LOCUS       NM_006391               6162 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens importin 7 (IPO7), mRNA.
ACCESSION   NM_006391
VERSION     NM_006391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6162)
  AUTHORS   Chen,S. and Pan,J.
  TITLE     Importin 7 enhances protective autophagy induced by nuclear
            translocation of homeobox A10 in oral squamous cell carcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (3), 241-247 (2024)
   PUBMED   38650127
  REMARK    GeneRIF: Importin 7 enhances protective autophagy induced by
            nuclear translocation of homeobox A10 in oral squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6162)
  AUTHORS   Li,M., Xu,D., Zhan,Y. and Tan,S.
  TITLE     IPO7 promotes pancreatic cancer progression via regulating ERBB
            pathway
  JOURNAL   Clinics (Sao Paulo) 77, 100044 (2022)
   PUBMED   35588577
  REMARK    GeneRIF: IPO7 promotes pancreatic cancer progression via regulating
            ERBB pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6162)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6162)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 6162)
  AUTHORS   Panagiotopoulos,A.A., Polioudaki,C., Ntallis,S.G., Dellis,D.,
            Notas,G., Panagiotidis,C.A., Theodoropoulos,P.A., Castanas,E. and
            Kampa,M.
  TITLE     The sequence [EKRKI(E/R)(K/L/R/S/T)] is a nuclear localization
            signal for importin 7 binding (NLS7)
  JOURNAL   Biochim Biophys Acta Gen Subj 1865 (5), 129851 (2021)
   PUBMED   33482249
  REMARK    GeneRIF: The sequence [EKRKI(E/R)(K/L/R/S/T)] is a nuclear
            localization signal for importin 7 binding (NLS7).
            Erratum:[Biochim Biophys Acta Gen Subj. 2021 Jul;1865(7):129887.
            doi: 10.1016/j.bbagen.2021.129887.. PMID: 33712300]
REFERENCE   6  (bases 1 to 6162)
  AUTHORS   Dean,K.A., von Ahsen,O., Gorlich,D. and Fried,H.M.
  TITLE     Signal recognition particle protein 19 is imported into the nucleus
            by importin 8 (RanBP8) and transportin
  JOURNAL   J Cell Sci 114 (Pt 19), 3479-3485 (2001)
   PUBMED   11682607
REFERENCE   7  (bases 1 to 6162)
  AUTHORS   Jakel,S., Albig,W., Kutay,U., Bischoff,F.R., Schwamborn,K.,
            Doenecke,D. and Gorlich,D.
  TITLE     The importin beta/importin 7 heterodimer is a functional nuclear
            import receptor for histone H1
  JOURNAL   EMBO J 18 (9), 2411-2423 (1999)
   PUBMED   10228156
REFERENCE   8  (bases 1 to 6162)
  AUTHORS   Paraskeva,E., Izaurralde,E., Bischoff,F.R., Huber,J., Kutay,U.,
            Hartmann,E., Luhrmann,R. and Gorlich,D.
  TITLE     CRM1-mediated recycling of snurportin 1 to the cytoplasm
  JOURNAL   J Cell Biol 145 (2), 255-264 (1999)
   PUBMED   10209022
REFERENCE   9  (bases 1 to 6162)
  AUTHORS   Jakel,S. and Gorlich,D.
  TITLE     Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear
            import of ribosomal proteins in mammalian cells
  JOURNAL   EMBO J 17 (15), 4491-4502 (1998)
   PUBMED   9687515
REFERENCE   10 (bases 1 to 6162)
  AUTHORS   Gorlich,D., Dabrowski,M., Bischoff,F.R., Kutay,U., Bork,P.,
            Hartmann,E., Prehn,S. and Izaurralde,E.
  TITLE     A novel class of RanGTP binding proteins
  JOURNAL   J Cell Biol 138 (1), 65-80 (1997)
   PUBMED   9214382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055845.15 and AC132192.3.
