LOCUS       NM_002271               6002 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens importin 5 (IPO5), mRNA.
ACCESSION   NM_002271
VERSION     NM_002271.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6002)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6002)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6002)
  AUTHORS   Swale,C., Da Costa,B., Sedano,L., Garzoni,F., McCarthy,A.A.,
            Berger,I., Bieniossek,C., Ruigrok,R.W.H., Delmas,B. and Crepin,T.
  TITLE     X-ray Structure of the Human Karyopherin RanBP5, an Essential
            Factor for Influenza Polymerase Nuclear Trafficking
  JOURNAL   J Mol Biol 432 (10), 3353-3359 (2020)
   PUBMED   32222384
  REMARK    GeneRIF: X-ray Structure of the Human Karyopherin RanBP5, an
            Essential Factor for Influenza Polymerase Nuclear Trafficking.
REFERENCE   4  (bases 1 to 6002)
  AUTHORS   Li,X.F., Aierken,A.L. and Shen,L.
  TITLE     IPO5 promotes malignant progression of esophageal cancer through
            activating MMP7
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (8), 4246-4254 (2020)
   PUBMED   32373960
  REMARK    GeneRIF: IPO5 promotes malignant progression of esophageal cancer
            through activating MMP7.
REFERENCE   5  (bases 1 to 6002)
  AUTHORS   Li,D., Fu,S., Wu,Z., Yang,W., Ru,Y., Shu,H., Liu,X. and Zheng,H.
  TITLE     DDX56 inhibits type I interferon by disrupting assembly of
            IRF3-IPO5 to inhibit IRF3 nucleus import
  JOURNAL   J Cell Sci 133 (5) (2019)
   PUBMED   31340999
  REMARK    GeneRIF: DDX56 inhibits type I interferon by disrupting assembly of
            IRF3-IPO5 to inhibit IRF3 nucleus import.
            Erratum:[J Cell Sci. 2020 Feb 20;133(4):jcs244681. doi:
            10.1242/jcs.244681.. PMID: 32079732]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6002)
  AUTHORS   Gallay,P., Hope,T., Chin,D. and Trono,D.
  TITLE     HIV-1 infection of nondividing cells through the recognition of
            integrase by the importin/karyopherin pathway
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9825-9830 (1997)
   PUBMED   9275210
REFERENCE   7  (bases 1 to 6002)
  AUTHORS   Deane,R., Schafer,W., Zimmermann,H.P., Mueller,L., Gorlich,D.,
            Prehn,S., Ponstingl,H. and Bischoff,F.R.
  TITLE     Ran-binding protein 5 (RanBP5) is related to the nuclear transport
            factor importin-beta but interacts differently with RanBP1
  JOURNAL   Mol Cell Biol 17 (9), 5087-5096 (1997)
   PUBMED   9271386
REFERENCE   8  (bases 1 to 6002)
  AUTHORS   Yaseen,N.R. and Blobel,G.
  TITLE     Cloning and characterization of human karyopherin beta3
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4451-4456 (1997)
   PUBMED   9114010
REFERENCE   9  (bases 1 to 6002)
  AUTHORS   Bukrinsky,M.I., Haggerty,S., Dempsey,M.P., Sharova,N., Adzhubel,A.,
            Spitz,L., Lewis,P., Goldfarb,D., Emerman,M. and Stevenson,M.
  TITLE     A nuclear localization signal within HIV-1 matrix protein that
            governs infection of non-dividing cells
  JOURNAL   Nature 365 (6447), 666-669 (1993)
   PUBMED   8105392
REFERENCE   10 (bases 1 to 6002)
  AUTHORS   Bukrinsky,M.I., Sharova,N., Dempsey,M.P., Stanwick,T.L.,
            Bukrinskaya,A.G., Haggerty,S. and Stevenson,M.
  TITLE     Active nuclear import of human immunodeficiency virus type 1
            preintegration complexes
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6580-6584 (1992)
   PUBMED   1631159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL705630.1, BC045640.1,
            BC001497.2, BC000947.2, AK125031.1, Y08890.1, AF339834.1,
            BU618294.1 and AL137120.13.
            
            On May 17, 2019 this sequence version replaced NM_002271.5.
            
            Summary: Nucleocytoplasmic transport, a signal- and
            energy-dependent process, takes place through nuclear pore
            complexes embedded in the nuclear envelope. The import of proteins
            containing a nuclear localization signal (NLS) requires the NLS
            import receptor, a heterodimer of importin alpha and beta subunits
            also known as karyopherins. Importin alpha binds the NLS-containing
            cargo in the cytoplasm and importin beta docks the complex at the
            cytoplasmic side of the nuclear pore complex. In the presence of
            nucleoside triphosphates and the small GTP binding protein Ran, the
            complex moves into the nuclear pore complex and the importin
            subunits dissociate. Importin alpha enters the nucleoplasm with its
            passenger protein and importin beta remains at the pore.
