LOCUS       NM_024658               3498 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens importin 4 (IPO4), transcript variant 1, mRNA.
ACCESSION   NM_024658
VERSION     NM_024658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Guo,Y., Tao,T., Wu,T., Hou,J. and Lin,W.
  TITLE     Nucleoporin Nup98 is an essential factor for ipo4 dependent protein
            import
  JOURNAL   J Cell Biochem 125 (7), e30573 (2024)
   PUBMED   38780165
  REMARK    GeneRIF: Nucleoporin Nup98 is an essential factor for ipo4
            dependent protein import.
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Zhou,Y., Liu,F., Xu,Q., Yang,B., Li,X., Jiang,S., Hu,L., Zhang,X.,
            Zhu,L., Li,Q., Zhu,X., Shao,H., Dai,M., Shen,Y., Ni,B., Wang,S.,
            Zhang,Z. and Teng,Y.
  TITLE     Inhibiting Importin 4-mediated nuclear import of CEBPD enhances
            chemosensitivity by repression of PRKDC-driven DNA damage repair in
            cervical cancer
  JOURNAL   Oncogene 39 (34), 5633-5648 (2020)
   PUBMED   32661323
  REMARK    GeneRIF: Inhibiting Importin 4-mediated nuclear import of CEBPD
            enhances chemosensitivity by repression of PRKDC-driven DNA damage
            repair in cervical cancer.
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Xu,X., Zhang,X., Xing,H., Liu,Z., Jia,J., Jin,C. and Zhang,Y.
  TITLE     Importin-4 functions as a driving force in human primary gastric
            cancer
  JOURNAL   J Cell Biochem 120 (8), 12638-12646 (2019)
   PUBMED   30861176
  REMARK    GeneRIF: Importin-4 functions as a driving force in human primary
            gastric cancer.
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Miyauchi,Y., Michigami,T., Sakaguchi,N., Sekimoto,T., Yoneda,Y.,
            Pike,J.W., Yamagata,M. and Ozono,K.
  TITLE     Importin 4 is responsible for ligand-independent nuclear
            translocation of vitamin D receptor
  JOURNAL   J Biol Chem 280 (49), 40901-40908 (2005)
   PUBMED   16207705
  REMARK    GeneRIF: demonstrated that vitamin D receptor (VDR) has two nuclear
            import systems: ligand-dependent & ligand-independent pathways, &
            that importin 4 fulfills the ligand-independent nuclear transport
            through the interaction with the amino terminus of VDR
REFERENCE   8  (bases 1 to 3498)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 3498)
  AUTHORS   Lischka,P., Sorg,G., Kann,M., Winkler,M. and Stamminger,T.
  TITLE     A nonconventional nuclear localization signal within the UL84
            protein of human cytomegalovirus mediates nuclear import via the
            importin alpha/beta pathway
  JOURNAL   J Virol 77 (6), 3734-3748 (2003)
   PUBMED   12610148
REFERENCE   10 (bases 1 to 3498)
  AUTHORS   Jakel,S., Mingot,J.M., Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Importins fulfil a dual function as nuclear import receptors and
            cytoplasmic chaperones for exposed basic domains
  JOURNAL   EMBO J 21 (3), 377-386 (2002)
   PUBMED   11823430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056527.1, BC003690.1 and AK094897.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024658.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110804.1, AK057277.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354464.11/ ENSP00000346453.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AK056527.1         7-313
            308-2073            AK056527.1         331-2096
            2074-2501           BC003690.1         1163-1590
            2502-3487           AK056527.1         2545-3530
            3488-3498           AK094897.1         3597-3607
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..3498
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /note="importin 4"
                     /db_xref="GeneID:79711"
                     /db_xref="HGNC:HGNC:19426"
     exon            1..98
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3275
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /note="imp4b; ranBP4; importin-4b; ran-binding protein 4"
