LOCUS       NM_014652               3883 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens importin 13 (IPO13), mRNA.
ACCESSION   NM_014652 XM_003403720
VERSION     NM_014652.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3883)
  AUTHORS   Gajewska,K.A., Jans,D.A. and Wagstaff,K.M.
  TITLE     The Nuclear Transporter Importin 13 Can Regulate Stress-Induced
            Cell Death through the Clusterin/KU70 Axis
  JOURNAL   Cells 12 (2), 279 (2023)
   PUBMED   36672214
  REMARK    GeneRIF: The Nuclear Transporter Importin 13 Can Regulate
            Stress-Induced Cell Death through the Clusterin/KU70 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3883)
  AUTHORS   Gajewska,K.A., Lescesen,H., Ramialison,M., Wagstaff,K.M. and
            Jans,D.A.
  TITLE     Nuclear transporter Importin-13 plays a key role in the oxidative
            stress transcriptional response
  JOURNAL   Nat Commun 12 (1), 5904 (2021)
   PUBMED   34625540
  REMARK    GeneRIF: Nuclear transporter Importin-13 plays a key role in the
            oxidative stress transcriptional response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3883)
  AUTHORS   Zohud,B.A., Guo,P., Zohud,B.A., Li,F., Hao,J.J., Shan,X., Yu,W.,
            Guo,W., Qin,Y. and Cai,X.
  TITLE     Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear
            translocation and hTERT expression upregulation
  JOURNAL   Cell Death Dis 11 (10), 879 (2020)
   PUBMED   33082305
  REMARK    GeneRIF: Importin 13 promotes NSCLC progression by mediating RFPL3
            nuclear translocation and hTERT expression upregulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3883)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3883)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3883)
  AUTHORS   Kahle,J., Baake,M., Doenecke,D. and Albig,W.
  TITLE     Subunits of the heterotrimeric transcription factor NF-Y are
            imported into the nucleus by distinct pathways involving importin
            beta and importin 13
  JOURNAL   Mol Cell Biol 25 (13), 5339-5354 (2005)
   PUBMED   15964792
REFERENCE   7  (bases 1 to 3883)
  AUTHORS   Ploski,J.E., Shamsher,M.K. and Radu,A.
  TITLE     Paired-type homeodomain transcription factors are imported into the
            nucleus by karyopherin 13
  JOURNAL   Mol Cell Biol 24 (11), 4824-4834 (2004)
   PUBMED   15143176
REFERENCE   8  (bases 1 to 3883)
  AUTHORS   Weis,K.
  TITLE     Regulating access to the genome: nucleocytoplasmic transport
            throughout the cell cycle
  JOURNAL   Cell 112 (4), 441-451 (2003)
   PUBMED   12600309
  REMARK    Review article
REFERENCE   9  (bases 1 to 3883)
  AUTHORS   Mingot,J.M., Kostka,S., Kraft,R., Hartmann,E. and Gorlich,D.
  TITLE     Importin 13: a novel mediator of nuclear import and export
  JOURNAL   EMBO J 20 (14), 3685-3694 (2001)
   PUBMED   11447110
REFERENCE   10 (bases 1 to 3883)
  AUTHORS   Zhang,C., Sweezey,N.B., Gagnon,S., Muskat,B., Koehler,D., Post,M.
            and Kaplan,F.
  TITLE     A novel karyopherin-beta homolog is developmentally and hormonally
            regulated in fetal lung
  JOURNAL   Am J Respir Cell Mol Biol 22 (4), 451-459 (2000)
   PUBMED   10745026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB018267.1, AL357079.24 and
            BX116797.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014652.3.
