LOCUS       NM_016338               4365 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens importin 11 (IPO11), transcript variant 2, mRNA.
ACCESSION   NM_016338
VERSION     NM_016338.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4365)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4365)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 4365)
  AUTHORS   Gu,Y., Wang,Y., He,L., Zhang,J., Zhu,X., Liu,N., Wang,J., Lu,T.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Circular RNA circIPO11 drives self-renewal of liver cancer
            initiating cells via Hedgehog signaling
  JOURNAL   Mol Cancer 20 (1), 132 (2021)
   PUBMED   34649567
  REMARK    GeneRIF: Circular RNA circIPO11 drives self-renewal of liver cancer
            initiating cells via Hedgehog signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4365)
  AUTHORS   Ni,H., Ji,D., Li,J., Zhao,Z. and Zuo,J.
  TITLE     The nuclear transporter importin-11 regulates the Wnt/beta-catenin
            pathway and acts as a tumor promoter in glioma
  JOURNAL   Int J Biol Macromol 176, 145-156 (2021)
   PUBMED   33571591
  REMARK    GeneRIF: The nuclear transporter importin-11 regulates the
            Wnt/beta-catenin pathway and acts as a tumor promoter in glioma.
REFERENCE   6  (bases 1 to 4365)
  AUTHORS   Plafker,K.S. and Plafker,S.M.
  TITLE     The ubiquitin-conjugating enzyme UBE2E3 and its import receptor
            importin-11 regulate the localization and activity of the
            antioxidant transcription factor NRF2
  JOURNAL   Mol Biol Cell 26 (2), 327-338 (2015)
   PUBMED   25378586
  REMARK    GeneRIF: Data indicate that ubiquitin-conjugating enzyme UBE2E3 and
            importin 11 (Imp-11)promote the nuclear accumulation and activity
            of transcription factor NF-E2 (Nrf2) by restricting the
            transcription factor from partitioning to the mitochondria
REFERENCE   7  (bases 1 to 4365)
  AUTHORS   Zuo,L., Zhang,X.Y., Wang,F., Li,C.S., Lu,L., Ye,L., Zhang,H.,
            Krystal,J.H., Deng,H.W. and Luo,X.
  TITLE     Genome-wide significant association signals in IPO11-HTR1A region
            specific for alcohol and nicotine codependence
  JOURNAL   Alcohol Clin Exp Res 37 (5), 730-739 (2013)
   PUBMED   23216389
REFERENCE   8  (bases 1 to 4365)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 4365)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Ribosomal protein L12 uses a distinct nuclear import pathway
            mediated by importin 11
  JOURNAL   Mol Cell Biol 22 (4), 1266-1275 (2002)
   PUBMED   11809816
REFERENCE   10 (bases 1 to 4365)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Importin-11, a nuclear import receptor for the
            ubiquitin-conjugating enzyme, UbcM2
  JOURNAL   EMBO J 19 (20), 5502-5513 (2000)
   PUBMED   11032817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA473424.1, BC033776.1, AF111109.1 and BM966917.1.
            
            On Feb 27, 2020 this sequence version replaced NM_016338.4.
            
            Summary: Importins, including IPO11, are a members of the
            karyopherin/importin-beta family of transport receptors (see KPNB1;
            602738) that mediate nucleocytoplasmic transport of protein and RNA
            cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by
            OMIM, Sep 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            a downstream translation initiation codon, compared to variant 1.
