LOCUS       NM_152230               6093 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate multikinase (IPMK), mRNA.
ACCESSION   NM_152230
VERSION     NM_152230.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6093)
  AUTHORS   Lee,H., Kim,E. and Kim,S.
  TITLE     miRNA-Induced Downregulation of IPMK in Macrophages Mediates
            Lipopolysaccharide-Triggered TLR4 Signaling
  JOURNAL   Biomolecules 13 (2), 332 (2023)
   PUBMED   36830701
  REMARK    GeneRIF: miRNA-Induced Downregulation of IPMK in Macrophages
            Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6093)
  AUTHORS   Dato,S., Crocco,P., De Rango,F., Iannone,F., Maletta,R.,
            Bruni,A.C., Saiardi,A., Rose,G. and Passarino,G.
  TITLE     IP6K3 and IPMK variations in LOAD and longevity: Evidence for a
            multifaceted signaling network at the crossroad between
            neurodegeneration and survival
  JOURNAL   Mech Ageing Dev 195, 111439 (2021)
   PUBMED   33497757
  REMARK    GeneRIF: IP6K3 and IPMK variations in LOAD and longevity: Evidence
            for a multifaceted signaling network at the crossroad between
            neurodegeneration and survival.
REFERENCE   3  (bases 1 to 6093)
  AUTHORS   Chen,D., Wang,Z., Zhao,Y.G., Zheng,H., Zhao,H., Liu,N. and Zhang,H.
  TITLE     Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase
            Separation of TFEB to Negatively Regulate Autophagy Activity
  JOURNAL   Dev Cell 55 (5), 588-602 (2020)
   PUBMED   33290695
  REMARK    GeneRIF: Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid
            Phase Separation of TFEB to Negatively Regulate Autophagy Activity.
REFERENCE   4  (bases 1 to 6093)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6093)
  AUTHORS   Morgan-Lappe,S., Woods,K.W., Li,Q., Anderson,M.G., Schurdak,M.E.,
            Luo,Y., Giranda,V.L., Fesik,S.W. and Leverson,J.D.
  TITLE     RNAi-based screening of the human kinome identifies Akt-cooperating
            kinases: a new approach to designing efficacious multitargeted
            kinase inhibitors
  JOURNAL   Oncogene 25 (9), 1340-1348 (2006)
   PUBMED   16247451
REFERENCE   6  (bases 1 to 6093)
  AUTHORS   Chang,S.C. and Majerus,P.W.
  TITLE     Inositol polyphosphate multikinase regulates inositol
            1,4,5,6-tetrakisphosphate
  JOURNAL   Biochem Biophys Res Commun 339 (1), 209-216 (2006)
   PUBMED   16293229
REFERENCE   7  (bases 1 to 6093)
  AUTHORS   Mayr,G.W., Windhorst,S. and Hillemeier,K.
  TITLE     Antiproliferative plant and synthetic polyphenolics are specific
            inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and
            inositol polyphosphate multikinase
  JOURNAL   J Biol Chem 280 (14), 13229-13240 (2005)
   PUBMED   15659385
  REMARK    Erratum:[J Biol Chem. 2007 Nov 30;282(48):35424]
REFERENCE   8  (bases 1 to 6093)
  AUTHORS   Nalaskowski,M.M. and Mayr,G.W.
  TITLE     The families of kinases removing the Ca2+ releasing second
            messenger Ins(1,4,5)P3
  JOURNAL   Curr Mol Med 4 (3), 277-290 (2004)
   PUBMED   15101685
  REMARK    Review article
REFERENCE   9  (bases 1 to 6093)
  AUTHORS   Chang,S.C., Miller,A.L., Feng,Y., Wente,S.R. and Majerus,P.W.
  TITLE     The human homolog of the rat inositol phosphate multikinase is an
            inositol 1,3,4,6-tetrakisphosphate 5-kinase
  JOURNAL   J Biol Chem 277 (46), 43836-43843 (2002)
   PUBMED   12223481
  REMARK    GeneRIF: the major activity of human InsP(4) 5-kinase is
            phosphorylation at the D-5 position [InsP(4) 5-kinase]
REFERENCE   10 (bases 1 to 6093)
  AUTHORS   Nalaskowski,M.M., Deschermeier,C., Fanick,W. and Mayr,G.W.
  TITLE     The human homologue of yeast ArgRIII protein is an inositol
            phosphate multikinase with predominantly nuclear localization
  JOURNAL   Biochem J 366 (Pt 2), 549-556 (2002)
   PUBMED   12027805
  REMARK    GeneRIF: cloning of a full-length 1248-bp cDNA encoding a human
            inositol phosphate multikinase (IPMK); localized predominantly in
            the nucleus when transiently expressed in mammalian cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065709.1 and AC026884.7.