            
            Summary: This gene encodes a member of the importin-beta family of
            nuclear transport proteins. The encoded protein mediates the import
            of specific cargo proteins from the cytoplasm to the nucleus and is
            dependent on the Ras-related nuclear protein-GTPase system. The
            encoded protein is also involved in nuclear export of the
            eukaryotic translation initiation factor 1A.[provided by RefSeq,
            Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018267.1, SRR1803615.249357.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372343.8/ ENSP00000361418.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1061              AB018267.1         12-1072
            1062-1062           AL357079.24        69804-69804
            1063-3882           AB018267.1         1074-3893
            3883-3883           BX116797.1         658-658
FEATURES             Location/Qualifiers
     source          1..3883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3883
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="importin 13"
                     /db_xref="GeneID:9670"
                     /db_xref="HGNC:HGNC:16853"
                     /db_xref="MIM:610411"
     exon            1..735
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             652..3543
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="karyopherin 13; Ran binding protein 13; late
                     gestation lung 2; ran-binding protein 13"
                     /codon_start=1
                     /product="importin-13"
                     /protein_id="NP_055467.3"
                     /db_xref="CCDS:CCDS503.1"
                     /db_xref="GeneID:9670"
                     /db_xref="HGNC:HGNC:16853"
                     /db_xref="MIM:610411"
                     /translation="MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNL
                     AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLK
                     AQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQ
                     GRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCV
                     RQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYV
                     NTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFL
                     ALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQ
                     LVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKL
                     GRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADT
                     VMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYA
                     ANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKL
                     AEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQ
                     QVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQ
                     ASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLA
                     QALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGK
                     VVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFP
                     SARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY"
     exon            736..1472
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1613
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1755
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1922
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2043
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2191
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2373
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2400
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2535
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2679
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2760
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2898
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..2995
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3048
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3115
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3174
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3264
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3446
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3883
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="hexamer: AGTAAA"
     polyA_site      3614
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="major polyA site"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="hexamer: ATTAAA"
     polyA_site      3883
                     /gene="IPO13"
                     /gene_synonym="IMP13; KAP13; LGL2; RANBP13"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtcttg tcagtcactg gggcggaggc agcggctgta gcggggctgt agccgggcgt
       61 tgagcacagc gcgggccagg ccgaacggaa gggacctgcc acagcccctc aactccacgg