            Interactions between importin beta and the FG repeats of
            nucleoporins are essential in translocation through the pore
            complex. The protein encoded by this gene is a member of the
            importin beta family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045640.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000651721.2/
                                                ENSP00000499125.1
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL705630.1         1-42
            43-1846             BC045640.1         24-1827
            1847-3583           BC001497.2         1615-3351
            3584-3588           BC045640.1         3565-3569
            3589-4190           BC000947.2         995-1596
            4191-4209           AK125031.1         3670-3688
            4210-4243           Y08890.1           4210-4243
            4244-4673           Y08890.1           4245-4674
            4674-5402           AF339834.1         694-1422
            5403-5982           BU618294.1         19-598              c
            5983-6002           AL137120.13        9376-9395
FEATURES             Location/Qualifiers
     source          1..6002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.2"
     gene            1..6002
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="importin 5"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
     exon            1..42
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            43..122
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            123..230
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            231..324
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..3528
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="karyopherin (importin) beta 3; RAN binding protein
                     5; Ran_GTP binding protein 5; importin beta-3 subunit;
                     karyopherin beta-3; ran-binding protein 5; importin
                     subunit beta-3; PSE1 homolog; Kap beta3 import receptor"
                     /codon_start=1
                     /product="importin-5"
                     /protein_id="NP_002262.4"
                     /db_xref="CCDS:CCDS31999.2"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
                     /translation="MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITF
                     LLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQ
                     SSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPG
                     IFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLL
                     PGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQR
                     QLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDS
                     NAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQ
                     MEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTM
                     EDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLV
                     LEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGL
                     AVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLP
                     VVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTAC
                     QMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPE
                     YLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILK
                     AKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEK
                     VLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYV
                     CDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENC
                     ISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGP
                     NNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQA
                     AIQELLNSA"
     exon            325..405
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            406..598
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            599..701
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            702..798
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            799..903
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1026
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1147
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1235
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1342
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1467
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1557