            
            On Nov 23, 2018 this sequence version replaced NM_152230.4.
            
            Summary: This gene encodes a member of the inositol phosphokinase
            family. The encoded protein has 3-kinase, 5-kinase and 6-kinase
            activities on phosphorylated inositol substrates. The encoded
            protein plays an important role in the biosynthesis of inositol
            1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity.
            This gene may play a role in nuclear mRNA export. Pseudogenes of
            this gene are located on the long arm of chromosome 13 and the
            short arm of chromosome 19. [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.200331.1,
                                           SRR1660803.36997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373935.4/ ENSP00000363046.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1753              BC065709.1         45-1797
            1754-6093           AC026884.7         133785-138124       c
FEATURES             Location/Qualifiers
     source          1..6093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..6093
                     /gene="IPMK"
                     /note="inositol polyphosphate multikinase"
                     /db_xref="GeneID:253430"
                     /db_xref="HGNC:HGNC:20739"
                     /db_xref="MIM:609851"
     exon            1..473
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1534
                     /gene="IPMK"
                     /EC_number="2.7.1.153"
                     /EC_number="2.7.1.151"
                     /EC_number="2.7.1.140"
                     /note="inositol 1,3,4,6-tetrakisphosphate 5-kinase"
                     /codon_start=1
                     /product="inositol polyphosphate multikinase"
                     /protein_id="NP_689416.1"
                     /db_xref="CCDS:CCDS7250.1"
                     /db_xref="GeneID:253430"
                     /db_xref="HGNC:HGNC:20739"
                     /db_xref="MIM:609851"
                     /translation="MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLN
                     GCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGV
                     LLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEK
                     IQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNG
                     YCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEK
                     FLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTS
                     LKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPS
                     NTIDEGYVYGLKHLISVLRSILDN"
     exon            474..559
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     exon            560..656
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     exon            657..829
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     exon            830..911
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     exon            912..6093
                     /gene="IPMK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6072..6077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPMK"
                     /note="hexamer: ATTAAA"
     polyA_site      6093
                     /gene="IPMK"
                     /note="major polyA site"
ORIGIN      
        1 gttcttcggc tcggttctgt ctaccgggca gcgccggggc cggcggctgc ggcggcagag
       61 gaacaggagc cgggagccgc gttccgccga gagttgggca gaggagcgcc cgcgccccgg
      121 cggcgtcatg ggccccctcc ccgcgcttca gagggcacca gccgcgggaa cccccgggcc
      181 tcctcgcgcc cgagcctgag cgaccctcgg gttctccggc gccccctccc tcgccctatt