            
            On Nov 23, 2018 this sequence version replaced NM_006391.2.
            
            Summary: The importin-alpha/beta complex and the GTPase Ran mediate
            nuclear import of proteins with a classical nuclear localization
            signal. The protein encoded by this gene is a member of a class of
            approximately 20 potential Ran targets that share a sequence motif
            related to the Ran-binding site of importin-beta. Similar to
            importin-beta, this protein prevents the activation of Ran's GTPase
            by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also
            binds directly to nuclear pore complexes where it competes for
            binding sites with importin-beta and transportin. This protein has
            a Ran-dependent transport cycle and it can cross the nuclear
            envelope rapidly and in both directions. At least four importin
            beta-like transport receptors, namely importin beta itself,
            transportin, RanBP5 and RanBP7, directly bind and import ribosomal
            proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.220723.1,
                                           SRR1660809.78558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379719.8/ ENSP00000369042.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC055845.15        25677-25872         c
            197-278             AC132192.3         97359-97440         c
            279-432             AC132192.3         92091-92244         c
            433-591             AC132192.3         90644-90802         c
            592-748             AC132192.3         86319-86475         c
            749-838             AC132192.3         83582-83671         c
            839-933             AC132192.3         80225-80319         c
            934-1018            AC132192.3         80032-80116         c
            1019-1153           AC132192.3         77590-77724         c
            1154-1253           AC132192.3         76854-76953         c
            1254-1330           AC132192.3         75740-75816         c
            1331-1447           AC132192.3         75468-75584         c
            1448-1537           AC132192.3         72101-72190         c
            1538-1703           AC132192.3         71534-71699         c
            1704-1864           AC132192.3         70896-71056         c
            1865-1993           AC132192.3         69727-69855         c
            1994-2060           AC132192.3         67094-67160         c
            2061-2186           AC132192.3         66884-67009         c
            2187-2284           AC132192.3         65699-65796         c
            2285-2380           AC132192.3         64364-64459         c
            2381-2601           AC132192.3         62756-62976         c
            2602-2807           AC132192.3         62445-62650         c
            2808-3014           AC132192.3         60069-60275         c
            3015-3131           AC132192.3         58533-58649         c
            3132-6162           AC132192.3         52603-55633         c
FEATURES             Location/Qualifiers
     source          1..6162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6162
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="importin 7"
                     /db_xref="GeneID:10527"
                     /db_xref="HGNC:HGNC:9852"
                     /db_xref="MIM:605586"
     exon            1..196
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..3229
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="RAN-binding protein 7"
                     /codon_start=1
                     /product="importin-7"
                     /protein_id="NP_006382.1"
                     /db_xref="CCDS:CCDS31425.1"
                     /db_xref="GeneID:10527"