                     /codon_start=1
                     /product="importin-4"
                     /protein_id="NP_078934.3"
                     /db_xref="CCDS:CCDS9616.1"
                     /db_xref="GeneID:79711"
                     /db_xref="HGNC:HGNC:19426"
                     /translation="MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDL
                     LASAADPQIRQFAAVLTRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQ
                     LSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHREL
                     LRLLNETLGEVGSPGLLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDE
                     AKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVK
                     VKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAV
                     QVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL
                     PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLG
                     HTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIA
                     TAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEEC
                     CQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVP
                     QYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGE
                     ISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPN
                     TAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCG
                     VLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFA
                     GFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPE
                     VRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMAS
                     PTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLI
                     LADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS"
     exon            99..185
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            186..265
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            266..307
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            308..437
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..617
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            618..683
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            684..785
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            786..869
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1034
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1088
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1198
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1307
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1437
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1551
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1665
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1786
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1898
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2014
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2092
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2150
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2256
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2450
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2501
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2627
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2836
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2969
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3074
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3144
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3498
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="IPO4"
                     /gene_synonym="Imp4"
                     /note="major polyA site"
ORIGIN      
        1 ggcccagtag cggcggctca gttgctgcca tggagtcagc cgggctagag cagctcctac
       61 gggagctgct gctaccggac accgagcgca tccgtcgggc cacggaacag ctccagatcg
      121 ttcttcgggc ccccgccgct ttgccggctc tctgcgacct gctagcctcg gcggccgacc
      181 cccagatccg ccagtttgcg gccgtgctga cccgcagacg actgaacacc cgctggcgac
      241 ggctggcggc ggagcaacgg gagagcctca agtccctgat cctgacggcc ctgcagagag