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1731
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1950
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2034
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2167
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2289
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2386
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2559
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2671
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2727
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2850
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3070
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3299
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3441
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..6002
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="hexamer: AATAAA"
     polyA_site      3588
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="major polyA site"
     regulatory      4764..4769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="hexamer: ATTAAA"
     polyA_site      4784
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="major polyA site"
     regulatory      5984..5989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /note="hexamer: AATAAA"
     polyA_site      6002
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
ORIGIN      
        1 gacctcccac aactggagca gccgggaaca gctctgacca cagtggttcc ggggagaagc
       61 ctttccagga cccatgtgta ggcacaactg ttttccctga tcaggatact tgcggcactc
      121 aacagaggaa agaaattcct aagggaacac tgctcagaaa gtactgcagc atgtcttcaa
      181 atgcctgagg atcaagttgg aaaactagaa gcaacagaaa acacaataag cgcaatggcg
      241 gcggccgcgg cggagcagca acagttctac ctgctcctgg gaaacctgct cagccccgac
      301 aatgtggtcc ggaaacaggc agaggaaacc tatgagaata tcccaggcca gtcaaagatc
      361 acattcctct tacaagccat cagaaataca acagctgctg aagaggctag acaaatggcc
      421 gccgttctcc taagacgtct cttgtcctct gcatttgatg aagtctatcc agcacttccc
      481 tctgatgttc agactgccat caagagtgag ctactcatga ttattcagat ggaaacacaa
      541 tctagcatga ggaaaaaagt ttgtgatatt gcggcagaac tggccaggaa tttaatagat
      601 gaggatggca ataaccagtg gcccgaaggt ttgaagttcc tttttgattc agtcagctct
      661 caaaatgtgg gactgcggga agctgccctt cacattttct ggaactttcc tggaattttt
      721 gggaaccagc aacaacacta tttagatgtc atcaaacgaa tgttagttca gtgtatgcaa
      781 gatcaggaac acccgtcgat caggacgtta tctgctagag ctacagctgc atttatactt
      841 gcaaatgagc ataatgttgc tctgttcaaa cattttgcag acttgctacc gggattccta
      901 caggcggtaa atgactcgtg ctaccagaat gatgattctg tcctaaaatc cctcgttgag
      961 attgcagata ctgttccaaa gtatttgcgt cctcacttgg aagcaactct acagctaagt
     1021 ctaaagttgt gtggagacac tagcctcaac aatatgcaac gccagcttgc ccttgaagtg
     1081 atcgtcaccc tctctgagac tgcagctgct atgttaagaa aacataccaa tattgttgca
     1141 cagactattc ctcagatgtt agcaatgatg gttgatttgg aagaagatga ggactgggca
     1201 aatgcagatg aactagaaga tgatgatttt gacagcaatg cagttgcagg cgagagtgct
     1261 ctagatcgaa tggcttgcgg acttggtgga aagctcgttc tgccgatgat caaggaacac
     1321 attatgcaaa tgcttcaaaa tcctgactgg aaataccggc atgcaggatt gatggcctta
     1381 tctgccattg gtgaagggtg ccaccagcaa atggaaggaa ttctaaatga gatcgtaaat
     1441 tttgttttac tttttctcca ggatcctcat ccaagagtaa ggtatgcagc ctgtaatgcc
     1501 gtgggacaga tggctacaga ttttgcacct ggtttccaaa agaaatttca tgagaaggtg
     1561 attgcagctc tgctgcagac catggaagac caaggcaatc aacgtgtgca ggcccatgca
     1621 gctgctgccc tcattaactt tactgaagac tgtcccaagt cactacttat tccatacttg
     1681 gataatttgg tgaaacatct gcattccatt atggtactga agcttcaaga gctgattcag
     1741 aaaggcacca agttagtttt ggaacaagtt gtgacatcca ttgcatcagt tgccgatact
     1801 gcagaagaaa aatttgtccc ctactatgat ttatttatgc catcactgaa gcacatcgtt
     1861 gagaatgcgg ttcaaaaaga actgagactt ctgagaggaa aaactattga atgcattagc
     1921 ctcattggtc tggctgttgg gaaggaaaaa ttcatgcagg atgcatcaga tgtgatgcag
     1981 cttttgttaa agacccagac agacttcaat gatatggaag atgatgatcc tcagatctct
     2041 tacatgatct cagcatgggc cagaatgtgc aaaatccttg gaaaagaatt tcagcaatac
     2101 cttccagtgg ttatggggcc tttaatgaag acggcttcaa ttaagcccga agtagccctt
     2161 ttagataccc aagacatgga gaatatgagt gatgatgatg gttgggaatt tgtgaacctt
     2221 ggagatcagc aaagctttgg tattaaaact gcaggactag aagaaaaatc aactgcttgc
     2281 cagatgttgg tttgctatgc taaggagtta aaggaaggct ttgtggagta caccgaacag
     2341 gttgtcaaac tgatggtccc tttactgaaa ttttatttcc acgatggtgt tcgagtggca
     2401 gcagcggaat ccatgcctct tctcctggag tgtgcaagag tccgtggtcc tgagtatctc