      241 ttttttccta ctctcgctgc cgttaccgct tctgctctcc gttatggcaa cagagccacc
      301 atcccccctc cgggtcgagg cgccgggccc cccagaaatg cggacctcac cggcgatcga
      361 gtccacccct gagggcaccc cgcagccggc gggcggcaga ctccgcttcc tcaacggctg
      421 cgtgcccctc tcgcatcagg tggccgggca catgtacggg aaggacaaag tgggtatact
      481 gcaacatcca gatggcacag ttttgaaaca gttacaacca cctccaaggg gcccaagaga
      541 gctggaattc tataatatgg tttatgctgc tgactgtttt gatggtgttc ttctagagct
      601 acgaaaatat ttgccaaaat attatggcat ctggtcacct cccactgcac caaacgattt
      661 atacctaaaa ctggaagatg tgacccataa atttaataag ccctgtataa tggatgtaaa
      721 gatagggcaa aaaagctatg atccttttgc ctcatctgag aagattcagc aacaggtcag
      781 caagtaccca ttaatggaag agattgggtt cttggtgctt ggcatgaggg tttatcatgt
      841 tcattccgat agctatgaga cagaaaacca gcattacgga agaagcttaa caaaagaaac
      901 tataaaggat ggagtctcca gattttttca taatgggtac tgcttaagaa aagatgctgt
      961 tgctgccagt attcagaaga ttgagaaaat tctgcagtgg tttgaaaacc agaagcagct
     1021 taatttttac gcaagttcat tactctttgt ttatgaaggt tcatctcagc caaccactac
     1081 aaaattgaat gacagaactt tggcagaaaa gtttttgtcc aaaggacaac tgtcagacac
     1141 agaagtacta gagtacaata ataactttca tgtgttaagt tccacagcta atggaaaaat
     1201 agagtcttca gtgggcaaaa gcttgtccaa gatgtatgcg cgtcacagga aaatatatac
     1261 aaaaaagcat cacagtcaga cttcattgaa agttgaaaat ctggagcaag acaatgggtg
     1321 gaaaagcatg tcacaggaac atttaaatgg aaatgtactt tcccaactgg aaaaagtttt
     1381 ctaccatctt cccactggtt gccaagagat tgctgaagta gaagtgcgaa tgatagattt
     1441 tgctcatgtg ttccctagca acacaataga tgagggatat gtttatgggc taaagcattt
     1501 aatttctgta cttcgaagta ttttagacaa ttgaatcctc tgttgcagtc tttttaaggg
     1561 gtgggccaat cataatgaag aggggcagtc aatatctgca cctttaatgc tatgtaaaaa
     1621 atttgtatta tgagtcgaca ttttatttgt ctttatactt ttggaagaat ggttaacttt
     1681 tttataatct tactcaggaa aactaactat ttgttcatta gaaaactatg aagaataaag
     1741 aaacttagga atgttaagca gggaatgtgg tggtacatgg cttaaacatc ttttttggct
     1801 caagcaaaat gcaaaccatt attcagtcat taagagttta gttagctttc tgtagccaat
     1861 tcatgaaatc tctgtccacc cagccttgac aatgagccat atctaaaata ttacattatt
     1921 agaacaccta ccaaaatctc gaaagcacag gttgatgtcc ttagtattgc tatgtatgaa
     1981 gttactaaaa ctggagaaaa ttctacttca gaaataagta ctgtttaggt tttatattaa
     2041 aagttcagac cagcatatca aagggtgctc cttagtgaaa tgatttagaa ttgttgcatt
     2101 ccaaaagcag gttttctctt taatttttac atctctctct caaaatatta tacttcatga
     2161 aaaagacaat tgatgtggat gacaacaaca aagtcttgaa attaagggca cactaattgt
     2221 ccttactggg gttaggggaa gagagatatt attttcaagg aacaaaatat tttcctttac
     2281 aatctttcat tcatgagaaa attggaatat aaatttatta cattgtgaaa gtatcataaa
     2341 ccatatacct ttgtatctaa atgcagcttc aaaaaagtaa ataattgaag ttttatttct
     2401 cctctaaata acttgaattt ttttctttaa aaatttatgt atttatatgt ccccatttag
     2461 ttaagtggta gtgtaaatgt atgttgttaa aaacagtttc tcagaattat agtaagcaat
     2521 gaaagacaat atctaattag gttgttatca aaaatactgt gtgtaaatta gtccgtaata
     2581 tagggtttgg tgcgtatcta tattcatgct tctatttcac tcttcctcaa aacagtttta
     2641 tattatgttg accagtgaaa ttgtaactta atttcatggg gacaggggca gtgctacagt
     2701 tcctggaaaa attagatttg tattatcttt gtttcacacc caccacctta aaaaaaaatc
     2761 aactagttat ttgtcattta aaacatttaa aactttgagt cttcaaatac atttgatgtt
     2821 aatgctgcca ttacttgcac ttccattcac taataacatt tctaggtagt tatcagtttt
     2881 gtcatattcc tggaaaatat tttggggttg taaattcttt ctcctctttt tcttctggag
     2941 ttacaaattg aatttttaaa tccgagcacc tttattgtgg tgtggagaaa attatcacaa
     3001 ttttatgttt attttacctt ctcagccttc tctgagggca ctttgcaaat acctgagtcc
     3061 aaacagaagt accaactaaa tgctctatga actctatcct tagtaaatct attaaacctg
     3121 aataatttaa aagatcatgt tcattttgta atagcaaaat ttgattttaa ttttttattt
