS1 is overexpressed in lung
            neoplasm and indicated that FAM83H-AS1 may not only be a potential
            biomarker for diagnosis and prognosis of lung cancer, but also play
            a critical role in lung cancer progression including cell
            proliferation, invasion, migration and colony formation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Yang,F., Lv,S.X., Lv,L., Liu,Y.H., Dong,S.Y., Yao,Z.H., Dai,X.X.,
            Zhang,X.H. and Wang,O.C.
  TITLE     Identification of lncRNA FAM83H-AS1 as a novel prognostic marker in
            luminal subtype breast cancer
  JOURNAL   Onco Targets Ther 9, 7039-7045 (2016)
   PUBMED   27895496
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Cabanski,C.R., White,N.M., Dang,H.X., Silva-Fisher,J.M.,
            Rauck,C.E., Cicka,D. and Maher,C.A.
  TITLE     Pan-cancer transcriptome analysis reveals long noncoding RNAs with
            conserved function
  JOURNAL   RNA Biol 12 (6), 628-642 (2015)
   PUBMED   25864709
  REMARK    GeneRIF: Study validated the role of 2 uncharacterized lncRNAs,
            onco-lncRNA-3 and onco-lncRNA-12, and a previously reported lncRNA,
            CCAT1, in S-phase cell cycle across cancer types.
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   White,N.M., Cabanski,C.R., Silva-Fisher,J.M., Dang,H.X.,
            Govindan,R. and Maher,C.A.
  TITLE     Transcriptome sequencing reveals altered long intergenic non-coding
            RNAs in lung cancer
  JOURNAL   Genome Biol 15 (8), 429 (2014)
   PUBMED   25116943
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105219.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968540, SAMEA1968968
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527139.7/ ENSP00000489685.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC105219.6         94576-94656         c
            82-170              AC105219.6         92857-92945         c
            171-260             AC105219.6         88847-88936         c
            261-391             AC105219.6         57177-57307         c
            392-556             AC105219.6         56830-56994         c
            557-748             AC105219.6         56552-56743         c
            749-874             AC105219.6         56313-56438         c
            875-1023            AC105219.6         39732-39880         c
            1024-1078           AC105219.6         39552-39606         c
            1079-1171           AC105219.6         39267-39359         c
            1172-1280           AC105219.6         38926-39034         c
            1281-1374           AC105219.6         38731-38824         c
            1375-1509           AC105219.6         38524-38658         c
            1510-1805           AC105219.6         38150-38445         c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1805
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /note="IQ motif and ankyrin repeat containing 1"
                     /db_xref="GeneID:642574"
                     /db_xref="HGNC:HGNC:49576"
                     /db_xref="MIM:618942"
     exon            1..81
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            82..170
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1768
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and ankyrin repeat domain-containing protein
                     LOC642574; FAM83H antisense RNA 1 (head to head); putative
                     IQ motif and ankyrin repeat domain-containing protein
                     LOC642574; IQ motif and ankyrin repeat domain-containing
                     protein 1; Chemoresistance Associated CRC lncRNA"
                     /codon_start=1
                     /product="IQ motif and ankyrin repeat domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001368803.1"
                     /db_xref="CCDS:CCDS94353.1"
                     /db_xref="GeneID:642574"
                     /db_xref="HGNC:HGNC:49576"
                     /db_xref="MIM:618942"
                     /translation="MDSKKGRPKAAAGKWQTLHPGPKTRAAAGKPGENRPPQRKAGWQ
                     AREPASAESPQAPTGPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKE
                     AYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQ
                     LLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASP
                     NSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS
                     WDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERCGSMTLKVQQLTREQQQCHKELQQ
                     AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLEL
                     REQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDT
                     NYVDTVNPEPLRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLL
                     RPTDGPEYSPTQFQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL"
     exon            171..260
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            261..391
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..556
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..748
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            749..874
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1023
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1078
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1171
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1280
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1374
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1509
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1805
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="IQANK1"
                     /gene_synonym="CACClnc; FAM83H-AS1; FAM83HAS1;
                     onco-lncRNA-3"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctagg aaacgagcga gcccgacgcc aggggcggag ctctggcctc ctcgccgagt
       61 tgggggaggc aggtgcgaca ggagaatgga cagtaagaag gggagaccca aagctgcagc
      121 tgggaagtgg cagacgctcc accctgggcc caagacaaga gctgctgctg ggaagcccgg
      181 ggagaaccgc ccgccgcaga ggaaagcggg ctggcaggcg agggagcccg cgtcggctga
      241 gagcccacag gcccccacag ggccggccga ggaccgagcg gccagagcga tccagggcgc
      301 cttccggcag ctccgggcca ggagggagct cgcccgccgc cgggaggagc gccgggagta
      361 cctggagcag atggagacgc cgcagaagga ggcctacctg gctccggtgc gccgggagca
      421 ggaggccgcg cggcggctgc gcgagcagga ggaggcggcg cagcgggagc ggcgggagga
      481 gctgcagcgt cgccgccgcc tgctggacgc cgccttcgac ggggacgtgg gcgagatccg
      541 ggcggtgctg aaggaggtgg agcagctgct gacgcgcgag ggcgtgggcc acgacgaggc
      601 aggcgaggcg cggcggctgc agcgacgcgt ggctctggcg gagtgcgagg acagctacgg
      661 gaacacgccg ctgtcggagg cggccgcagg cgggcagccc ctggccatcc agctgcgggc
      721 cgagctcggc gccagcccca acagcaaggg cgctttcggt ccgacgccgc tgtaccgtgc
      781 agcctttggg ggccacctgg cagctgtgga ggtgctcctg aagctcggag cagacccccg
      841 ggtgtacgca gaggacggga gcacccctga gcgggtggcc tcactggaca cagtggtgag
      901 cgtgctgcgc tcgtgggacc tgagcctcac ggaggccatg ctccagaaca tggaggctga
      961 gcagcagcgc cgggcccagg aggcccagag gcacaaggag gccgaggctg agcggtgtgg
     1021 aagtatgacc ctcaaggtcc aacagctgac cagggagcag cagcagtgtc acaaggagct
     1081 gcaacaggcc tactgtgagc ttagccggag gatctcagag cacgaccagt gtgagtggag
     1141 gtgcatggac aagaccaagc tcacgctgca ggccatcaag gacacagagg cccaggtgga
     1201 caggctgcgg caggaggccc agaaggccga ggaggcgctg gctatggcca ggctggagct
     1261 tcgggagcag acgcaggagg gggaggaaga ggcgcctggg ctgaagtgcc aggtcaccga
     1321 gctgcacgat gtgctgatga aagatgtagg caaccgcatc cgtgccgatg gccggtggcc
     1381 tcttgttatt gaccctttgg gccaggcggc caccttcctg cgctaccagg ataccaacta
     1441 tgtggacacg gtgaacccgg agcccctgag gccggagacg atgtggctgg ctctgctggg
     1501 ggctctgcgg tatgggaagc cgctggtgtt cgacctgcga gaggaagacc tgttcccagt
     1561 cgtgcagcgg cagctggagg cggtgcagga gaggtacctg tcgctgctgc ggcccacgga
     1621 cgggcctgag tatagcccca cgcagttcca ggagcagcgg ctggagcact tccgcctctt
     1681 tttcgtcacc aaggtccagt ggccgccagc tgagcagctg caggtgctgc tcccagtgcg
     1741 cgtgcagctg ccaggcacag gcctctagtg ctggccccag tcccaataaa acgtgtgccc
     1801 cgggg
//