     2461 acacagatgt ggcattttat gtgtgatgct ctaattaagg ccattggtac agaaccagat
     2521 tcagacgtcc tctcagaaat aatgcattct tttgcaaagt gcattgaagt aatgggagat
     2581 ggatgcctta ataatgaaca ctttgaagaa ctgggaggta tattgaaagc aaagcttgaa
     2641 gaacatttta aaaatcaaga attacgacaa gttaaaagac aagatgaaga ctatgatgaa
     2701 caggtcgaag agtcactaca agatgaggat gataatgatg tttatattct gaccaaagtg
     2761 tcagatattt tacactcaat attcagtagc tacaaagaaa aggtgttacc atggtttgaa
     2821 cagctgcttc cattaattgt caacctcatt tgtccacata gaccatggcc agacagacaa
     2881 tggggattat gcatctttga tgatgtcata gaacactgta gtccagcctc atttaaatac
     2941 gcagaatatt tcttaagacc aatgctccaa tatgtatgtg acaacagccc agaagtcagg
     3001 caagcagctg catatggcct gggagtcatg gcacagtacg gtggagataa ttatcgccct
     3061 ttttgtacag aagcacttcc cctgctggta agagttattc agtctgcgga ttctaagacc
     3121 aaagaaaatg tcaatgctac agagaactgc atctcagcag tagggaaaat catgaagttc
     3181 aagcctgact gtgtaaacgt tgaagaggtc cttccacact ggttgtcttg gcttccacta
     3241 catgaagata aagaagaagc tgttcagact ttcaattatc tgtgtgacct gattgaaagt
     3301 aatcatccaa ttgttcttgg cccaaacaat accaatctgc ccaaaatatt tagtataatt
     3361 gcggaaggag aaatgcacga ggcaattaaa catgaagatc cttgtgccaa acgtctggcc
     3421 aatgtcgttc gccaagtaca gacttctgga ggactgtgga ctgagtgcat agcacagctc
     3481 agtcctgagc agcaggccgc cattcaggag ctcctgaact ctgcgtgaag ggccttaatg
     3541 tcacccacca gaaaactaac tccaaataaa cgcttaccct ttcctttagg tttctttgtt
     3601 ttgtttttga gcaaaagaga tcggtagtgt tgtgtgtagg ccattcttct ggagagccac
     3661 aagcaggaag agcagcgctg tgttgcagaa tggagtttcc atggatttct accagaccac
     3721 tgaaggagtt cctggaagcc ctgcggtagc tagcactgaa gactattttt ctattggtat
     3781 aacccgccca cctgaagggg aaagggaaat caaattaatt tttctcgtta gacataagga
     3841 aatttaagga aaaacagctt taagaacagt tactcagcgt agatgtgtgt tcacacaaat
     3901 tgctctgcat tcagtgttca ttgtgaattg ggagtgtgag tctttctgta gggtagaaag
     3961 aagcctccta cccagcaaac cagtagaccc aaaagttgaa aaaaactgat gacagacaac
     4021 aagcatgaag atggcatatt tgatgtcact ttggttcttt ttcccagaag gcttatacag
     4081 tgactcagtc gggaagcttt ccagcttcca gcccttgaat gtgaagtgtc attggcatgt
     4141 ctggcagtag tctctcattc actcctcaat aaacaacatt gaatacaaaa gaggcttgtg
     4201 taaaaactca gtactgtctg gcttggattc atttcatgtt tttaatataa gaatgatcta
     4261 atattttttt aaagtaatag ctatcagtaa tagctgagtg ttttttcccc taatattttc
     4321 cttgtgcaat tcagacttaa gcatcgagtt tttaccatct tccactttaa gctaagttat
     4381 gatacctatt ccattcacaa ttggtgttct ttttaaggtt tgcaaatttc agccaatttt
     4441 gtagctaaga ttgttctgat cagctcaaaa agatttggct tagtgttttc attgcaaatt
     4501 ataattgctg tagagccaca cacaactttt gaacttttaa ttataagtgt tatggctaaa
     4561 gttatttact gaaaatttca gtaaaatgtg tgaatgtttc tttatgtatt aacctcatag
     4621 cagtaaatga cttgctgttg tttaattttt ctaaggcatc ttaatagact tctgttgaaa
     4681 acttcagtgt taacattttt atagtttgta ctaaatttaa ccgtgatata aaaatgaatt
     4741 ttatgcatag atcagaattt taaattaaag gttttttctt taaatgattt gtattacttt
     4801 attaaaacta aatctgaaat ggaatagaaa atagaatgga ttacatacag atggtttcct
     4861 tgttagcaga tgcccttcaa atatatttta cgtttgcagc acaacaccat tgcccggagg
     4921 cttccgaatc tagcaaagca gcatattaaa tgactccacc tgcgcagtcc ttgtgttcag
     4981 tggatgaata cctgtgggct cttgtaatgt gtggtaatat ttggagcttt atagcctgta
     5041 ttccttggga gaaaaaaatg ggaattggag taaaaagtgt gtcaagacaa cccctttctg
     5101 ctttcttatg tagcatctgc aaagccgatt catgtactga tgccaatcag ctagagcaat
     5161 gtaggctttt tttaatttaa attattacta cactttatta ctacacttgc agaaaagaaa
     5221 catgttaaaa tcatggcaca cctgcagaat ttcagatgac agtgtggtca gaagatgttt
     5281 tttgggagaa cctagtgttt gctgggcact atgctaagca ctttgggagc aagaacctcc
     5341 taccttccag tttaaacact agtggtattg tcagatgccg ttagtatctg agatgtactt
     5401 acagcagggt tctaagagct ctgaaagaag cgctctgtta gatgcagact ggcagcatcc
     5461 tccttgataa aagcagaaaa gcaaagaggt aattggagtt gaatcaagtt aatagggaag
     5521 gttggtagta aatgctgtta gtgtgacatg attctgaaac ccagagctca gaactaactg
     5581 tgagatgtac catgaactaa caattctttg aaaggacctg cagaagcatt tttaatacct
     5641 cattctgtct atgcaagatg aaaatccatg gagttttttc ttggcttttg taccaaattt
     5701 aggggtcttg catgtcagca agtgatatat attgtttata aatgcaagct atttctggag
     5761 gggaaaaatg tgtgtggctc ttacgttttc tgggaatttt gtaacaagtt acacgcacaa
     5821 gtgttagaaa ctttggcata actcaatttg gagtattttt taaatgctgt atctttaaag
     5881 aaaagtaaaa ttgtcttaaa tctaattgac acttctgtaa tgagaggcaa ccttataact
     5941 ctggagttgt agtttgacag aaccatcagt aaagacataa gcaaataaat ggtcttggtg
     6001 ca
//