      301 aaacagagca ctgtgtgagc ctcagcctgg cccagctctc agccaccatt tttcgaaagg
      361 aaggcttgga ggcctggcca cagcttttgc agctgcttca gcacagtacc cacagccccc
      421 acagcccaga gagagagatg gggcttttgc tgctaagtgt ggtggtgacc tcccggcccg
      481 aggccttcca accccaccac cgggagcttc ttcggcttct gaatgagact cttggtgagg
      541 tgggctctcc tgggctgctc ttctactccc tgcgcactct gaccaccatg gctccctacc
      601 tcagcactga agatgtgcct ctcgctcgga tgttggtgcc caagctgatc atggccatgc
      661 agactctgat ccccatagat gaggcaaagg cctgtgaggc ccttgaggct ttggatgaac
      721 tgttggagtc agaggtgccg gtcatcaccc cctacctctc tgaagtcctc acattctgcc
      781 tggaggtagc tagaaatgtg gccctgggca atgcgatacg catacgtatt ctctgctgcc
      841 tcactttctt ggtcaaagtc aagagcaagg ccttactgaa gaatcgtctc ctgccaccct
      901 tgctgcacac ccttttcccc attgtggctg ctgagccccc accaggccag ttggatcccg
      961 aggaccagga ttcagaagag gaagagttgg agattgagct gatgggggag actcccaagc
     1021 atttcgctgt acaagttgtg gacatgctgg cactacacct gccccccgag aagctctgtc
     1081 cccagctgat gcccatgttg gaagaggctt tgcggagcga gagcccatac cagcgcaaag
     1141 ctggactcct ggtgctggcc gtgctgtctg acggagctgg cgaccacatc aggcagagac
     1201 tgctgccccc actgctgcag attgtgtgca agggcctgga ggacccctcg caagttgtac
     1261 gcaatgctgc gctgtttgcc ctgggccagt tctcagaaaa cctacagccc catatcagca
     1321 gctattcaag ggaggtaatg ccactgctcc tcgcctactt gaagtcggtg cctcttggac
     1381 acacacacca cctagccaag gcctgctatg ccctggagaa ttttgtggag aacctagggc
     1441 ccaaggtgca gccctacctt ccggagctta tggaatgcat gctgcagctt ctgaggaacc
     1501 ccagcagtcc ccgggccaag gagctggctg tgagcgccct gggagccatt gctacggctg
     1561 cccaggcctc gctgctgccc tacttccctg ccatcatgga gcacctgcgg gaattcctgt
     1621 taacaggccg tgaggacctt cagcctgtgc agatccagag cctggagaca ctgggggtgc
     1681 tggcacgagc agtgggggag cccatgaggc cgctggctga ggaatgctgc cagctgggtc
     1741 tgggcctctg cgaccaggta gacgaccctg acttgcggcg ctgcacgtac agcctatttg
     1801 cagccttatc gggtctgatg ggtgagggcc tggcgcccca cttggaacag atcaccacgc
     1861 tcatgctgct gtcactgcgt tccaccgagg gcattgtgcc tcagtatgac gggagcagct
     1921 ccttccttct gtttgacgat gagagtgatg gggaagaaga ggaggagctc atggatgagg
     1981 atgtggaaga agaggatgac tcagagatct cagggtacag cgtggagaat gccttcttcg
     2041 atgagaagga agacacctgt gctgccgtgg gggagatctc tgtgaacacc agtgtggcct
     2101 tccttccata catggaaagt gtctttgaag aagtatttaa actgctggag tgccctcacc
     2161 tgaatgtgcg gaaggcagcc catgaggctc tgggtcagtt ttgctgtgca ctgcacaagg
     2221 cctgtcaaag ctgcccctcg gaacccaaca ctgctgcttt gcaggctgcc ctggcccgag
     2281 tcgtgccatc ctacatgcag gcagtgaaca gggagcggga acgccaggtg gtgatggccg
     2341 tgctggaggc cctgacaggg gtgctccgca gctgtgggac cctcacactg aagccccctg
     2401 ggcgcctcgc tgagctctgt ggcgtgctca aggctgtgct gcagaggaag acagcctgtc
     2461 aggatactga cgaggaggag gaagaggaag atgatgatca ggctgaatac gacgccatgt
     2521 tgctggagca cgctggagag gccatccctg ccctggcagc cgcggctggg ggagactcct
     2581 ttgccccatt ctttgccggt ttcctgccat tattggtgtg caagacaaaa cagggctgca
     2641 cagtggcaga gaagtccttt gcagtgggga ccttggcaga gactattcag ggcctgggtg
     2701 ctgcctcagc ccagtttgtg tctcggctgc tccctgtgct gttgagcacc gcccaagagg
     2761 cagaccccga ggtgcgaagc aatgccatct tcgggatggg cgtgctggca gagcatgggg
     2821 gccaccctgc ccaggaacac ttccccaagc tgctggggct cctttttccc ctcctggcgc
     2881 gggagcgaca tgatcgtgtc cgtgacaaca tctgtggggc acttgcccgc ctgttgatgg
     2941 ccagtcccac caggaaacca gagccccagg tgctggctgc cctactgcat gccctgccac
     3001 tgaaggagga cttggaggag tgggtcacca ttgggcgcct cttcagcttc ctgtaccaga
     3061 gcagccctga ccaggttata gatgtggctc ccgagcttct gcgtatctgc agcctcattc
     3121 tggctgacaa caagatccca ccagacacca aggccgcact gttgctgctc ctgacgttcc
     3181 tggccaaaca gcacaccgac agctttcaag cagctctggg ctcactgcct gttgacaagg
     3241 ctcaggagct ccaggctgta ctgggcctct cctagactgc aggctgcagc cagtccagag
     3301 agaatagagc ctgcccaggc cttaagacca cctctcagcc cagttcagtt ctgccttacc
     3361 aaagattctg agactcatac ccatttggag ccagccccac ttgctgcctt acagggctgt
     3421 ccctgaggct ggatctgtta caaatgagtc atgacatcat actgtaataa aagcagcttg
     3481 ttttctgctt gaacaata
//