            The resulting isoform (2) is shorter at the N-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.26399.1, BC033776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325324.11/ ENSP00000316651.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA473424.1         18-49
            33-955              BC033776.1         12-934
            956-2569            AF111109.1         783-2396
            2570-4360           BC033776.1         2549-4339
            4361-4365           BM966917.1         284-288
FEATURES             Location/Qualifiers
     source          1..4365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..4365
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /note="importin 11"
                     /db_xref="GeneID:51194"
                     /db_xref="HGNC:HGNC:20628"
                     /db_xref="MIM:610889"
     exon            1..167
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            168..311
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..3101
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /note="isoform 2 is encoded by transcript variant 2; Ran
                     binding protein 11; imp11; ran-binding protein 11"
                     /codon_start=1
                     /product="importin-11 isoform 2"
                     /protein_id="NP_057422.3"
                     /db_xref="CCDS:CCDS34167.1"
                     /db_xref="GeneID:51194"
                     /db_xref="HGNC:HGNC:20628"
                     /db_xref="MIM:610889"
                     /translation="MDLNSASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSV
                     LLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPI
                     NQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLAS
                     KRLAADRKLFYDLASGIYNFACSLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVL
                     RKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKV
                     LLDFLDQHPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYK
                     PSKNFEDSSPETLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFT
                     VEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIK
                     DAVYNAVGLAAYELFDSVDFDQWFKNQLLPELQVIHNRYKPLRRRVIWLIGQWISVKF
                     KSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQ
                     LLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEHNMLRCAIL
                     TTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCIT
                     PELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEI
                     TTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRV
                     LLQNTSFFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERRKLSALALLSLL
                     PSDNSVIQDKFCGIINISVEGLHDVMTEDPETGTYKDCMLMSHLEEPKVTEDEEPPTE
                     QDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETVDTEIVTQLQEFL
                     QGF"
     exon            312..412
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            413..485
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            486..689
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            690..822
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            823..881
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            882..930
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1001
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1194
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1347
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1391
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1482
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1530
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1636
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1763
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1797
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1838
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1955
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2069
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2185
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2262
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2342
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2423
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2519
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2633
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2755
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2851
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2936
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..4365
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /note="hexamer: ATTAAA"
     polyA_site      4365
                     /gene="IPO11"
                     /gene_synonym="RanBP11"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtttgga gctgcgacgc caaacatggc gtgttcctag aagccgcttt cggcatcagt
       61 aggcggcggc gtggggtctg gcagcgtggg gagagggacc aaccgacgcc acttcgtgtt
      121 gggaagtggg agcgggaggg ccgggcaatt cccgaccgaa ccaaacggtt tccatggatc
      181 tcaatagtgc cagcactgtt gttcttcagg tgttaacaca ggccaccagt caggatactg