                     /db_xref="HGNC:HGNC:9852"
                     /db_xref="MIM:605586"
                     /translation="MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITM
                     SEQLDLPVRQAGVIYLKNMITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHS
                     PELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYE
                     YKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLE
                     LINQQNLTEWIEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYG
                     SPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVS
                     HALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTA
                     AQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYK
                     DQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDD
                     REMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMI
                     CEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVED
                     HKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVF
                     QQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAK
                     LLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLL
                     NTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQ
                     VSGQILPAFILLFNGLKRAYACHAEHENDSDDDDEAEDDDETEELGSDEDDIDEDGQE
                     YLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNR
                     NPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNF
                     GGPAPGMN"
     exon            197..278
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            279..432
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            433..591
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            592..748
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            749..838
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            839..933
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1018
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1153
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1253
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1330
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1447
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1537
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1703
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1864
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1993
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2060
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2186
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2284
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2380
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2601
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2807
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..3014
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3131
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..6162
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4239..4244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="hexamer: ATTAAA"
     polyA_site      4264
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="major polyA site"
     regulatory      5255..5260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="hexamer: AATAAA"
     polyA_site      5277
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="major polyA site"
     regulatory      6136..6141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="hexamer: AATAAA"
     polyA_site      6162
                     /gene="IPO7"
                     /gene_synonym="Imp7; RANBP7"
                     /note="major polyA site"
ORIGIN      
        1 cctttcgcgc cggttgccgc tgcggagcgc ggcgggtcca tgtgcgcagt gagtggcgct
