LOCUS       NM_006390               5208 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens importin 8 (IPO8), transcript variant 1, mRNA.
ACCESSION   NM_006390
VERSION     NM_006390.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5208)
  AUTHORS   Van Gucht,I., Meester,J.A.N., Bento,J.R., Bastiaansen,M.,
            Bastianen,J., Luyckx,I., Van Den Heuvel,L., Neutel,C.H.G.,
            Guns,P.J., Vermont,M., Fransen,E., Perik,M.H.A.M., Velchev,J.D.,
            Alaerts,M., Schepers,D., Peeters,S., Pintelon,I., Almesned,A.,
            Ferla,M.P., Taylor,J.C., Dallosso,A.R., Williams,M., Evans,J.,
            Rosenfeld,J.A., Sluysmans,T., Rodrigues,D., Chikermane,A.,
            Bharmappanavara,G., Vijayakumar,K., Mottaghi Moghaddam Shahri,H.,
            Hashemi,N., Torbati,P.N., Toosi,M.B., Al-Hassnan,Z.N., Vogt,J.,
            Revencu,N., Maystadt,I., Miller,E.M., Weaver,K.N., Begtrup,A.,
            Houlden,H., Murphy,D., Maroofian,R., Pagnamenta,A.T., Van Laer,L.,
            Loeys,B.L. and Verstraeten,A.
  CONSRTM   Genomics England Research Consortium
  TITLE     A human importin-beta-related disorder: Syndromic thoracic aortic
            aneurysm caused by bi-allelic loss-of-function variants in IPO8
  JOURNAL   Am J Hum Genet 108 (6), 1115-1125 (2021)
   PUBMED   34010605
  REMARK    GeneRIF: A human importin-beta-related disorder: Syndromic thoracic
            aortic aneurysm caused by bi-allelic loss-of-function variants in
            IPO8.
REFERENCE   2  (bases 1 to 5208)
  AUTHORS   Ziegler,A., Duclaux-Loras,R., Revenu,C., Charbit-Henrion,F.,
            Begue,B., Duroure,K., Grimaud,L., Guihot,A.L., Desquiret-Dumas,V.,
            Zarhrate,M., Cagnard,N., Mas,E., Breton,A., Edouard,T., Billon,C.,
            Frank,M., Colin,E., Lenaers,G., Henrion,D., Lyonnet,S., Faivre,L.,
            Alembik,Y., Philippe,A., Moulin,B., Reinstein,E., Tzur,S.,
            Attali,R., McGillivray,G., White,S.M., Gallacher,L., Kutsche,K.,
            Schneeberger,P., Girisha,K.M., Nayak,S.S., Pais,L., Maroofian,R.,
            Rad,A., Vona,B., Karimiani,E.G., Lekszas,C., Haaf,T., Martin,L.,
            Ruemmele,F., Bonneau,D., Cerf-Bensussan,N., Del Bene,F. and
            Parlato,M.
  TITLE     Bi-allelic variants in IPO8 cause a connective tissue disorder
            associated with cardiovascular defects, skeletal abnormalities, and
            immune dysregulation
  JOURNAL   Am J Hum Genet 108 (6), 1126-1137 (2021)
   PUBMED   34010604
  REMARK    GeneRIF: Bi-allelic variants in IPO8 cause a connective tissue
            disorder associated with cardiovascular defects, skeletal
            abnormalities, and immune dysregulation.
REFERENCE   3  (bases 1 to 5208)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5208)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5208)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5208)
  AUTHORS   Lunetta,K.L., D'Agostino,R.B. Sr., Karasik,D., Benjamin,E.J.,
            Guo,C.Y., Govindaraju,R., Kiel,D.P., Kelly-Hayes,M., Massaro,J.M.,
            Pencina,M.J., Seshadri,S. and Murabito,J.M.
  TITLE     Genetic correlates of longevity and selected age-related
            phenotypes: a genome-wide association study in the Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S13 (2007)
   PUBMED   17903295
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5208)
  AUTHORS   Xu,L., Yao,X., Chen,X., Lu,P., Zhang,B. and Ip,Y.T.
  TITLE     Msk is required for nuclear import of TGF-{beta}/BMP-activated
            Smads
  JOURNAL   J Cell Biol 178 (6), 981-994 (2007)
   PUBMED   17785517
REFERENCE   8  (bases 1 to 5208)
  AUTHORS   Dean,K.A., von Ahsen,O., Gorlich,D. and Fried,H.M.