     3181 agaattggtg tatttatcat agggacttcc aatttttctt cactttttga atggatattg
     3241 gctatagttt tatgttttaa cgggaatgaa tttcaagtca taataatcag aatttttagt
     3301 tttacttttt tcttttacaa tatggatttt gttgttattt ggatagtggt tcaataaatc
     3361 ttaagctcag ataattaaac actattttga atcttaacaa gatactgagg ctttttttgt
     3421 atgggatgat atcaacctat gtacaatgaa tttaataaac ttaagtattg tcagattttt
     3481 tgcacatttt agctcaataa aatcttaatg ttcaagattt ttttatctgc atttggaaat
     3541 acaattttgt aaaatcaatg tcttaccttt ttgatacaat agatcatgtt ttgtttttaa
     3601 taaagcaaga agccctttta tctgttgttt ttcagggaag ggattaacat ttaattctgt
     3661 ttgtttacat ttgttatcat tgttatccaa tgctcatttt atgttgcttt ataagtaggc
     3721 ttaggtataa cagaataagt atctgtttat ctaatctaca tgtgactatc ttagtctctc
     3781 tcggtcactt aatattatgc tgaaatttac cactgtgggg atgaatgatc gctattcacc
     3841 aagtatattt gaacatgtaa atgcttaaga aataagcata atgcggatat agtttgggtt
     3901 aataggattc tcatagtttt ttttccccta tgaaacataa gtaatgattt tagtgtattt
     3961 cttatggaat acactcattt aaaaaggact ttaagaaatt gtggatgtga ataatacctt
     4021 tctctaataa aaatttaaat tgtataatag ttttataata tttacattaa ttgatatttt
     4081 aatatggata gacattgcat agattcaaat aaattaaaat caatgataaa tgctaaatat
     4141 tttatctaaa tagtttttca agaaacagtt atggaaatgt gtatattaaa tggctctaat
     4201 gtggagcttg tggtatttca actcagtatt cattattagt tgtgtgtctg gaaagattgt
     4261 acttactttt cctctttaca ctacagtttg ctcttatggg gctctaaact gtttaactga
     4321 agaaccttcg tctgtatttt gattgagcat aatttagtat tttatgattt ccaagatgat
     4381 gttcttatgt ctatcaagtc tatgtatcaa atttataaca tcatttaaga aaaaggaatt
     4441 tccacagata cttcagttgc aattttttgt ttcatgctac tgaaaataca tttgtttcta
     4501 ggggttggaa tattatagaa gatgtaggat gaaagaaaac gatagaacaa cgaaagaatt
     4561 ctgtttatga aattacagga attgtgtcca ctatggtaaa gcattgtcat tttagtacat
     4621 tttctcttag tagtttggca ttttatactt taaaacttgt tttgctttaa aaattgttta
     4681 taatgcttac cttctttctc cagtgccttt agtcttgatt tgatatgttt gtaccctcag
     4741 ttaccctttc tattacatgt ttttgatgtt ttcatagcct aggaaacatc gattcctttt
     4801 taataattgt caatctgatt atttaaagag gtaacaatta tctgttaatg ctttggaaaa
     4861 acaagtaggg ttgcctttgg aggccaggct tcttagttca ttcaaaaata ttccttggat
     4921 ttatgccatg tattaagcat ttttagcccc cagtattaca actgtgaacc aaacggataa
     4981 ggccctaacc attttcagca ttctctttgg atggggtggg attggggact taattaaaat
     5041 agagatatag aaaaataggc atctaaataa gataataagt gtggggttga aatgaagcat
     5101 ctaacaatag ttgaagttag aagtaatatt ttacagtatt gtaacctcta tttaagtttg
     5161 ggtattagtt acagatagca taaaaaagcc ttaatttttc actttccttg ctggcaaagg
     5221 tacatttatt tagactgtcc atttaaagta atgtttaaca taaacattac tgtgaaaaac
     5281 attccattac atattcccaa gcaaatgagc tgcatcttct ttactgtatt ttacaattta
     5341 gtacaacagt tttaggcctc aatcttaaca tcactggtat tttaaatttg gcaatgaata
     5401 tgaaattact tttgacttac agattgatta tattattact ttgaaaatgc attaatttct
     5461 tagaaaagtt tggagcctct atcttttttt gagttaatac ttaaattctc attacttata
     5521 ttaatagcct gtactaagtg aaaatattat ttatgcaagt aaacaagtca ctataggctt
     5581 ttaagacttt tctttaattt tagattttgt catcaaagtt taaatttttt acctactgtc
     5641 cacttaaata taatttaaca gtttgtaaag tgaaatagtt ttaagtatga tgtatgatgc
     5701 acctgcatat aaatgaaaat ggcgtgcaca aagacacttt actatgggaa ctgtactgga
     5761 agatttatga aagcatgtga aattgcacct aaaattgtgt tattagtgac tataagcagc
     5821 aatgctaaat ttattgtact tgatgaatga atgtatttag tcacagttac tttggtttaa
     5881 atgtataaat gtctttaggg ttttttttta aatgtgtttg taatttgtac tattgtgggg
     5941 gtatacttgg actgcagggg ttattgtcaa tgtgtgattt gtgtttttat tttatagaat
     6001 catctaatgt gatataccaa tttttataag tgatatttac ataattctaa taactgtata
     6061 tttgacaacc tattaaaatg ttttgcattg gaa
//