       61 attcctggcc cagtagcacc cgagccccgg gtttgaccga gtccgcgctg cgatggaccc
      121 caacaccatt atcgaggccc tgcggggcac tatggaccca gccctgcgtg aggccgcgga
      181 gcgccagctc aatgaagcac acaagtctct gaattttgtc tcaacactgc tccagattac
      241 tatgtcggaa cagctggatt tacctgtgag acaggcaggt gttatctatc tgaaaaatat
      301 gataacacag tattggcctg atcgagaaac agcaccaggg gatatatccc cttatactat
      361 tccagaagaa gatcgccatt gtattcgaga aaatattgta gaagccatta tccattctcc
      421 tgagctcatc agggtacagc ttactacatg cattcatcac atcatcaaac atgattatcc
      481 aagccgctgg actgccattg tggacaaaat tggcttttat cttcagtccg ataacagtgc
      541 ttgttggcta ggaattcttc tttgccttta tcagcttgtg aaaaattatg agtataaaaa
      601 accagaggag cggagtccat tggtagcagc aatgcagcat tttctgccag ttctaaagga
      661 tcgttttatc cagcttcttt ctgaccagtc tgatcagtct gtcctcatcc agaaacagat
      721 attcaagatc ttctatgctc ttgttcagta tacactacca ctggaactga taaaccaaca
      781 gaacctgaca gaatggatag aaattttaaa gactgttgtg aacagggatg tacctaatga
      841 aacacttcaa gttgaagaag atgatcgacc tgagttacca tggtggaaat gcaagaagtg
      901 ggccttacat attttagcaa gactttttga aagatatgga agccctggca atgtttccaa
      961 ggagtataat gaatttgctg aagtatttct gaaggcattt gctgttggtg tccagcaagt
     1021 tttattgaag gtgttatatc agtacaagga gaagcaatat atggctcctc gagttttaca
     1081 acagacatta aattatatta atcaaggagt ttctcatgct ctcacctgga agaatctgaa
     1141 gccccatata caaggcatta tccaagatgt tatttttcca ttgatgtgct atacagatgc
     1201 tgatgaggaa ctttggcaag aagaccctta cgaatatata cgcatgaagt ttgatgtgtt
     1261 tgaagatttc atttctccta ccactgctgc ccagacactt ttgtttacag cctgtagtaa
     1321 gaggaaagag gtactgcaaa agactatggg attttgttac cagattctta cagaaccaaa
     1381 tgctgaccct cgaaaaaaag atggagccct gcatatgatt ggctctttag ctgaaatact
     1441 tctgaagaaa aagatctata aagatcagat ggaatacatg ttgcagaatc atgtattccc
     1501 tctcttcagc agtgaactag gctacatgag agcaagggct tgctgggtac ttcactattt
     1561 ttgtgaagtg aagttcaaaa gtgatcagaa ccttcaaaca gccttagagc taacaagaag
     1621 atgtctgatt gatgatagag aaatgcctgt gaaagtggaa gctgccattg cccttcaagt
     1681 attgatcagc aatcaagaaa aagctaaaga atatatcaca ccattcatca gacctgtaat
     1741 gcaggctctt cttcacatta taagagaaac agaaaatgat gaccttacca atgtaattca
     1801 gaaaatgatc tgtgaatata gtgaagaagt tactcctatt gcagtagaaa tgacacaaca
     1861 tttggcaatg acatttaacc aagtaatcca gacggggcca gatgaagaag gtagtgatga
     1921 caaagcagtt actgctatgg gaattctgaa tacaattgat acacttctta gtgtagttga
     1981 agatcataaa gagataaccc aacagcttga gggaatctgc ttacaggtca ttggtactgt
     2041 tttacaacag catgtcttag aattctatga ggagatcttc tctttagcgc acagtttgac
     2101 atgtcaacaa gtgtctccac agatgtggca gctactaccc cttgtatttg aagtctttca
     2161 gcaagatggc tttgattact ttacagatat gatgcccctc cttcataatt atgtaacagt
     2221 tgatacagac acacttctgt ctgacaccaa gtatcttgaa atgatataca gtatgtgcaa
     2281 aaaggttctt acaggagttg caggagaaga tgcagagtgt catgcagcaa aattgttaga
     2341 ggtcatcatt ctgcagtgca aagggcgtgg cattgaccag tgcattccct tattcgtgga
     2401 agcagcctta gaaagactga caagagaggt taagacaagt gaacttcgaa ctatgtgtct
     2461 gcaagttgca attgcagctt tgtattataa tccacaccta ctactcaata ccttagaaaa
     2521 tcttcgcttc cctaataatg ttgaaccagt tacaaatcat tttattacac agtggcttaa
     2581 tgatgttgac tgtttcttgg ggcttcatga cagaaagatg tgtgttctcg gactctgtgc
     2641 tcttattgat atggaacaga taccccaagt tttaaatcag gtttctggac agattttgcc
     2701 ggcttttatc cttttattta acggattgaa aagagcatat gcctgccatg cagaacatga
     2761 gaatgacagt gatgatgatg atgaagctga agatgatgat gaaaccgagg aactggggag
     2821 tgatgaagat gatattgatg aagatgggca agaatatttg gagattctgg ctaagcaggc
     2881 tggtgaagat ggagatgatg aagattggga agaagatgat gctgaagaga ctgctctgga
     2941 aggctattcc acaatcattg atgatgaaga taaccctgtt gatgagtatc agatatttaa
     3001 agctatcttt caaactattc aaaatcgtaa tcctgtgtgg tatcaggcac tgactcacgg
     3061 tcttaatgaa gaacaaagaa aacagttaca ggacatagca actctggctg atcaaagaag