  TITLE     Signal recognition particle protein 19 is imported into the nucleus
            by importin 8 (RanBP8) and transportin
  JOURNAL   J Cell Sci 114 (Pt 19), 3479-3485 (2001)
   PUBMED   11682607
REFERENCE   9  (bases 1 to 5208)
  AUTHORS   Gorlich,D., Dabrowski,M., Bischoff,F.R., Kutay,U., Bork,P.,
            Hartmann,E., Prehn,S. and Izaurralde,E.
  TITLE     A novel class of RanGTP binding proteins
  JOURNAL   J Cell Biol 138 (1), 65-80 (1997)
   PUBMED   9214382
REFERENCE   10 (bases 1 to 5208)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB072643.1, DB088518.1,
            U77494.1, AK302260.1, DB067822.1, AK130090.1, EB387074.1 and
            BG574795.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006390.3.
            
            Summary: The importin-alpha/beta complex and the GTPase Ran mediate
            nuclear import of proteins with a classical nuclear localization
            signal. The protein encoded by this gene is a member of a class of
            approximately 20 potential Ran targets that share a sequence motif
            related to the Ran-binding site of importin-beta. This protein
            binds to the nuclear pore complex and, along with RanGTP and
            RANBP1, inhibits the GAP stimulation of the Ran GTPase.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2010].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.170067.1,
                                           SRR1660807.262017.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256079.9/ ENSP00000256079.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               DB072643.1         127-276
            151-537             DB088518.1         152-538
            538-1056            U77494.1           486-1004
            1057-1190           AK302260.1         511-644
            1191-1645           DB067822.1         115-569
            1646-2837           AK302260.1         1100-2291
            2838-4328           AK130090.1         143-1633
            4329-4639           EB387074.1         488-798
            4640-5208           BG574795.1         90-658
FEATURES             Location/Qualifiers
     source          1..5208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..5208
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /note="importin 8"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
     exon            1..306
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3336
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /note="isoform 1 is encoded by transcript variant 1; RAN
                     binding protein 8; imp8; ran-binding protein 8"
                     /codon_start=1
                     /product="importin-8 isoform 1"
                     /protein_id="NP_006381.2"
                     /db_xref="CCDS:CCDS8719.1"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
                     /translation="MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIV
                     SDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIR
                     SPDLVRVQLTMCLRAIIKHDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTY
                     EYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQYALPL
                     QLVNNQTMTTWMEIFRTIIDRTVPPETLHIDEDDRPELVWWKCKKWALHIVARLFERY
                     GSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGV
                     VHSITWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTT
                     AAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLF
                     KDQMELFLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIE
                     DKEMPVKVEAALALQSLISNQIQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKM
                     ICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVED
                     HKEITQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHSISPQMWQLLGILYEVF
                     QQDCFEYFTDMMPLLHNYVTIDTDTLLSNAKHLEILFTMCRKVLCGDAGEDAECHAAK
                     LLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLL
                     HTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDA
                     VVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEEISSDEEETNVTAQA
                     MQSNNGRGEDEEEEDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALITVQSRD
                     AAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNF
                     GTVPSNN"
     exon            307..388
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            389..545
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            546..704
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            705..861
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            862..951
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1046
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1131
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1266
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1366
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1443
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1560
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1650
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1816
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1977
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2103
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2170
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2296
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2394
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2490
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2711
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2917
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3121
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3238
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..5208
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5183..5188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /note="hexamer: AATAAA"
     polyA_site      5208
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /note="major polyA site"
ORIGIN      
        1 gtaaaacggt gaatggagag cgagttgtgg gggggaaaaa gggaggacag ggggcgcgga
       61 gtcagagtgg cgcagcaagt ggccgcaggt ggcgacggtg gcggggggtg gggtgtgagg
      121 taatccaggg gtcgcggaag aggaggctga gagggtcaaa agaaaactaa agctgcagtc
      181 cggcctactg ttccgggggc cgcggagccc ccacccgggg agatggacct caaccggatc
      241 atccaggcgc tgaagggcac catcgacccg aagttgcgga ttgcagccga gaacgagctc
      301 aaccagtcct acaagattat caattttgcc cccagtttac ttcggattat agtctctgac
      361 catgtggaat tcccagtacg acaggcagct gccatttacc tgaagaacat ggtgacacaa
      421 tactggccag atcgagaacc tccaccagga gaagcaatat ttccattcaa cattcacgaa
      481 aacgatcgcc agcaaatacg tgataacatt gtggaaggaa taattcggtc tccagattta
      541 gtgagagtcc aattaacaat gtgtctccgt gccatcataa aacatgattt tcctggtcac
      601 tggccaggag tggtcgacaa gatagactat tacttgcaat cacagagcag tgcaagctgg
      661 cttggcagtt tattatgcct gtatcaactg gtgaagacat atgaatataa gaaagcagaa
      721 gagagagaac ctcttataat agcaatgcag atattcctgc ctcgtattca gcaacaaatt
      781 gttcagctcc ttcctgattc ctcctattat tctgtattac tgcagaaaca aattctgaaa
      841 atcttttatg cacttgttca gtatgcattg cctcttcagc tagtgaataa ccaaaccatg
      901 acaacatgga tggagatctt ccgaactatt atcgacagga ccgttcctcc tgagactctg
      961 cacattgatg aggatgatag accagaactg gtatggtgga agtgtaagaa gtgggcactg
     1021 catattgtag ctcggctctt tgaacgatat ggaagcccag gaaatgtcac aaaagaatac
     1081 tttgaatttt ctgaattctt tttgaaaacc tatgcagtgg gcattcagca ggtgctacta
     1141 aaaattttag atcaatatag acagaaagaa tatgtagctc cccgtgttct tcagcaagca
     1201 ttcaactatc tcaaccaagg ggtggttcat tctataacct ggaagcagat gaagccacac
     1261 atacagaata tctctgaaga tgtgattttt tctgtgatgt gttataaaga tgaggatgaa
     1321 gagctgtggc aagaagatcc atatgagtat ataaggatga aatttgatat ttttgaagat
     1381 tatgcttctc ccaccacagc agcccagact ctcttatata ctgctgcaaa gaaaagaaaa
     1441 gaggtgttgc caaaaatgat ggcattctgt tatcaaatcc tgacagaccc gaactttgac
     1501 cctaggaaga aagatggagc cctgcatgtg attggttccc tagctgagat tttactgaag
     1561 aagagtttat tcaaggacca aatggagctg tttctacaaa atcatgtatt tccattatta
     1621 ttgtctaacc tgggatatct tcgagctaga tcttgctggg tacttcatgc atttagttct
     1681 ttgaagttcc ataatgagct caatctaaga aatgccgttg aattagcgaa gaagagcctg
     1741 attgaagata aagagatgcc tgtcaaagtt gaagctgccc ttgctcttca gtctttaatt
     1801 tctaaccaga tacaagctaa ggaatatatg aagccacatg tgaggcctat tatgcaggaa
