LOCUS       NM_005897               3117 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens intracisternal A particle-promoted polypeptide (IPP),
            transcript variant 1, mRNA.
ACCESSION   NM_005897
VERSION     NM_005897.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Nikou,S., Arbi,M., Dimitrakopoulos,F.D., Sirinian,C., Chadla,P.,
            Pappa,I., Ntaliarda,G., Stathopoulos,G.T., Papadaki,H., Zolota,V.,
            Lygerou,Z., Kalofonos,H.P. and Bravou,V.
  TITLE     Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras
            suppressor-1 (RSU1) promoting lung adenocarcinoma progression and
            poor survival
  JOURNAL   J Mol Histol 51 (4), 385-400 (2020)
   PUBMED   32592097
  REMARK    GeneRIF: Integrin-linked kinase (ILK) regulates KRAS, IPP complex
            and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma
            progression and poor survival.
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Kim,Y.C. and Cutler,M.L.
  TITLE     MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex
            Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell
            Lines
  JOURNAL   Int J Mol Sci 21 (15), 5458 (2020)
   PUBMED   32751711
  REMARK    GeneRIF: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion
            Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast
            Cancer Cell Lines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Dhanoa,B.S., Cogliati,T., Satish,A.G., Bruford,E.A. and
            Friedman,J.S.
  TITLE     Update on the Kelch-like (KLHL) gene family
  JOURNAL   Hum Genomics 7 (1), 13 (2013)
   PUBMED   23676014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   VanHouten,J.N., Asch,H.L. and Asch,B.B.
  TITLE     Cloning and characterization of ectopically expressed transcripts
            for the actin-binding protein MIPP in mouse mammary carcinomas
  JOURNAL   Oncogene 20 (38), 5366-5372 (2001)
   PUBMED   11536049
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Kim,I.F., Mohammadi,E. and Huang,R.C.
  TITLE     Isolation and characterization of IPP, a novel human gene encoding
            an actin-binding, kelch-like protein
  JOURNAL   Gene 228 (1-2), 73-83 (1999)
   PUBMED   10072760
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Chang-Yeh,A., Jabs,E.W., Li,X., Dracopoli,N.C. and Huang,R.C.
  TITLE     The IPP gene is assigned to human chromosome 1p32-1p22
  JOURNAL   Genomics 15 (1), 239-241 (1993)
   PUBMED   8432546
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Chang-Yeh,A., Mold,D.E. and Huang,R.C.
  TITLE     Identification of a novel murine IAP-promoted placenta-expressed
            gene
  JOURNAL   Nucleic Acids Res 19 (13), 3667-3672 (1991)
   PUBMED   1906605
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Mold,D.E., Chang-Yeh,A. and Huang,R.C.
  TITLE     Cell lineage-specific expression of the MIPP gene
  JOURNAL   Biochem Biophys Res Commun 177 (3), 1062-1067 (1991)
   PUBMED   1905535
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA905423.1, AK023880.1 and
            AL604028.15.
            
            On May 17, 2019 this sequence version replaced NM_005897.2.
            
            Summary: The protein encoded by this gene is a member of the kelch
            family of proteins, which is characterized by a 50 amino acid
            repeat which interacts with actin. Transcript variants have been
            described but their full-length nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.179904.1,
                                           SRR1660805.199385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396478.4/ ENSP00000379739.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA905423.1         163-166
            5-2149              AK023880.1         1-2145
            2150-3117           AL604028.15        73812-74779         c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3117
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /note="intracisternal A particle-promoted polypeptide"
                     /db_xref="GeneID:3652"
                     /db_xref="HGNC:HGNC:6108"
                     /db_xref="MIM:147485"
     exon            1..57
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            58..399
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1862
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin-binding protein IPP; kelch-like protein 27;
                     kelch-like family member 27"
                     /codon_start=1
                     /product="actin-binding protein IPP isoform 1"
                     /protein_id="NP_005888.1"
                     /db_xref="CCDS:CCDS30702.1"
                     /db_xref="GeneID:3652"
                     /db_xref="HGNC:HGNC:6108"
                     /db_xref="MIM:147485"
                     /translation="MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVG
                     QESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNI
                     GVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSEN
                     YIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKH
                     VVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQ
                     TSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARS
                     GLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAI
                     YALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI
                     ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF
                     EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW
                     TEIGNMITSRCEGGVAVL"
     exon            400..831
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            832..987
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1155
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1293
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1416
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1637
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..3107
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1948
                     /gene="IPP"
                     /gene_synonym="KLHL27"
     regulatory      2160..2165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /note="major polyA site"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPP"
                     /gene_synonym="KLHL27"
                     /note="hexamer: AATAAA"
     polyA_site      2242
                     /gene="IPP"
                     /gene_synonym="KLHL27"
ORIGIN      
        1 ggtcgcgact gcgcgcgcag ggcctgagcg ggcgccggag ggaaggggaa gcggcggggt
       61 agtaacagat tatgggcaac agtcctttta attaatctac cgtcatcatg gctaatgagg
      121 actgtcccaa ggctgctgat agtccttttt catcagataa acatgcccaa ctcatcttgg
      181 cccaaatcaa taagatgaga aatggacagc atttctgtga tgtgcagctg caagttggac
      241 aggaaagttt taaagctcat cggctggttt tggctgccag cagtccttac tttgcagctt
      301 tgttcactgg aggaatgaaa gagtcctcaa aagatgttgt accgattcta ggaattgaag
      361 caggaatctt tcagatactt ctagatttca tttacacagg tatagtgaac ataggtgtga
      421 ataatgtcca ggagttgatt attgcagcag acatgctaca gttgactgaa gttgttcatc
      481 tttgctgtga atttctgaaa ggacaaattg atccactgaa ctgcattgga atttttcagt
      541 tctctgagca aattgcctgc catgatctct tggaattctc agaaaactac attcatgtcc
      601 atttcttgga ggttcatagt ggagaagagt tcctggcact tacgaaagat cagctgatca
      661 aaattttgcg aagtgaagag cttagcattg aggatgaata ccaggtcttc ttagctgcaa
      721 tgcaatggat tctgaaagat ttgggaaaaa gaagaaaaca tgtggtggaa gtgctagacc
      781 caattcgatt ccctttatta cctcctcaga gacttttaaa gtatatagaa ggagtatccg
      841 attttaatct tcgtgttgca ttgcaaacac ttctgaaaga gtactgtgaa gtatgcaaat
      901 ctcccaaaga gaacaagttt tgtagttttc tgcagacatc taaggttcga cctcggaaga
      961 aagcaagaaa gtacctgtat gcagtaggtg gatatactcg gttgcagggg ggtcgctgga
     1021 gtgatagcag agccctcagc tgtgtagaac gttttgacac ctttagccag tactggacca
     1081 ctgtgtcttc acttcatcag gctcgaagtg ggctgggagt aacagttctg ggagggatgg
     1141 tctacgctat tggaggtgaa aaggattcaa tgatttttga ttgtactgaa tgctatgatc
     1201 cagttactaa acagtggaca actgtagctt cgatgaatca tccccgctgc ggcttaggag
     1261 tgtgtgtgtg ttatggggct atctatgctt tgggtggatg ggttggagct gagataggga
     1321 acaccattga acgatttgat cctgatgaaa ataaatggga agtagttggt aacatggctg
     1381 tgtcacgcta ctactttggg tgctgtgaaa tgcaaggttt aatttatgta attgggggca
     1441 tcagcaatga aggaatagaa cttcgttctt ttgaagtcta tgatccactt tctaagcgtt
     1501 ggtctccact tcctccaatg ggaaccagga gagcatatct tggtgtggct gcactcaatg
     1561 actgcatcta ttctgttgga ggatggaatg agacccaaga tgctcttcat actgtagaaa
     1621 aatattcctt tgaagaggaa aagtgggttg aagttgcctc aatgaaagtg cctagagcag
     1681 gcatgtgtgt tgtggcagtc aatggtcttc tgtatgtttc tggaggtcga tcttccagcc
     1741 atgatttttt ggctccaggt accttggact cagttgaagt ttataaccct cattcagata
     1801 catggacaga aattggtaac atgatcacca gtcgttgtga agggggcgtt gctgtgctat
     1861 gaaatataaa gcataacaga gcacaaggaa cattttgaaa atgcaggacc tgaccttttg
     1921 caaagcaaac atagatttgg tgataagacc ctctgattct gtgagttttc catgtatttg
     1981 gtagataaat gactaacgag gctgggcgca gtggcctcat gcctataatc ccagcacttt
     2041 ggaaggctga ggcagaagga tcacttgagc ccaggaattt gaggttgtag taagctacga
     2101 tcatgccact gcactccact ctgggcaaca gaatgagatc ctgtctctta aagaaaaaaa
     2161 ataaactcaa gaatgatttt tctaaaaata tgagtgagaa tggatatgga atatatccca
     2221 attaataaag agctcacaca gatttgccag gtttactaat aatagaaatg ccatttatgc
     2281 tgtagaattc tccagtttaa gtgtagacaa ctcctatttt acaaatttgt agaaattatt
     2341 tactagaagc ttcctggcaa atagtccctt tagctacttc tccagtgcag tataaattgt
     2401 aacataaaac tttatgtgat ataggaatag tgtcaatgac acagtttaaa gacctctata
     2461 ttcacaatta tatccagagc ataattttcc atggccatag tttgagccac agagaaagcc
     2521 aatgaaatag attcctactt ttatttaatg ccaagagttt tcactagccc caaacttttt
     2581 attggcagca gatatcctag gaggggtgtt tgggaaatat ctagctattt taatagatag
     2641 ataccttttt gcttgatgat aagtttttgc ttgctcatat tttttgtctt gatcctgaga
     2701 atgcaagtaa ggaattaata ggaggttctt agtgaccaga tgttgtaatg ggctatacag
     2761 tccagcaggc agtatgcacc tagaaatttc tccctttttt aggctgggca tggtggctca
     2821 cacctgtaat cccagcactt tgagaggccg aggtgagacg ggaagatggc ttgaactcag
     2881 gagttcgaga ctagcctggg caacgtgatg agactccgtc tctaccaaaa aatatataaa
     2941 aattagccgg gcgttgtggc ttgtacctgt ggtcccatct gcttgggagg ctgaggttgc
     3001 aggatcactt gagcccagga ggtcaaggct gcagtgagcc aagattgtgc cactgcacac
     3061 cggcctgggt gacagcatga gaacctgtct caaaaaaaaa aaaaaaaaaa gaaaaaa
//