      241 ctgtgttaaa accagctgag gagcagttga agcagtggga gacacagcca ggtttctatt
      301 cagtgttgct gaatattttc accaaccaca ctttggatat aaatgtaagg tggcttgctg
      361 tactgtattt taaacatgga attgatcgct actggagacg tgtagcacct catgctctct
      421 cagaggagga gaaaactact ctgcgtgcag ggctcatcac caacttcaat gaaccaataa
      481 accagattgc aactcagatt gcagtgctca ttgcaaaagt tgctagattg gattgtccca
      541 gacagtggcc tgaactaatt cccactctta tagagtctgt taaagtccag gatgatcttc
      601 gacagcacag agcattactt accttctatc atgttaccaa gacactggca tctaaacgac
      661 ttgctgctga tagaaaacta ttttatgatt tagcttctgg aatttataat tttgcctgct
      721 ctctgtggaa tcaccacaca gacacattcc tgcaagaagt ttcttctggc aatgaagctg
      781 caattttgag ttcactagaa cgaacactgc tatcattgaa agtgctgcgt aagttaactg
      841 ttaatggatt tgtggaacct cataagaata tggaggtgat gggtttttta catggaatat
      901 ttgaacgtct aaaacagttt ctggaatgca gtagaagtat aggtacagat aatgtgtgta
      961 gagatagact ggaaaagacc atcattcttt ttactaaagt gcttttggac ttcttggatc
     1021 agcatccttt ttcatttact cctctaattc agagatcact ggaattttct gtaagctatg
     1081 tttttacaga agttggtgaa ggcgttacat ttgaacgatt cattgtccaa tgtatgaatc
     1141 ttattaagat gattgtcaaa aattatgctt ataagccatc caaaaatttt gaagatagca
     1201 gccctgaaac tcttgaagcc cataagatta agatggcatt cttcacatat cctactttga
     1261 cagagatatg tagaagatta gtctctcatt atttcctatt aactgaagaa gaactgacaa
     1321 tgtgggaaga agacccagaa ggctttacag tggaagaaac aggaggagat tcttggaaat
     1381 atagtttgag gccatgcact gaagtattat ttatagatat attccatgaa tataatcaga
     1441 ctcttactcc tgtacttcta gaaatgatgc aaacacttca aggacccaca aatgtggaag
     1501 atatgaatgc actgttaatc aaagatgctg tgtataatgc tgttggatta gctgcttatg
     1561 agctctttga cagtgttgat tttgatcagt ggtttaaaaa ccagcttctt ccagaattac
     1621 aagtcattca caataggtat aagccattgc gacgcagggt gatttggctc atcggtcagt
     1681 ggatttctgt gaaattcaag tctgacttaa gacccatgct ttatgaagca atctgtaact
     1741 tgcttcaaga tcaagattta gtggtccgta ttgaaacagc tacaactttg aagttaactg
     1801 ttgatgattt tgaatttaga acagatcagt ttctaccgta tttggaaacc atgttcacac
     1861 tactttttca gttactgcag caagttacag aatgtgacac aaagatgcat gttttgcatg
     1921 tcctttcttg tgtgatcgaa agagtcaaca tgcagatacg accatatgtg ggatgtttgg
     1981 tacaatattt gcccctcctt tggaagcaga gtgaagaaca caatatgttg agatgtgcta
     2041 ttttgacaac acttattcat cttgttcagg gattaggagc agacagcaag aacctgtacc
     2101 ctttcctgct cccagttatt caactgagta cagatgtttc acagcctcca catgtttatc
     2161 ttctggaaga tggtttagaa ttatggttag taactttgga aaacagtcca tgtattacac
     2221 cagagttgct tcgtatattt cagaatatgt caccacttct tgaactaagt tcagaaaatc
     2281 ttagaacttg ctttaagatc atcaatggtt atatcttttt atcatcaaca gaatttttac
     2341 agacatacgc agtaggtcta tgccagtcct tttgtgaact tttaaaggaa attactacag
     2401 aaggtcaagt tcaggtgctc aaggttgtgg aaaatgccct taaagtgaac ccaatactag
     2461 gtccacaaat gtttcaaccg attttaccct atgttttcaa gggtattata gaaggggaga
     2521 ggtatcctgt agtgatgtcc acgtatcttg gagttatggg tcgagttcta ctacaaaaca
     2581 ctagtttttt ttcttcacta cttaatgaga tggcccataa atttaatcag gagatggacc
     2641 agcttttggg aaatatgatt gaaatgtggg ttgatcgaat ggacaacatt acccagcctg
     2701 aaagaagaaa actttcagct ttggctttgc tctctcttct gccatctgat aatagtgtta
     2761 tccaagataa attctgtggg attataaaca tttcagtaga aggcctgcat gatgtcatga
     2821 cggaagatcc tgaaacagga acttataaag actgtatgtt gatgtctcat cttgaggaac
     2881 caaaagtaac agaagatgaa gaaccaccca cagaacaaga taagaggaaa aagatgctgg
     2941 ccctgaagga ccctgttcat acagtgtcac tgcagcagtt catctacgag aagctcaagg
     3001 cacagcagga gatgctagga gaacaaggtt tccagtccct catggaaaca gtggatacgg
     3061 agattgtcac ccagctacag gagtttttgc aaggattcta agagcacatg acatgtggct
     3121 gcctcccctt tcagaaacaa gctgagtaac ccagcctgcc gtttgtatgt gagagcctgc
     3181 tgagatgaag aaatcacttc atgaaaataa gcaaagacca cacatttttt actacaaaat
     3241 gtaaaggata aatgtaaatc ctgcataact aaaatcacaa acctattcct caaaagaatt
     3301 taattttata tttatgaggg ggcccttcac taaaaagtac atgtaaaagt acatttgatg
     3361 acaatagctg cttagtttcc tgttaagaga agaaacttta tcttttaatt atgtgctctt
     3421 aatatttgaa gatgagagtt aatacctgag atgtttttct gcaaccaaaa ttcattaaat
     3481 ttggctgcct tatccttttt ttaagctaat gaaactacag gtttgaaaaa tgacaaagct
     3541 gttcagatga tgctattaaa gaaatgtgtg tactaagcaa aaatatataa atagtgacaa
     3601 atacacatta ccaagcttat cttgcaaggg agttattttc atctaacata gaaagtgtgt
     3661 tttatcagac aaatgctttt attttcattc taataatttg atacagaaat tagtaaaggc
     3721 atttttttct ttttttttcc agtaaataca ttgggtctat aaatgtgcat ttgtaagggc
     3781 cacaaaagtg aacgtgtggt actgtagtac cacgtgggag acctctggtt atggtttagt
     3841 cctagttcct ttgttactcc tgtgagcacc gagaagaact gggcgactcc cagtcccacc
     3901 tgtgctgtga cagtcccacg tggctatgac agactgttta gtacttaccc ttctcaggtt
     3961 cctcagtgca ggggtgcatc agggcctcaa taataggggt atacctggga ggatccagca
     4021 gtaatcccca gggtactagg attactagta ctctgatgga actagtcttc cttccttatt
     4081 cctcgaacat gcagtacata aaaaggggaa aaggagaaaa aaaaagcctt actttgtttt
     4141 acttgccatt tattgtaagg aaactttaaa gcatttttta ggaaatactc aaaagcaagg
     4201 ttggaaaatg ttttatcttt ctatagaaag ttgggtacag tatgtaactg cgggaaaccc
     4261 actgcccctt tgtaagctgt ggaacccaaa ctgtatgggg atatttgatg ttttcagaaa
     4321 gaggaagaaa atatggtcca aattaaattt tccaaagata cctca
//