     3121 agcagcccat gaatccaaaa tgattgagaa gcatggagga tacaaattca gtgctccagt
     3181 tgtgccaagt tctttcaatt ttggaggccc agcaccaggg atgaattgag ttatctcttt
     3241 ctttcctgct gtgtgcttgt agtgaagagc ttgtgttcct cctagtagtg gttccagaac
     3301 tggttcatgt tatctattct aaactaataa tcaatagatg gacaaaagaa acaacaaccc
     3361 caggagatgg gacctgatca tgcaacctgg cactggaaaa gaaatcagcg ggattttggg
     3421 ggtggggggg gatgggaggt accttagagg gagtattttc tttatttttt gaagaaagta
     3481 agatcctgac tctgaagctt caaagtgaca ctgtggaaat ctgaaacgag gggatgtcat
     3541 gaaggcagct tttctttttc tgaggaaaaa ataggcatgg gctacaggac tatttaaaat
     3601 gtctcattta cagtataaaa ctcaaaggta gatgtaattt ttacacctat gagtatttgt
     3661 ccaatttctg tctcttcctc accattgggt atctattctt tatatgtaaa taagataagg
     3721 tcatctgata gccttattca gtcttcatca ttttcatcat tgttcctatg tagattattg
     3781 gacatttatt gtagcactac ataactgatt ataaaaatct gtaaatgaat tagcactttc
     3841 atattgaaac aagcctgcta gcctatgtat aaaatagcaa aatgtttgct gtttataaaa
     3901 agatgtaatg gggtgggggg caggggtaat ttcaagttat taatttaaaa atgaactagc
     3961 aattttgtac ctggtgactt tgtggtgcac tcacctctga tagtgacttg aattcggtat
     4021 gtaaaaaggg gttagtggta tttcattgct gctaaaaatg acaactccct ctgtgtcctg
     4081 tttttcttaa agctgtcagt gtacaagtgg gtatttgaat accagacctt actgtaaaaa
     4141 ataaaaaagg tggtatctag agcatgtaaa ttggatataa agttctgctc ttaaagagtt
     4201 gatctaagag tatggctaaa catctatata tgcaatctat taaaagaact taattcggct
     4261 attatgtctt gatttgattg cagttttttc ctaattataa caaatttttc ctcattggcc
     4321 tgtttttaat cctgtgccta gaaggagtac aaaatgcaca ctttacaaaa ttgatattta
     4381 acacttaccc actccccttt ccccatctct tctaccgctc ttgttgatcg tggtatctga
     4441 tcttgactag ataggctgaa ggcacatggt tccctccaaa aaccactatt gataccacta
     4501 caaaaacaag ccagcaaaaa gatactgtag agaggttggc ttgcttccct ctcttcctaa
     4561 ctgcatgttg aaaaataagc cgttattgat cttaaacatc ggtcagatga gtcatacatt
     4621 gggttatttt ttatatacat gtatacacaa aatatttcaa attgaaagca acatcttaat
     4681 ggattcaaaa ctattacaag ctgttgtcta aaacaggtga gaaaaaaatt tataactgta
     4741 aaaacaaatg cacatattga tatttaaaat gcgtaattaa gaaaacccat tgttgttgtg
     4801 tttttcttgt ataccaataa ttaagccact actgttggca ctgtttggtt ttctatttta
     4861 acactgaagg agtgaaagta tttcctatat ttatgaattt actactaaaa tcttggcaaa
     4921 aaaagaaaaa aattgtctaa cgtgtgtggg tgaaaactgt taatcaagtg tttctactcc
     4981 cccccgaaaa tcccctgaaa gttggacacc aactgtatac cctaggttgc ttaaagggat
     5041 ttcactatta tataaagtca ataaaaatga agtagttgta tatatgcaac attgtgtaca
     5101 gaggggaaat aatgaatagt attaaagaaa cattctcgtc ttcctttacc tttaatcccc
     5161 taatacctag tctacttttt aaattttcag acttcactgc tttttgaatt cataattcta
     5221 attttcacat tattgttaat ggaaaatcat atctaataaa ggttttagtt attcccatgc
     5281 acagtatgaa aattctcatt tgctgaggtt ttgtttcaag aaaatgtatt ggcatgtctt
     5341 tgagaacatg ttttattgtc tcctgtgtca tataatccaa actaatctcc gtttacagac
     5401 tttaacttga aattagacct tataattaaa ctatttaaat agtgttcaaa tgatagtttc
     5461 taatgcatca aatatatacc tcagttttca tgatttcctt taacattata atttggtata
     5521 gatcaagaat cttaacatgt atcagtttct agatgaggct gcaggatttt tggaaaactt
     5581 tttgaatgta tttacaatat tctcttgtaa ttagctacat agggacttgt ctttttttct
     5641 ttttacatac agcttttcct acagttttat taccctgtaa ttttttttta gttgtagaag
     5701 ttaattctga ttttgtgtgg atttcagtat ttgtctttgt taatggcaca tattagcata
     5761 aatcactttt gtaaatgtaa gctttctttt tttttcttga aaaagccttt ctatttatca
     5821 gtattaaata aaggaagtta atctgtttct ctgcaggtaa taaaatagtg acacactgta
     5881 ttaagatagt gactgctata ctcaactctg gaagagacta gagtatagag catgagtggc
     5941 aaaaccacag cccttgggcc atatgctgct attcagtccc agatgtagcc cctgaagcaa
     6001 gcataaagaa aaatgaatta aaaattaaat taatatggaa agttaaaaaa tggattacat
     6061 tagtatgact aaaccatgtc tttggcaaag atctaacaca atgtcttaag tataataggt
     6121 agtctctgtt tgtaaaataa atgacttaaa tttaaaacat ca
//