     1861 ctgttgcaca ttgttagaga gacagaaaat gatgatgtta ctaatgtcat ccagaagatg
     1921 atatgtgaat acagtcaaga ggtagcctca attgctgttg atatgaccca acacttggct
     1981 gagatatttg gcaaagttct tcaaagtgat gaatatgaag aagttgaaga caaaacagta
     2041 atggctatgg gaattttaca taccattgat actatcttaa cagttgtaga agatcataaa
     2101 gagattaccc agcagttaga gaatatctgt ctacggatca ttgatcttgt tctgcagaaa
     2161 catgtaattg aattctatga agaaattctt tccctggcat acagtttaac ctgccacagt
     2221 atttcccctc aaatgtggca gcttctaggt atactatatg aagtgtttca gcaggattgc
     2281 tttgaatact ttacagacat gatgcctctc ctgcataatt atgtgacaat agatacagat
     2341 accttactat caaatgcaaa acatttagaa attcttttta caatgtgtag gaaggtacta
     2401 tgtggagatg caggagaaga tgcagagtgt catgcagcta aacttctgga agtcatcatt
     2461 cttcagtgca aaggaagggg aattgatcag tgcattccac tcttcgttca acttgttttg
     2521 gagagattaa ctcgaggggt caaaactagt gagcttcgta ctatgtgtct tcaggttgca
     2581 attgctgcct tgtactacaa ccctgatttg ctgctacata ctttagaacg aattcagttg
     2641 cctcacaacc ctggacctat cactgtacag tttataaatc aatggatgaa tgatacagat
     2701 tgttttcttg ggcatcatga ccggaagatg tgtataatag gactgagtat ccttttggaa
     2761 ttgcaaaatc gacctcctgc agtagatgct gtggtgggac agattgttcc ctcaattctt
     2821 ttccttttcc ttggcctaaa gcaggtctgt gctactagac aactggtaaa ccgggaagat
     2881 cgttcaaaag cagagaaagc tgatatggaa gaaaatgagg agatttcaag tgatgaagag
     2941 gagacaaatg taactgctca agcaatgcag tcaaataatg gaagaggtga agatgaggag
     3001 gaggaagatg atgactggga tgaagaagta ttggaagaaa ccgcgcttga ggggttcagt
     3061 actccacttg accttgacaa tagtgtggat gaatatcagt tttttacaca agctctgata
     3121 actgtgcaga gtcgagatgc agcctggtac cagctgctga tggcaccact cagcgaggat
     3181 cagaggacag cactgcagga ggtgtacaca ctggcagagc accgacggac ggtggcagag
     3241 gcaaagaaga agattgaaca acagggaggc ttcacctttg aaaacaaagg agtcctctcc
     3301 gcatttaatt ttgggactgt gcccagcaac aactgaagga aagaacatca gctgaccaaa
     3361 tgtcatcgct gcattttatt tcacaagagg agtgtgaggg tcaaggggat gaaatgaggg
     3421 gctgctttta gggccctcct gctgtgccag ttaccatctg gcattaggca gcacttttat
     3481 ctactctttc ccctttgacc tttgtcaccc tgaaatatat attttaaaca gctactgtaa
     3541 gtatgaaatg aaagaaaaac aatcattgga cggaaaagga caacccatat gttccaaagg
     3601 ctgaatgccc aaggttgttt tagaggattg gatagacttg cacgtctcag gtttttgcca
     3661 tgcagaatca atggatttat gcggataaca gtgccttctg ttgtacatga attatcagaa
     3721 aaaaattttt ggagtgcatt gcaatttttt ttaaagcata aaacatattt ctagatacaa
     3781 cataaacctt ggttatatgt caactattct gcattttact ctgtgaattt attgttaggc
     3841 agttactgca agtcactctg gtttcaaaat cttcacggct ccctctgctc accctgctgc
     3901 tggggggctt ttttcagggg ttgtattata aaatatgcac tggctgtggt ttttcataag
     3961 atgttttgtg gctttttaaa gaagtgtctt actccctctt ctctcatttt tttctgcctt
     4021 gaaaaggggt ggtatttctt ttggggtcaa caaatacaca tatcagtttc actcctaacc
     4081 ttgtaagttc aggactcatt ttcttggcag caagtggcag gggctcttta gtcactggag
     4141 ttaacagtaa gtctgagtat attctgaata atgtaattat gcaattaatt gataatcata
     4201 cctaaagcac attgaacttc taagagacag gtgctacgta agcacactgt ctttctggat
     4261 ggggacttgt attttaaata acttatcatt ccagctatgt tggactaggg tccaaagcat
     4321 tttataatat ttttttttaa tctaggaaaa agacccaaac aaatctaact tcttgctttc
     4381 tcacctattt gaattttctc ctacctaatt tgtttgtgtc tttattatag ctcagtttga
     4441 cttctcaaac ttttcaaggg ttggggcagc tgcactttta ggttgcctat aggaaatatt
     4501 gcatatggag attacagtgt ttttctgacc tagttcaaga ccagaacatg ggtcataggg
     4561 tttttattca gcaaaatgaa aacgtatctt cagaacttaa catattactg gatgtgatac
     4621 agattttgct ttctgtggaa ttgaaaattc acaaaaattc acagcttaaa tttcccatca
     4681 gtgactggag gaattttttt caggtgcttc ctatattacc atccctcatg catattaact
     4741 ctttagaatt ttaggttaag tgatgtctat agaagtagcc tggaaaacca tgagttttgg
     4801 agttcagtga ccccctgctt tcctctgctc ctcccttccc aaggcattga agctgaatgt
     4861 gccaactggc agttagaagc gaaagatggc attgggagaa attttagaga gctttcaaac
     4921 tctttattct catgttccac atggtctaat tttaacataa ataatatgcc ttcacactgg
     4981 attgtaaaag gcatgtgatt tttgagattt tattttgtga tgtattgtct tctgcagtat
     5041 taaagggaaa gagatattaa tgtgcattac cctatcttgt ttttgaagcc agggtagttg
     5101 tatgattttg ttaccagcag tgctaacctg aatgtgacct ggttaccttg gaaatgcagg
     5161 aacttatatg aatgtactat aaaataaaat gcggactgat tcccagga
//