      121 actcttcgcc ctagactagc ggagctgcat ctccgcgctt cgttggacgc ctccgtaacc
      181 acgaagggct ctctctctcc cgtgaccctc cagccccatg acctgttcat agcagccgag
      241 agctcaccca ggcgggggtg ttgtgggtac aggccatcga ccctgtgacc cctcaagagc
      301 cagggactcg gtttcccccg caggcctccc tcccctgtga ctccctccac acagattctg
      361 gggacagagc tgttacctgc cactaggatc cccgcctgag agctcctcac tgacggctcc
      421 ctcctcggag tccccttcat tgggtctcct aagagcacca attttggtct ctggcaagcc
      481 tcccaccccc aaacgaggtg gggaggcctc ggcagccatg cccgccctgg gccccccctc
      541 accccaccac tccctgggca cccaagccgg ggtctagcag ggggccagca gccaaggggc
      601 tggggcagga gacagatcag ggcccacctc cctgccaggg agggagcaaa gatggagcgg
      661 cgggaggagc agccgggggc tgcaggggct ggagcagcac cagccttgga cttcactgtg
      721 gagaacgtgg agaaggcgct gcaccagctc tactatgatc ccaacattga gaataagaac
      781 ctggctcaga agtggctgat gcaggcccag gtctccccac aggcctggca cttcagctgg
      841 cagctactgc agcccgacaa ggtaccagag atccagtact ttggggccag tgctcttcac
      901 atcaagatct ctcgctactg gagtgacatc cccactgacc agtatgaaag cctaaaggca
      961 cagctcttca cccagatcac ccgctttgcc agtggctcca agattgtact gactcggctg
     1021 tgcgtggcac tggcctcact ggctctcagc atgatgcctg acgcttggcc atgtgctgtg
     1081 gcagatatgg tacgactctt ccaggctgag gactcaccag tggatgggca gggccgctgc
     1141 ctagccctgt tagagctgct gacagtgctg cctgaggagt tccagaccag tcgcctaccc
     1201 cagtaccgca aaggcctggt gcggaccagc ctggcggtgg aatgtggggc tgtcttcccg
     1261 ctgctggagc agctgctaca gcagcccagc tcacccagct gtgtgcgtca gaaggtgctc
     1321 aagtgtttct ccagctgggt gcagctggag gtgccgctgc aggactgtga ggcgctcatt
     1381 caggctgcct ttgctgctct gcaggactcg gagctcttcg acagcagtgt ggaggccatt
     1441 gtgaatgcca tctcacagcc tgatgcccag aggtacgtga acacactcct gaaactcatc
     1501 ccgctggtgc tgggtctgca ggaacaactg cggcaggcag tgcagaatgg ggacatggag
     1561 acctcccatg gcatctgtcg catcgctgtg gccctgggcg agaaccactc ccgggccttg
     1621 ctggaccaag tagagcactg gcagagtttc ctggcactcg tcaacatgat tatgttctgc
     1681 acaggcatcc ctggccacta tcctgtcaat gagaccacca gctccctaac cctcaccttc
     1741 tggtacacac tgcaggatga tattctatcc tttgaggcag agaagcaggc tgtataccag
     1801 caggtgtacc ggccagtcta cttccagctg gtggatgtgc ttctgcacaa ggcccagttc
     1861 ccttctgatg aggaatatgg attctggtcc tcagacgaga aggagcagtt ccgaatttac
     1921 agggtggaca tctcagacac gctcatgtat gtctatgaga tgttgggggc cgagctgctc
     1981 agcaacctct atgacaagct gggtcgtttg ctcaccagct cagaggagcc ctactcctgg
     2041 cagcacacag aggccctcct ctacggcttc caatccatcg cagagaccat tgacgtcaac
     2101 tattctgatg tggtgcctgg gctcattggc ctcatcccac ggatcagcat cagcaacgtg
     2161 cagctggcag acactgtcat gttcaccatt ggagctctgt ctgaatggct ggctgaccac
     2221 cccgtcatga tcaacagtgt tctgcccttg gtactgcatg ccctaggcaa tcctgagctg
     2281 tctgtctctt ctgtgtccac cctcaagaag atctgccgag agtgcaagta tgacctgcct
     2341 ccctatgctg ccaacattgt ggctgtgtcc caggatgtgc tgatgaaaca gatccacaag
     2401 acaagccagt gcatgtggct gatgcaggcg ctgggcttcc tgctgtcagc tcttcaagtg
     2461 gaggagatcc ttaagaacct gcactcgctt atctcaccct atatccagca actggagaag
     2521 ctggcagagg agatacccaa tccctccaac aagctggcca ttgttcacat cttggggctt
     2581 ctctccaacc tcttcaccac actggacatc agtcatcatg aggatgatca tgaaggccct
     2641 gagcttcgga agctgccagt gccacaggga cccaaccccg tggtggtggt gctgcagcag
     2701 gtcttccagc ttatccagaa ggtgctgagc aaatggttga atgatgccca ggttgtggag
     2761 gcggtgtgcg ctatctttga gaagtctgtt aagacgctgc tggatgactt tgcccccatg
     2821 gtgccacagc tgtgtgagat gctgggtcgg atgtacagca ccatccccca ggcctctgct
     2881 cttgacctca ctcgacagct ggtccacatc tttgctcatg agcctgccca ctttccccca
     2941 attgaggccc tcttcctgct cgtcacctcc gtcacactca ctctcttcca gcaagggccc
     3001 agggatcatc ctgatattgt tgattcattt atgcaactcc tggcacaggc tctgaagcgg
     3061 aagccagatt tgttcctgtg tgaacgattg gatgtcaaag ctgtgttcca gtgtgctgtg
     3121 ctggccctca agttccctga ggcacctact gtcaaggcct cctgtggctt ctttacagag
     3181 ctgctgcctc ggtgtgggga agtagagtct gtgggaaagg tggtacagga agacggtcgt
     3241 atgctgctca tagcagtgct ggaggccatt gggggccagg cctcccgcag cctcatggac
     3301 tgctttgccg atatcctgtt cgccctgaac aagcactgct tcagcctcct gagcatgtgg
     3361 atcaaggagg ccctgcagcc acctggtttc ccctctgccc gcctcagccc tgaacagaag
     3421 gataccttca gccagcagat ccttcgcgag cgagtgaaca agaggcgggt gaaggagatg
     3481 gtgaaggagt tcacactgct gtgccggggt ctccatggca cagattacac agctgactac
     3541 tgaggggtgc ccccatccca tccacccctt ctcttcatcc ttccctattc ccaaagagta
     3601 aacctggacc ctcactgctg tctctgcctc ctttctgctg tcaccaccac ctaactgaaa
     3661 gcctgggtcc agaaggcctg ggggaaggat gggaggatgc ttggacccag gccttgggag
     3721 ggaatggtgg gaacatcctc tagctcccag gttggaagag atactactgt agccaagcca
     3781 cctaggctgg agcccttcag aatactgtca ttgtccttgg ggcggggtgg ttgcagtagt
     3841 gtcatcaacc cccccatccc cattaaatta atcccaacat gca
//
